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Protein

Formin-binding protein 4

Gene

FNBP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8N3X1.

Names & Taxonomyi

Protein namesi
Recommended name:
Formin-binding protein 4
Alternative name(s):
Formin-binding protein 30
Gene namesi
Name:FNBP4
Synonyms:FBP30, KIAA1014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19752. FNBP4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109920.
PharmGKBiPA134971679.

Polymorphism and mutation databases

BioMutaiFNBP4.
DMDMi313104235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002898631 – 1017Formin-binding protein 4Add BLAST1017

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei124PhosphoserineBy similarity1
Modified residuei172PhosphothreonineCombined sources1
Modified residuei290N6-acetyllysineBy similarity1
Cross-linki301Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei427PhosphoserineBy similarity1
Modified residuei432PhosphoserineCombined sources1
Modified residuei435PhosphoserineCombined sources1
Modified residuei438PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1
Modified residuei464PhosphoserineCombined sources1
Modified residuei479PhosphothreonineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei508PhosphoserineCombined sources1
Modified residuei516PhosphothreonineCombined sources1
Modified residuei517PhosphothreonineCombined sources1
Cross-linki519Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki519Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei963PhosphoserineCombined sources1
Modified residuei964PhosphoserineCombined sources1
Modified residuei965PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8N3X1.
MaxQBiQ8N3X1.
PaxDbiQ8N3X1.
PeptideAtlasiQ8N3X1.
PRIDEiQ8N3X1.

PTM databases

iPTMnetiQ8N3X1.
PhosphoSitePlusiQ8N3X1.

Miscellaneous databases

PMAP-CutDBQ8N3X1.

Expressioni

Tissue specificityi

Highly expressed in the eye.1 Publication

Gene expression databases

BgeeiENSG00000109920.
CleanExiHS_FNBP4.
ExpressionAtlasiQ8N3X1. baseline and differential.
GenevisibleiQ8N3X1. HS.

Organism-specific databases

HPAiHPA039485.
HPA040029.

Interactioni

Subunit structurei

Binds FMN1. Interacts with the Arg/Gly-rich-flanked Pro-rich of KHDRBS1/SAM68. Arginine methylation in these regions has no effect on this binding.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428586EBI-310600,EBI-466029

Protein-protein interaction databases

BioGridi116941. 14 interactors.
IntActiQ8N3X1. 6 interactors.
MINTiMINT-127221.
STRINGi9606.ENSP00000263773.

Structurei

3D structure databases

ProteinModelPortaliQ8N3X1.
SMRiQ8N3X1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 248WW 1PROSITE-ProRule annotationAdd BLAST35
Domaini595 – 629WW 2PROSITE-ProRule annotationAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi630 – 635Poly-Glu6
Compositional biasi701 – 731Pro-richAdd BLAST31
Compositional biasi905 – 925Pro-richAdd BLAST21

Domaini

These WW domains interact with Arg/Gly-rich-flanked Pro-rich domains found in several WW domain-binding proteins (WBPs). The N-terminal WW domain has the greater ligand-binding ability (By similarity).By similarity

Sequence similaritiesi

Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIQY. Eukaryota.
ENOG4111F8J. LUCA.
GeneTreeiENSGT00390000003450.
HOGENOMiHOG000168238.
HOVERGENiHBG066308.
InParanoidiQ8N3X1.
OMAiSHPATGM.
OrthoDBiEOG091G0KMM.
PhylomeDBiQ8N3X1.
TreeFamiTF331046.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3X1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKKSRAVPG RRPILQLSPP GPRGSTPGRD PEPEPDTEPD STAAVPSQPA
60 70 80 90 100
PSAATTTTTA VTAAAASDDS PSEDEQEAVQ EVPRVVQNPP KPVMTTRPTA
110 120 130 140 150
VKATGGLCLL GAYADSDDDD NDVSEKLAQS KETNGNQSTD IDSTLANFLA
160 170 180 190 200
EIDAITAPQP AAPVGASAPP PTPPRPEPKE AATSTLSSST SNGTDSTQTS
210 220 230 240 250
GWQYDTQCSL AGVGIEMGDW QEVWDENTGC YYYWNTQTNE VTWELPQYLA
260 270 280 290 300
TQVQGLQHYQ PSSVPGAETS FVVNTDIYSK EKTISVSSSK SGPVIAKREV
310 320 330 340 350
KKEVNEGIQA LSNSEEEKKG VAASLLAPLL PEGIKEEEER WRRKVICKEE
360 370 380 390 400
PVSEVKETST TVEEATTIVK PQEIMLDNIE DPSQEDLCSV VQSGESEEEE
410 420 430 440 450
EQDTLELELV LERKKAELRA LEEGDGSVSG SSPRSDISQP ASQDGMRRLM
460 470 480 490 500
SKRGKWKMFV RATSPESTSR SSSKTGRDTP ENGETAIGAE NSEKIDENSD
510 520 530 540 550
KEMEVEESPE KIKVQTTPKV EEEQDLKFQI GELANTLTSK FEFLGINRQS
560 570 580 590 600
ISNFHVLLLQ TETRIADWRE GALNGNYLKR KLQDAAEQLK QYEINATPKG
610 620 630 640 650
WSCHWDRDHR RYFYVNEQSG ESQWEFPDGE EEEEESQAQE NRDETLAKQT
660 670 680 690 700
LKDKTGTDSN STESSETSTG SLCKESFSGQ VSSSSLMPLT PFWTLLQSNV
710 720 730 740 750
PVLQPPLPLE MPPPPPPPPE SPPPPPPPPP PAEDGEIQEV EMEDEGSEEP
760 770 780 790 800
PAPGTEEDTP LKPSAQTTVV TSQSSVDSTI SSSSSTKGIK RKATEISTAV
810 820 830 840 850
VQRSATIGSS PVLYSQSAIA TGHQAAGIGN QATGIGHQTI PVSLPAAGMG
860 870 880 890 900
HQARGMSLQS NYLGLAAAPA IMSYAECSVP IGVTAPSLQP VQARGAVPTA
910 920 930 940 950
TIIEPPPPPP PPPPPPPPAP KMPPPEKTKK GRKDKAKKSK TKMPSLVKKW
960 970 980 990 1000
QSIQRELDEE DNSSSSEEDR ESTAQKRIEE WKQQQLVSGM AERNANFEAL
1010
PEDWRARLKR RKMAPNT
Length:1,017
Mass (Da):110,266
Last modified:November 30, 2010 - v3
Checksum:i510DC8011B5973AD
GO
Isoform 2 (identifier: Q8N3X1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-73: E → EGK

Show »
Length:1,019
Mass (Da):110,451
Checksum:i2D60B6B14CC4CE16
GO

Sequence cautioni

The sequence BAA76858 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55 – 56Missing in BAA76858 (PubMed:10231032).Curated2
Sequence conflicti55 – 56Missing in AAH37404 (PubMed:15489334).Curated2
Sequence conflicti55 – 56Missing in CAB70761 (PubMed:17974005).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032623125E → G.Corresponds to variant rs34962598dbSNPEnsembl.1
Natural variantiVAR_075345228T → M Rare variant found in a patient with microphthalmia with limb anomalies; unknown pathological significance. 1 PublicationCorresponds to variant rs780064080dbSNPEnsembl.1
Natural variantiVAR_032624794T → A.Corresponds to variant rs35040940dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04029273E → EGK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023231 mRNA. Translation: BAA76858.2. Different initiation.
AC021443 Genomic DNA. No translation available.
BC037404 mRNA. Translation: AAH37404.1.
AL137480 mRNA. Translation: CAB70761.1.
AK022987 mRNA. Translation: BAB14348.1.
CCDSiCCDS41644.1. [Q8N3X1-1]
PIRiT46422.
RefSeqiNP_001305268.1. NM_001318339.1. [Q8N3X1-2]
NP_056123.2. NM_015308.3. [Q8N3X1-1]
UniGeneiHs.6834.

Genome annotation databases

EnsembliENST00000263773; ENSP00000263773; ENSG00000109920. [Q8N3X1-1]
GeneIDi23360.
KEGGihsa:23360.
UCSCiuc009ylv.4. human. [Q8N3X1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023231 mRNA. Translation: BAA76858.2. Different initiation.
AC021443 Genomic DNA. No translation available.
BC037404 mRNA. Translation: AAH37404.1.
AL137480 mRNA. Translation: CAB70761.1.
AK022987 mRNA. Translation: BAB14348.1.
CCDSiCCDS41644.1. [Q8N3X1-1]
PIRiT46422.
RefSeqiNP_001305268.1. NM_001318339.1. [Q8N3X1-2]
NP_056123.2. NM_015308.3. [Q8N3X1-1]
UniGeneiHs.6834.

3D structure databases

ProteinModelPortaliQ8N3X1.
SMRiQ8N3X1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116941. 14 interactors.
IntActiQ8N3X1. 6 interactors.
MINTiMINT-127221.
STRINGi9606.ENSP00000263773.

PTM databases

iPTMnetiQ8N3X1.
PhosphoSitePlusiQ8N3X1.

Polymorphism and mutation databases

BioMutaiFNBP4.
DMDMi313104235.

Proteomic databases

EPDiQ8N3X1.
MaxQBiQ8N3X1.
PaxDbiQ8N3X1.
PeptideAtlasiQ8N3X1.
PRIDEiQ8N3X1.

Protocols and materials databases

DNASUi23360.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263773; ENSP00000263773; ENSG00000109920. [Q8N3X1-1]
GeneIDi23360.
KEGGihsa:23360.
UCSCiuc009ylv.4. human. [Q8N3X1-1]

Organism-specific databases

CTDi23360.
GeneCardsiFNBP4.
H-InvDBHIX0201592.
HGNCiHGNC:19752. FNBP4.
HPAiHPA039485.
HPA040029.
MIMi615265. gene.
neXtProtiNX_Q8N3X1.
OpenTargetsiENSG00000109920.
PharmGKBiPA134971679.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIQY. Eukaryota.
ENOG4111F8J. LUCA.
GeneTreeiENSGT00390000003450.
HOGENOMiHOG000168238.
HOVERGENiHBG066308.
InParanoidiQ8N3X1.
OMAiSHPATGM.
OrthoDBiEOG091G0KMM.
PhylomeDBiQ8N3X1.
TreeFamiTF331046.

Enzyme and pathway databases

SignaLinkiQ8N3X1.

Miscellaneous databases

ChiTaRSiFNBP4. human.
GeneWikiiFNBP4.
GenomeRNAii23360.
PMAP-CutDBQ8N3X1.
PROiQ8N3X1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109920.
CleanExiHS_FNBP4.
ExpressionAtlasiQ8N3X1. baseline and differential.
GenevisibleiQ8N3X1. HS.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 2 hits.
[Graphical view]
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFNBP4_HUMAN
AccessioniPrimary (citable) accession number: Q8N3X1
Secondary accession number(s): Q9H985, Q9NT81, Q9Y2L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 30, 2010
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.