Q8N3P4 (VPS8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vacuolar protein sorting-associated protein 8 homolog

Gene names

Name:	VPS8
Synonyms:	KIAA0804

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1428 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the VPS8 family. Contains 1 RING-type zinc finger. Contains 1 WD repeat.
Sequence caution	The sequence BAB14322.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAH56195.1 differs from that shown. Reason: Frameshift at position 325. Isoform 2: The sequence CAH56195.1 differs from that shown. Reason: Frameshift at position 326.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	WD repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N3P4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N3P4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     179-180: Missing.
     578-667: Missing.

Isoform 3 (identifier: Q8N3P4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     179-180: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1428	1428	Vacuolar protein sorting-associated protein 8 homolog		PRO_0000278267
Regions
	Repeat	195 – 236	42	WD
	Zinc finger	1258 – 1310	53	RING-type; atypical
Amino acid modifications
	Modified residue	26	1	Phosphoserine Ref.6 Ref.7 Ref.8
Natural variations
	Alternative sequence	179 – 180	2	Missing in isoform 2 and isoform 3.		VSP_023249
	Alternative sequence	578 – 667	90	Missing in isoform 2.		VSP_023250
	Natural variant	83	1	I → V. Ref.2 Corresponds to variant rs9830734 [ dbSNP | Ensembl ].		VAR_030730
	Natural variant	1165	1	H → Y. Ref.2 Corresponds to variant rs11555405 [ dbSNP | Ensembl ].		VAR_030731
	Natural variant	1364	1	I → T. Corresponds to variant rs3821750 [ dbSNP | Ensembl ].		VAR_030732
	Natural variant	1372	1	R → H. Corresponds to variant rs16859527 [ dbSNP | Ensembl ].		VAR_030733
Experimental info
	Sequence conflict	433	1	E → G in CAH56195. Ref.2
	Sequence conflict	471	1	K → N in CAH56195. Ref.2
	Sequence conflict	765	1	A → S in BAB14322. Ref.1
	Sequence conflict	932	1	Missing in CAH56195. Ref.2
	Sequence conflict	1042	1	T → A in BAB14322. Ref.1
	Sequence conflict	1043	1	Q → L in CAH56195. Ref.2
	Sequence conflict	1167	1	E → G in BAB14322. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 97FB5E8D453BBCB6	FASTA	1,428	161,754
	10 20 30 40 50 60 MENEPDHENV EQSLCAKTSE EELNKSFNLE ASLSKFSYID MDKELEFKND LIDDKEFDIP 70 80 90 100 110 120 QVDTPPTLES ILNETDDEDE SFILEDPTLL NIDTIDSHSY DTSSVASSDS GDRTNLKRKK 130 140 150 160 170 180 KLPDSFSLHG SVMRHSLLKG ISAQIVSAAD KVDAGLPTAI AVSSLIAVGT SHGLALIFGK 190 200 210 220 230 240 DQNQALRLCL GSTSVGGQYG AISALSINND CSRLLCGFAK GQITMWDLAS GKLLRSITDA 250 260 270 280 290 300 HPPGTAILHI KFTDDPTLAI CNDSGGSVFE LTFKRVMGVR TCESRCLFSG SKGEVCCIEP 310 320 330 340 350 360 LHSKPELKDH PITQFSLLAM ASLTKILVIG LKPSLKVWMT FPYGRMDPSS VPLLAWHFVA 370 380 390 400 410 420 VQNYVNPMLA FCRGDVVHFL LVKRDESGAI HVTKQKHLHL YYDLINFTWI NSRTVVLLDS 430 440 450 460 470 480 VEKLHVIDRQ TQEELETVEI SEVQLVYNSS HFKSLATGGN VSQALALVGE KACYQSISSY 490 500 510 520 530 540 GGQIFYLGTK SVYVMMLRSW RERVDHLLKQ DCLTEALALA WSFHEGKAKA VVGLSGDASK 550 560 570 580 590 600 RKAIVADRMV EILFHYADRA LKKCPDQGKI QVMEQHFQDM VPVIVDYCLL LQRKDLLFSQ 610 620 630 640 650 660 MYDKLSENSV AKGVFLECLE PYILSDKLVG ITPQVMKDLI VHFQDKKLME NVEALIVHMD 670 680 690 700 710 720 ITSLDIQQVV LMCWENRLYD AMIYVYNRGM NEFISPMEKL FRVIAPPLNA GKTLTDEQVV 730 740 750 760 770 780 MGNKLLVYIS CCLAGRAYPL GDIPEDLVPL VKNQVFEFLI RLHSAEASPE EEIYPYIRTL 790 800 810 820 830 840 LHFDTREFLN VLALTFEDFK NDKQAVEYQQ RIVDILLKVM VENSDFTPSQ VGCLFTFLAR 850 860 870 880 890 900 QLAKPDNTLF VNRTLFDQVL EFLCSPDDDS RHSERQQVLL ELLQAGGIVQ FEESRLIRMA 910 920 930 940 950 960 EKAEFYQICE FMYEREHQYD KIIDCYLRDP LREEEVFNYI HNILSIPGHS AEEKQSVWQK 970 980 990 1000 1010 1020 AMDHIEELVS LKPCKAAELV ATHFSGHIET VIKKLQNQVL LFKFLRSLLD PREGIHVNQE 1030 1040 1050 1060 1070 1080 LLQISPCITE QFIELLCQFN PTQVIETLQV LECYRLEETI QITQKYQLHE VTAYLLEKKG 1090 1100 1110 1120 1130 1140 DIHGAFLIML ERLQSKLQEV THQGENTKED PSLKDVEDTM VETIALCQRN SHNLNQQQRE 1150 1160 1170 1180 1190 1200 ALWFPLLEAM MAPQKLSSSA IPHLHSEALK SLTMQVLNSM AAFIALPSIL QRILQDPVYG 1210 1220 1230 1240 1250 1260 KGKLGEIQGL ILGMLDTFNY EQTLLETTTS LLNQDLHWSL CNLRASVTRG LNPKQDYCSI 1270 1280 1290 1300 1310 1320 CLQQYKRRQE MADEIIVFSC GHLYHSFCLQ NKECTVEFEG QTRWTCYKCS SSNKVGKLSE 1330 1340 1350 1360 1370 1380 NSSEIKKGRI TPSQVKMSPS YHQSKGDPTA KKGTSEPVLD PQQIQAFDQL CRLYRGSSRL 1390 1400 1410 1420 ALLTELSQNR SSESYRPFSG SQSAPAFNSI FQNENFQLQL IPPPVTED
	Isoform 2 [UniParc]. Checksum: 67DBD2AE6D4FBEE6	FASTA	1,336	151,216
	10 20 30 40 50 60 MENEPDHENV EQSLCAKTSE EELNKSFNLE ASLSKFSYID MDKELEFKND LIDDKEFDIP 70 80 90 100 110 120 QVDTPPTLES ILNETDDEDE SFILEDPTLL NIDTIDSHSY DTSSVASSDS GDRTNLKRKK 130 140 150 160 170 180 KLPDSFSLHG SVMRHSLLKG ISAQIVSAAD KVDAGLPTAI AVSSLIAVGT SHGLALIFDQ 190 200 210 220 230 240 NQALRLCLGS TSVGGQYGAI SALSINNDCS RLLCGFAKGQ ITMWDLASGK LLRSITDAHP 250 260 270 280 290 300 PGTAILHIKF TDDPTLAICN DSGGSVFELT FKRVMGVRTC ESRCLFSGSK GEVCCIEPLH 310 320 330 340 350 360 SKPELKDHPI TQFSLLAMAS LTKILVIGLK PSLKVWMTFP YGRMDPSSVP LLAWHFVAVQ 370 380 390 400 410 420 NYVNPMLAFC RGDVVHFLLV KRDESGAIHV TKQKHLHLYY DLINFTWINS RTVVLLDSVE 430 440 450 460 470 480 KLHVIDRQTQ EELETVEISE VQLVYNSSHF KSLATGGNVS QALALVGEKA CYQSISSYGG 490 500 510 520 530 540 QIFYLGTKSV YVMMLRSWRE RVDHLLKQDC LTEALALAWS FHEGKAKAVV GLSGDASKRK 550 560 570 580 590 600 AIVADRMVEI LFHYADRALK KCPDQGKIQV MEQHFQVVLM CWENRLYDAM IYVYNRGMNE 610 620 630 640 650 660 FISPMEKLFR VIAPPLNAGK TLTDEQVVMG NKLLVYISCC LAGRAYPLGD IPEDLVPLVK 670 680 690 700 710 720 NQVFEFLIRL HSAEASPEEE IYPYIRTLLH FDTREFLNVL ALTFEDFKND KQAVEYQQRI 730 740 750 760 770 780 VDILLKVMVE NSDFTPSQVG CLFTFLARQL AKPDNTLFVN RTLFDQVLEF LCSPDDDSRH 790 800 810 820 830 840 SERQQVLLEL LQAGGIVQFE ESRLIRMAEK AEFYQICEFM YEREHQYDKI IDCYLRDPLR 850 860 870 880 890 900 EEEVFNYIHN ILSIPGHSAE EKQSVWQKAM DHIEELVSLK PCKAAELVAT HFSGHIETVI 910 920 930 940 950 960 KKLQNQVLLF KFLRSLLDPR EGIHVNQELL QISPCITEQF IELLCQFNPT QVIETLQVLE 970 980 990 1000 1010 1020 CYRLEETIQI TQKYQLHEVT AYLLEKKGDI HGAFLIMLER LQSKLQEVTH QGENTKEDPS 1030 1040 1050 1060 1070 1080 LKDVEDTMVE TIALCQRNSH NLNQQQREAL WFPLLEAMMA PQKLSSSAIP HLHSEALKSL 1090 1100 1110 1120 1130 1140 TMQVLNSMAA FIALPSILQR ILQDPVYGKG KLGEIQGLIL GMLDTFNYEQ TLLETTTSLL 1150 1160 1170 1180 1190 1200 NQDLHWSLCN LRASVTRGLN PKQDYCSICL QQYKRRQEMA DEIIVFSCGH LYHSFCLQNK 1210 1220 1230 1240 1250 1260 ECTVEFEGQT RWTCYKCSSS NKVGKLSENS SEIKKGRITP SQVKMSPSYH QSKGDPTAKK 1270 1280 1290 1300 1310 1320 GTSEPVLDPQ QIQAFDQLCR LYRGSSRLAL LTELSQNRSS ESYRPFSGSQ SAPAFNSIFQ 1330 NENFQLQLIP PPVTED
	Isoform 3 [UniParc]. Checksum: ECF6DAC303CC7B16	FASTA	1,426	161,568
	10 20 30 40 50 60 MENEPDHENV EQSLCAKTSE EELNKSFNLE ASLSKFSYID MDKELEFKND LIDDKEFDIP 70 80 90 100 110 120 QVDTPPTLES ILNETDDEDE SFILEDPTLL NIDTIDSHSY DTSSVASSDS GDRTNLKRKK 130 140 150 160 170 180 KLPDSFSLHG SVMRHSLLKG ISAQIVSAAD KVDAGLPTAI AVSSLIAVGT SHGLALIFDQ 190 200 210 220 230 240 NQALRLCLGS TSVGGQYGAI SALSINNDCS RLLCGFAKGQ ITMWDLASGK LLRSITDAHP 250 260 270 280 290 300 PGTAILHIKF TDDPTLAICN DSGGSVFELT FKRVMGVRTC ESRCLFSGSK GEVCCIEPLH 310 320 330 340 350 360 SKPELKDHPI TQFSLLAMAS LTKILVIGLK PSLKVWMTFP YGRMDPSSVP LLAWHFVAVQ 370 380 390 400 410 420 NYVNPMLAFC RGDVVHFLLV KRDESGAIHV TKQKHLHLYY DLINFTWINS RTVVLLDSVE 430 440 450 460 470 480 KLHVIDRQTQ EELETVEISE VQLVYNSSHF KSLATGGNVS QALALVGEKA CYQSISSYGG 490 500 510 520 530 540 QIFYLGTKSV YVMMLRSWRE RVDHLLKQDC LTEALALAWS FHEGKAKAVV GLSGDASKRK 550 560 570 580 590 600 AIVADRMVEI LFHYADRALK KCPDQGKIQV MEQHFQDMVP VIVDYCLLLQ RKDLLFSQMY 610 620 630 640 650 660 DKLSENSVAK GVFLECLEPY ILSDKLVGIT PQVMKDLIVH FQDKKLMENV EALIVHMDIT 670 680 690 700 710 720 SLDIQQVVLM CWENRLYDAM IYVYNRGMNE FISPMEKLFR VIAPPLNAGK TLTDEQVVMG 730 740 750 760 770 780 NKLLVYISCC LAGRAYPLGD IPEDLVPLVK NQVFEFLIRL HSAEASPEEE IYPYIRTLLH 790 800 810 820 830 840 FDTREFLNVL ALTFEDFKND KQAVEYQQRI VDILLKVMVE NSDFTPSQVG CLFTFLARQL 850 860 870 880 890 900 AKPDNTLFVN RTLFDQVLEF LCSPDDDSRH SERQQVLLEL LQAGGIVQFE ESRLIRMAEK 910 920 930 940 950 960 AEFYQICEFM YEREHQYDKI IDCYLRDPLR EEEVFNYIHN ILSIPGHSAE EKQSVWQKAM 970 980 990 1000 1010 1020 DHIEELVSLK PCKAAELVAT HFSGHIETVI KKLQNQVLLF KFLRSLLDPR EGIHVNQELL 1030 1040 1050 1060 1070 1080 QISPCITEQF IELLCQFNPT QVIETLQVLE CYRLEETIQI TQKYQLHEVT AYLLEKKGDI 1090 1100 1110 1120 1130 1140 HGAFLIMLER LQSKLQEVTH QGENTKEDPS LKDVEDTMVE TIALCQRNSH NLNQQQREAL 1150 1160 1170 1180 1190 1200 WFPLLEAMMA PQKLSSSAIP HLHSEALKSL TMQVLNSMAA FIALPSILQR ILQDPVYGKG 1210 1220 1230 1240 1250 1260 KLGEIQGLIL GMLDTFNYEQ TLLETTTSLL NQDLHWSLCN LRASVTRGLN PKQDYCSICL 1270 1280 1290 1300 1310 1320 QQYKRRQEMA DEIIVFSCGH LYHSFCLQNK ECTVEFEGQT RWTCYKCSSS NKVGKLSENS 1330 1340 1350 1360 1370 1380 SEIKKGRITP SQVKMSPSYH QSKGDPTAKK GTSEPVLDPQ QIQAFDQLCR LYRGSSRLAL 1390 1400 1410 1420 LTELSQNRSS ESYRPFSGSQ SAPAFNSIFQ NENFQLQLIP PPVTED

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 608-1428 (ISOFORM 1). Tissue: Teratocarcinoma and Testis.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-1428 (ISOFORM 1), VARIANTS VAL-83 AND TYR-1165. Tissue: Amygdala and Colon endothelium.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Placenta.
[5]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-1428 (ISOFORM 1). Tissue: Brain.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022945 mRNA. Translation: BAB14322.1. Different initiation. AK292423 mRNA. Translation: BAF85112.1. AL833838 mRNA. Translation: CAD38698.1. BX647915 mRNA. Translation: CAH56195.1. Frameshift. AC025573 Genomic DNA. No translation available. AC107294 Genomic DNA. No translation available. AC117436 Genomic DNA. No translation available. BC001001 mRNA. Translation: AAH01001.2. BC140768 mRNA. Translation: AAI40769.1. AB018347 mRNA. Translation: BAA34524.1.
IPI	IPI00464985. IPI00549242.
RefSeq	NP_001009921.1. NM_001009921.2. NP_056118.2. NM_015303.3.
UniGene	Hs.269263.
3D structure databases
ProteinModelPortal	Q8N3P4.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1196904.
STRING	9606.ENSP00000397879.
PTM databases
PhosphoSite	Q8N3P4.
Polymorphism databases
DMDM	296452997.
Proteomic databases
PaxDb	Q8N3P4.
PRIDE	Q8N3P4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000436792; ENSP00000404704; ENSG00000156931. ENST00000437079; ENSP00000397879; ENSG00000156931. ENST00000446204; ENSP00000405483; ENSG00000156931.
GeneID	23355.
KEGG	hsa:23355.
UCSC	uc010hyd.1. human. uc010hye.1. human.
Organism-specific databases
CTD	23355.
GeneCards	GC03P184529.
HGNC	HGNC:29122. VPS8.
HPA	HPA036871.
neXtProt	NX_Q8N3P4.
PharmGKB	PA142671617. PA142671888.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327467.
HOGENOM	HOG000013171.
HOVERGEN	HBG071091.
InParanoid	Q8N3P4.
OrthoDB	EOG4ZPDTD.
Gene expression databases
ArrayExpress	Q8N3P4.
Bgee	Q8N3P4.
CleanEx	HS_VPS8.
Genevestigator	Q8N3P4.
Family and domain databases
Gene3D	2.130.10.10. 1 hit. 3.30.40.10. 1 hit.
InterPro	IPR011047. Quinonprotein_ADH-like_supfam. IPR025941. Vps8_central_dom. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF12816. Vps8. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF50998. Quin_alc_DH_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23355.
NextBio	45370.

Entry information

Entry name

VPS8_HUMAN

Accession

Primary (citable) accession number: Q8N3P4
Secondary accession number(s): A8K8Q8 , B9EIQ1, C9JB61, O94896, Q63HP2, Q9BVP9, Q9H9B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 95 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.