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Protein

Cell adhesion molecule 2

Gene

CADM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.1 Publication

GO - Biological processi

  1. adherens junction organization Source: Reactome
  2. brain development Source: Ensembl
  3. cell adhesion Source: UniProtKB-KW
  4. cell-cell junction organization Source: Reactome
  5. cell junction assembly Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 2
Alternative name(s):
Immunoglobulin superfamily member 4D
Short name:
IgSF4D
Nectin-like protein 3
Short name:
NECL-3
Synaptic cell adhesion molecule 2
Short name:
SynCAM 2
Gene namesi
Name:CADM2
Synonyms:IGSF4D, NECL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29849. CADM2.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cell junctionsynapse 1 Publication. Cell projectionaxon 1 Publication
Note: Found in the axoplasm of myelinated axons.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 367343ExtracellularSequence AnalysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence AnalysisAdd
BLAST
Topological domaini389 – 43547CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB-SubCell
  2. cell junction Source: UniProtKB-KW
  3. cytoplasm Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. neuronal cell body membrane Source: Ensembl
  6. plasma membrane Source: Reactome
  7. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 435411Cell adhesion molecule 2PRO_0000291970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi44 ↔ 104PROSITE-ProRule annotation
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi146 ↔ 203PROSITE-ProRule annotation
Disulfide bondi248 ↔ 296PROSITE-ProRule annotation
Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N3J6.
PRIDEiQ8N3J6.

PTM databases

PhosphoSiteiQ8N3J6.

Expressioni

Gene expression databases

BgeeiQ8N3J6.
CleanExiHS_CADM2.
ExpressionAtlasiQ8N3J6. baseline and differential.
GenevestigatoriQ8N3J6.

Organism-specific databases

HPAiHPA010024.

Interactioni

Protein-protein interaction databases

BioGridi128973. 1 interaction.
MINTiMINT-4724723.
STRINGi9606.ENSP00000384193.

Structurei

3D structure databases

ProteinModelPortaliQ8N3J6.
SMRiQ8N3J6. Positions 24-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11993Ig-like V-typeAdd
BLAST
Domaini127 – 21993Ig-like C2-type 1Add
BLAST
Domaini227 – 31286Ig-like C2-type 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi319 – 35032Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151182.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ8N3J6.
KOiK06782.
OMAiQYPLVQN.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ8N3J6.
TreeFamiTF326804.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND
60 70 80 90 100
NTSLQWSNPA QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG
110 120 130 140 150
QYTCSLFTMP VKTSKAYLTV LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG
160 170 180 190 200
SKPAADIRWF KNDKEIKDVK YLKEEDANRK TFTVSSTLDF RVDRSDDGVA
210 220 230 240 250
VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE GQPLILTCES
260 270 280 290 300
KGKPLPEPVL WTKDGGELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN
310 320 330 340 350
TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TATVTTTVAI TTSPTTSATT
360 370 380 390 400
SSIRDPNALA GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL
410 420 430
TNEAKGAEDA PDADTAIINA EGSQVNAEEK KEYFI
Length:435
Mass (Da):47,554
Last modified:October 1, 2002 - v1
Checksum:i59DDD41B7F34D446
GO
Isoform 2 (identifier: Q8N3J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Q → QAAASKNKVK
     316-355: Missing.

Show »
Length:404
Mass (Da):44,423
Checksum:i736AC87C03FDE1B7
GO
Isoform 3 (identifier: Q8N3J6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MIWKRSAVLRFYSVCGLLLQ → MFVLFLCNLSLVPAAASKNKVK

Show »
Length:437
Mass (Da):47,564
Checksum:iE94A18403F9B774C
GO
Isoform 5 (identifier: Q8N3J6-4) [UniParc]FASTAAdd to basket

Also known as: 7

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.
     315-354: Missing.

Show »
Length:287
Mass (Da):31,382
Checksum:iBC731D7DAE4DCC7F
GO
Isoform 6 (identifier: Q8N3J6-5) [UniParc]FASTAAdd to basket

Also known as: 8

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Show »
Length:327
Mass (Da):35,410
Checksum:i5F453DC33C818100
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741E → K in AAN16368 (Ref. 2) Curated
Sequence conflicti212 – 2121A → T in AAN16368 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 108108Missing in isoform 5 and isoform 6. 1 PublicationVSP_055355Add
BLAST
Alternative sequencei1 – 2020MIWKR…GLLLQ → MFVLFLCNLSLVPAAASKNK VK in isoform 3. 1 PublicationVSP_026333Add
BLAST
Alternative sequencei20 – 201Q → QAAASKNKVK in isoform 2. 2 PublicationsVSP_026334
Alternative sequencei315 – 35440Missing in isoform 5. 1 PublicationVSP_055356Add
BLAST
Alternative sequencei316 – 35540Missing in isoform 2. 2 PublicationsVSP_026335Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB646740 mRNA. Translation: BAK93303.1.
AB646741 mRNA. Translation: BAK93304.1.
AB646742 mRNA. Translation: BAK93305.1.
AB646743 mRNA. Translation: BAK93306.1.
AF538973 mRNA. Translation: AAN16368.1.
AL833049 mRNA. Translation: CAH56314.1.
AL834270 mRNA. Translation: CAD38945.1.
BC105999 mRNA. Translation: AAI06000.1.
CCDSiCCDS33792.1. [Q8N3J6-3]
CCDS54613.1. [Q8N3J6-2]
CCDS54614.1. [Q8N3J6-1]
RefSeqiNP_001161146.1. NM_001167674.1. [Q8N3J6-1]
NP_001161147.1. NM_001167675.1. [Q8N3J6-2]
NP_001243431.1. NM_001256502.1. [Q8N3J6-5]
NP_001243432.1. NM_001256503.1. [Q8N3J6-5]
NP_001243433.1. NM_001256504.1. [Q8N3J6-4]
NP_001243434.1. NM_001256505.1. [Q8N3J6-4]
NP_694854.2. NM_153184.3. [Q8N3J6-3]
XP_006713144.1. XM_006713081.1. [Q8N3J6-1]
UniGeneiHs.164578.

Genome annotation databases

EnsembliENST00000383699; ENSP00000373200; ENSG00000175161. [Q8N3J6-2]
ENST00000405615; ENSP00000384193; ENSG00000175161. [Q8N3J6-3]
ENST00000407528; ENSP00000384575; ENSG00000175161. [Q8N3J6-1]
GeneIDi253559.
KEGGihsa:253559.
UCSCiuc003dqj.3. human. [Q8N3J6-1]
uc003dql.3. human. [Q8N3J6-3]

Polymorphism databases

DMDMi74759850.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB646740 mRNA. Translation: BAK93303.1.
AB646741 mRNA. Translation: BAK93304.1.
AB646742 mRNA. Translation: BAK93305.1.
AB646743 mRNA. Translation: BAK93306.1.
AF538973 mRNA. Translation: AAN16368.1.
AL833049 mRNA. Translation: CAH56314.1.
AL834270 mRNA. Translation: CAD38945.1.
BC105999 mRNA. Translation: AAI06000.1.
CCDSiCCDS33792.1. [Q8N3J6-3]
CCDS54613.1. [Q8N3J6-2]
CCDS54614.1. [Q8N3J6-1]
RefSeqiNP_001161146.1. NM_001167674.1. [Q8N3J6-1]
NP_001161147.1. NM_001167675.1. [Q8N3J6-2]
NP_001243431.1. NM_001256502.1. [Q8N3J6-5]
NP_001243432.1. NM_001256503.1. [Q8N3J6-5]
NP_001243433.1. NM_001256504.1. [Q8N3J6-4]
NP_001243434.1. NM_001256505.1. [Q8N3J6-4]
NP_694854.2. NM_153184.3. [Q8N3J6-3]
XP_006713144.1. XM_006713081.1. [Q8N3J6-1]
UniGeneiHs.164578.

3D structure databases

ProteinModelPortaliQ8N3J6.
SMRiQ8N3J6. Positions 24-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128973. 1 interaction.
MINTiMINT-4724723.
STRINGi9606.ENSP00000384193.

PTM databases

PhosphoSiteiQ8N3J6.

Polymorphism databases

DMDMi74759850.

Proteomic databases

PaxDbiQ8N3J6.
PRIDEiQ8N3J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383699; ENSP00000373200; ENSG00000175161. [Q8N3J6-2]
ENST00000405615; ENSP00000384193; ENSG00000175161. [Q8N3J6-3]
ENST00000407528; ENSP00000384575; ENSG00000175161. [Q8N3J6-1]
GeneIDi253559.
KEGGihsa:253559.
UCSCiuc003dqj.3. human. [Q8N3J6-1]
uc003dql.3. human. [Q8N3J6-3]

Organism-specific databases

CTDi253559.
GeneCardsiGC03P085008.
HGNCiHGNC:29849. CADM2.
HPAiHPA010024.
MIMi609938. gene.
neXtProtiNX_Q8N3J6.
PharmGKBiPA162380882.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG151182.
GeneTreeiENSGT00770000120518.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
InParanoidiQ8N3J6.
KOiK06782.
OMAiQYPLVQN.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ8N3J6.
TreeFamiTF326804.

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.

Miscellaneous databases

ChiTaRSiCADM2. human.
GenomeRNAii253559.
NextBioi92122.
PROiQ8N3J6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N3J6.
CleanExiHS_CADM2.
ExpressionAtlasiQ8N3J6. baseline and differential.
GenevestigatoriQ8N3J6.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), ALTERNATIVE SPLICING.
  2. Gingrich J.R., D'Angelo A., Chang G.M., Greenberg N.M.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-435 (ISOFORM 2).
    Tissue: Amygdala and Stomach.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion."
    Pellissier F., Gerber A., Bauer C., Ballivet M., Ossipow V.
    BMC Neurosci. 8:90-90(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCADM2_HUMAN
AccessioniPrimary (citable) accession number: Q8N3J6
Secondary accession number(s): G3XHN7
, G3XHN8, Q3KQY9, Q658Q7, Q8IZP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.