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Q8N3J6

- CADM2_HUMAN

UniProt

Q8N3J6 - CADM2_HUMAN

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Protein
Cell adhesion molecule 2
Gene
CADM2, IGSF4D, NECL3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.1 Publication

GO - Biological processi

  1. adherens junction organization Source: Reactome
  2. brain development Source: Ensembl
  3. cell adhesion Source: UniProtKB-KW
  4. cell junction assembly Source: Reactome
  5. cell-cell junction organization Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 2
Alternative name(s):
Immunoglobulin superfamily member 4D
Short name:
IgSF4D
Nectin-like protein 3
Short name:
NECL-3
Synaptic cell adhesion molecule 2
Short name:
SynCAM 2
Gene namesi
Name:CADM2
Synonyms:IGSF4D, NECL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:29849. CADM2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein. Cell junctionsynapse. Cell projectionaxon
Note: Found in the axoplasm of myelinated axons.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 367343Extracellular Reviewed prediction
Add
BLAST
Transmembranei368 – 38821Helical; Reviewed prediction
Add
BLAST
Topological domaini389 – 43547Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: UniProtKB-SubCell
  2. cell junction Source: UniProtKB-KW
  3. cytoplasm Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. membrane Source: UniProtKB-KW
  6. neuronal cell body membrane Source: Ensembl
  7. plasma membrane Source: Reactome
  8. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 435411Cell adhesion molecule 2
PRO_0000291970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi31 – 311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi44 ↔ 104 By similarity
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi146 ↔ 203 By similarity
Disulfide bondi248 ↔ 296 By similarity
Glycosylationi291 – 2911N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N3J6.
PRIDEiQ8N3J6.

PTM databases

PhosphoSiteiQ8N3J6.

Expressioni

Gene expression databases

ArrayExpressiQ8N3J6.
BgeeiQ8N3J6.
CleanExiHS_CADM2.
GenevestigatoriQ8N3J6.

Organism-specific databases

HPAiHPA010024.

Interactioni

Protein-protein interaction databases

MINTiMINT-4724723.
STRINGi9606.ENSP00000384193.

Structurei

3D structure databases

ProteinModelPortaliQ8N3J6.
SMRiQ8N3J6. Positions 24-363.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11993Ig-like V-type
Add
BLAST
Domaini127 – 21993Ig-like C2-type 1
Add
BLAST
Domaini227 – 31286Ig-like C2-type 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi319 – 35032Thr-rich
Add
BLAST

Sequence similaritiesi

Belongs to the nectin family.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151182.
HOGENOMiHOG000036057.
HOVERGENiHBG057086.
KOiK06782.
OMAiQYPLVQN.
OrthoDBiEOG7PVWPD.
PhylomeDBiQ8N3J6.
TreeFamiTF326804.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N3J6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND    50
NTSLQWSNPA QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG 100
QYTCSLFTMP VKTSKAYLTV LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG 150
SKPAADIRWF KNDKEIKDVK YLKEEDANRK TFTVSSTLDF RVDRSDDGVA 200
VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE GQPLILTCES 250
KGKPLPEPVL WTKDGGELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN 300
TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TATVTTTVAI TTSPTTSATT 350
SSIRDPNALA GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL 400
TNEAKGAEDA PDADTAIINA EGSQVNAEEK KEYFI 435
Length:435
Mass (Da):47,554
Last modified:October 1, 2002 - v1
Checksum:i59DDD41B7F34D446
GO
Isoform 2 (identifier: Q8N3J6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Q → QAAASKNKVK
     316-355: Missing.

Show »
Length:404
Mass (Da):44,423
Checksum:i736AC87C03FDE1B7
GO
Isoform 3 (identifier: Q8N3J6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MIWKRSAVLRFYSVCGLLLQ → MFVLFLCNLSLVPAAASKNKVK

Show »
Length:437
Mass (Da):47,564
Checksum:iE94A18403F9B774C
GO
Isoform 5 (identifier: Q8N3J6-4) [UniParc]FASTAAdd to Basket

Also known as: 7

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.
     315-354: Missing.

Show »
Length:287
Mass (Da):31,382
Checksum:iBC731D7DAE4DCC7F
GO
Isoform 6 (identifier: Q8N3J6-5) [UniParc]FASTAAdd to Basket

Also known as: 8

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Show »
Length:327
Mass (Da):35,410
Checksum:i5F453DC33C818100
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 108108Missing in isoform 5 and isoform 6.
VSP_055355Add
BLAST
Alternative sequencei1 – 2020MIWKR…GLLLQ → MFVLFLCNLSLVPAAASKNK VK in isoform 3.
VSP_026333Add
BLAST
Alternative sequencei20 – 201Q → QAAASKNKVK in isoform 2.
VSP_026334
Alternative sequencei315 – 35440Missing in isoform 5.
VSP_055356Add
BLAST
Alternative sequencei316 – 35540Missing in isoform 2.
VSP_026335Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741E → K in AAN16368. 1 Publication
Sequence conflicti212 – 2121A → T in AAN16368. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB646740 mRNA. Translation: BAK93303.1.
AB646741 mRNA. Translation: BAK93304.1.
AB646742 mRNA. Translation: BAK93305.1.
AB646743 mRNA. Translation: BAK93306.1.
AF538973 mRNA. Translation: AAN16368.1.
AL833049 mRNA. Translation: CAH56314.1.
AL834270 mRNA. Translation: CAD38945.1.
BC105999 mRNA. Translation: AAI06000.1.
CCDSiCCDS33792.1. [Q8N3J6-3]
CCDS54613.1. [Q8N3J6-2]
CCDS54614.1. [Q8N3J6-1]
RefSeqiNP_001161146.1. NM_001167674.1. [Q8N3J6-1]
NP_001161147.1. NM_001167675.1. [Q8N3J6-2]
NP_001243431.1. NM_001256502.1.
NP_001243432.1. NM_001256503.1.
NP_001243433.1. NM_001256504.1.
NP_001243434.1. NM_001256505.1.
NP_694854.2. NM_153184.3. [Q8N3J6-3]
XP_006713144.1. XM_006713081.1. [Q8N3J6-1]
UniGeneiHs.164578.

Genome annotation databases

EnsembliENST00000383699; ENSP00000373200; ENSG00000175161. [Q8N3J6-2]
ENST00000405615; ENSP00000384193; ENSG00000175161. [Q8N3J6-3]
ENST00000407528; ENSP00000384575; ENSG00000175161. [Q8N3J6-1]
GeneIDi253559.
KEGGihsa:253559.
UCSCiuc003dqj.3. human. [Q8N3J6-1]
uc003dql.3. human. [Q8N3J6-3]

Polymorphism databases

DMDMi74759850.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB646740 mRNA. Translation: BAK93303.1 .
AB646741 mRNA. Translation: BAK93304.1 .
AB646742 mRNA. Translation: BAK93305.1 .
AB646743 mRNA. Translation: BAK93306.1 .
AF538973 mRNA. Translation: AAN16368.1 .
AL833049 mRNA. Translation: CAH56314.1 .
AL834270 mRNA. Translation: CAD38945.1 .
BC105999 mRNA. Translation: AAI06000.1 .
CCDSi CCDS33792.1. [Q8N3J6-3 ]
CCDS54613.1. [Q8N3J6-2 ]
CCDS54614.1. [Q8N3J6-1 ]
RefSeqi NP_001161146.1. NM_001167674.1. [Q8N3J6-1 ]
NP_001161147.1. NM_001167675.1. [Q8N3J6-2 ]
NP_001243431.1. NM_001256502.1.
NP_001243432.1. NM_001256503.1.
NP_001243433.1. NM_001256504.1.
NP_001243434.1. NM_001256505.1.
NP_694854.2. NM_153184.3. [Q8N3J6-3 ]
XP_006713144.1. XM_006713081.1. [Q8N3J6-1 ]
UniGenei Hs.164578.

3D structure databases

ProteinModelPortali Q8N3J6.
SMRi Q8N3J6. Positions 24-363.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4724723.
STRINGi 9606.ENSP00000384193.

PTM databases

PhosphoSitei Q8N3J6.

Polymorphism databases

DMDMi 74759850.

Proteomic databases

PaxDbi Q8N3J6.
PRIDEi Q8N3J6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000383699 ; ENSP00000373200 ; ENSG00000175161 . [Q8N3J6-2 ]
ENST00000405615 ; ENSP00000384193 ; ENSG00000175161 . [Q8N3J6-3 ]
ENST00000407528 ; ENSP00000384575 ; ENSG00000175161 . [Q8N3J6-1 ]
GeneIDi 253559.
KEGGi hsa:253559.
UCSCi uc003dqj.3. human. [Q8N3J6-1 ]
uc003dql.3. human. [Q8N3J6-3 ]

Organism-specific databases

CTDi 253559.
GeneCardsi GC03P085008.
HGNCi HGNC:29849. CADM2.
HPAi HPA010024.
MIMi 609938. gene.
neXtProti NX_Q8N3J6.
PharmGKBi PA162380882.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG151182.
HOGENOMi HOG000036057.
HOVERGENi HBG057086.
KOi K06782.
OMAi QYPLVQN.
OrthoDBi EOG7PVWPD.
PhylomeDBi Q8N3J6.
TreeFami TF326804.

Enzyme and pathway databases

Reactomei REACT_19195. Adherens junctions interactions.

Miscellaneous databases

GenomeRNAii 253559.
NextBioi 92122.
PROi Q8N3J6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N3J6.
Bgeei Q8N3J6.
CleanExi HS_CADM2.
Genevestigatori Q8N3J6.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), ALTERNATIVE SPLICING.
  2. Gingrich J.R., D'Angelo A., Chang G.M., Greenberg N.M.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-435 (ISOFORM 2).
    Tissue: Amygdala and Stomach.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  5. "The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion."
    Pellissier F., Gerber A., Bauer C., Ballivet M., Ossipow V.
    BMC Neurosci. 8:90-90(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCADM2_HUMAN
AccessioniPrimary (citable) accession number: Q8N3J6
Secondary accession number(s): G3XHN7
, G3XHN8, Q3KQY9, Q658Q7, Q8IZP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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