Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8N3R9

- MPP5_HUMAN

UniProt

Q8N3R9 - MPP5_HUMAN

Protein

MAGUK p55 subfamily member 5

Gene

MPP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein domain specific binding Source: BHF-UCL

    GO - Biological processi

    1. cell-cell junction organization Source: Reactome
    2. cell junction assembly Source: Reactome
    3. establishment of protein localization to plasma membrane Source: Ensembl
    4. morphogenesis of an epithelial sheet Source: UniProt
    5. myelin assembly Source: Ensembl
    6. peripheral nervous system myelin maintenance Source: Ensembl
    7. protein localization to myelin sheath abaxonal region Source: Ensembl
    8. tight junction assembly Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MAGUK p55 subfamily member 5
    Gene namesi
    Name:MPP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:18669. MPP5.

    Subcellular locationi

    Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junctiontight junction
    Note: Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membrane (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Colocalizes with MPP1 in the retina at the outer limiting membrane (OLM). Localized to the Purkinje cell body and axon.

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb
    2. endomembrane system Source: UniProtKB-SubCell
    3. extracellular vesicular exosome Source: UniProt
    4. lateral loop Source: Ensembl
    5. myelin sheath adaxonal region Source: Ensembl
    6. nucleus Source: HPA
    7. plasma membrane Source: HPA
    8. protein complex Source: Ensembl
    9. Schmidt-Lanterman incisure Source: Ensembl
    10. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38631.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 675675MAGUK p55 subfamily member 5PRO_0000094580Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8N3R9.
    PaxDbiQ8N3R9.
    PRIDEiQ8N3R9.

    PTM databases

    PhosphoSiteiQ8N3R9.

    Expressioni

    Tissue specificityi

    Expressed in the retina (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ8N3R9.
    BgeeiQ8N3R9.
    CleanExiHS_MPP5.
    GenevestigatoriQ8N3R9.

    Organism-specific databases

    HPAiHPA000993.

    Interactioni

    Subunit structurei

    Interacts with CRB3, LIN7C and MPDZ. Interacts with INADL, PARD6B, SC6A1 and EZR By similarity. Forms a complex with CRB1 and MPP4. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Heterodimer with MPP1. Interacts with MPP7.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    INADLQ8NI354EBI-2513978,EBI-724390

    Protein-protein interaction databases

    BioGridi122155. 15 interactions.
    IntActiQ8N3R9. 18 interactions.
    MINTiMINT-1772982.
    STRINGi9606.ENSP00000261681.

    Structurei

    Secondary structure

    1
    675
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi124 – 13714
    Helixi141 – 15515
    Helixi157 – 17317
    Helixi186 – 19712
    Turni198 – 2003
    Helixi203 – 21311
    Helixi215 – 22915
    Beta strandi230 – 2323

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1Y76NMR-B/D118-177[»]
    3UITX-ray2.05A/B/C/D119-232[»]
    ProteinModelPortaliQ8N3R9.
    SMRiQ8N3R9. Positions 119-232, 236-335, 349-671.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8N3R9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini120 – 17758L27 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini179 – 23557L27 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini256 – 33681PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini345 – 41773SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini479 – 660182Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 140120Interaction with PARD6BBy similarityAdd
    BLAST
    Regioni181 – 24363Interaction with LIN7CBy similarityAdd
    BLAST

    Domaini

    The L27 domain 1 functions in targeting to the tight junctions by binding to INADL.By similarity
    The PDZ domain binds to the C-terminus of SC6A1.By similarity

    Sequence similaritiesi

    Belongs to the MAGUK family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 2 L27 domains.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0194.
    HOGENOMiHOG000233034.
    HOVERGENiHBG001858.
    InParanoidiQ8N3R9.
    KOiK06091.
    OMAiVHQKEGQ.
    OrthoDBiEOG79CXZ5.
    PhylomeDBiQ8N3R9.
    TreeFamiTF314263.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR004172. L27.
    IPR014775. L27_C.
    IPR015145. L27_N.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    PF02828. L27. 1 hit.
    PF09060. L27_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    SM00569. L27. 2 hits.
    SM00228. PDZ. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS51022. L27. 2 hits.
    PS50106. PDZ. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N3R9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTSHMNGHV TEESDSEVKN VDLASPEEHQ KHREMAVDCP GDLGTRMMPI    50
    RRSAQLERIR QQQEDMRRRR EEEGKKQELD LNSSMRLKKL AQIPPKTGID 100
    NPMFDTEEGI VLESPHYAVK ILEIEDLFSS LKHIQHTLVD SQSQEDISLL 150
    LQLVQNKDFQ NAFKIHNAIT VHMNKASPPF PLISNAQDLA QEVQTVLKPV 200
    HHKEGQELTA LLNTPHIQAL LLAHDKVAEQ EMQLEPITDE RVYESIGQYG 250
    GETVKIVRIE KARDIPLGAT VRNEMDSVII SRIVKGGAAE KSGLLHEGDE 300
    VLEINGIEIR GKDVNEVFDL LSDMHGTLTF VLIPSQQIKP PPAKETVIHV 350
    KAHFDYDPSD DPYVPCRELG LSFQKGDILH VISQEDPNWW QAYREGDEDN 400
    QPLAGLVPGK SFQQQREAMK QTIEEDKEPE KSGKLWCAKK NKKKRKKVLY 450
    NANKNDDYDN EEILTYEEMS LYHQPANRKR PIILIGPQNC GQNELRQRLM 500
    NKEKDRFASA VPHTTRSRRD QEVAGRDYHF VSRQAFEADI AAGKFIEHGE 550
    FEKNLYGTSI DSVRQVINSG KICLLSLRTQ SLKTLRNSDL KPYIIFIAPP 600
    SQERLRALLA KEGKNPKPEE LREIIEKTRE MEQNNGHYFD TAIVNSDLDK 650
    AYQELLRLIN KLDTEPQWVP STWLR 675
    Length:675
    Mass (Da):77,294
    Last modified:October 17, 2006 - v3
    Checksum:iA3B2CB594E0908CA
    GO
    Isoform 2 (identifier: Q8N3R9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-34: Missing.

    Show »
    Length:641
    Mass (Da):73,421
    Checksum:iAD604D26B3580FDB
    GO

    Sequence cautioni

    The sequence AAH53366.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence BAB14172.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti100 – 1001D → G in CAD38620. (PubMed:17974005)Curated
    Sequence conflicti141 – 1411S → Y in CAD89937. (PubMed:17974005)Curated
    Sequence conflicti161 – 1611N → S in BAC05295. (PubMed:14702039)Curated
    Sequence conflicti324 – 3241M → L in BAC05295. (PubMed:14702039)Curated
    Sequence conflicti401 – 4011Q → H in CAD89937. (PubMed:17974005)Curated
    Sequence conflicti460 – 4601N → H in CAD89937. (PubMed:17974005)Curated
    Sequence conflicti490 – 4901C → F in BAB14172. (PubMed:14702039)Curated
    Sequence conflicti613 – 6131G → V in CAD38620. (PubMed:17974005)Curated
    Sequence conflicti634 – 6341N → S in CAD38620. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3434Missing in isoform 2. 1 PublicationVSP_014002Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL832326 mRNA. Translation: CAD38620.1.
    AL832578 mRNA. Translation: CAD89937.1.
    CH471061 Genomic DNA. Translation: EAW80930.1.
    BC053366 mRNA. Translation: AAH53366.1. Sequence problems.
    BC129933 mRNA. Translation: AAI29934.1.
    AK022677 mRNA. Translation: BAB14172.1. Different initiation.
    AK098373 mRNA. Translation: BAC05295.1.
    CCDSiCCDS58325.1. [Q8N3R9-2]
    CCDS9779.1. [Q8N3R9-1]
    RefSeqiNP_001243479.1. NM_001256550.1. [Q8N3R9-2]
    NP_071919.2. NM_022474.3. [Q8N3R9-1]
    XP_005268060.1. XM_005268003.1. [Q8N3R9-2]
    UniGeneiHs.652312.
    Hs.740524.

    Genome annotation databases

    EnsembliENST00000261681; ENSP00000261681; ENSG00000072415. [Q8N3R9-1]
    ENST00000555925; ENSP00000451488; ENSG00000072415. [Q8N3R9-2]
    GeneIDi64398.
    KEGGihsa:64398.
    UCSCiuc001xjc.4. human. [Q8N3R9-1]

    Polymorphism databases

    DMDMi116242632.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL832326 mRNA. Translation: CAD38620.1 .
    AL832578 mRNA. Translation: CAD89937.1 .
    CH471061 Genomic DNA. Translation: EAW80930.1 .
    BC053366 mRNA. Translation: AAH53366.1 . Sequence problems.
    BC129933 mRNA. Translation: AAI29934.1 .
    AK022677 mRNA. Translation: BAB14172.1 . Different initiation.
    AK098373 mRNA. Translation: BAC05295.1 .
    CCDSi CCDS58325.1. [Q8N3R9-2 ]
    CCDS9779.1. [Q8N3R9-1 ]
    RefSeqi NP_001243479.1. NM_001256550.1. [Q8N3R9-2 ]
    NP_071919.2. NM_022474.3. [Q8N3R9-1 ]
    XP_005268060.1. XM_005268003.1. [Q8N3R9-2 ]
    UniGenei Hs.652312.
    Hs.740524.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1Y76 NMR - B/D 118-177 [» ]
    3UIT X-ray 2.05 A/B/C/D 119-232 [» ]
    ProteinModelPortali Q8N3R9.
    SMRi Q8N3R9. Positions 119-232, 236-335, 349-671.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122155. 15 interactions.
    IntActi Q8N3R9. 18 interactions.
    MINTi MINT-1772982.
    STRINGi 9606.ENSP00000261681.

    PTM databases

    PhosphoSitei Q8N3R9.

    Polymorphism databases

    DMDMi 116242632.

    Proteomic databases

    MaxQBi Q8N3R9.
    PaxDbi Q8N3R9.
    PRIDEi Q8N3R9.

    Protocols and materials databases

    DNASUi 64398.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261681 ; ENSP00000261681 ; ENSG00000072415 . [Q8N3R9-1 ]
    ENST00000555925 ; ENSP00000451488 ; ENSG00000072415 . [Q8N3R9-2 ]
    GeneIDi 64398.
    KEGGi hsa:64398.
    UCSCi uc001xjc.4. human. [Q8N3R9-1 ]

    Organism-specific databases

    CTDi 64398.
    GeneCardsi GC14P067708.
    HGNCi HGNC:18669. MPP5.
    HPAi HPA000993.
    MIMi 606958. gene.
    neXtProti NX_Q8N3R9.
    PharmGKBi PA38631.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0194.
    HOGENOMi HOG000233034.
    HOVERGENi HBG001858.
    InParanoidi Q8N3R9.
    KOi K06091.
    OMAi VHQKEGQ.
    OrthoDBi EOG79CXZ5.
    PhylomeDBi Q8N3R9.
    TreeFami TF314263.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    EvolutionaryTracei Q8N3R9.
    GeneWikii MPP5.
    GenomeRNAii 64398.
    NextBioi 66338.
    PROi Q8N3R9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N3R9.
    Bgeei Q8N3R9.
    CleanExi HS_MPP5.
    Genevestigatori Q8N3R9.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR004172. L27.
    IPR014775. L27_C.
    IPR015145. L27_N.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    PF02828. L27. 1 hit.
    PF09060. L27_N. 1 hit.
    PF00595. PDZ. 1 hit.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    SM00569. L27. 2 hits.
    SM00228. PDZ. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF50156. SSF50156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS51022. L27. 2 hits.
    PS50106. PDZ. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Skeletal muscle and Spinal cord.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-441 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-675.
      Tissue: Brain.
    5. Cited for: COMPLEX FORMATION WITH CRB1 AND MPP4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina."
      Stoehr H., Molday L.L., Molday R.S., Weber B.H.F., Biedermann B., Reichenbach A., Kraemer F.
      J. Comp. Neurol. 481:31-41(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    7. "A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells."
      Wells C.D., Fawcett J.P., Traweger A., Yamanaka Y., Goudreault M., Elder K., Kulkarni S., Gish G., Virag C., Lim C., Colwill K., Starostine A., Metalnikov P., Pawson T.
      Cell 125:535-548(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH ARHGAP17; AMOT; INADL AND PARD3, INTERACTION WITH MPP7.
    8. "The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation."
      Stucke V.M., Timmerman E., Vandekerckhove J., Gevaert K., Hall A.
      Mol. Biol. Cell 18:1744-1755(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MPP7.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins."
      Feng W., Long J.-F., Zhang M.
      Proc. Natl. Acad. Sci. U.S.A. 102:6861-6866(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 118-177, INTERACTION WITH MPDZ.
    12. Cited for: INTERACTION WITH MPP1, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMPP5_HUMAN
    AccessioniPrimary (citable) accession number: Q8N3R9
    Secondary accession number(s): A1L380
    , Q7Z631, Q86T98, Q8N7I5, Q9H9Q0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3