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Protein

Transmembrane protein 132C

Gene

TMEM132C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181234-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 132C
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25436. TMEM132C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 922ExtracellularSequence analysisAdd BLAST895
Transmembranei923 – 943HelicalSequence analysisAdd BLAST21
Topological domaini944 – 1108CytoplasmicSequence analysisAdd BLAST165

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi92293.
OpenTargetsiENSG00000181234.
PharmGKBiPA143485653.

Polymorphism and mutation databases

BioMutaiTMEM132C.
DMDMi288558838.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000032457728 – 1108Transmembrane protein 132CAdd BLAST1081

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi316N-linked (GlcNAc...)Sequence analysis1
Glycosylationi373N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N3T6.
PeptideAtlasiQ8N3T6.
PRIDEiQ8N3T6.

PTM databases

iPTMnetiQ8N3T6.
PhosphoSitePlusiQ8N3T6.

Expressioni

Gene expression databases

BgeeiENSG00000181234.
CleanExiHS_TMEM132C.
GenevisibleiQ8N3T6. HS.

Organism-specific databases

HPAiHPA015633.
HPA015984.

Interactioni

Protein-protein interaction databases

BioGridi124930. 1 interactor.
IntActiQ8N3T6. 1 interactor.
STRINGi9606.ENSP00000410852.

Structurei

3D structure databases

ProteinModelPortaliQ8N3T6.
SMRiQ8N3T6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM132 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4789. Eukaryota.
ENOG410XQCD. LUCA.
GeneTreeiENSGT00550000074550.
HOGENOMiHOG000154481.
HOVERGENiHBG108534.
InParanoidiQ8N3T6.
KOiK17599.
OMAiLMLTSNF.
OrthoDBiEOG091G013Z.
PhylomeDBiQ8N3T6.
TreeFamiTF314981.

Family and domain databases

InterProiIPR026307. TMEM132.
IPR031436. TMEM132_C.
IPR031437. TMEM132_M.
IPR031435. TMEM132_N.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.
PfamiPF16070. TMEM132. 1 hit.
PF15706. TMEM132D_C. 1 hit.
PF15705. TMEM132D_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N3T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSEGAAPGP AAPLCGALSL LLGALLGKVI EGHGVTDNIQ RFSSLPPYLP
60 70 80 90 100
VSYHILRAET SFFLKEANQD LLRNSSLQAR VESFFTYKTR QPPVLNASYG
110 120 130 140 150
PFSVEKVVPL DLMLTSNFLG PTNKFSFDWK LKAHILRDKV YLSRPKVQVL
160 170 180 190 200
FHIMGRDWDD HGAGEKLPCL RVFAFRETRE VRGSCRLKGD LGLCVAELEL
210 220 230 240 250
LSSWFSAPTV GAGRKKSMDQ PEGTPVELYY TVHPGNERGD CAGGDFRKGN
260 270 280 290 300
AIRPGKDGLE ETTSHLQRIG TVGLYRAQDS AQLSELRLDG NVVIWLPSRP
310 320 330 340 350
VKQGEVVTAY VTISSNSSVD LFILRAKVKK GVNILSAQTR EPRQWGVKQE
360 370 380 390 400
VGSGGKHVTA TVACQRLGPS PRNRSSSLFN EVVQMNFEIA SFSSLSGTQP
410 420 430 440 450
ITWQVEYPRK GTTDIAVSEI FVSQKDLVGI VPLAMDTEIL NTAVLTGKTV
460 470 480 490 500
AMPIKVVSVE ENSAVMDISE SVECKSTDED VIKVSERCDY IFVNGKEIKG
510 520 530 540 550
KMDAVVNFTY QYLSAPLCVT VWVPRLPLQI EVSDTELSQI KGWRVPIVTN
560 570 580 590 600
KRPTRESEDE DEEERRGRGC ALQYQHATVR VLTQFVSEGA GPWGQPNYLL
610 620 630 640 650
SPNWQFDITH LVADFMKLEE PHVATLQDSR VLVGREVGMT TIQVLSPLSD
660 670 680 690 700
SILAEKTITV LDDKVSVTDL AIQLVAGLSV ALYPNAENSK AVTAVVTAEE
710 720 730 740 750
VLRTPKQEAV FSTWLQFSDG SVTPLDIYDT KDFSLAATSQ DEAVVSVPQP
760 770 780 790 800
RSPRWPVVVA EGEGQGPLIR VDMTIAEACQ KSKRKSILAV GVGNVRVKFG
810 820 830 840 850
QNDADSSPGG DYEEDEIKNH ASDRRQKGQH HERTGQDGHL YGSSPVEREE
860 870 880 890 900
GALRRATTTA RSLLDNKVVK NSRADGGRLA GEGQLQNIPI DFTNFPAHVD
910 920 930 940 950
LPKAGSGLEE NDLVQTPRGL SDLEIGMYAL LGVFCLAILV FLINCATFAL
960 970 980 990 1000
KYRHKQVPLE GQASMTHSHD WVWLGNEAEL LESMGDAPPP QDEHTTIIDR
1010 1020 1030 1040 1050
GPGACEESNH LLLNGGSHKH VQSQIHRSAD SGGRQGREQK QDPLHSPTSK
1060 1070 1080 1090 1100
RKKVKFTTFT TIPPDDSCPT VNSIVSSNDE DIKWVCQDVA VGAPKELRNY

LEKLKDKA
Length:1,108
Mass (Da):121,787
Last modified:February 9, 2010 - v3
Checksum:iFB0298520B3AAE2B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039832161H → R.Corresponds to variant rs11059681dbSNPEnsembl.1
Natural variantiVAR_039833232V → M.Corresponds to variant rs12307622dbSNPEnsembl.1
Natural variantiVAR_039834272V → I.Corresponds to variant rs1683723dbSNPEnsembl.1
Natural variantiVAR_039835444V → I.Corresponds to variant rs4272850dbSNPEnsembl.1
Natural variantiVAR_039836730T → S.Corresponds to variant rs12426596dbSNPEnsembl.1
Natural variantiVAR_039837799F → I.Corresponds to variant rs12301587dbSNPEnsembl.1
Natural variantiVAR_039838810G → R.Corresponds to variant rs12424159dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023595 Genomic DNA. No translation available.
AC061709 Genomic DNA. No translation available.
AC090424 Genomic DNA. No translation available.
AC107020 Genomic DNA. No translation available.
AC126612 Genomic DNA. No translation available.
AL122107 mRNA. Translation: CAH10715.1.
AL831921 mRNA. Translation: CAD38581.1.
CCDSiCCDS45009.2.
RefSeqiNP_001129575.2. NM_001136103.2.
UniGeneiHs.49599.

Genome annotation databases

EnsembliENST00000435159; ENSP00000410852; ENSG00000181234.
GeneIDi92293.
KEGGihsa:92293.
UCSCiuc021rgn.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC023595 Genomic DNA. No translation available.
AC061709 Genomic DNA. No translation available.
AC090424 Genomic DNA. No translation available.
AC107020 Genomic DNA. No translation available.
AC126612 Genomic DNA. No translation available.
AL122107 mRNA. Translation: CAH10715.1.
AL831921 mRNA. Translation: CAD38581.1.
CCDSiCCDS45009.2.
RefSeqiNP_001129575.2. NM_001136103.2.
UniGeneiHs.49599.

3D structure databases

ProteinModelPortaliQ8N3T6.
SMRiQ8N3T6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124930. 1 interactor.
IntActiQ8N3T6. 1 interactor.
STRINGi9606.ENSP00000410852.

PTM databases

iPTMnetiQ8N3T6.
PhosphoSitePlusiQ8N3T6.

Polymorphism and mutation databases

BioMutaiTMEM132C.
DMDMi288558838.

Proteomic databases

PaxDbiQ8N3T6.
PeptideAtlasiQ8N3T6.
PRIDEiQ8N3T6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000435159; ENSP00000410852; ENSG00000181234.
GeneIDi92293.
KEGGihsa:92293.
UCSCiuc021rgn.1. human.

Organism-specific databases

CTDi92293.
DisGeNETi92293.
GeneCardsiTMEM132C.
H-InvDBHIX0011128.
HGNCiHGNC:25436. TMEM132C.
HPAiHPA015633.
HPA015984.
neXtProtiNX_Q8N3T6.
OpenTargetsiENSG00000181234.
PharmGKBiPA143485653.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4789. Eukaryota.
ENOG410XQCD. LUCA.
GeneTreeiENSGT00550000074550.
HOGENOMiHOG000154481.
HOVERGENiHBG108534.
InParanoidiQ8N3T6.
KOiK17599.
OMAiLMLTSNF.
OrthoDBiEOG091G013Z.
PhylomeDBiQ8N3T6.
TreeFamiTF314981.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181234-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM132C. human.
GenomeRNAii92293.
PROiQ8N3T6.

Gene expression databases

BgeeiENSG00000181234.
CleanExiHS_TMEM132C.
GenevisibleiQ8N3T6. HS.

Family and domain databases

InterProiIPR026307. TMEM132.
IPR031436. TMEM132_C.
IPR031437. TMEM132_M.
IPR031435. TMEM132_N.
[Graphical view]
PANTHERiPTHR13388. PTHR13388. 1 hit.
PfamiPF16070. TMEM132. 1 hit.
PF15706. TMEM132D_C. 1 hit.
PF15705. TMEM132D_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT132C_HUMAN
AccessioniPrimary (citable) accession number: Q8N3T6
Secondary accession number(s): Q69YX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: February 9, 2010
Last modified: November 2, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.