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Protein

Synaptopodin

Gene

SYNPO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptopodin
Gene namesi
Name:SYNPO
Synonyms:KIAA1029
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30672. SYNPO.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell junctiontight junction By similarity
  • Perikaryon By similarity
  • Cell projectiondendritic spine By similarity
  • Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity
  • Cell junctionsynapse By similarity

  • Note: Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses.By similarity

GO - Cellular componenti

  • actin cytoskeleton Source: UniProtKB
  • bicellular tight junction Source: UniProtKB-SubCell
  • dendritic spine Source: UniProtKB
  • nucleus Source: GO_Central
  • perikaryon Source: UniProtKB-SubCell
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
  • Z disc Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi11346.
OpenTargetsiENSG00000171992.
PharmGKBiPA134863299.

Polymorphism and mutation databases

BioMutaiSYNPO.
DMDMi48428650.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001876701 – 929SynaptopodinAdd BLAST929

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei140PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei263PhosphoserineCombined sources1
Glycosylationi330N-linked (GlcNAc...)1 Publication1
Modified residuei501PhosphoserineBy similarity1
Modified residuei525PhosphoserineCombined sources1
Modified residuei560PhosphothreonineBy similarity1
Modified residuei580PhosphoserineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Modified residuei746PhosphothreonineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei758PhosphoserineBy similarity1
Modified residuei779PhosphoserineBy similarity1
Modified residuei783PhosphothreonineBy similarity1
Modified residuei833PhosphoserineCombined sources1
Modified residuei854PhosphoserineCombined sources1
Isoform 2 (identifier: Q8N3V7-2)
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei738PhosphoserineCombined sources1
Modified residuei784PhosphoserineCombined sources1
Modified residuei804PhosphoserineCombined sources1
Modified residuei812PhosphoserineCombined sources1
Modified residuei826PhosphoserineCombined sources1
Modified residuei854PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei894PhosphoserineCombined sources1
Isoform 3 (identifier: Q8N3V7-3)
Modified residuei1N-acetylmethionineCombined sources1

Post-translational modificationi

O-glycosylated.By similarity
Isoform 2 is phosphorylated on Ser-826, Thr-836, Ser-840 and Ser-871.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8N3V7.
MaxQBiQ8N3V7.
PaxDbiQ8N3V7.
PeptideAtlasiQ8N3V7.
PRIDEiQ8N3V7.

PTM databases

iPTMnetiQ8N3V7.
PhosphoSitePlusiQ8N3V7.

Expressioni

Tissue specificityi

Expressed in cerebral cortex.1 Publication

Gene expression databases

BgeeiENSG00000171992.
CleanExiHS_SYNPO.
GenevisibleiQ8N3V7. HS.

Organism-specific databases

HPAiCAB033265.
CAB037325.
HPA034631.

Interactioni

Subunit structurei

Interacts with BAIAP1. Interacts with actin (By similarity). Interacts (via PPxY motifs) with WWC1 (via WW domains).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116474. 167 interactors.
IntActiQ8N3V7. 165 interactors.
MINTiMINT-4136464.
STRINGi9606.ENSP00000377789.

Structurei

3D structure databases

ProteinModelPortaliQ8N3V7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi562 – 565PPxY motif4
Motifi581 – 584PPxY motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi753 – 908Pro-richAdd BLAST156

Sequence similaritiesi

Belongs to the synaptopodin family.Curated

Phylogenomic databases

eggNOGiENOG410IHBK. Eukaryota.
ENOG4111RGH. LUCA.
GeneTreeiENSGT00530000063754.
HOGENOMiHOG000132998.
HOVERGENiHBG056954.
InParanoidiQ8N3V7.
OMAiPSSLDGW.
OrthoDBiEOG091G017K.
PhylomeDBiQ8N3V7.
TreeFamiTF330867.

Family and domain databases

InterProiIPR028753. Synpo.
[Graphical view]
PANTHERiPTHR24217:SF13. PTHR24217:SF13. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3V7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGPHLPPPP LAPSEGRPTP CAFQIPDGSY RCLALEAEES SGEEGLQGEV
60 70 80 90 100
GPTDLEEDEG VSRSGDDSAC RVTQGTPQLP KALGIQPPSC SREEQGASQH
110 120 130 140 150
DDRASQDWDV VKAGQMMTAS PSPGPGPRVA QKPALGRSTS LTEKDLKEAK
160 170 180 190 200
ARSQQIAAQL TTPPSSNSRG VQLFNRRRQR VNEFTLESHG QRGQKPSQES
210 220 230 240 250
LRVLPSSLPG HAPGLSLSST SLPEPGPPRH PSPQSPDRGV PGHSMEGYSE
260 270 280 290 300
EASLLRHLEK VASEEEEVPL VVYLKENAAL LTANGLHLSQ NREAQQSSPA
310 320 330 340 350
PPPAEVHSPA ADVNQNLASP SATLTTPTSN SSHNPPATDV NQNPPATVVP
360 370 380 390 400
QSLPLSSIQQ NSSEAQLPSN GTGPASKPST LCADGQPQAP AEEVRCSTLL
410 420 430 440 450
IDKVSTPATT TSTFSREATL IPSSRPPASD FMSSSLLIDI QPNTLVVSAD
460 470 480 490 500
QEMSGRAAAT TPTKVYSEVH FTLAKPPSVV NRTARPFGIQ APGGTSQMER
510 520 530 540 550
SPMLERRHFG EKAPAPQPPS LPDRSPRPQR HIMSRSPMVE RRMMGQRSPA
560 570 580 590 600
SERRPLGNFT APPTYTETLS TAPLASWVRS PPSYSVLYPS SDPKSSHLKG
610 620 630 640 650
QAVPASKTGI LEESMARRGS RKSMFTFVEK PKVTPNPDLL DLVQTADEKR
660 670 680 690 700
RQRDQGEVGV EEEPFALGAE ASNFQQEPAP RDRASPAAAE EVVPEWASCL
710 720 730 740 750
KSPRIQAKPK PKPNQNLSEA SGKGAELYAR RQSRMEKYVI ESSSHTPELA
760 770 780 790 800
RCPSPTMSLP SSWKYPTNAP GAFRVASRSP ARTPPASLYH GYLPENGVLR
810 820 830 840 850
PEPTKQPPYQ LRPSLFVLSP IKEPAKVSPR AASPAKPSSL DLVPNLPKGA
860 870 880 890 900
LPPSPALPRP SRSSPGLYTS PGQDSLQPTA VSPPYGGDIS PVSPSRAWSP
910 920
RAKQAPRPSF STRNAGIEAQ VWKPSFCFK
Length:929
Mass (Da):99,463
Last modified:June 7, 2004 - v2
Checksum:i38723B6FDD046F15
GO
Isoform 2 (identifier: Q8N3V7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.
     921-929: VWKPSFCFK → DRRESLPTSP...SLPAEASCTT

Show »
Length:903
Mass (Da):96,397
Checksum:i5F0C0A39635750E4
GO
Isoform 3 (identifier: Q8N3V7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.

Show »
Length:685
Mass (Da):73,667
Checksum:iBE102B27B2C0BCC8
GO

Sequence cautioni

The sequence BAA82981 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95Q → R in CAD38532 (PubMed:17974005).Curated1
Sequence conflicti417E → G (PubMed:14702039).Curated1
Sequence conflicti428A → V in CAA71955 (PubMed:9314539).Curated1
Sequence conflicti744S → G in CAA71955 (PubMed:9314539).Curated1
Sequence conflicti836K → R (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0104761 – 244Missing in isoform 2 and isoform 3. 5 PublicationsAdd BLAST244
Alternative sequenceiVSP_010477921 – 929VWKPSFCFK → DRRESLPTSPPWTPGASRPP SSLDGWVSPGPWEPGRGSSM SSPPPLPPPPPMSPSWSERS VSPLRPETEARPPSRQLQAL LARNIINAARRKSASPRSAG AENPRPFSPPRAPPPPPPPP PPPPRMRSPQPARPGSAAVP GAAFAPIPRSPLPAGPSSCT SPRSPLPAPPRPFLYRRSPT DSDVSLDSEDSGAKSPGILG YNICPRGWNGSLRLKRGSLP AEASCTT in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11072 mRNA. Translation: CAA71955.1.
AF499136 mRNA. Translation: AAQ07402.1.
AF499137 mRNA. Translation: AAQ07403.1.
AB028952 mRNA. Translation: BAA82981.2. Different initiation.
AK127049 mRNA. No translation available.
AK290178 mRNA. Translation: BAF82867.1.
AL831818 mRNA. Translation: CAD38532.1.
CH471062 Genomic DNA. Translation: EAW61715.1.
CH471062 Genomic DNA. Translation: EAW61716.1.
BC142683 mRNA. Translation: AAI42684.1.
BC146665 mRNA. Translation: AAI46666.1.
CCDSiCCDS4308.1. [Q8N3V7-2]
CCDS54937.1. [Q8N3V7-1]
CCDS54938.1. [Q8N3V7-3]
RefSeqiNP_001103444.1. NM_001109974.2. [Q8N3V7-3]
NP_001159680.1. NM_001166208.1. [Q8N3V7-1]
NP_001159681.1. NM_001166209.1. [Q8N3V7-1]
NP_009217.3. NM_007286.5. [Q8N3V7-2]
XP_005268427.1. XM_005268370.1. [Q8N3V7-2]
XP_005268428.1. XM_005268371.1. [Q8N3V7-2]
XP_011535854.1. XM_011537552.2. [Q8N3V7-1]
UniGeneiHs.435228.

Genome annotation databases

EnsembliENST00000307662; ENSP00000302139; ENSG00000171992. [Q8N3V7-2]
ENST00000394243; ENSP00000377789; ENSG00000171992. [Q8N3V7-1]
ENST00000519664; ENSP00000429268; ENSG00000171992. [Q8N3V7-3]
ENST00000522122; ENSP00000428378; ENSG00000171992. [Q8N3V7-1]
GeneIDi11346.
KEGGihsa:11346.
UCSCiuc003lsn.4. human. [Q8N3V7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11072 mRNA. Translation: CAA71955.1.
AF499136 mRNA. Translation: AAQ07402.1.
AF499137 mRNA. Translation: AAQ07403.1.
AB028952 mRNA. Translation: BAA82981.2. Different initiation.
AK127049 mRNA. No translation available.
AK290178 mRNA. Translation: BAF82867.1.
AL831818 mRNA. Translation: CAD38532.1.
CH471062 Genomic DNA. Translation: EAW61715.1.
CH471062 Genomic DNA. Translation: EAW61716.1.
BC142683 mRNA. Translation: AAI42684.1.
BC146665 mRNA. Translation: AAI46666.1.
CCDSiCCDS4308.1. [Q8N3V7-2]
CCDS54937.1. [Q8N3V7-1]
CCDS54938.1. [Q8N3V7-3]
RefSeqiNP_001103444.1. NM_001109974.2. [Q8N3V7-3]
NP_001159680.1. NM_001166208.1. [Q8N3V7-1]
NP_001159681.1. NM_001166209.1. [Q8N3V7-1]
NP_009217.3. NM_007286.5. [Q8N3V7-2]
XP_005268427.1. XM_005268370.1. [Q8N3V7-2]
XP_005268428.1. XM_005268371.1. [Q8N3V7-2]
XP_011535854.1. XM_011537552.2. [Q8N3V7-1]
UniGeneiHs.435228.

3D structure databases

ProteinModelPortaliQ8N3V7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116474. 167 interactors.
IntActiQ8N3V7. 165 interactors.
MINTiMINT-4136464.
STRINGi9606.ENSP00000377789.

PTM databases

iPTMnetiQ8N3V7.
PhosphoSitePlusiQ8N3V7.

Polymorphism and mutation databases

BioMutaiSYNPO.
DMDMi48428650.

Proteomic databases

EPDiQ8N3V7.
MaxQBiQ8N3V7.
PaxDbiQ8N3V7.
PeptideAtlasiQ8N3V7.
PRIDEiQ8N3V7.

Protocols and materials databases

DNASUi11346.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307662; ENSP00000302139; ENSG00000171992. [Q8N3V7-2]
ENST00000394243; ENSP00000377789; ENSG00000171992. [Q8N3V7-1]
ENST00000519664; ENSP00000429268; ENSG00000171992. [Q8N3V7-3]
ENST00000522122; ENSP00000428378; ENSG00000171992. [Q8N3V7-1]
GeneIDi11346.
KEGGihsa:11346.
UCSCiuc003lsn.4. human. [Q8N3V7-1]

Organism-specific databases

CTDi11346.
DisGeNETi11346.
GeneCardsiSYNPO.
H-InvDBHIX0164291.
HGNCiHGNC:30672. SYNPO.
HPAiCAB033265.
CAB037325.
HPA034631.
MIMi608155. gene.
neXtProtiNX_Q8N3V7.
OpenTargetsiENSG00000171992.
PharmGKBiPA134863299.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHBK. Eukaryota.
ENOG4111RGH. LUCA.
GeneTreeiENSGT00530000063754.
HOGENOMiHOG000132998.
HOVERGENiHBG056954.
InParanoidiQ8N3V7.
OMAiPSSLDGW.
OrthoDBiEOG091G017K.
PhylomeDBiQ8N3V7.
TreeFamiTF330867.

Miscellaneous databases

ChiTaRSiSYNPO. human.
GeneWikiiSYNPO.
GenomeRNAii11346.
PROiQ8N3V7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171992.
CleanExiHS_SYNPO.
GenevisibleiQ8N3V7. HS.

Family and domain databases

InterProiIPR028753. Synpo.
[Graphical view]
PANTHERiPTHR24217:SF13. PTHR24217:SF13. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSYNPO_HUMAN
AccessioniPrimary (citable) accession number: Q8N3V7
Secondary accession number(s): A5PKZ8
, D3DQG8, O15271, Q9UPX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.