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Protein

Putative homeodomain transcription factor 2

Gene

PHTF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in transcription regulation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative homeodomain transcription factor 2
Gene namesi
Name:PHTF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000006576.16.
HGNCiHGNC:13411. PHTF2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000006576.
PharmGKBiPA33279.

Polymorphism and mutation databases

BioMutaiPHTF2.
DMDMi166987998.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185091 – 785Putative homeodomain transcription factor 2Add BLAST785

Proteomic databases

MaxQBiQ8N3S3.
PaxDbiQ8N3S3.
PeptideAtlasiQ8N3S3.
PRIDEiQ8N3S3.

PTM databases

iPTMnetiQ8N3S3.
PhosphoSitePlusiQ8N3S3.

Expressioni

Gene expression databases

BgeeiENSG00000006576.
CleanExiHS_PHTF2.
GenevisibleiQ8N3S3. HS.

Organism-specific databases

HPAiHPA012312.

Interactioni

Protein-protein interaction databases

BioGridi121413. 9 interactors.
IntActiQ8N3S3. 2 interactors.
MINTiMINT-3039847.

Structurei

3D structure databases

ProteinModelPortaliQ8N3S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IF1F. Eukaryota.
ENOG410ZM0V. LUCA.
GeneTreeiENSGT00390000011648.
HOGENOMiHOG000069931.
HOVERGENiHBG061164.
InParanoidiQ8N3S3.
OMAiTEDVLWE.
OrthoDBiEOG091G0334.
PhylomeDBiQ8N3S3.
TreeFamiTF323570.

Family and domain databases

InterProiView protein in InterPro
IPR021980. TF_homeodomain_male.
PfamiView protein in Pfam
PF12129. Phtf-FEM1B_bdg. 1 hit.

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3S3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASKVTDAIV WYQKKEFLSV ATTAPGPQQV LPGYCQCSLK DQGLFIQCLI
60 70 80 90 100
GAYDQQIWEK SVEQREIKFI KLGLRNKPKK TAHVKPDLID VDLVRGSAFA
110 120 130 140 150
KAKPESPWTS LTRKGIVRVV FFPFFFRWWL QVTSKVIFFW LLVLYLLQVA
160 170 180 190 200
AIVLFCSTSS PHSIPLTEVI GPIWLMLLLG TVHCQIVSTR TPKPPLSTGG
210 220 230 240 250
KRRRKLRKAA HLEVHREGDG SSTTDNTQEG AVQNHGTSTS HSVGTVFRDL
260 270 280 290 300
WHAAFFLSGS KKAKNSIDKS TETDNGYVSL DGKKTVKSGE DGIQNHEPQC
310 320 330 340 350
ETIRPEETAW NTGTLRNGPS KDTQRTITNV SDEVSSEEGP ETGYSLRRHV
360 370 380 390 400
DRTSEGVLRN RKSHHYKKHY PNEDAPKSGT SCSSRCSSSR QDSESARPES
410 420 430 440 450
ETEDVLWEDL LHCAECHSSC TSETDVENHQ INPCVKKEYR DDPFHQSHLP
460 470 480 490 500
WLHSSHPGLE KISAIVWEGN DCKKADMSVL EISGMIMNRV NSHIPGIGYQ
510 520 530 540 550
IFGNAVSLIL GLTPFVFRLS QATDLEQLTA HSASELYVIA FGSNEDVIVL
560 570 580 590 600
SMVIISFVVR VSLVWIFFFL LCVAERTYKQ RLLFAKLFGH LTSARRARKS
610 620 630 640 650
EVPHFRLKKV QNIKMWLSLR SYLKRRGPQR SVDVIVSSAF LLTISVVFIC
660 670 680 690 700
CAQLLHVHEI FLDCHYNWEL VIWCISLTLF LLRFVTLGSE TSKKYSNTSI
710 720 730 740 750
LLTEQINLYL KMEKKPNKKE ELTLVNNVLK LATKLLKELD SPFRLYGLTM
760 770 780
NPLLYNITQV VILSAVSGVI SDLLGFNLKL WKIKS
Length:785
Mass (Da):88,757
Last modified:February 5, 2008 - v2
Checksum:iF4260D28E7261126
GO
Isoform 2 (identifier: Q8N3S3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-49: Missing.

Show »
Length:751
Mass (Da):85,119
Checksum:i7CA846B7D407F9EF
GO
Isoform 3 (identifier: Q8N3S3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-49: Missing.
     69-72: Missing.

Show »
Length:747
Mass (Da):84,617
Checksum:i3A99B57488A6403E
GO
Isoform 4 (identifier: Q8N3S3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-49: Missing.
     69-72: Missing.
     654-705: Missing.

Show »
Length:695
Mass (Da):78,466
Checksum:i0A1016AAE34B4797
GO
Isoform 5 (identifier: Q8N3S3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-49: Missing.
     374-390: DAPKSGTSCSSRCSSSR → VYTLSLSVYIRIYFICY
     391-785: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:356
Mass (Da):40,391
Checksum:i7FD3D788E1E21D16
GO
Isoform 6 (identifier: Q8N3S3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-49: Missing.
     69-72: Missing.
     374-390: DAPKSGTSCSSRCSSSR → VYTLSLSVYIRIYFICY
     391-785: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:352
Mass (Da):39,889
Checksum:i918A5FB4EF70206A
GO
Isoform 7 (identifier: Q8N3S3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-49: Missing.
     69-72: Missing.
     581-584: RLLF → VGIM
     585-785: Missing.

Note: No experimental confirmation available.
Show »
Length:546
Mass (Da):61,298
Checksum:i934145F91E37171C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → P in CAD38610 (PubMed:17974005).Curated1
Isoform 6 (identifier: Q8N3S3-6)
Sequence conflicti346R → H in AAH67742 (PubMed:15489334).Curated1
Isoform 5 (identifier: Q8N3S3-5)
Sequence conflicti350R → H in AAH22419 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03119216 – 49Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 3 PublicationsAdd BLAST34
Alternative sequenceiVSP_03119369 – 72Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 3 Publications4
Alternative sequenceiVSP_046275374 – 390DAPKS…CSSSR → VYTLSLSVYIRIYFICY in isoform 5 and isoform 6. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_046276391 – 785Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST395
Alternative sequenceiVSP_057299581 – 584RLLF → VGIM in isoform 7. 1 Publication4
Alternative sequenceiVSP_057300585 – 785Missing in isoform 7. 1 PublicationAdd BLAST201
Alternative sequenceiVSP_031194654 – 705Missing in isoform 4. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090643 mRNA. Translation: BAG52204.1.
AL136883 mRNA. Translation: CAB66817.1.
AL831969 mRNA. Translation: CAD38610.1.
AC004955 Genomic DNA. No translation available.
AC004990 Genomic DNA. No translation available.
AC073520 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24195.1.
CH471091 Genomic DNA. Translation: EAW77027.1.
CH471091 Genomic DNA. Translation: EAW77028.1.
CH471091 Genomic DNA. Translation: EAW77031.1.
BC022419 mRNA. Translation: AAH22419.1.
BC067742 mRNA. Translation: AAH67742.1.
BC127093 mRNA. Translation: AAI27094.1.
BC127094 mRNA. Translation: AAI27095.1.
CCDSiCCDS47621.1. [Q8N3S3-2]
CCDS47622.1. [Q8N3S3-3]
CCDS47623.1. [Q8N3S3-5]
CCDS47624.1. [Q8N3S3-6]
RefSeqiNP_001120829.1. NM_001127357.1. [Q8N3S3-2]
NP_001120830.1. NM_001127358.1. [Q8N3S3-3]
NP_001120831.1. NM_001127359.1. [Q8N3S3-5]
NP_001120832.1. NM_001127360.1. [Q8N3S3-6]
NP_065165.3. NM_020432.4. [Q8N3S3-3]
XP_005250565.1. XM_005250508.4. [Q8N3S3-2]
XP_005250566.1. XM_005250509.4. [Q8N3S3-2]
UniGeneiHs.203965.
Hs.601884.

Genome annotation databases

EnsembliENST00000248550; ENSP00000248550; ENSG00000006576. [Q8N3S3-1]
ENST00000275575; ENSP00000275575; ENSG00000006576. [Q8N3S3-4]
ENST00000307305; ENSP00000307699; ENSG00000006576. [Q8N3S3-3]
ENST00000415251; ENSP00000408035; ENSG00000006576. [Q8N3S3-6]
ENST00000416283; ENSP00000400958; ENSG00000006576. [Q8N3S3-1]
ENST00000422959; ENSP00000403042; ENSG00000006576. [Q8N3S3-2]
ENST00000424760; ENSP00000403620; ENSG00000006576. [Q8N3S3-7]
ENST00000450574; ENSP00000387355; ENSG00000006576. [Q8N3S3-5]
GeneIDi57157.
KEGGihsa:57157.
UCSCiuc003ugo.5. human. [Q8N3S3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPHTF2_HUMAN
AccessioniPrimary (citable) accession number: Q8N3S3
Secondary accession number(s): A0JP04
, A0JP05, A4D1C2, B3KQZ2, E9PEE3, G5E9H7, Q6NW35, Q8TBW4, Q9H099
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 27, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM