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Protein

Zinc finger protein 664

Gene

ZNF664

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3 – 2523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri31 – 5323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri59 – 8123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri87 – 10923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri115 – 13723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 664
Alternative name(s):
Zinc finger protein 176
Zinc finger protein from organ of Corti
Gene namesi
Name:ZNF664
Synonyms:ZFOC1, ZNF196
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25406. ZNF664.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37547.

Polymorphism and mutation databases

BioMutaiZNF664.
DMDMi74759851.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Zinc finger protein 664PRO_0000296273Add
BLAST

Proteomic databases

MaxQBiQ8N3J9.
PaxDbiQ8N3J9.
PRIDEiQ8N3J9.

PTM databases

iPTMnetiQ8N3J9.
PhosphoSiteiQ8N3J9.

Expressioni

Gene expression databases

BgeeiQ8N3J9.
CleanExiHS_ZNF664.
ExpressionAtlasiQ8N3J9. baseline and differential.
GenevisibleiQ8N3J9. HS.

Interactioni

Protein-protein interaction databases

BioGridi126844. 6 interactions.
IntActiQ8N3J9. 2 interactions.
MINTiMINT-4719499.
STRINGi9606.ENSP00000337320.

Structurei

3D structure databases

ProteinModelPortaliQ8N3J9.
SMRiQ8N3J9. Positions 3-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri3 – 2523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri31 – 5323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri59 – 8123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri87 – 10923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri115 – 13723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri171 – 19323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri199 – 22123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri227 – 24923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N3J9.
OMAiHICPVVE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N3J9.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N3J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYKCPMCRE FFSERADLFM HQKIHTAEKP HKCDKCDKGF FHISELHIHW
60 70 80 90 100
RDHTGEKVYK CDDCGKDFST TTKLNRHKKI HTVEKPYKCY ECGKAFNWSS
110 120 130 140 150
HLQIHMRVHT GEKPYVCSEC GRGFSNSSNL CMHQRVHTGE KPFKCEECGK
160 170 180 190 200
AFRHTSSLCM HQRVHTGEKP YKCYECGKAF SQSSSLCIHQ RVHTGEKPYR
210 220 230 240 250
CCGCGKAFSQ SSSLCIHQRV HTGEKPFKCD ECGKAFSQST SLCIHQRVHT
260
KERNHLKISV I
Length:261
Mass (Da):30,284
Last modified:October 1, 2002 - v1
Checksum:i783FE11E5FBACAA5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241I → V in AAC41997 (PubMed:8634327).Curated
Sequence conflicti113 – 1131K → E in AAC41997 (PubMed:8634327).Curated
Sequence conflicti139 – 1391G → R in AAH51696 (PubMed:15489334).Curated
Sequence conflicti183 – 1831S → R in AAC41997 (PubMed:8634327).Curated
Sequence conflicti198 – 1981P → H in AAH51696 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056034 mRNA. Translation: BAG51609.1.
AL834266 mRNA. Translation: CAD38941.1.
BX647762 mRNA. Translation: CAH10567.1.
CH471054 Genomic DNA. Translation: EAW98441.1.
BC051696 mRNA. Translation: AAH51696.1.
BC093848 mRNA. Translation: AAH93848.1.
BC101530 mRNA. Translation: AAI01531.1.
L41669 mRNA. Translation: AAC41997.1.
CCDSiCCDS9257.1.
PIRiS70007.
RefSeqiNP_001191227.1. NM_001204298.1.
NP_689650.1. NM_152437.2.
UniGeneiHs.524828.

Genome annotation databases

EnsembliENST00000337815; ENSP00000337320; ENSG00000179195.
ENST00000392404; ENSP00000376205; ENSG00000179195.
ENST00000538932; ENSP00000440645; ENSG00000179195.
ENST00000539644; ENSP00000441405; ENSG00000179195.
GeneIDi144348.
KEGGihsa:144348.
UCSCiuc001uga.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056034 mRNA. Translation: BAG51609.1.
AL834266 mRNA. Translation: CAD38941.1.
BX647762 mRNA. Translation: CAH10567.1.
CH471054 Genomic DNA. Translation: EAW98441.1.
BC051696 mRNA. Translation: AAH51696.1.
BC093848 mRNA. Translation: AAH93848.1.
BC101530 mRNA. Translation: AAI01531.1.
L41669 mRNA. Translation: AAC41997.1.
CCDSiCCDS9257.1.
PIRiS70007.
RefSeqiNP_001191227.1. NM_001204298.1.
NP_689650.1. NM_152437.2.
UniGeneiHs.524828.

3D structure databases

ProteinModelPortaliQ8N3J9.
SMRiQ8N3J9. Positions 3-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126844. 6 interactions.
IntActiQ8N3J9. 2 interactions.
MINTiMINT-4719499.
STRINGi9606.ENSP00000337320.

PTM databases

iPTMnetiQ8N3J9.
PhosphoSiteiQ8N3J9.

Polymorphism and mutation databases

BioMutaiZNF664.
DMDMi74759851.

Proteomic databases

MaxQBiQ8N3J9.
PaxDbiQ8N3J9.
PRIDEiQ8N3J9.

Protocols and materials databases

DNASUi144348.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337815; ENSP00000337320; ENSG00000179195.
ENST00000392404; ENSP00000376205; ENSG00000179195.
ENST00000538932; ENSP00000440645; ENSG00000179195.
ENST00000539644; ENSP00000441405; ENSG00000179195.
GeneIDi144348.
KEGGihsa:144348.
UCSCiuc001uga.4. human.

Organism-specific databases

CTDi144348.
GeneCardsiZNF664.
HGNCiHGNC:25406. ZNF664.
neXtProtiNX_Q8N3J9.
PharmGKBiPA37547.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129740.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N3J9.
OMAiHICPVVE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N3J9.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF664. human.
GeneWikiiZNF664.
GenomeRNAii144348.
PROiQ8N3J9.

Gene expression databases

BgeeiQ8N3J9.
CleanExiHS_ZNF664.
ExpressionAtlasiQ8N3J9. baseline and differential.
GenevisibleiQ8N3J9. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala and Cervix adenocarcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "A novel zinc finger gene preferentially expressed in the retina and the organ of Corti localizes to human chromosome 12q24.3."
    Rivolta M.N., Negrini C., Wilcox E.R.
    Biochim. Biophys. Acta 1306:127-132(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-207.
    Tissue: Retina.

Entry informationi

Entry nameiZN664_HUMAN
AccessioniPrimary (citable) accession number: Q8N3J9
Secondary accession number(s): B3KP97, Q15914, Q3ZCQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.