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Q8N3T6

- T132C_HUMAN

UniProt

Q8N3T6 - T132C_HUMAN

Protein

Transmembrane protein 132C

Gene

TMEM132C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 3 (09 Feb 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 132C
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:25436. TMEM132C.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485653.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 11081081Transmembrane protein 132CPRO_0000324577Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8N3T6.
    PRIDEiQ8N3T6.

    PTM databases

    PhosphoSiteiQ8N3T6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N3T6.
    BgeeiQ8N3T6.
    CleanExiHS_TMEM132C.
    GenevestigatoriQ8N3T6.

    Organism-specific databases

    HPAiHPA015633.
    HPA015984.

    Interactioni

    Protein-protein interaction databases

    BioGridi124930. 1 interaction.
    IntActiQ8N3T6. 1 interaction.
    STRINGi9606.ENSP00000324458.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N3T6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 922895ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini944 – 1108165CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei923 – 94321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM132 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148422.
    HOGENOMiHOG000154481.
    HOVERGENiHBG108534.
    InParanoidiQ8N3T6.
    KOiK17599.
    OMAiIPPDDSC.
    PhylomeDBiQ8N3T6.
    TreeFamiTF314981.

    Family and domain databases

    InterProiIPR026307. TMEM132.
    [Graphical view]
    PANTHERiPTHR13388. PTHR13388. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N3T6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSEGAAPGP AAPLCGALSL LLGALLGKVI EGHGVTDNIQ RFSSLPPYLP     50
    VSYHILRAET SFFLKEANQD LLRNSSLQAR VESFFTYKTR QPPVLNASYG 100
    PFSVEKVVPL DLMLTSNFLG PTNKFSFDWK LKAHILRDKV YLSRPKVQVL 150
    FHIMGRDWDD HGAGEKLPCL RVFAFRETRE VRGSCRLKGD LGLCVAELEL 200
    LSSWFSAPTV GAGRKKSMDQ PEGTPVELYY TVHPGNERGD CAGGDFRKGN 250
    AIRPGKDGLE ETTSHLQRIG TVGLYRAQDS AQLSELRLDG NVVIWLPSRP 300
    VKQGEVVTAY VTISSNSSVD LFILRAKVKK GVNILSAQTR EPRQWGVKQE 350
    VGSGGKHVTA TVACQRLGPS PRNRSSSLFN EVVQMNFEIA SFSSLSGTQP 400
    ITWQVEYPRK GTTDIAVSEI FVSQKDLVGI VPLAMDTEIL NTAVLTGKTV 450
    AMPIKVVSVE ENSAVMDISE SVECKSTDED VIKVSERCDY IFVNGKEIKG 500
    KMDAVVNFTY QYLSAPLCVT VWVPRLPLQI EVSDTELSQI KGWRVPIVTN 550
    KRPTRESEDE DEEERRGRGC ALQYQHATVR VLTQFVSEGA GPWGQPNYLL 600
    SPNWQFDITH LVADFMKLEE PHVATLQDSR VLVGREVGMT TIQVLSPLSD 650
    SILAEKTITV LDDKVSVTDL AIQLVAGLSV ALYPNAENSK AVTAVVTAEE 700
    VLRTPKQEAV FSTWLQFSDG SVTPLDIYDT KDFSLAATSQ DEAVVSVPQP 750
    RSPRWPVVVA EGEGQGPLIR VDMTIAEACQ KSKRKSILAV GVGNVRVKFG 800
    QNDADSSPGG DYEEDEIKNH ASDRRQKGQH HERTGQDGHL YGSSPVEREE 850
    GALRRATTTA RSLLDNKVVK NSRADGGRLA GEGQLQNIPI DFTNFPAHVD 900
    LPKAGSGLEE NDLVQTPRGL SDLEIGMYAL LGVFCLAILV FLINCATFAL 950
    KYRHKQVPLE GQASMTHSHD WVWLGNEAEL LESMGDAPPP QDEHTTIIDR 1000
    GPGACEESNH LLLNGGSHKH VQSQIHRSAD SGGRQGREQK QDPLHSPTSK 1050
    RKKVKFTTFT TIPPDDSCPT VNSIVSSNDE DIKWVCQDVA VGAPKELRNY 1100
    LEKLKDKA 1108
    Length:1,108
    Mass (Da):121,787
    Last modified:February 9, 2010 - v3
    Checksum:iFB0298520B3AAE2B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti161 – 1611H → R.
    Corresponds to variant rs11059681 [ dbSNP | Ensembl ].
    VAR_039832
    Natural varianti232 – 2321V → M.
    Corresponds to variant rs12307622 [ dbSNP | Ensembl ].
    VAR_039833
    Natural varianti272 – 2721V → I.
    Corresponds to variant rs1683723 [ dbSNP | Ensembl ].
    VAR_039834
    Natural varianti444 – 4441V → I.
    Corresponds to variant rs4272850 [ dbSNP | Ensembl ].
    VAR_039835
    Natural varianti730 – 7301T → S.
    Corresponds to variant rs12426596 [ dbSNP | Ensembl ].
    VAR_039836
    Natural varianti799 – 7991F → I.
    Corresponds to variant rs12301587 [ dbSNP | Ensembl ].
    VAR_039837
    Natural varianti810 – 8101G → R.
    Corresponds to variant rs12424159 [ dbSNP | Ensembl ].
    VAR_039838

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC023595 Genomic DNA. No translation available.
    AC061709 Genomic DNA. No translation available.
    AC090424 Genomic DNA. No translation available.
    AC107020 Genomic DNA. No translation available.
    AC126612 Genomic DNA. No translation available.
    AL122107 mRNA. Translation: CAH10715.1.
    AL831921 mRNA. Translation: CAD38581.1.
    RefSeqiNP_001129575.2. NM_001136103.2.
    UniGeneiHs.49599.

    Genome annotation databases

    EnsembliENST00000435159; ENSP00000410852; ENSG00000181234.
    GeneIDi92293.
    KEGGihsa:92293.
    UCSCiuc021rgn.1. human.

    Polymorphism databases

    DMDMi288558838.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC023595 Genomic DNA. No translation available.
    AC061709 Genomic DNA. No translation available.
    AC090424 Genomic DNA. No translation available.
    AC107020 Genomic DNA. No translation available.
    AC126612 Genomic DNA. No translation available.
    AL122107 mRNA. Translation: CAH10715.1 .
    AL831921 mRNA. Translation: CAD38581.1 .
    RefSeqi NP_001129575.2. NM_001136103.2.
    UniGenei Hs.49599.

    3D structure databases

    ProteinModelPortali Q8N3T6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124930. 1 interaction.
    IntActi Q8N3T6. 1 interaction.
    STRINGi 9606.ENSP00000324458.

    PTM databases

    PhosphoSitei Q8N3T6.

    Polymorphism databases

    DMDMi 288558838.

    Proteomic databases

    PaxDbi Q8N3T6.
    PRIDEi Q8N3T6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000435159 ; ENSP00000410852 ; ENSG00000181234 .
    GeneIDi 92293.
    KEGGi hsa:92293.
    UCSCi uc021rgn.1. human.

    Organism-specific databases

    CTDi 92293.
    GeneCardsi GC12P128751.
    H-InvDB HIX0011128.
    HGNCi HGNC:25436. TMEM132C.
    HPAi HPA015633.
    HPA015984.
    neXtProti NX_Q8N3T6.
    PharmGKBi PA143485653.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG148422.
    HOGENOMi HOG000154481.
    HOVERGENi HBG108534.
    InParanoidi Q8N3T6.
    KOi K17599.
    OMAi IPPDDSC.
    PhylomeDBi Q8N3T6.
    TreeFami TF314981.

    Miscellaneous databases

    ChiTaRSi TMEM132C. human.
    GenomeRNAii 92293.
    NextBioi 77678.
    PROi Q8N3T6.

    Gene expression databases

    ArrayExpressi Q8N3T6.
    Bgeei Q8N3T6.
    CleanExi HS_TMEM132C.
    Genevestigatori Q8N3T6.

    Family and domain databases

    InterProi IPR026307. TMEM132.
    [Graphical view ]
    PANTHERi PTHR13388. PTHR13388. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 386-1108.
      Tissue: Amygdala and Testis.

    Entry informationi

    Entry nameiT132C_HUMAN
    AccessioniPrimary (citable) accession number: Q8N3T6
    Secondary accession number(s): Q69YX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: February 9, 2010
    Last modified: October 1, 2014
    This is version 69 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3