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Protein

Transmembrane protein 132C

Gene

TMEM132C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 132C
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25436. TMEM132C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 922895ExtracellularSequence AnalysisAdd
BLAST
Transmembranei923 – 94321HelicalSequence AnalysisAdd
BLAST
Topological domaini944 – 1108165CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 11081081Transmembrane protein 132CPRO_0000324577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N3T6.
PRIDEiQ8N3T6.

PTM databases

PhosphoSiteiQ8N3T6.

Expressioni

Gene expression databases

BgeeiQ8N3T6.
CleanExiHS_TMEM132C.
GenevestigatoriQ8N3T6.

Organism-specific databases

HPAiHPA015633.
HPA015984.

Interactioni

Protein-protein interaction databases

BioGridi124930. 1 interaction.
IntActiQ8N3T6. 1 interaction.
STRINGi9606.ENSP00000324458.

Structurei

3D structure databases

ProteinModelPortaliQ8N3T6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM132 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148422.
GeneTreeiENSGT00550000074550.
HOGENOMiHOG000154481.
HOVERGENiHBG108534.
InParanoidiQ8N3T6.
KOiK17599.
OMAiLFILRAK.
PhylomeDBiQ8N3T6.
TreeFamiTF314981.

Family and domain databases

InterProiIPR026307. TMEM132.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N3T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSEGAAPGP AAPLCGALSL LLGALLGKVI EGHGVTDNIQ RFSSLPPYLP
60 70 80 90 100
VSYHILRAET SFFLKEANQD LLRNSSLQAR VESFFTYKTR QPPVLNASYG
110 120 130 140 150
PFSVEKVVPL DLMLTSNFLG PTNKFSFDWK LKAHILRDKV YLSRPKVQVL
160 170 180 190 200
FHIMGRDWDD HGAGEKLPCL RVFAFRETRE VRGSCRLKGD LGLCVAELEL
210 220 230 240 250
LSSWFSAPTV GAGRKKSMDQ PEGTPVELYY TVHPGNERGD CAGGDFRKGN
260 270 280 290 300
AIRPGKDGLE ETTSHLQRIG TVGLYRAQDS AQLSELRLDG NVVIWLPSRP
310 320 330 340 350
VKQGEVVTAY VTISSNSSVD LFILRAKVKK GVNILSAQTR EPRQWGVKQE
360 370 380 390 400
VGSGGKHVTA TVACQRLGPS PRNRSSSLFN EVVQMNFEIA SFSSLSGTQP
410 420 430 440 450
ITWQVEYPRK GTTDIAVSEI FVSQKDLVGI VPLAMDTEIL NTAVLTGKTV
460 470 480 490 500
AMPIKVVSVE ENSAVMDISE SVECKSTDED VIKVSERCDY IFVNGKEIKG
510 520 530 540 550
KMDAVVNFTY QYLSAPLCVT VWVPRLPLQI EVSDTELSQI KGWRVPIVTN
560 570 580 590 600
KRPTRESEDE DEEERRGRGC ALQYQHATVR VLTQFVSEGA GPWGQPNYLL
610 620 630 640 650
SPNWQFDITH LVADFMKLEE PHVATLQDSR VLVGREVGMT TIQVLSPLSD
660 670 680 690 700
SILAEKTITV LDDKVSVTDL AIQLVAGLSV ALYPNAENSK AVTAVVTAEE
710 720 730 740 750
VLRTPKQEAV FSTWLQFSDG SVTPLDIYDT KDFSLAATSQ DEAVVSVPQP
760 770 780 790 800
RSPRWPVVVA EGEGQGPLIR VDMTIAEACQ KSKRKSILAV GVGNVRVKFG
810 820 830 840 850
QNDADSSPGG DYEEDEIKNH ASDRRQKGQH HERTGQDGHL YGSSPVEREE
860 870 880 890 900
GALRRATTTA RSLLDNKVVK NSRADGGRLA GEGQLQNIPI DFTNFPAHVD
910 920 930 940 950
LPKAGSGLEE NDLVQTPRGL SDLEIGMYAL LGVFCLAILV FLINCATFAL
960 970 980 990 1000
KYRHKQVPLE GQASMTHSHD WVWLGNEAEL LESMGDAPPP QDEHTTIIDR
1010 1020 1030 1040 1050
GPGACEESNH LLLNGGSHKH VQSQIHRSAD SGGRQGREQK QDPLHSPTSK
1060 1070 1080 1090 1100
RKKVKFTTFT TIPPDDSCPT VNSIVSSNDE DIKWVCQDVA VGAPKELRNY

LEKLKDKA
Length:1,108
Mass (Da):121,787
Last modified:February 9, 2010 - v3
Checksum:iFB0298520B3AAE2B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti161 – 1611H → R.
Corresponds to variant rs11059681 [ dbSNP | Ensembl ].
VAR_039832
Natural varianti232 – 2321V → M.
Corresponds to variant rs12307622 [ dbSNP | Ensembl ].
VAR_039833
Natural varianti272 – 2721V → I.
Corresponds to variant rs1683723 [ dbSNP | Ensembl ].
VAR_039834
Natural varianti444 – 4441V → I.
Corresponds to variant rs4272850 [ dbSNP | Ensembl ].
VAR_039835
Natural varianti730 – 7301T → S.
Corresponds to variant rs12426596 [ dbSNP | Ensembl ].
VAR_039836
Natural varianti799 – 7991F → I.
Corresponds to variant rs12301587 [ dbSNP | Ensembl ].
VAR_039837
Natural varianti810 – 8101G → R.
Corresponds to variant rs12424159 [ dbSNP | Ensembl ].
VAR_039838

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023595 Genomic DNA. No translation available.
AC061709 Genomic DNA. No translation available.
AC090424 Genomic DNA. No translation available.
AC107020 Genomic DNA. No translation available.
AC126612 Genomic DNA. No translation available.
AL122107 mRNA. Translation: CAH10715.1.
AL831921 mRNA. Translation: CAD38581.1.
RefSeqiNP_001129575.2. NM_001136103.2.
UniGeneiHs.49599.

Genome annotation databases

EnsembliENST00000435159; ENSP00000410852; ENSG00000181234.
GeneIDi92293.
KEGGihsa:92293.
UCSCiuc021rgn.1. human.

Polymorphism databases

DMDMi288558838.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023595 Genomic DNA. No translation available.
AC061709 Genomic DNA. No translation available.
AC090424 Genomic DNA. No translation available.
AC107020 Genomic DNA. No translation available.
AC126612 Genomic DNA. No translation available.
AL122107 mRNA. Translation: CAH10715.1.
AL831921 mRNA. Translation: CAD38581.1.
RefSeqiNP_001129575.2. NM_001136103.2.
UniGeneiHs.49599.

3D structure databases

ProteinModelPortaliQ8N3T6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124930. 1 interaction.
IntActiQ8N3T6. 1 interaction.
STRINGi9606.ENSP00000324458.

PTM databases

PhosphoSiteiQ8N3T6.

Polymorphism databases

DMDMi288558838.

Proteomic databases

PaxDbiQ8N3T6.
PRIDEiQ8N3T6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435159; ENSP00000410852; ENSG00000181234.
GeneIDi92293.
KEGGihsa:92293.
UCSCiuc021rgn.1. human.

Organism-specific databases

CTDi92293.
GeneCardsiGC12P128751.
H-InvDBHIX0011128.
HGNCiHGNC:25436. TMEM132C.
HPAiHPA015633.
HPA015984.
neXtProtiNX_Q8N3T6.
PharmGKBiPA143485653.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG148422.
GeneTreeiENSGT00550000074550.
HOGENOMiHOG000154481.
HOVERGENiHBG108534.
InParanoidiQ8N3T6.
KOiK17599.
OMAiLFILRAK.
PhylomeDBiQ8N3T6.
TreeFamiTF314981.

Miscellaneous databases

ChiTaRSiTMEM132C. human.
GenomeRNAii92293.
NextBioi77678.
PROiQ8N3T6.

Gene expression databases

BgeeiQ8N3T6.
CleanExiHS_TMEM132C.
GenevestigatoriQ8N3T6.

Family and domain databases

InterProiIPR026307. TMEM132.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 386-1108.
    Tissue: Amygdala and Testis.

Entry informationi

Entry nameiT132C_HUMAN
AccessioniPrimary (citable) accession number: Q8N3T6
Secondary accession number(s): Q69YX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 9, 2010
Last modified: March 4, 2015
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.