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Protein

Cell adhesion molecule 2

Gene

CADM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-418990 Adherens junctions interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cell adhesion molecule 2
Alternative name(s):
Immunoglobulin superfamily member 4D
Short name:
IgSF4D
Nectin-like protein 3
Short name:
NECL-3
Synaptic cell adhesion molecule 2
Short name:
SynCAM 2
Gene namesi
Name:CADM2
Synonyms:IGSF4D, NECL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000175161.13
HGNCiHGNC:29849 CADM2
MIMi609938 gene
neXtProtiNX_Q8N3J6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 367ExtracellularSequence analysisAdd BLAST343
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389 – 435CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi253559
OpenTargetsiENSG00000175161
PharmGKBiPA162380882

Polymorphism and mutation databases

BioMutaiCADM2
DMDMi74759850

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000029197025 – 435Cell adhesion molecule 2Add BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi44 ↔ 104PROSITE-ProRule annotation
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 203PROSITE-ProRule annotation
Disulfide bondi248 ↔ 296PROSITE-ProRule annotation
Glycosylationi291N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei423PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8N3J6
PeptideAtlasiQ8N3J6
PRIDEiQ8N3J6
ProteomicsDBi71814
71815 [Q8N3J6-2]
71816 [Q8N3J6-3]
TopDownProteomicsiQ8N3J6-3 [Q8N3J6-3]

PTM databases

iPTMnetiQ8N3J6
PhosphoSitePlusiQ8N3J6

Expressioni

Gene expression databases

BgeeiENSG00000175161
CleanExiHS_CADM2
ExpressionAtlasiQ8N3J6 baseline and differential
GenevisibleiQ8N3J6 HS

Organism-specific databases

HPAiHPA010024

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128973, 1 interactor
STRINGi9606.ENSP00000384193

Structurei

3D structure databases

ProteinModelPortaliQ8N3J6
SMRiQ8N3J6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 119Ig-like V-typeAdd BLAST93
Domaini127 – 219Ig-like C2-type 1Add BLAST93
Domaini227 – 312Ig-like C2-type 2Add BLAST86

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi319 – 350Thr-richAdd BLAST32

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFCE Eukaryota
ENOG411017U LUCA
GeneTreeiENSGT00900000140811
HOGENOMiHOG000036057
HOVERGENiHBG057086
InParanoidiQ8N3J6
KOiK06782
OMAiWFRNEKE
OrthoDBiEOG091G0BHE
PhylomeDBiQ8N3J6
TreeFamiTF326804

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR003585 Neurexin-like
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIWKRSAVLR FYSVCGLLLQ GSQGQFPLTQ NVTVVEGGTA ILTCRVDQND
60 70 80 90 100
NTSLQWSNPA QQTLYFDDKK ALRDNRIELV RASWHELSIS VSDVSLSDEG
110 120 130 140 150
QYTCSLFTMP VKTSKAYLTV LGVPEKPQIS GFSSPVMEGD LMQLTCKTSG
160 170 180 190 200
SKPAADIRWF KNDKEIKDVK YLKEEDANRK TFTVSSTLDF RVDRSDDGVA
210 220 230 240 250
VICRVDHESL NATPQVAMQV LEIHYTPSVK IIPSTPFPQE GQPLILTCES
260 270 280 290 300
KGKPLPEPVL WTKDGGELPD PDRMVVSGRE LNILFLNKTD NGTYRCEATN
310 320 330 340 350
TIGQSSAEYV LIVHDVPNTL LPTTIIPSLT TATVTTTVAI TTSPTTSATT
360 370 380 390 400
SSIRDPNALA GQNGPDHALI GGIVAVVVFV TLCSIFLLGR YLARHKGTYL
410 420 430
TNEAKGAEDA PDADTAIINA EGSQVNAEEK KEYFI
Length:435
Mass (Da):47,554
Last modified:October 1, 2002 - v1
Checksum:i59DDD41B7F34D446
GO
Isoform 2 (identifier: Q8N3J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Q → QAAASKNKVK
     316-355: Missing.

Show »
Length:404
Mass (Da):44,423
Checksum:i736AC87C03FDE1B7
GO
Isoform 3 (identifier: Q8N3J6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MIWKRSAVLRFYSVCGLLLQ → MFVLFLCNLSLVPAAASKNKVK

Show »
Length:437
Mass (Da):47,564
Checksum:iE94A18403F9B774C
GO
Isoform 5 (identifier: Q8N3J6-4) [UniParc]FASTAAdd to basket
Also known as: 7

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.
     315-354: Missing.

Show »
Length:287
Mass (Da):31,382
Checksum:iBC731D7DAE4DCC7F
GO
Isoform 6 (identifier: Q8N3J6-5) [UniParc]FASTAAdd to basket
Also known as: 8

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Show »
Length:327
Mass (Da):35,410
Checksum:i5F453DC33C818100
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174E → K in AAN16368 (Ref. 2) Curated1
Sequence conflicti212A → T in AAN16368 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0553551 – 108Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_0263331 – 20MIWKR…GLLLQ → MFVLFLCNLSLVPAAASKNK VK in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_02633420Q → QAAASKNKVK in isoform 2. 2 Publications1
Alternative sequenceiVSP_055356315 – 354Missing in isoform 5. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_026335316 – 355Missing in isoform 2. 2 PublicationsAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB646740 mRNA Translation: BAK93303.1
AB646741 mRNA Translation: BAK93304.1
AB646742 mRNA Translation: BAK93305.1
AB646743 mRNA Translation: BAK93306.1
AF538973 mRNA Translation: AAN16368.1
AL833049 mRNA Translation: CAH56314.1
AL834270 mRNA Translation: CAD38945.1
BC105999 mRNA Translation: AAI06000.1
CCDSiCCDS33792.1 [Q8N3J6-3]
CCDS54613.1 [Q8N3J6-2]
CCDS54614.1 [Q8N3J6-1]
RefSeqiNP_001161146.1, NM_001167674.1 [Q8N3J6-1]
NP_001161147.1, NM_001167675.1 [Q8N3J6-2]
NP_001243431.1, NM_001256502.1 [Q8N3J6-5]
NP_001243432.1, NM_001256503.1 [Q8N3J6-5]
NP_001243433.1, NM_001256504.1 [Q8N3J6-4]
NP_001243434.1, NM_001256505.1 [Q8N3J6-4]
NP_694854.2, NM_153184.3 [Q8N3J6-3]
XP_006713144.1, XM_006713081.3 [Q8N3J6-1]
UniGeneiHs.164578

Genome annotation databases

EnsembliENST00000383699; ENSP00000373200; ENSG00000175161 [Q8N3J6-2]
ENST00000405615; ENSP00000384193; ENSG00000175161 [Q8N3J6-3]
ENST00000407528; ENSP00000384575; ENSG00000175161 [Q8N3J6-1]
ENST00000644573; ENSP00000496096; ENSG00000284780 [Q8N3J6-2]
ENST00000644749; ENSP00000495354; ENSG00000284780 [Q8N3J6-3]
ENST00000647099; ENSP00000494084; ENSG00000284780 [Q8N3J6-1]
GeneIDi253559
KEGGihsa:253559
UCSCiuc003dqj.4 human [Q8N3J6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCADM2_HUMAN
AccessioniPrimary (citable) accession number: Q8N3J6
Secondary accession number(s): G3XHN7
, G3XHN8, Q3KQY9, Q658Q7, Q8IZP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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