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Q8N3X1

- FNBP4_HUMAN

UniProt

Q8N3X1 - FNBP4_HUMAN

Protein

Formin-binding protein 4

Gene

FNBP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Enzyme and pathway databases

    SignaLinkiQ8N3X1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formin-binding protein 4
    Alternative name(s):
    Formin-binding protein 30
    Gene namesi
    Name:FNBP4
    Synonyms:FBP30, KIAA1014
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19752. FNBP4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti1106. Microphthalmia with limb anomalies.
    PharmGKBiPA134971679.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10171017Formin-binding protein 4PRO_0000289863Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181Phosphoserine2 Publications
    Modified residuei116 – 1161Phosphoserine2 Publications
    Modified residuei172 – 1721Phosphothreonine1 Publication
    Modified residuei290 – 2901N6-acetyllysineBy similarity
    Modified residuei432 – 4321Phosphoserine5 Publications
    Modified residuei435 – 4351Phosphoserine1 Publication
    Modified residuei464 – 4641Phosphoserine1 Publication
    Modified residuei479 – 4791Phosphothreonine1 Publication
    Modified residuei499 – 4991Phosphoserine1 Publication
    Modified residuei508 – 5081Phosphoserine3 Publications
    Modified residuei963 – 9631Phosphoserine1 Publication
    Modified residuei964 – 9641Phosphoserine1 Publication
    Modified residuei965 – 9651Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8N3X1.
    PaxDbiQ8N3X1.
    PRIDEiQ8N3X1.

    PTM databases

    PhosphoSiteiQ8N3X1.

    Miscellaneous databases

    PMAP-CutDBQ8N3X1.

    Expressioni

    Gene expression databases

    BgeeiQ8N3X1.
    CleanExiHS_FNBP4.
    GenevestigatoriQ8N3X1.

    Organism-specific databases

    HPAiHPA039485.
    HPA040029.

    Interactioni

    Subunit structurei

    Binds FMN1. Interacts with the Arg/Gly-rich-flanked Pro-rich of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HTTP428586EBI-310600,EBI-466029

    Protein-protein interaction databases

    BioGridi116941. 13 interactions.
    IntActiQ8N3X1. 4 interactions.
    MINTiMINT-127221.
    STRINGi9606.ENSP00000263773.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N3X1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini214 – 24835WW 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini595 – 62935WW 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi630 – 6356Poly-Glu
    Compositional biasi701 – 73131Pro-richAdd
    BLAST
    Compositional biasi905 – 92521Pro-richAdd
    BLAST

    Domaini

    These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability By similarity.By similarity

    Sequence similaritiesi

    Contains 2 WW domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG46362.
    HOGENOMiHOG000168238.
    HOVERGENiHBG066308.
    InParanoidiQ8N3X1.
    OMAiKMPPPEK.
    OrthoDBiEOG75F4GV.
    PhylomeDBiQ8N3X1.
    TreeFamiTF331046.

    Family and domain databases

    InterProiIPR001202. WW_dom.
    [Graphical view]
    PfamiPF00397. WW. 2 hits.
    [Graphical view]
    SMARTiSM00456. WW. 2 hits.
    [Graphical view]
    SUPFAMiSSF51045. SSF51045. 2 hits.
    PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N3X1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGKKSRAVPG RRPILQLSPP GPRGSTPGRD PEPEPDTEPD STAAVPSQPA     50
    PSAATTTTTA VTAAAASDDS PSEDEQEAVQ EVPRVVQNPP KPVMTTRPTA 100
    VKATGGLCLL GAYADSDDDD NDVSEKLAQS KETNGNQSTD IDSTLANFLA 150
    EIDAITAPQP AAPVGASAPP PTPPRPEPKE AATSTLSSST SNGTDSTQTS 200
    GWQYDTQCSL AGVGIEMGDW QEVWDENTGC YYYWNTQTNE VTWELPQYLA 250
    TQVQGLQHYQ PSSVPGAETS FVVNTDIYSK EKTISVSSSK SGPVIAKREV 300
    KKEVNEGIQA LSNSEEEKKG VAASLLAPLL PEGIKEEEER WRRKVICKEE 350
    PVSEVKETST TVEEATTIVK PQEIMLDNIE DPSQEDLCSV VQSGESEEEE 400
    EQDTLELELV LERKKAELRA LEEGDGSVSG SSPRSDISQP ASQDGMRRLM 450
    SKRGKWKMFV RATSPESTSR SSSKTGRDTP ENGETAIGAE NSEKIDENSD 500
    KEMEVEESPE KIKVQTTPKV EEEQDLKFQI GELANTLTSK FEFLGINRQS 550
    ISNFHVLLLQ TETRIADWRE GALNGNYLKR KLQDAAEQLK QYEINATPKG 600
    WSCHWDRDHR RYFYVNEQSG ESQWEFPDGE EEEEESQAQE NRDETLAKQT 650
    LKDKTGTDSN STESSETSTG SLCKESFSGQ VSSSSLMPLT PFWTLLQSNV 700
    PVLQPPLPLE MPPPPPPPPE SPPPPPPPPP PAEDGEIQEV EMEDEGSEEP 750
    PAPGTEEDTP LKPSAQTTVV TSQSSVDSTI SSSSSTKGIK RKATEISTAV 800
    VQRSATIGSS PVLYSQSAIA TGHQAAGIGN QATGIGHQTI PVSLPAAGMG 850
    HQARGMSLQS NYLGLAAAPA IMSYAECSVP IGVTAPSLQP VQARGAVPTA 900
    TIIEPPPPPP PPPPPPPPAP KMPPPEKTKK GRKDKAKKSK TKMPSLVKKW 950
    QSIQRELDEE DNSSSSEEDR ESTAQKRIEE WKQQQLVSGM AERNANFEAL 1000
    PEDWRARLKR RKMAPNT 1017
    Length:1,017
    Mass (Da):110,266
    Last modified:November 30, 2010 - v3
    Checksum:i510DC8011B5973AD
    GO
    Isoform 2 (identifier: Q8N3X1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         73-73: E → EGK

    Show »
    Length:1,019
    Mass (Da):110,451
    Checksum:i2D60B6B14CC4CE16
    GO

    Sequence cautioni

    The sequence BAA76858.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti55 – 562Missing in BAA76858. (PubMed:10231032)Curated
    Sequence conflicti55 – 562Missing in AAH37404. (PubMed:15489334)Curated
    Sequence conflicti55 – 562Missing in CAB70761. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti125 – 1251E → G.
    Corresponds to variant rs34962598 [ dbSNP | Ensembl ].
    VAR_032623
    Natural varianti794 – 7941T → A.
    Corresponds to variant rs35040940 [ dbSNP | Ensembl ].
    VAR_032624

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei73 – 731E → EGK in isoform 2. 1 PublicationVSP_040292

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023231 mRNA. Translation: BAA76858.2. Different initiation.
    AC021443 Genomic DNA. No translation available.
    BC037404 mRNA. Translation: AAH37404.1.
    AL137480 mRNA. Translation: CAB70761.1.
    AK022987 mRNA. Translation: BAB14348.1.
    CCDSiCCDS41644.1. [Q8N3X1-1]
    PIRiT46422.
    RefSeqiNP_056123.2. NM_015308.2. [Q8N3X1-1]
    XP_005252890.1. XM_005252833.1. [Q8N3X1-2]
    UniGeneiHs.6834.

    Genome annotation databases

    EnsembliENST00000263773; ENSP00000263773; ENSG00000109920. [Q8N3X1-1]
    GeneIDi23360.
    KEGGihsa:23360.
    UCSCiuc001ngj.3. human. [Q8N3X1-1]

    Polymorphism databases

    DMDMi313104235.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB023231 mRNA. Translation: BAA76858.2 . Different initiation.
    AC021443 Genomic DNA. No translation available.
    BC037404 mRNA. Translation: AAH37404.1 .
    AL137480 mRNA. Translation: CAB70761.1 .
    AK022987 mRNA. Translation: BAB14348.1 .
    CCDSi CCDS41644.1. [Q8N3X1-1 ]
    PIRi T46422.
    RefSeqi NP_056123.2. NM_015308.2. [Q8N3X1-1 ]
    XP_005252890.1. XM_005252833.1. [Q8N3X1-2 ]
    UniGenei Hs.6834.

    3D structure databases

    ProteinModelPortali Q8N3X1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116941. 13 interactions.
    IntActi Q8N3X1. 4 interactions.
    MINTi MINT-127221.
    STRINGi 9606.ENSP00000263773.

    PTM databases

    PhosphoSitei Q8N3X1.

    Polymorphism databases

    DMDMi 313104235.

    Proteomic databases

    MaxQBi Q8N3X1.
    PaxDbi Q8N3X1.
    PRIDEi Q8N3X1.

    Protocols and materials databases

    DNASUi 23360.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263773 ; ENSP00000263773 ; ENSG00000109920 . [Q8N3X1-1 ]
    GeneIDi 23360.
    KEGGi hsa:23360.
    UCSCi uc001ngj.3. human. [Q8N3X1-1 ]

    Organism-specific databases

    CTDi 23360.
    GeneCardsi GC11M048805.
    H-InvDB HIX0201592.
    HGNCi HGNC:19752. FNBP4.
    HPAi HPA039485.
    HPA040029.
    MIMi 615265. gene.
    neXtProti NX_Q8N3X1.
    Orphaneti 1106. Microphthalmia with limb anomalies.
    PharmGKBi PA134971679.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46362.
    HOGENOMi HOG000168238.
    HOVERGENi HBG066308.
    InParanoidi Q8N3X1.
    OMAi KMPPPEK.
    OrthoDBi EOG75F4GV.
    PhylomeDBi Q8N3X1.
    TreeFami TF331046.

    Enzyme and pathway databases

    SignaLinki Q8N3X1.

    Miscellaneous databases

    ChiTaRSi FNBP4. human.
    GeneWikii FNBP4.
    GenomeRNAii 23360.
    NextBioi 45391.
    PMAP-CutDB Q8N3X1.
    PROi Q8N3X1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8N3X1.
    CleanExi HS_FNBP4.
    Genevestigatori Q8N3X1.

    Family and domain databases

    InterProi IPR001202. WW_dom.
    [Graphical view ]
    Pfami PF00397. WW. 2 hits.
    [Graphical view ]
    SMARTi SM00456. WW. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51045. SSF51045. 2 hits.
    PROSITEi PS01159. WW_DOMAIN_1. 1 hit.
    PS50020. WW_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cervix.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1017 (ISOFORM 1).
      Tissue: Testis.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 457-1017 (ISOFORMS 1/2).
    7. "Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains."
      Bedford M.T., Frankel A., Yaffe M.B., Clarke S., Leder P., Richard S.
      J. Biol. Chem. 275:16030-16036(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KHDRBS1.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND THR-172, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-116; SER-432; SER-963; SER-964 AND SER-965, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432; SER-435; SER-499 AND SER-508, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-116; SER-432; SER-464; THR-479 AND SER-508, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432 AND SER-508, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFNBP4_HUMAN
    AccessioniPrimary (citable) accession number: Q8N3X1
    Secondary accession number(s): Q9H985, Q9NT81, Q9Y2L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3