SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8N3T6

- T132C_HUMAN

UniProt

Q8N3T6 - T132C_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Transmembrane protein 132C
Gene
TMEM132C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 132C
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:25436. TMEM132C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 922895Extracellular Reviewed prediction
Add
BLAST
Transmembranei923 – 94321Helical; Reviewed prediction
Add
BLAST
Topological domaini944 – 1108165Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 11081081Transmembrane protein 132C
PRO_0000324577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi373 – 3731N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N3T6.
PRIDEiQ8N3T6.

PTM databases

PhosphoSiteiQ8N3T6.

Expressioni

Gene expression databases

ArrayExpressiQ8N3T6.
BgeeiQ8N3T6.
CleanExiHS_TMEM132C.
GenevestigatoriQ8N3T6.

Organism-specific databases

HPAiHPA015633.
HPA015984.

Interactioni

Protein-protein interaction databases

BioGridi124930. 1 interaction.
IntActiQ8N3T6. 1 interaction.
STRINGi9606.ENSP00000324458.

Structurei

3D structure databases

ProteinModelPortaliQ8N3T6.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM132 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148422.
HOGENOMiHOG000154481.
HOVERGENiHBG108534.
InParanoidiQ8N3T6.
KOiK17599.
OMAiIPPDDSC.
PhylomeDBiQ8N3T6.
TreeFamiTF314981.

Family and domain databases

InterProiIPR026307. TMEM132.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N3T6-1 [UniParc]FASTAAdd to Basket

« Hide

MRSEGAAPGP AAPLCGALSL LLGALLGKVI EGHGVTDNIQ RFSSLPPYLP     50
VSYHILRAET SFFLKEANQD LLRNSSLQAR VESFFTYKTR QPPVLNASYG 100
PFSVEKVVPL DLMLTSNFLG PTNKFSFDWK LKAHILRDKV YLSRPKVQVL 150
FHIMGRDWDD HGAGEKLPCL RVFAFRETRE VRGSCRLKGD LGLCVAELEL 200
LSSWFSAPTV GAGRKKSMDQ PEGTPVELYY TVHPGNERGD CAGGDFRKGN 250
AIRPGKDGLE ETTSHLQRIG TVGLYRAQDS AQLSELRLDG NVVIWLPSRP 300
VKQGEVVTAY VTISSNSSVD LFILRAKVKK GVNILSAQTR EPRQWGVKQE 350
VGSGGKHVTA TVACQRLGPS PRNRSSSLFN EVVQMNFEIA SFSSLSGTQP 400
ITWQVEYPRK GTTDIAVSEI FVSQKDLVGI VPLAMDTEIL NTAVLTGKTV 450
AMPIKVVSVE ENSAVMDISE SVECKSTDED VIKVSERCDY IFVNGKEIKG 500
KMDAVVNFTY QYLSAPLCVT VWVPRLPLQI EVSDTELSQI KGWRVPIVTN 550
KRPTRESEDE DEEERRGRGC ALQYQHATVR VLTQFVSEGA GPWGQPNYLL 600
SPNWQFDITH LVADFMKLEE PHVATLQDSR VLVGREVGMT TIQVLSPLSD 650
SILAEKTITV LDDKVSVTDL AIQLVAGLSV ALYPNAENSK AVTAVVTAEE 700
VLRTPKQEAV FSTWLQFSDG SVTPLDIYDT KDFSLAATSQ DEAVVSVPQP 750
RSPRWPVVVA EGEGQGPLIR VDMTIAEACQ KSKRKSILAV GVGNVRVKFG 800
QNDADSSPGG DYEEDEIKNH ASDRRQKGQH HERTGQDGHL YGSSPVEREE 850
GALRRATTTA RSLLDNKVVK NSRADGGRLA GEGQLQNIPI DFTNFPAHVD 900
LPKAGSGLEE NDLVQTPRGL SDLEIGMYAL LGVFCLAILV FLINCATFAL 950
KYRHKQVPLE GQASMTHSHD WVWLGNEAEL LESMGDAPPP QDEHTTIIDR 1000
GPGACEESNH LLLNGGSHKH VQSQIHRSAD SGGRQGREQK QDPLHSPTSK 1050
RKKVKFTTFT TIPPDDSCPT VNSIVSSNDE DIKWVCQDVA VGAPKELRNY 1100
LEKLKDKA 1108
Length:1,108
Mass (Da):121,787
Last modified:February 9, 2010 - v3
Checksum:iFB0298520B3AAE2B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti161 – 1611H → R.
Corresponds to variant rs11059681 [ dbSNP | Ensembl ].
VAR_039832
Natural varianti232 – 2321V → M.
Corresponds to variant rs12307622 [ dbSNP | Ensembl ].
VAR_039833
Natural varianti272 – 2721V → I.
Corresponds to variant rs1683723 [ dbSNP | Ensembl ].
VAR_039834
Natural varianti444 – 4441V → I.
Corresponds to variant rs4272850 [ dbSNP | Ensembl ].
VAR_039835
Natural varianti730 – 7301T → S.
Corresponds to variant rs12426596 [ dbSNP | Ensembl ].
VAR_039836
Natural varianti799 – 7991F → I.
Corresponds to variant rs12301587 [ dbSNP | Ensembl ].
VAR_039837
Natural varianti810 – 8101G → R.
Corresponds to variant rs12424159 [ dbSNP | Ensembl ].
VAR_039838

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC023595 Genomic DNA. No translation available.
AC061709 Genomic DNA. No translation available.
AC090424 Genomic DNA. No translation available.
AC107020 Genomic DNA. No translation available.
AC126612 Genomic DNA. No translation available.
AL122107 mRNA. Translation: CAH10715.1.
AL831921 mRNA. Translation: CAD38581.1.
RefSeqiNP_001129575.2. NM_001136103.2.
UniGeneiHs.49599.

Genome annotation databases

EnsembliENST00000435159; ENSP00000410852; ENSG00000181234.
GeneIDi92293.
KEGGihsa:92293.
UCSCiuc021rgn.1. human.

Polymorphism databases

DMDMi288558838.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC023595 Genomic DNA. No translation available.
AC061709 Genomic DNA. No translation available.
AC090424 Genomic DNA. No translation available.
AC107020 Genomic DNA. No translation available.
AC126612 Genomic DNA. No translation available.
AL122107 mRNA. Translation: CAH10715.1 .
AL831921 mRNA. Translation: CAD38581.1 .
RefSeqi NP_001129575.2. NM_001136103.2.
UniGenei Hs.49599.

3D structure databases

ProteinModelPortali Q8N3T6.
ModBasei Search...

Protein-protein interaction databases

BioGridi 124930. 1 interaction.
IntActi Q8N3T6. 1 interaction.
STRINGi 9606.ENSP00000324458.

PTM databases

PhosphoSitei Q8N3T6.

Polymorphism databases

DMDMi 288558838.

Proteomic databases

PaxDbi Q8N3T6.
PRIDEi Q8N3T6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000435159 ; ENSP00000410852 ; ENSG00000181234 .
GeneIDi 92293.
KEGGi hsa:92293.
UCSCi uc021rgn.1. human.

Organism-specific databases

CTDi 92293.
GeneCardsi GC12P128751.
H-InvDB HIX0011128.
HGNCi HGNC:25436. TMEM132C.
HPAi HPA015633.
HPA015984.
neXtProti NX_Q8N3T6.
PharmGKBi PA143485653.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148422.
HOGENOMi HOG000154481.
HOVERGENi HBG108534.
InParanoidi Q8N3T6.
KOi K17599.
OMAi IPPDDSC.
PhylomeDBi Q8N3T6.
TreeFami TF314981.

Miscellaneous databases

ChiTaRSi TMEM132C. human.
GenomeRNAii 92293.
NextBioi 77678.
PROi Q8N3T6.

Gene expression databases

ArrayExpressi Q8N3T6.
Bgeei Q8N3T6.
CleanExi HS_TMEM132C.
Genevestigatori Q8N3T6.

Family and domain databases

InterProi IPR026307. TMEM132.
[Graphical view ]
PANTHERi PTHR13388. PTHR13388. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 386-1108.
    Tissue: Amygdala and Testis.

Entry informationi

Entry nameiT132C_HUMAN
AccessioniPrimary (citable) accession number: Q8N3T6
Secondary accession number(s): Q69YX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 9, 2010
Last modified: April 16, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi