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Q8N3J6 (CADM2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cell adhesion molecule 2
Alternative name(s):
Immunoglobulin superfamily member 4D
Short name=IgSF4D
Nectin-like protein 3
Short name=NECL-3
Synaptic cell adhesion molecule 2
Short name=SynCAM 2
Gene names
Name:CADM2
Synonyms:IGSF4D, NECL3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. Ref.5

Subcellular location

Cell membrane; Single-pass type I membrane protein. Cell junctionsynapse. Cell projectionaxon. Note: Found in the axoplasm of myelinated axons. Ref.5

Sequence similarities

Belongs to the nectin family.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N3J6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N3J6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Q → QAAASKNKVK
     316-355: Missing.
Isoform 3 (identifier: Q8N3J6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MIWKRSAVLRFYSVCGLLLQ → MFVLFLCNLSLVPAAASKNKVK
Isoform 5 (identifier: Q8N3J6-4)

Also known as: 7;

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.
     315-354: Missing.
Isoform 6 (identifier: Q8N3J6-5)

Also known as: 8;

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 435411Cell adhesion molecule 2
PRO_0000291970

Regions

Topological domain25 – 367343Extracellular Potential
Transmembrane368 – 38821Helical; Potential
Topological domain389 – 43547Cytoplasmic Potential
Domain27 – 11993Ig-like V-type
Domain127 – 21993Ig-like C2-type 1
Domain227 – 31286Ig-like C2-type 2
Compositional bias319 – 35032Thr-rich

Amino acid modifications

Glycosylation311N-linked (GlcNAc...) Potential
Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation2911N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 104 By similarity
Disulfide bond146 ↔ 203 By similarity
Disulfide bond248 ↔ 296 By similarity

Natural variations

Alternative sequence1 – 108108Missing in isoform 5 and isoform 6.
VSP_055355
Alternative sequence1 – 2020MIWKR…GLLLQ → MFVLFLCNLSLVPAAASKNK VK in isoform 3.
VSP_026333
Alternative sequence201Q → QAAASKNKVK in isoform 2.
VSP_026334
Alternative sequence315 – 35440Missing in isoform 5.
VSP_055356
Alternative sequence316 – 35540Missing in isoform 2.
VSP_026335

Experimental info

Sequence conflict1741E → K in AAN16368. Ref.2
Sequence conflict2121A → T in AAN16368. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 59DDD41B7F34D446

FASTA43547,554
        10         20         30         40         50         60 
MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND NTSLQWSNPA 

        70         80         90        100        110        120 
QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG QYTCSLFTMP VKTSKAYLTV 

       130        140        150        160        170        180 
LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG SKPAADIRWF KNDKEIKDVK YLKEEDANRK 

       190        200        210        220        230        240 
TFTVSSTLDF RVDRSDDGVA VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE 

       250        260        270        280        290        300 
GQPLILTCES KGKPLPEPVL WTKDGGELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN 

       310        320        330        340        350        360 
TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TATVTTTVAI TTSPTTSATT SSIRDPNALA 

       370        380        390        400        410        420 
GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL TNEAKGAEDA PDADTAIINA 

       430 
EGSQVNAEEK KEYFI 

« Hide

Isoform 2 [UniParc].

Checksum: 736AC87C03FDE1B7
Show »

FASTA40444,423
Isoform 3 [UniParc].

Checksum: E94A18403F9B774C
Show »

FASTA43747,564
Isoform 5 (7) [UniParc].

Checksum: BC731D7DAE4DCC7F
Show »

FASTA28731,382
Isoform 6 (8) [UniParc].

Checksum: 5F453DC33C818100
Show »

FASTA32735,410

References

« Hide 'large scale' references
[1]"A novel splicing variant of CADM2 as a protective transcript of psoriasis."
Hiruma A., Ikeda I., Terui T., Ozawa M., Hashimoto T., Yasumoto S., Nakayama J., Kubota Y., Iijima M., Sueki H., Matsumoto Y., Kato M., Akasaka E., Ikoma N., Mabuchi T., Tamiya S., Matsuyama T., Ozawa A., Inoko H., Oka A.
Biochem. Biophys. Res. Commun. 412:626-632(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), ALTERNATIVE SPLICING.
[2]Gingrich J.R., D'Angelo A., Chang G.M., Greenberg N.M.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-435 (ISOFORM 2).
Tissue: Amygdala and Stomach.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[5]"The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion."
Pellissier F., Gerber A., Bauer C., Ballivet M., Ossipow V.
BMC Neurosci. 8:90-90(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB646740 mRNA. Translation: BAK93303.1.
AB646741 mRNA. Translation: BAK93304.1.
AB646742 mRNA. Translation: BAK93305.1.
AB646743 mRNA. Translation: BAK93306.1.
AF538973 mRNA. Translation: AAN16368.1.
AL833049 mRNA. Translation: CAH56314.1.
AL834270 mRNA. Translation: CAD38945.1.
BC105999 mRNA. Translation: AAI06000.1.
CCDSCCDS33792.1. [Q8N3J6-3]
CCDS54613.1. [Q8N3J6-2]
CCDS54614.1. [Q8N3J6-1]
RefSeqNP_001161146.1. NM_001167674.1. [Q8N3J6-1]
NP_001161147.1. NM_001167675.1. [Q8N3J6-2]
NP_694854.2. NM_153184.3. [Q8N3J6-3]
XP_006713144.1. XM_006713081.1. [Q8N3J6-1]
UniGeneHs.164578.

3D structure databases

ProteinModelPortalQ8N3J6.
SMRQ8N3J6. Positions 24-363.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4724723.
STRING9606.ENSP00000384193.

PTM databases

PhosphoSiteQ8N3J6.

Polymorphism databases

DMDM74759850.

Proteomic databases

PaxDbQ8N3J6.
PRIDEQ8N3J6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000383699; ENSP00000373200; ENSG00000175161. [Q8N3J6-2]
ENST00000405615; ENSP00000384193; ENSG00000175161. [Q8N3J6-3]
ENST00000407528; ENSP00000384575; ENSG00000175161. [Q8N3J6-1]
GeneID253559.
KEGGhsa:253559.
UCSCuc003dqj.3. human. [Q8N3J6-1]
uc003dql.3. human. [Q8N3J6-3]

Organism-specific databases

CTD253559.
GeneCardsGC03P085008.
HGNCHGNC:29849. CADM2.
HPAHPA010024.
MIM609938. gene.
neXtProtNX_Q8N3J6.
PharmGKBPA162380882.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG151182.
HOGENOMHOG000036057.
HOVERGENHBG057086.
KOK06782.
OMAQYPLVQN.
OrthoDBEOG7PVWPD.
PhylomeDBQ8N3J6.
TreeFamTF326804.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

ArrayExpressQ8N3J6.
BgeeQ8N3J6.
CleanExHS_CADM2.
GenevestigatorQ8N3J6.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
IPR003585. Neurexin-like.
[Graphical view]
PfamPF08205. C2-set_2. 1 hit.
PF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00294. 4.1m. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi253559.
NextBio92122.
PROQ8N3J6.
SOURCESearch...

Entry information

Entry nameCADM2_HUMAN
AccessionPrimary (citable) accession number: Q8N3J6
Secondary accession number(s): G3XHN7 expand/collapse secondary AC list , G3XHN8, Q3KQY9, Q658Q7, Q8IZP8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM