Q8N3J6 (CADM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cell adhesion molecule 2

Alternative name(s):
Immunoglobulin superfamily member 4D
Short name=IgSF4D
Nectin-like protein 3
Short name=NECL-3
Synaptic cell adhesion molecule 2
Short name=SynCAM 2

Gene names

Name:	CADM2
Synonyms:	IGSF4D, NECL3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. Ref.4
Subcellular location	Cell membrane; Single-pass type I membrane protein. Cell junction › synapse. Cell projection › axon. Note: Found in the axoplasm of myelinated axons. Ref.4
Sequence similarities	Belongs to the nectin family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cell membrane Cell projection Membrane Synapse
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adherens junction organization Traceable author statement. Source: Reactome brain development Inferred from electronic annotation. Source: Compara cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW cell junction assembly Traceable author statement. Source: Reactome
Cellular_component	axon Inferred from electronic annotation. Source: UniProtKB-SubCell cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoplasm Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuronal cell body membrane Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement. Source: Reactome synapse Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N3J6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N3J6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Q → QAAASKNKVK
     316-355: Missing.

Isoform 3 (identifier: Q8N3J6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MIWKRSAVLRFYSVCGLLLQ → MFVLFLCNLSLVPAAASKNKVK

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 435	411	Cell adhesion molecule 2		PRO_0000291970
Regions
	Topological domain	25 – 367	343	Extracellular Potential
	Transmembrane	368 – 388	21	Helical; Potential
	Topological domain	389 – 435	47	Cytoplasmic Potential
	Domain	27 – 119	93	Ig-like V-type
	Domain	127 – 219	93	Ig-like C2-type 1
	Domain	227 – 312	86	Ig-like C2-type 2
	Compositional bias	319 – 350	32	Thr-rich
Amino acid modifications
	Glycosylation	31	1	N-linked (GlcNAc...) Potential
	Glycosylation	51	1	N-linked (GlcNAc...) Potential
	Glycosylation	291	1	N-linked (GlcNAc...) Potential
	Disulfide bond	44 ↔ 104		By similarity
	Disulfide bond	146 ↔ 203		By similarity
	Disulfide bond	248 ↔ 296		By similarity
Natural variations
	Alternative sequence	1 – 20	20	MIWKR…GLLLQ → MFVLFLCNLSLVPAAASKNK VK in isoform 3.		VSP_026333
	Alternative sequence	20	1	Q → QAAASKNKVK in isoform 2.		VSP_026334
	Alternative sequence	316 – 355	40	Missing in isoform 2.		VSP_026335
Experimental info
	Sequence conflict	174	1	E → K in AAN16368. Ref.1
	Sequence conflict	212	1	A → T in AAN16368. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 59DDD41B7F34D446	FASTA	435	47,554
	10 20 30 40 50 60 MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND NTSLQWSNPA 70 80 90 100 110 120 QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG QYTCSLFTMP VKTSKAYLTV 130 140 150 160 170 180 LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG SKPAADIRWF KNDKEIKDVK YLKEEDANRK 190 200 210 220 230 240 TFTVSSTLDF RVDRSDDGVA VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE 250 260 270 280 290 300 GQPLILTCES KGKPLPEPVL WTKDGGELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN 310 320 330 340 350 360 TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TATVTTTVAI TTSPTTSATT SSIRDPNALA 370 380 390 400 410 420 GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL TNEAKGAEDA PDADTAIINA 430 EGSQVNAEEK KEYFI
	Isoform 2 [UniParc]. Checksum: 736AC87C03FDE1B7	FASTA	404	44,423
	10 20 30 40 50 60 MIWKRSAVLR FYSVCGLLLQ AAASKNKVKG SQGQFPLTQN VTVVEGGTAI LTCRVDQNDN 70 80 90 100 110 120 TSLQWSNPAQ QTLYFDDKKA LRDNRIELVR ASWHELSISV SDVSLSDEGQ YTCSLFTMPV 130 140 150 160 170 180 KTSKAYLTVL GVPEKPQISG FSSPVMEGDL MQLTCKTSGS KPAADIRWFK NDKEIKDVKY 190 200 210 220 230 240 LKEEDANRKT FTVSSTLDFR VDRSDDGVAV ICRVDHESLN ATPQVAMQVL EIHYTPSVKI 250 260 270 280 290 300 IPSTPFPQEG QPLILTCESK GKPLPEPVLW TKDGGELPDP DRMVVSGREL NILFLNKTDN 310 320 330 340 350 360 GTYRCEATNT IGQSSAEYVL IVHDPNALAG QNGPDHALIG GIVAVVVFVT LCSIFLLGRY 370 380 390 400 LARHKGTYLT NEAKGAEDAP DADTAIINAE GSQVNAEEKK EYFI
	Isoform 3 [UniParc]. Checksum: E94A18403F9B774C	FASTA	437	47,564
	10 20 30 40 50 60 MFVLFLCNLS LVPAAASKNK VKGSQGQFPL TQNVTVVEGG TAILTCRVDQ NDNTSLQWSN 70 80 90 100 110 120 PAQQTLYFDD KKALRDNRIE LVRASWHELS ISVSDVSLSD EGQYTCSLFT MPVKTSKAYL 130 140 150 160 170 180 TVLGVPEKPQ ISGFSSPVME GDLMQLTCKT SGSKPAADIR WFKNDKEIKD VKYLKEEDAN 190 200 210 220 230 240 RKTFTVSSTL DFRVDRSDDG VAVICRVDHE SLNATPQVAM QVLEIHYTPS VKIIPSTPFP 250 260 270 280 290 300 QEGQPLILTC ESKGKPLPEP VLWTKDGGEL PDPDRMVVSG RELNILFLNK TDNGTYRCEA 310 320 330 340 350 360 TNTIGQSSAE YVLIVHDVPN TLLPTTIIPS LTTATVTTTV AITTSPTTSA TTSSIRDPNA 370 380 390 400 410 420 LAGQNGPDHA LIGGIVAVVV FVTLCSIFLL GRYLARHKGT YLTNEAKGAE DAPDADTAII 430 NAEGSQVNAE EKKEYFI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Gingrich J.R., D'Angelo A., Chang G.M., Greenberg N.M. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-435 (ISOFORM 2). Tissue: Amygdala and Stomach.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion." Pellissier F., Gerber A., Bauer C., Ballivet M., Ossipow V. BMC Neurosci. 8:90-90(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF538973 mRNA. Translation: AAN16368.1. AL833049 mRNA. Translation: CAH56314.1. AL834270 mRNA. Translation: CAD38945.1. BC105999 mRNA. Translation: AAI06000.1.
IPI	IPI00293836. IPI00413016. IPI00470388.
RefSeq	NP_001161146.1. NM_001167674.1. NP_001161147.1. NM_001167675.1. NP_694854.2. NM_153184.3.
UniGene	Hs.164578.
3D structure databases
HSSP	HSSP built from PDB template 1Z9M based on UniProtKB Q8IZQ9.
ProteinModelPortal	Q8N3J6.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000384193.
PTM databases
PhosphoSite	Q8N3J6.
Polymorphism databases
DMDM	74759850.
Proteomic databases
PaxDb	Q8N3J6.
PRIDE	Q8N3J6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000383699; ENSP00000373200; ENSG00000175161. ENST00000405615; ENSP00000384193; ENSG00000175161. ENST00000407528; ENSP00000384575; ENSG00000175161.
GeneID	253559.
KEGG	hsa:253559.
UCSC	uc003dqj.3. human. uc003dqk.3. human. uc003dql.3. human.
Organism-specific databases
CTD	253559.
GeneCards	GC03P085008.
HGNC	HGNC:29849. CADM2.
HPA	HPA010024.
MIM	609938. gene.
neXtProt	NX_Q8N3J6.
PharmGKB	PA162380882.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG151182.
HOGENOM	HOG000036057.
HOVERGEN	HBG057086.
KO	K06782.
OMA	QYPLVQN.
OrthoDB	EOG4P8FJ5.
Enzyme and pathway databases
Reactome	REACT_111155. Cell-Cell communication.
Gene expression databases
ArrayExpress	Q8N3J6.
Bgee	Q8N3J6.
CleanEx	HS_CADM2.
Genevestigator	Q8N3J6.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR013162. CD80_C2-set. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013106. Ig_V-set. IPR003585. Neurexin-like. [Graphical view]
Pfam	PF08205. C2-set_2. 1 hit. PF07679. I-set. 1 hit. PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00294. 4.1m. 1 hit. SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	253559.
NextBio	92122.
SOURCE	Search...

Entry information

Entry name

CADM2_HUMAN

Accession

Primary (citable) accession number: Q8N3J6
Secondary accession number(s): Q3KQY9, Q658Q7, Q8IZP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.