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Protein

Beta-taxilin

Gene

TXLNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-taxilin
Alternative name(s):
Muscle-derived protein 77
Short name:
hMDP77
Gene namesi
Name:TXLNB
Synonyms:C6orf198, MDP77
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21617. TXLNB.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi167838.
OpenTargetsiENSG00000164440.
PharmGKBiPA134878600.

Polymorphism and mutation databases

BioMutaiTXLNB.
DMDMi55583953.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894231 – 684Beta-taxilinAdd BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei474PhosphoserineBy similarity1
Modified residuei483PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N3L3.
PaxDbiQ8N3L3.
PeptideAtlasiQ8N3L3.
PRIDEiQ8N3L3.

PTM databases

iPTMnetiQ8N3L3.
PhosphoSitePlusiQ8N3L3.

Expressioni

Tissue specificityi

Expressed in skeletal muscle.

Gene expression databases

BgeeiENSG00000164440.
CleanExiHS_TXLNB.
ExpressionAtlasiQ8N3L3. baseline and differential.
GenevisibleiQ8N3L3. HS.

Organism-specific databases

HPAiHPA030401.
HPA030402.
HPA030403.

Interactioni

Subunit structurei

Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preference for STX1A.

Binary interactionsi

WithEntry#Exp.IntActNotes
TXLNAP402224EBI-6116822,EBI-359793

Protein-protein interaction databases

BioGridi127952. 42 interactors.
IntActiQ8N3L3. 27 interactors.
MINTiMINT-4717196.
STRINGi9606.ENSP00000351206.

Structurei

3D structure databases

ProteinModelPortaliQ8N3L3.
SMRiQ8N3L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili135 – 351Sequence analysisAdd BLAST217
Coiled coili378 – 467Sequence analysisAdd BLAST90

Sequence similaritiesi

Belongs to the taxilin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1850. Eukaryota.
ENOG410XQH1. LUCA.
GeneTreeiENSGT00390000001482.
HOGENOMiHOG000231384.
HOVERGENiHBG104385.
InParanoidiQ8N3L3.
OMAiDQSQHTS.
OrthoDBiEOG091G0GVB.
PhylomeDBiQ8N3L3.
TreeFamiTF318595.

Family and domain databases

InterProiIPR026183. Taxilin_fam.
[Graphical view]
PANTHERiPTHR16127. PTHR16127. 1 hit.
PfamiPF09728. Taxilin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N3L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANHSEQLS AERQSTPPGD SSSLPSHNGL EKEDGQDSPT PVQPPEKEAS
60 70 80 90 100
VHPDISEELN RQLEDIINTY GSAASTAGKE GSARASEQPE NAESPDNEDG
110 120 130 140 150
DCEETTEEAG REPVASGEPP TVKEPVSNKE QKLEKKILKG LGKEANLLMQ
160 170 180 190 200
NLNKLQTPEE KFDFLFKKYA ELLDEHRTEQ KKLKLLQKKQ VQIQKEKDQL
210 220 230 240 250
QGEHSRAILA RSKLESLCRE LQRHNKTLKE EALQRAREEE EKRKEITSHF
260 270 280 290 300
QSTLTDIQGQ IEQQSERNMK LCQENTELAE KLKSIIDQYE LREEHLDKIF
310 320 330 340 350
KHRELQQKLV DAKLEQAQEM MKEAEERHKR EKEYLLNQAA EWKLQAKVLK
360 370 380 390 400
EQETVLQAQL TLYSGRFEEF QSTLTKSNEV FATFKQEMDK TTKKMKKLEK
410 420 430 440 450
DTATWKARFE NCNKALLDMI EEKALRAKEY ECFVMKIGRL ENLCRALQEE
460 470 480 490 500
RNELHKKIRD AEISEKDDQS QHNSDEEPES NVSVDQEIDA EEVNSVQTAV
510 520 530 540 550
KNLATAFMII HHPESTPHQS KETQPEIGSS QESADAALKE PEQPPLIPSR
560 570 580 590 600
DSESPLPPLT PQAEAEGGSD AEPPSKASNS PAGLGAETQC EGLPVGAQAD
610 620 630 640 650
QASWKPEAEA SGQAPQAPTE ASLQKMEADV PAPACAAEEH VAAMVPACEP
660 670 680
SRQPPRAAAE ELPVGASAGP QPRNVADTNL EGVD
Length:684
Mass (Da):76,519
Last modified:November 9, 2004 - v3
Checksum:i5C40DF4B3085C590
GO

Sequence cautioni

The sequence CAD38924 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD91140 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270K → E in CAD38617 (PubMed:17974005).Curated1
Sequence conflicti597A → T in CAD91140 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01980711A → T.Corresponds to variant rs9321712dbSNPEnsembl.1
Natural variantiVAR_057729348V → M.1 PublicationCorresponds to variant rs17068451dbSNPEnsembl.1
Natural variantiVAR_057730527I → T.Corresponds to variant rs9495392dbSNPEnsembl.1
Natural variantiVAR_057731602A → P.1 PublicationCorresponds to variant rs9495391dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085905 mRNA. Translation: BAC92688.1.
AL832322 mRNA. Translation: CAD38617.1.
AL834248 mRNA. Translation: CAD38924.2. Different initiation.
AL831988 mRNA. Translation: CAD91140.1. Different initiation.
AL592434, AL158850 Genomic DNA. Translation: CAH73884.1.
AL158850, AL592434 Genomic DNA. Translation: CAI42896.1.
BC115384 mRNA. Translation: AAI15385.1.
CCDSiCCDS34545.1.
RefSeqiNP_694967.3. NM_153235.3.
XP_005266893.1. XM_005266836.1.
XP_011533807.1. XM_011535505.2.
XP_016865811.1. XM_017010322.1.
UniGeneiHs.535820.

Genome annotation databases

EnsembliENST00000358430; ENSP00000351206; ENSG00000164440.
GeneIDi167838.
KEGGihsa:167838.
UCSCiuc063rxd.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085905 mRNA. Translation: BAC92688.1.
AL832322 mRNA. Translation: CAD38617.1.
AL834248 mRNA. Translation: CAD38924.2. Different initiation.
AL831988 mRNA. Translation: CAD91140.1. Different initiation.
AL592434, AL158850 Genomic DNA. Translation: CAH73884.1.
AL158850, AL592434 Genomic DNA. Translation: CAI42896.1.
BC115384 mRNA. Translation: AAI15385.1.
CCDSiCCDS34545.1.
RefSeqiNP_694967.3. NM_153235.3.
XP_005266893.1. XM_005266836.1.
XP_011533807.1. XM_011535505.2.
XP_016865811.1. XM_017010322.1.
UniGeneiHs.535820.

3D structure databases

ProteinModelPortaliQ8N3L3.
SMRiQ8N3L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127952. 42 interactors.
IntActiQ8N3L3. 27 interactors.
MINTiMINT-4717196.
STRINGi9606.ENSP00000351206.

PTM databases

iPTMnetiQ8N3L3.
PhosphoSitePlusiQ8N3L3.

Polymorphism and mutation databases

BioMutaiTXLNB.
DMDMi55583953.

Proteomic databases

MaxQBiQ8N3L3.
PaxDbiQ8N3L3.
PeptideAtlasiQ8N3L3.
PRIDEiQ8N3L3.

Protocols and materials databases

DNASUi167838.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358430; ENSP00000351206; ENSG00000164440.
GeneIDi167838.
KEGGihsa:167838.
UCSCiuc063rxd.1. human.

Organism-specific databases

CTDi167838.
DisGeNETi167838.
GeneCardsiTXLNB.
HGNCiHGNC:21617. TXLNB.
HPAiHPA030401.
HPA030402.
HPA030403.
MIMi611438. gene.
neXtProtiNX_Q8N3L3.
OpenTargetsiENSG00000164440.
PharmGKBiPA134878600.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1850. Eukaryota.
ENOG410XQH1. LUCA.
GeneTreeiENSGT00390000001482.
HOGENOMiHOG000231384.
HOVERGENiHBG104385.
InParanoidiQ8N3L3.
OMAiDQSQHTS.
OrthoDBiEOG091G0GVB.
PhylomeDBiQ8N3L3.
TreeFamiTF318595.

Miscellaneous databases

ChiTaRSiTXLNB. human.
GeneWikiiTXLNB.
GenomeRNAii167838.
PROiQ8N3L3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164440.
CleanExiHS_TXLNB.
ExpressionAtlasiQ8N3L3. baseline and differential.
GenevisibleiQ8N3L3. HS.

Family and domain databases

InterProiIPR026183. Taxilin_fam.
[Graphical view]
PANTHERiPTHR16127. PTHR16127. 1 hit.
PfamiPF09728. Taxilin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXLNB_HUMAN
AccessioniPrimary (citable) accession number: Q8N3L3
Secondary accession number(s): Q5VTF3
, Q76L25, Q86T52, Q8N3S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: November 30, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.