Reviewed, UniProtKB/Swiss-Prot Q8N3K9 (CMYA5_HUMAN)

Names and origin

Protein names

Recommended name:
    Cardiomyopathy-associated protein 5
Alternative name(s):
    Myospryn
    Dystrobrevin-binding protein 2
    SPRY domain-containing protein 2
    Tripartite motif-containing protein 76
    Genethonin-3

Gene names

Name:	CMYA5
Synonyms:	C5orf10, DTNBP2, SPRYD2, TRIM76

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	4069 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Interacts with ACTN2, DTNBP1/dysbindin and PRKAR2A By similarity. Interacts with DES.
Subcellular location	Cytoplasm By similarity. Cytoplasm › perinuclear region By similarity. Note: Found predominantly at the periphery of the nucleus but also throughout the cell. Localized at the Z-line costamere connection level of the sarcolemma and in lysosomes By similarity.
Tissue specificity	Expressed in skeletal muscle; at a strong level and in heart. Ref.5
Induction	Down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy (DMD). Ref.5 Ref.8
Domain	Amphipathic helix regions act as an anchoring domain for PKA, and appear to be responsible of the interaction between myospryn and PRKAR2A.
Sequence similarities	Contains 1 B30.2/SPRY domain. Contains 2 fibronectin type-III domains.
Sequence caution	The sequence AAD55265.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. The sequence AAH20856.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. The sequence AAH22422.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. The sequence AAH62664.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. The sequence AAH63134.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. The sequence AAI11530.1 differs from that shown. Reason: Erroneous termination at position 3283. Translated as Trp. The sequence CAH10406.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	Coiled coil Repeat
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BZW1	Q9BUY0	1	EBI-2323272,EBI-1046727
PSMC4	P43686	1	EBI-2323272,EBI-743997

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4069	4069	Cardiomyopathy-associated protein 5		PRO_0000328722
Regions
	Domain	3705 – 3801	97	Fibronectin type-III 1
	Domain	3802 – 3894	93	Fibronectin type-III 2
	Domain	3880 – 4065	186	B30.2/SPRY
	Region	3517 – 3544	28	Amphipathic helix H1
	Region	3545 – 3672	128	B-box coiled-coil; BBC
	Region	3631 – 3648	18	Amphipathic helix H2
	Region	3751 – 3767	17	Amphipathic helix H3
	Coiled coil	2964 – 2988	25	Potential
	Coiled coil	3544 – 3653	110	Potential
	Compositional bias	20 – 57	38	Glu-rich
	Compositional bias	483 – 639	157	Glu-rich
	Compositional bias	1584 – 1587	4	Poly-Leu
	Compositional bias	1918 – 1921	4	Poly-Ser
Amino acid modifications
	Modified residue	209	1	Phosphotyrosine Ref.7
Natural variations
	Natural variant	64	1	Y → C: dbSNP rs16877109.		VAR_042471
	Natural variant	175	1	Q → H: dbSNP rs6895605.		VAR_042472
	Natural variant	190	1	D → G: dbSNP rs10942901. Ref.2		VAR_042473
	Natural variant	349	1	G → D: dbSNP rs1366271.		VAR_042474
	Natural variant	591	1	G → D: dbSNP rs16877124.		VAR_042475
	Natural variant	1006	1	V → A: dbSNP rs6893869.		VAR_042476
	Natural variant	1295	1	A → V: dbSNP rs4704585. Ref.2		VAR_042477
	Natural variant	1309	1	I → V: dbSNP rs16877133.		VAR_042478
	Natural variant	1333	1	A → V: dbSNP rs16877135.		VAR_042479
	Natural variant	1380	1	I → V: dbSNP rs13158477.		VAR_042480
	Natural variant	1567	1	A → E: dbSNP rs1428223.		VAR_042481
	Natural variant	1599	1	S → A: dbSNP rs1428224.		VAR_042482
	Natural variant	1669	1	L → S: dbSNP rs1019762.		VAR_042483
	Natural variant	1713	1	I → N: dbSNP rs16877141.		VAR_042484
	Natural variant	1721	1	I → V: dbSNP rs1428225.		VAR_042485
	Natural variant	1875	1	A → V: dbSNP rs16877147.		VAR_042486
	Natural variant	1917	1	D → G: dbSNP rs16877150.		VAR_042487
	Natural variant	1920	1	S → G: dbSNP rs16877151. Ref.3		VAR_042488
	Natural variant	2262	1	V → L: dbSNP rs6859595. Ref.3		VAR_042489
	Natural variant	2383	1	K → E: dbSNP rs7721884.		VAR_042490
	Natural variant	2693	1	T → I: dbSNP rs28362541.		VAR_042491
	Natural variant	2906	1	K → N: dbSNP rs2278239.		VAR_042492
	Natural variant	2935	1	G → R: dbSNP rs2278240.		VAR_042493
	Natural variant	3358	1	H → Q: dbSNP rs3828611. Ref.3		VAR_042494
	Natural variant	3583	1	K → E: dbSNP rs12514461. Ref.2 Ref.3		VAR_042495
	Natural variant	3927	1	R → Q: dbSNP rs1129770. Ref.3 Ref.6		VAR_042496
	Natural variant	4063	1	P → L: dbSNP rs10043986. Ref.2		VAR_042497
Experimental info
	Sequence conflict	79	1	E → D in CAH10406. Ref.2
	Sequence conflict	445	1	A → V in CAH10406. Ref.2
	Sequence conflict	616	1	V → I in CAH10402. Ref.2
	Sequence conflict	654	1	S → L in CAH10406. Ref.2
	Sequence conflict	924	1	N → D in CAH10402. Ref.2
	Sequence conflict	995	1	A → T in CAH10406. Ref.2
	Sequence conflict	1283	1	S → P in CAH10406. Ref.2
	Sequence conflict	1606	1	F → L in CAH10406. Ref.2
	Sequence conflict	1681	1	G → E in CAH10406. Ref.2
	Sequence conflict	1855	1	S → G in AAH63134. Ref.3
	Sequence conflict	2038	1	E → K in AAH63134. Ref.3
	Sequence conflict	2148	1	S → A in AAD55265. Ref.5
	Sequence conflict	2538	1	G → D in AAD55265. Ref.5
	Sequence conflict	2782 – 2784	3	MKE → TKD in CAD38607. Ref.2
	Sequence conflict	2788	1	S → P in CAD38928. Ref.2
	Sequence conflict	2933	1	P → L in CAD38607. Ref.2
	Sequence conflict	3073 – 3113	41	PQKLN…VKLDE → SFKTIPLPDDSETVACHKTL KSRLEDEKVTPLKENKQKET Q in AAH62664. Ref.3
	Sequence conflict	3291	1	R → W in CAD91143. Ref.2
	Sequence conflict	3321	1	K → R in CAD91143. Ref.2
	Sequence conflict	3331	1	V → A in CAD91158. Ref.2
	Sequence conflict	3348	1	V → A in CAD91158. Ref.2
	Sequence conflict	3361	1	E → G in CAD91158. Ref.2
	Sequence conflict	3803 – 3822	20	APSTP…WNTAT → GKEMDAKGALEDNAQFFTDS in CAD91143. Ref.2
	Sequence conflict	3852	1	R → S in CAD91158. Ref.2
	Sequence conflict	3880	1	N → S in CAD91158. Ref.2
	Sequence conflict	3929	1	T → A in CAD91158. Ref.2
	Sequence conflict	3948	1	E → K in CAD91158. Ref.2
	Sequence conflict	4050	1	K → E in CAD38607. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8N3K9-1 [UniParc]. Last modified April 8, 2008. Version 3. Checksum: F5A25F1C53640EB8	FASTA	4,069	449,211
	10 20 30 40 50 60 MASRDSNHAG ESFLGSDGDE EATRELETEE ESEGEEDETA AESEEEPDSR LSDQDEEGKI 70 80 90 100 110 120 KQEYIISDPS FSMVTVQRED SGITWETNSS RSSTPWASEE SQTSGVCSRE GSTVNSPPGN 130 140 150 160 170 180 VSFIVDEVKK VRKRTHKSKH GSPSLRRKGN RKRNSFESQD VPTNKKGSPL TSASQVLTTE 190 200 210 220 230 240 KEKSYTGIYD KARKKKTTSN TPPITGAIYK EHKPLVLRPV YIGTVQYKIK MFNSVKEELI 250 260 270 280 290 300 PLQFYGTLPK GYVIKEIHYR KGKDASISLE PDLDNSGSNT VSKTRKLVAQ SIEDKVKEVF 310 320 330 340 350 360 PPWRGALSKG SESLTLMFSH EDQKKIYADS PLNATSALEH TVPSYSSSGR AEQGIQLRHS 370 380 390 400 410 420 QSVPQQPEDE AKPHEVEPPS VTPDTPATMF LRTTKEECEL ASPGTAASEN DSSVSPSFAN 430 440 450 460 470 480 EVKKEDVYSA HHSISLEAAS PGLAASTQDG LDPDQEQPDL TSIERAEPVS AKLTPTHPSV 490 500 510 520 530 540 KGEKEENMLE PSISLSEPLM LEEPEKEEIE TSLPIAITPE PEDSNLVEEE IVELDYPESP 550 560 570 580 590 600 LVSEKPFPPH MSPEVEHKEE ELILPLLAAS SPEHVALSEE EREEIASVST GSAFVSEYSV 610 620 630 640 650 660 PQDLNHELQE QEGEPVPPSN VEAIAEHAVL SEEENEEFEA YSPAAAPTSE SSLSPSTTEK 670 680 690 700 710 720 TSENQSPLFS TVTPEYMVLS GDEASESGCY TPDSTSASEY SVPSLATKES LKKTIDRKSP 730 740 750 760 770 780 LILKGVSEYM IPSEEKEDTG SFTPAVAPAS EPSLSPSTTE KTSECQSPLP STATSEHVVP 790 800 810 820 830 840 SEGEDLGSER FTPDSKLISK YAAPLNATQE SQKKIINEAS QFKPKGISEH TVLSVDGKEV 850 860 870 880 890 900 IGPSSPDLVV ASEHSFPPHT TEMTSECQAP PLSATPSEYV VLSDEEAVEL ERYTPSSTSA 910 920 930 940 950 960 SEFSVPPYAT PEAQEEEIVH RSLNLKGASS PMNLSEEDQE DIGPFSPDSA FVSEFSFPPY 970 980 990 1000 1010 1020 ATQEAEKREF ECDSPICLTS PSEHTILSDE DTEEAELFSP DSASQVSIPP FRISETEKNE 1030 1040 1050 1060 1070 1080 LEPDSLLTAV SASGYSCFSE ADEEDIGSTA ATPVSEQFSS SQKQKAETFP LMSPLEDLSL 1090 1100 1110 1120 1130 1140 PPSTDKSEKA EIKPEIPTTS TSVSEYLILA QKQKTQAYLE PESEDLIPSH LTSEVEKGER 1150 1160 1170 1180 1190 1200 EASSSVAAIP AALPAQSSIV KEETKPASPH SVLPDSVPAI KKEQEPTAAL TLKAADEQMA 1210 1220 1230 1240 1250 1260 LSKVRKEEIV PDSQEATAHV SQDQKMEPQP PNVPESEMKY SVLPDMVDEP KKGVKPKLVL 1270 1280 1290 1300 1310 1320 NVTSELEQRK LSKNEPEVIK PYSPLKETSL SGPEALSAVK MEMKHDSKIT TTPIVLHSAS 1330 1340 1350 1360 1370 1380 SGVEKQVEHG PPALAFSALS EEIKKEIEPS SSTTTASVTK LDSNLTRAVK EEIPTDSSLI 1390 1400 1410 1420 1430 1440 TPVDRPVLTK VGKGELGSGL PPLVTSADEH SVLAEEDKVA IKGASPIETS SKHLAWSEAE 1450 1460 1470 1480 1490 1500 KEIKFDSLPS VSSIAEHSVL SEVEAKEVKA GLPVIKTSSS QHSDKSEEAR VEDKQDLLFS 1510 1520 1530 1540 1550 1560 TVCDSERLVS SQKKSLMSTS EVLEPEHELP LSLWGEIKKK ETELPSSQNV SPASKHIIPK 1570 1580 1590 1600 1610 1620 GKDEETASSS PELENLASGL APTLLLLSDD KNKPAVEVSS TAQGDFPSEK QDVALAELSL 1630 1640 1650 1660 1670 1680 EPEKKDKPHQ PLELPNAGSE FSSDLGRQSG SIGTKQAKSP ITETEDSVLE KGPAELRSRE 1690 1700 1710 1720 1730 1740 GKEENRELCA SSTMPAISEL SSLLREESQN EEIKPFSPKI ISLESKEPPA SVAEGGNPEE 1750 1760 1770 1780 1790 1800 FQPFTFSLKG LSEEVSHPAD FKKGGNQEIG PLPPTGNLKA QVMGDILDKL SEETGHPNSS 1810 1820 1830 1840 1850 1860 QVLQSITEPS KIAPSDLLVE QKKTEKALHS DQTVKLPDVS TSSEDKQDLG IKQFSLMREN 1870 1880 1890 1900 1910 1920 LPLEQSKSFM TTKPADVKET KMEEFFISPK DENWMLGKPE NVASQHEQRI AGSVQLDSSS 1930 1940 1950 1960 1970 1980 SNELRPGQLK AAVSSKDHTC EVRKQVLPHS AEESHLSSQE AVSALDTSSG NTETLSSKSY 1990 2000 2010 2020 2030 2040 SSEEVKLAEE PKSLVLAGNV ERNIAEGKEI HSLMESESLL LEKANTELSW PSKEDSQEKI 2050 2060 2070 2080 2090 2100 KLPPERFFQK PVSGLSVEQV KSETISSSVK TAHFPAEGVE PALGNEKEAH RSTPPFPEEK 2110 2120 2130 2140 2150 2160 PLEESKMVQS KVIDDADEGK KPSPEVKIPT QRKPISSIHA REPQSPESPE VTQNPPTQPK 2170 2180 2190 2200 2210 2220 VAKPDLPEEK GKKGISSFKS WMSSLFFGSS TPDNKVAEQE DLETQPSPSV EKAVTVIDPE 2230 2240 2250 2260 2270 2280 GTIPTNFNVA EKPADHSLSE VKLKTADEPR GTLVKSGDGQ NVKEKSMILS NVEDLQQPKF 2290 2300 2310 2320 2330 2340 ISEVSREDYG KKEISGDSEE MNINSVVTSA DGENLEIQSY SLIGEKLVME EAKTIVPPHV 2350 2360 2370 2380 2390 2400 TDSKRVQKPA IAPPSKWNIS IFKEEPRSDQ KQKSLLSFDV VDKVPQQPKS ASSNFASKNI 2410 2420 2430 2440 2450 2460 TKESEKPESI ILPVEESKGS LIDFSEDRLK KEMQNPTSLK ISEEETKLRS VSPTEKKDNL 2470 2480 2490 2500 2510 2520 ENRSYTLAEK KVLAEKQNSV APLELRDSNE IGKTQITLGS RSTELKESKA DAMPQHFYQN 2530 2540 2550 2560 2570 2580 EDYNERPKII VGSEKEKGEE KENQVYVLSE GKKQQEHQPY SVNVAESMSR ESDISLGHSL 2590 2600 2610 2620 2630 2640 GETQSFSLVK ATSVTEKSEA MLAEAHPEIR EAKAVGTQPH PLEESKVLVE KTKTFLPVAL 2650 2660 2670 2680 2690 2700 SCRDEIENHS LSQEGNLVLE KSSRDMPDHS EEKEQFRESE LSKGGSVDIT KETVKQGFQE 2710 2720 2730 2740 2750 2760 KAVGTQPRPL EESKVLVEKT KTFLPVVLSC HDEIENHSLS QEGNLVLEKS SRDMPDHSEE 2770 2780 2790 2800 2810 2820 KEQFKESELW KGGSVDITKE SMKEGFPSKE SERTLARPFD ETKSSETPPY LLSPVKPQTL 2830 2840 2850 2860 2870 2880 ASGASPEINA VKKKEMPRSE LTPERHTVHT IQTSKDDTSD VPKQSVLVSK HHLEAAEDTR 2890 2900 2910 2920 2930 2940 VKEPLSSAKS NYAQFISNTS ASNADKMVSN KEMPKEPEDT YAKGEDFTVT SKPAGLSEDQ 2950 2960 2970 2980 2990 3000 KTAFSIISEG CEILNIHAPA FISSIDQEES EQMQDKLEYL EEKASFKTIP LPDDSETVAC 3010 3020 3030 3040 3050 3060 HKTLKSRLED EKVTPLKENK QKETHKTKEE ISTDSETDLS FIQPTIPSEE DYFEKYTLID 3070 3080 3090 3100 3110 3120 YNISPDPEKQ KAPQKLNVEE KLSKEVTEET ISFPVSSVES ALEHEYDLVK LDESFYGPEK 3130 3140 3150 3160 3170 3180 GHNILSHPET QSQNSADRNV SKDTKRDVDS KSPGMPLFEA EEGVLSRTQI FPTTIKVIDP 3190 3200 3210 3220 3230 3240 EFLEEPPALA FLYKDLYEEA VGEKKKEEET ASEGDSVNSE ASFPSRNSDT DDGTGIYFEK 3250 3260 3270 3280 3290 3300 YILKDDILHD TSLTQKDQGQ GLEEKRVGKD DSYQPIAAEG EIWGKFGTIC REKSLEEQKG 3310 3320 3330 3340 3350 3360 VYGEGESVDH VETVGNVAMQ KKAPITEDVR VATQKISYAV PFEDTHHVLE RADEAGSHGN 3370 3380 3390 3400 3410 3420 EVGNASPEVN LNVPVQVSFP EEEFASGATH VQETSLEEPK ILVPPEPSEE RLRNSPVQDE 3430 3440 3450 3460 3470 3480 YEFTESLHNE VVPQDILSEE LSSESTPEDV LSQGKESFEH ISENEFASEA EQSTPAEQKE 3490 3500 3510 3520 3530 3540 LGSERKEEDQ LSSEVVTEKA QKELKKSQID TYCYTCKCPI SATDKVFGTH KDHEVSTLDT 3550 3560 3570 3580 3590 3600 AISAVKVQLA EFLENLQEKS LRIEAFVSEI ESFFNTIEEN CSKNEKRLEE QNEEMMKKVL 3610 3620 3630 3640 3650 3660 AQYDEKAQSF EEVKKKKMEF LHEQMVHFLQ SMDTAKDTLE TIVREAEELD EAVFLTSFEE 3670 3680 3690 3700 3710 3720 INERLLSAME STASLEKMPA AFSLFEHYDD SSARSDQMLK QVAVPQPPRL EPQEPNSATS 3730 3740 3750 3760 3770 3780 TTIAVYWSMN KEDVIDSFQV YCMEEPQDDQ EVNELVEEYR LTVKESYCIF EDLEPDRCYQ 3790 3800 3810 3820 3830 3840 VWVMAVNFTG CSLPSERAIF RTAPSTPVIR AEDCTVCWNT ATIRWRPTTP EATETYTLEY 3850 3860 3870 3880 3890 3900 CRQHSPEGEG LRSFSGIKGL QLKVNLQPND NYFFYVRAIN AFGTSEQSEA ALISTRGTRF 3910 3920 3930 3940 3950 3960 LLLRETAHPA LHISSSGTVI SFGERRRLTE IPSVLGEELP SCGQHYWETT VTDCPAYRLG 3970 3980 3990 4000 4010 4020 ICSSSAVQAG ALGQGETSWY MHCSEPQRYT FFYSGIVSDV HVTERPARVG ILLDYNNQRL 4030 4040 4050 4060 IFINAESEQL LFIIRHRFNE GVHPAFALEK PGKCTLHLGI EPPDSVRHK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1682 AND 2600-4069, VARIANTS GLY-190; VAL-1295; GLU-3583 AND LEU-4063. Tissue: Skeletal muscle.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-283; 1067-1340; 1604-2691 AND 2754-4069, VARIANTS GLY-1920; LEU-2262; GLN-3358; GLU-3583 AND GLN-3927. Tissue: Liver and Skeletal muscle.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1067-1340. Tissue: Skeletal muscle.
[5]	"Identification of altered gene expression in skeletal muscles from Duchenne muscular dystrophy patients." Tkatchenko A.V., Pietu G., Cros N., Gannoun-Zaki L., Auffray C., Leger J.J., Dechesne C.A. Neuromuscul. Disord. 11:269-277(2001) [PubMed: 11297942] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1736-2539, INDUCTION, TISSUE SPECIFICITY.
[6]	Ding P., Han W., Wang L., Wang Y., Qiu X., Xu M., Ma D. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3155-4069, VARIANT GLN-3927. Tissue: Mammary gland.
[7]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-209, MASS SPECTROMETRY. Tissue: Epithelium.
[8]	"Myospryn is a novel binding partner for dysbindin in muscle." Benson M.A., Tinsley C.L., Blake D.J. J. Biol. Chem. 279:10450-10458(2004) [PubMed: 14688250] [Abstract] Cited for: INDUCTION.
[9]	"Proper perinuclear localization of the TRIM-like protein myospryn requires its binding partner desmin." Kouloumenta A., Mavroidis M., Capetanaki Y. J. Biol. Chem. 282:35211-35221(2007) [PubMed: 17872945] [Abstract] Cited for: INTERACTION WITH DES.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC008482 Genomic DNA. No translation available. AC109488 Genomic DNA. No translation available. AC008496 Genomic DNA. No translation available. AL831966 mRNA. Translation: CAD38607.1. AL831968 mRNA. Translation: CAD38609.2. AL831986 mRNA. Translation: CAD91143.1. AL832347 mRNA. Translation: CAH10406.1. Sequence problems. AL832368 mRNA. Translation: CAD91158.1. AL832376 mRNA. Translation: CAH10402.1. AL834252 mRNA. Translation: CAD38928.2. BC020856 mRNA. Translation: AAH20856.1. Sequence problems. BC022422 mRNA. Translation: AAH22422.1. Sequence problems. BC062664 mRNA. Translation: AAH62664.1. Sequence problems. BC063134 mRNA. Translation: AAH63134.1. Sequence problems. BC111529 mRNA. Translation: AAI11530.1. Sequence problems. BC111530 mRNA. Translation: AAI11531.1. AK092699 mRNA. No translation available. AF177292 mRNA. Translation: AAD55265.1. Sequence problems. AF533705 mRNA. Translation: AAQ09018.1. Different initiation.
IPI	IPI00166612.
RefSeq	NP_705838.3.
UniGene	Hs.482625
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8N3K9.
Proteomic databases
PRIDE	Q8N3K9.
Genome annotation databases
Ensembl	ENSG00000164309. Homo sapiens. [Contig view]
GeneID	202333.
KEGG	hsa:202333.
UCSC	uc003kgc.1. human.
Organism-specific databases
GeneCards	GC05P079067.
HGNC	HGNC:14305. CMYA5.
PharmGKB	PA37868.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8N3K9.
Gene expression databases
Bgee	Q8N3K9.
CleanEx	HS_CMYA5.
Family and domain databases
InterPro	IPR001870. B302. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003877. SPRY_rcpt. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 2 hits.
Pfam	PF00041. fn3. 2 hits. PF00622. SPRY. 1 hit. [Graphical view]
SMART	SM00060. FN3. 2 hits. [Graphical view]
PROSITE	PS50188. B302_SPRY. 1 hit. PS50853. FN3. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	90280.

Entry information

Entry name

CMYA5_HUMAN

Accession

Primary (citable) accession number: Q8N3K9
Secondary accession number(s): A0PJB7 , Q05CT4, Q2NKX1, Q2T9G9, Q69YQ8, Q69YQ9, Q6P517, Q6P5U3, Q7Z4I1, Q86T34, Q86T49, Q8N3S4, Q8N3S7, Q8NAG8, Q9UK88

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	July 7, 2009
This is version 47 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)