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Q8N3J6

- CADM2_HUMAN

UniProt

Q8N3J6 - CADM2_HUMAN

Protein

Cell adhesion molecule 2

Gene

CADM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.1 Publication

    GO - Biological processi

    1. adherens junction organization Source: Reactome
    2. brain development Source: Ensembl
    3. cell adhesion Source: UniProtKB-KW
    4. cell-cell junction organization Source: Reactome
    5. cell junction assembly Source: Reactome

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_19195. Adherens junctions interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell adhesion molecule 2
    Alternative name(s):
    Immunoglobulin superfamily member 4D
    Short name:
    IgSF4D
    Nectin-like protein 3
    Short name:
    NECL-3
    Synaptic cell adhesion molecule 2
    Short name:
    SynCAM 2
    Gene namesi
    Name:CADM2
    Synonyms:IGSF4D, NECL3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:29849. CADM2.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cell junctionsynapse 1 Publication. Cell projectionaxon 1 Publication
    Note: Found in the axoplasm of myelinated axons.

    GO - Cellular componenti

    1. axon Source: UniProtKB-SubCell
    2. cell junction Source: UniProtKB-KW
    3. cytoplasm Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. neuronal cell body membrane Source: Ensembl
    6. plasma membrane Source: Reactome
    7. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162380882.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 435411Cell adhesion molecule 2PRO_0000291970Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi31 – 311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi44 ↔ 104PROSITE-ProRule annotation
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi146 ↔ 203PROSITE-ProRule annotation
    Disulfide bondi248 ↔ 296PROSITE-ProRule annotation
    Glycosylationi291 – 2911N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8N3J6.
    PRIDEiQ8N3J6.

    PTM databases

    PhosphoSiteiQ8N3J6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N3J6.
    BgeeiQ8N3J6.
    CleanExiHS_CADM2.
    GenevestigatoriQ8N3J6.

    Organism-specific databases

    HPAiHPA010024.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4724723.
    STRINGi9606.ENSP00000384193.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N3J6.
    SMRiQ8N3J6. Positions 24-363.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 367343ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini389 – 43547CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei368 – 38821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 11993Ig-like V-typeAdd
    BLAST
    Domaini127 – 21993Ig-like C2-type 1Add
    BLAST
    Domaini227 – 31286Ig-like C2-type 2Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi319 – 35032Thr-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nectin family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151182.
    HOGENOMiHOG000036057.
    HOVERGENiHBG057086.
    KOiK06782.
    OMAiQYPLVQN.
    OrthoDBiEOG7PVWPD.
    PhylomeDBiQ8N3J6.
    TreeFamiTF326804.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    IPR003585. Neurexin-like.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF07679. I-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00294. 4.1m. 1 hit.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N3J6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND    50
    NTSLQWSNPA QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG 100
    QYTCSLFTMP VKTSKAYLTV LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG 150
    SKPAADIRWF KNDKEIKDVK YLKEEDANRK TFTVSSTLDF RVDRSDDGVA 200
    VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE GQPLILTCES 250
    KGKPLPEPVL WTKDGGELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN 300
    TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TATVTTTVAI TTSPTTSATT 350
    SSIRDPNALA GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL 400
    TNEAKGAEDA PDADTAIINA EGSQVNAEEK KEYFI 435
    Length:435
    Mass (Da):47,554
    Last modified:October 1, 2002 - v1
    Checksum:i59DDD41B7F34D446
    GO
    Isoform 2 (identifier: Q8N3J6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         20-20: Q → QAAASKNKVK
         316-355: Missing.

    Show »
    Length:404
    Mass (Da):44,423
    Checksum:i736AC87C03FDE1B7
    GO
    Isoform 3 (identifier: Q8N3J6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: MIWKRSAVLRFYSVCGLLLQ → MFVLFLCNLSLVPAAASKNKVK

    Show »
    Length:437
    Mass (Da):47,564
    Checksum:iE94A18403F9B774C
    GO
    Isoform 5 (identifier: Q8N3J6-4) [UniParc]FASTAAdd to Basket

    Also known as: 7

    The sequence of this isoform differs from the canonical sequence as follows:
         1-108: Missing.
         315-354: Missing.

    Show »
    Length:287
    Mass (Da):31,382
    Checksum:iBC731D7DAE4DCC7F
    GO
    Isoform 6 (identifier: Q8N3J6-5) [UniParc]FASTAAdd to Basket

    Also known as: 8

    The sequence of this isoform differs from the canonical sequence as follows:
         1-108: Missing.

    Show »
    Length:327
    Mass (Da):35,410
    Checksum:i5F453DC33C818100
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti174 – 1741E → K in AAN16368. 1 PublicationCurated
    Sequence conflicti212 – 2121A → T in AAN16368. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 108108Missing in isoform 5 and isoform 6. 1 PublicationVSP_055355Add
    BLAST
    Alternative sequencei1 – 2020MIWKR…GLLLQ → MFVLFLCNLSLVPAAASKNK VK in isoform 3. 1 PublicationVSP_026333Add
    BLAST
    Alternative sequencei20 – 201Q → QAAASKNKVK in isoform 2. 2 PublicationsVSP_026334
    Alternative sequencei315 – 35440Missing in isoform 5. 1 PublicationVSP_055356Add
    BLAST
    Alternative sequencei316 – 35540Missing in isoform 2. 2 PublicationsVSP_026335Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB646740 mRNA. Translation: BAK93303.1.
    AB646741 mRNA. Translation: BAK93304.1.
    AB646742 mRNA. Translation: BAK93305.1.
    AB646743 mRNA. Translation: BAK93306.1.
    AF538973 mRNA. Translation: AAN16368.1.
    AL833049 mRNA. Translation: CAH56314.1.
    AL834270 mRNA. Translation: CAD38945.1.
    BC105999 mRNA. Translation: AAI06000.1.
    CCDSiCCDS33792.1. [Q8N3J6-3]
    CCDS54613.1. [Q8N3J6-2]
    CCDS54614.1. [Q8N3J6-1]
    RefSeqiNP_001161146.1. NM_001167674.1. [Q8N3J6-1]
    NP_001161147.1. NM_001167675.1. [Q8N3J6-2]
    NP_001243431.1. NM_001256502.1.
    NP_001243432.1. NM_001256503.1.
    NP_001243433.1. NM_001256504.1.
    NP_001243434.1. NM_001256505.1.
    NP_694854.2. NM_153184.3. [Q8N3J6-3]
    XP_006713144.1. XM_006713081.1. [Q8N3J6-1]
    UniGeneiHs.164578.

    Genome annotation databases

    EnsembliENST00000383699; ENSP00000373200; ENSG00000175161. [Q8N3J6-2]
    ENST00000405615; ENSP00000384193; ENSG00000175161. [Q8N3J6-3]
    ENST00000407528; ENSP00000384575; ENSG00000175161. [Q8N3J6-1]
    GeneIDi253559.
    KEGGihsa:253559.
    UCSCiuc003dqj.3. human. [Q8N3J6-1]
    uc003dql.3. human. [Q8N3J6-3]

    Polymorphism databases

    DMDMi74759850.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB646740 mRNA. Translation: BAK93303.1 .
    AB646741 mRNA. Translation: BAK93304.1 .
    AB646742 mRNA. Translation: BAK93305.1 .
    AB646743 mRNA. Translation: BAK93306.1 .
    AF538973 mRNA. Translation: AAN16368.1 .
    AL833049 mRNA. Translation: CAH56314.1 .
    AL834270 mRNA. Translation: CAD38945.1 .
    BC105999 mRNA. Translation: AAI06000.1 .
    CCDSi CCDS33792.1. [Q8N3J6-3 ]
    CCDS54613.1. [Q8N3J6-2 ]
    CCDS54614.1. [Q8N3J6-1 ]
    RefSeqi NP_001161146.1. NM_001167674.1. [Q8N3J6-1 ]
    NP_001161147.1. NM_001167675.1. [Q8N3J6-2 ]
    NP_001243431.1. NM_001256502.1.
    NP_001243432.1. NM_001256503.1.
    NP_001243433.1. NM_001256504.1.
    NP_001243434.1. NM_001256505.1.
    NP_694854.2. NM_153184.3. [Q8N3J6-3 ]
    XP_006713144.1. XM_006713081.1. [Q8N3J6-1 ]
    UniGenei Hs.164578.

    3D structure databases

    ProteinModelPortali Q8N3J6.
    SMRi Q8N3J6. Positions 24-363.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4724723.
    STRINGi 9606.ENSP00000384193.

    PTM databases

    PhosphoSitei Q8N3J6.

    Polymorphism databases

    DMDMi 74759850.

    Proteomic databases

    PaxDbi Q8N3J6.
    PRIDEi Q8N3J6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000383699 ; ENSP00000373200 ; ENSG00000175161 . [Q8N3J6-2 ]
    ENST00000405615 ; ENSP00000384193 ; ENSG00000175161 . [Q8N3J6-3 ]
    ENST00000407528 ; ENSP00000384575 ; ENSG00000175161 . [Q8N3J6-1 ]
    GeneIDi 253559.
    KEGGi hsa:253559.
    UCSCi uc003dqj.3. human. [Q8N3J6-1 ]
    uc003dql.3. human. [Q8N3J6-3 ]

    Organism-specific databases

    CTDi 253559.
    GeneCardsi GC03P085008.
    HGNCi HGNC:29849. CADM2.
    HPAi HPA010024.
    MIMi 609938. gene.
    neXtProti NX_Q8N3J6.
    PharmGKBi PA162380882.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG151182.
    HOGENOMi HOG000036057.
    HOVERGENi HBG057086.
    KOi K06782.
    OMAi QYPLVQN.
    OrthoDBi EOG7PVWPD.
    PhylomeDBi Q8N3J6.
    TreeFami TF326804.

    Enzyme and pathway databases

    Reactomei REACT_19195. Adherens junctions interactions.

    Miscellaneous databases

    GenomeRNAii 253559.
    NextBioi 92122.
    PROi Q8N3J6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N3J6.
    Bgeei Q8N3J6.
    CleanExi HS_CADM2.
    Genevestigatori Q8N3J6.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    IPR003585. Neurexin-like.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF07679. I-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00294. 4.1m. 1 hit.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), ALTERNATIVE SPLICING.
    2. Gingrich J.R., D'Angelo A., Chang G.M., Greenberg N.M.
      Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-435 (ISOFORM 2).
      Tissue: Amygdala and Stomach.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. "The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion."
      Pellissier F., Gerber A., Bauer C., Ballivet M., Ossipow V.
      BMC Neurosci. 8:90-90(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCADM2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N3J6
    Secondary accession number(s): G3XHN7
    , G3XHN8, Q3KQY9, Q658Q7, Q8IZP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3