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Q8N3V7

- SYNPO_HUMAN

UniProt

Q8N3V7 - SYNPO_HUMAN

Protein

Synaptopodin

Gene

SYNPO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity By similarity.By similarity

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. positive regulation of actin filament bundle assembly Source: Ensembl
    2. regulation of stress fiber assembly Source: Ensembl

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptopodin
    Gene namesi
    Name:SYNPO
    Synonyms:KIAA1029
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30672. SYNPO.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cell junctiontight junction By similarity. Perikaryon By similarity. Cell projectiondendritic spine By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity. Cell junctionsynapse By similarity
    Note: Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses By similarity.By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: UniProtKB
    2. cytoplasm Source: UniProtKB-KW
    3. dendritic spine Source: UniProtKB
    4. perikaryon Source: UniProtKB-SubCell
    5. postsynaptic density Source: UniProtKB-SubCell
    6. postsynaptic membrane Source: UniProtKB-KW
    7. stress fiber Source: Ensembl
    8. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134863299.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 929929SynaptopodinPRO_0000187670Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei263 – 2631Phosphoserine2 Publications
    Glycosylationi330 – 3301N-linked (GlcNAc...)1 Publication
    Modified residuei525 – 5251Phosphoserine1 Publication
    Modified residuei580 – 5801Phosphoserine2 Publications
    Modified residuei685 – 6851Phosphoserine4 Publications
    Modified residuei702 – 7021Phosphoserine1 Publication
    Modified residuei746 – 7461Phosphothreonine2 Publications
    Modified residuei754 – 7541Phosphoserine1 Publication
    Modified residuei833 – 8331Phosphoserine2 Publications

    Post-translational modificationi

    O-glycosylated.By similarity
    Isoform 2 is phosphorylated on Ser-826, Thr-836, Ser-840 and Ser-871.4 Publications

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8N3V7.
    PaxDbiQ8N3V7.
    PRIDEiQ8N3V7.

    PTM databases

    PhosphoSiteiQ8N3V7.

    Expressioni

    Tissue specificityi

    Expressed in cerebral cortex.1 Publication

    Gene expression databases

    ArrayExpressiQ8N3V7.
    BgeeiQ8N3V7.
    CleanExiHS_SYNPO.
    GenevestigatoriQ8N3V7.

    Organism-specific databases

    HPAiHPA034631.

    Interactioni

    Subunit structurei

    Interacts with BAIAP1. Interacts with actin By similarity. Interacts (via PPxY motifs) with WWC1 (via WW domains).By similarity2 Publications

    Protein-protein interaction databases

    BioGridi116474. 8 interactions.
    IntActiQ8N3V7. 5 interactions.
    MINTiMINT-4136464.
    STRINGi9606.ENSP00000302139.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N3V7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi562 – 5654PPxY motif
    Motifi581 – 5844PPxY motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi753 – 908156Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptopodin family.Curated

    Phylogenomic databases

    eggNOGiNOG43259.
    HOGENOMiHOG000132998.
    HOVERGENiHBG056954.
    InParanoidiQ8N3V7.
    OMAiSWKYSTN.
    OrthoDBiEOG7GN2PF.
    PhylomeDBiQ8N3V7.
    TreeFamiTF330867.

    Family and domain databases

    InterProiIPR028753. Synpo.
    [Graphical view]
    PANTHERiPTHR24217:SF11. PTHR24217:SF11. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N3V7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLGPHLPPPP LAPSEGRPTP CAFQIPDGSY RCLALEAEES SGEEGLQGEV    50
    GPTDLEEDEG VSRSGDDSAC RVTQGTPQLP KALGIQPPSC SREEQGASQH 100
    DDRASQDWDV VKAGQMMTAS PSPGPGPRVA QKPALGRSTS LTEKDLKEAK 150
    ARSQQIAAQL TTPPSSNSRG VQLFNRRRQR VNEFTLESHG QRGQKPSQES 200
    LRVLPSSLPG HAPGLSLSST SLPEPGPPRH PSPQSPDRGV PGHSMEGYSE 250
    EASLLRHLEK VASEEEEVPL VVYLKENAAL LTANGLHLSQ NREAQQSSPA 300
    PPPAEVHSPA ADVNQNLASP SATLTTPTSN SSHNPPATDV NQNPPATVVP 350
    QSLPLSSIQQ NSSEAQLPSN GTGPASKPST LCADGQPQAP AEEVRCSTLL 400
    IDKVSTPATT TSTFSREATL IPSSRPPASD FMSSSLLIDI QPNTLVVSAD 450
    QEMSGRAAAT TPTKVYSEVH FTLAKPPSVV NRTARPFGIQ APGGTSQMER 500
    SPMLERRHFG EKAPAPQPPS LPDRSPRPQR HIMSRSPMVE RRMMGQRSPA 550
    SERRPLGNFT APPTYTETLS TAPLASWVRS PPSYSVLYPS SDPKSSHLKG 600
    QAVPASKTGI LEESMARRGS RKSMFTFVEK PKVTPNPDLL DLVQTADEKR 650
    RQRDQGEVGV EEEPFALGAE ASNFQQEPAP RDRASPAAAE EVVPEWASCL 700
    KSPRIQAKPK PKPNQNLSEA SGKGAELYAR RQSRMEKYVI ESSSHTPELA 750
    RCPSPTMSLP SSWKYPTNAP GAFRVASRSP ARTPPASLYH GYLPENGVLR 800
    PEPTKQPPYQ LRPSLFVLSP IKEPAKVSPR AASPAKPSSL DLVPNLPKGA 850
    LPPSPALPRP SRSSPGLYTS PGQDSLQPTA VSPPYGGDIS PVSPSRAWSP 900
    RAKQAPRPSF STRNAGIEAQ VWKPSFCFK 929
    Length:929
    Mass (Da):99,463
    Last modified:June 7, 2004 - v2
    Checksum:i38723B6FDD046F15
    GO
    Isoform 2 (identifier: Q8N3V7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-244: Missing.
         921-929: VWKPSFCFK → DRRESLPTSP...SLPAEASCTT

    Note: Contains a phosphoserine at position 871. Contains a phosphoserine at position 826. Contains a phosphoserine at position 894. Contains a phosphoserine at position 854.

    Show »
    Length:903
    Mass (Da):96,397
    Checksum:i5F0C0A39635750E4
    GO
    Isoform 3 (identifier: Q8N3V7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-244: Missing.

    Show »
    Length:685
    Mass (Da):73,667
    Checksum:iBE102B27B2C0BCC8
    GO

    Sequence cautioni

    The sequence BAA82981.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 951Q → R in CAD38532. (PubMed:17974005)Curated
    Sequence conflicti417 – 4171E → G(PubMed:14702039)Curated
    Sequence conflicti428 – 4281A → V in CAA71955. (PubMed:9314539)Curated
    Sequence conflicti744 – 7441S → G in CAA71955. (PubMed:9314539)Curated
    Sequence conflicti836 – 8361K → R(PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 244244Missing in isoform 2 and isoform 3. 5 PublicationsVSP_010476Add
    BLAST
    Alternative sequencei921 – 9299VWKPSFCFK → DRRESLPTSPPWTPGASRPP SSLDGWVSPGPWEPGRGSSM SSPPPLPPPPPMSPSWSERS VSPLRPETEARPPSRQLQAL LARNIINAARRKSASPRSAG AENPRPFSPPRAPPPPPPPP PPPPRMRSPQPARPGSAAVP GAAFAPIPRSPLPAGPSSCT SPRSPLPAPPRPFLYRRSPT DSDVSLDSEDSGAKSPGILG YNICPRGWNGSLRLKRGSLP AEASCTT in isoform 2. 2 PublicationsVSP_010477

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11072 mRNA. Translation: CAA71955.1.
    AF499136 mRNA. Translation: AAQ07402.1.
    AF499137 mRNA. Translation: AAQ07403.1.
    AB028952 mRNA. Translation: BAA82981.2. Different initiation.
    AK127049 mRNA. No translation available.
    AK290178 mRNA. Translation: BAF82867.1.
    AL831818 mRNA. Translation: CAD38532.1.
    CH471062 Genomic DNA. Translation: EAW61715.1.
    CH471062 Genomic DNA. Translation: EAW61716.1.
    BC142683 mRNA. Translation: AAI42684.1.
    BC146665 mRNA. Translation: AAI46666.1.
    CCDSiCCDS4308.1. [Q8N3V7-2]
    CCDS54937.1. [Q8N3V7-1]
    CCDS54938.1. [Q8N3V7-3]
    RefSeqiNP_001103444.1. NM_001109974.2. [Q8N3V7-3]
    NP_001159680.1. NM_001166208.1. [Q8N3V7-1]
    NP_001159681.1. NM_001166209.1. [Q8N3V7-1]
    NP_009217.3. NM_007286.5. [Q8N3V7-2]
    XP_005268426.1. XM_005268369.1. [Q8N3V7-2]
    XP_005268427.1. XM_005268370.1. [Q8N3V7-2]
    XP_005268428.1. XM_005268371.1. [Q8N3V7-2]
    UniGeneiHs.435228.

    Genome annotation databases

    EnsembliENST00000307662; ENSP00000302139; ENSG00000171992. [Q8N3V7-2]
    ENST00000394243; ENSP00000377789; ENSG00000171992. [Q8N3V7-1]
    ENST00000519664; ENSP00000429268; ENSG00000171992. [Q8N3V7-3]
    ENST00000522122; ENSP00000428378; ENSG00000171992. [Q8N3V7-1]
    GeneIDi11346.
    KEGGihsa:11346.
    UCSCiuc003lsn.3. human. [Q8N3V7-1]
    uc003lsp.3. human. [Q8N3V7-2]

    Polymorphism databases

    DMDMi48428650.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11072 mRNA. Translation: CAA71955.1 .
    AF499136 mRNA. Translation: AAQ07402.1 .
    AF499137 mRNA. Translation: AAQ07403.1 .
    AB028952 mRNA. Translation: BAA82981.2 . Different initiation.
    AK127049 mRNA. No translation available.
    AK290178 mRNA. Translation: BAF82867.1 .
    AL831818 mRNA. Translation: CAD38532.1 .
    CH471062 Genomic DNA. Translation: EAW61715.1 .
    CH471062 Genomic DNA. Translation: EAW61716.1 .
    BC142683 mRNA. Translation: AAI42684.1 .
    BC146665 mRNA. Translation: AAI46666.1 .
    CCDSi CCDS4308.1. [Q8N3V7-2 ]
    CCDS54937.1. [Q8N3V7-1 ]
    CCDS54938.1. [Q8N3V7-3 ]
    RefSeqi NP_001103444.1. NM_001109974.2. [Q8N3V7-3 ]
    NP_001159680.1. NM_001166208.1. [Q8N3V7-1 ]
    NP_001159681.1. NM_001166209.1. [Q8N3V7-1 ]
    NP_009217.3. NM_007286.5. [Q8N3V7-2 ]
    XP_005268426.1. XM_005268369.1. [Q8N3V7-2 ]
    XP_005268427.1. XM_005268370.1. [Q8N3V7-2 ]
    XP_005268428.1. XM_005268371.1. [Q8N3V7-2 ]
    UniGenei Hs.435228.

    3D structure databases

    ProteinModelPortali Q8N3V7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116474. 8 interactions.
    IntActi Q8N3V7. 5 interactions.
    MINTi MINT-4136464.
    STRINGi 9606.ENSP00000302139.

    PTM databases

    PhosphoSitei Q8N3V7.

    Polymorphism databases

    DMDMi 48428650.

    Proteomic databases

    MaxQBi Q8N3V7.
    PaxDbi Q8N3V7.
    PRIDEi Q8N3V7.

    Protocols and materials databases

    DNASUi 11346.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307662 ; ENSP00000302139 ; ENSG00000171992 . [Q8N3V7-2 ]
    ENST00000394243 ; ENSP00000377789 ; ENSG00000171992 . [Q8N3V7-1 ]
    ENST00000519664 ; ENSP00000429268 ; ENSG00000171992 . [Q8N3V7-3 ]
    ENST00000522122 ; ENSP00000428378 ; ENSG00000171992 . [Q8N3V7-1 ]
    GeneIDi 11346.
    KEGGi hsa:11346.
    UCSCi uc003lsn.3. human. [Q8N3V7-1 ]
    uc003lsp.3. human. [Q8N3V7-2 ]

    Organism-specific databases

    CTDi 11346.
    GeneCardsi GC05P149960.
    H-InvDB HIX0164291.
    HGNCi HGNC:30672. SYNPO.
    HPAi HPA034631.
    MIMi 608155. gene.
    neXtProti NX_Q8N3V7.
    PharmGKBi PA134863299.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43259.
    HOGENOMi HOG000132998.
    HOVERGENi HBG056954.
    InParanoidi Q8N3V7.
    OMAi SWKYSTN.
    OrthoDBi EOG7GN2PF.
    PhylomeDBi Q8N3V7.
    TreeFami TF330867.

    Miscellaneous databases

    ChiTaRSi SYNPO. human.
    GeneWikii SYNPO.
    GenomeRNAii 11346.
    NextBioi 43120.
    PROi Q8N3V7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N3V7.
    Bgeei Q8N3V7.
    CleanExi HS_SYNPO.
    Genevestigatori Q8N3V7.

    Family and domain databases

    InterProi IPR028753. Synpo.
    [Graphical view ]
    PANTHERi PTHR24217:SF11. PTHR24217:SF11. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes."
      Mundel P., Heid H.W., Mundel T.M., Krueger M., Reiser J., Kriz W.
      J. Cell Biol. 139:193-204(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Loss of spine apparatus associated protein synaptopodin in Alzheimer's disease."
      Reddy P.H., Gutala R.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain and Kidney.
    3. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Thalamus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    8. "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1."
      Patrie K.M., Drescher A.J., Welihinda A., Mundel P., Margolis B.
      J. Biol. Chem. 277:30183-30190(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BAIAP1, SUBCELLULAR LOCATION.
    9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-685, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-871 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: INTERACTION WITH WWC1.
    12. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-685, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-871 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263; SER-525; SER-580; SER-685; SER-702; THR-746; SER-754 AND SER-833, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-826 AND SER-894 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-330.
      Tissue: Liver.
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263; SER-580; SER-685; THR-746 AND SER-833, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-854 AND SER-871 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSYNPO_HUMAN
    AccessioniPrimary (citable) accession number: Q8N3V7
    Secondary accession number(s): A5PKZ8
    , D3DQG8, O15271, Q9UPX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

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