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Protein

Uncharacterized protein C17orf53

Gene

C17orf53

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C17orf53
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000125319.14
HGNCiHGNC:28460 C17orf53
neXtProtiNX_Q8N3J3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125319
PharmGKBiPA142672236

Polymorphism and mutation databases

BioMutaiC17orf53
DMDMi74714855

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880921 – 647Uncharacterized protein C17orf53Add BLAST647

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineCombined sources1
Modified residuei285Asymmetric dimethylarginineCombined sources1
Modified residuei295Asymmetric dimethylarginineCombined sources1
Modified residuei329Asymmetric dimethylarginineCombined sources1
Modified residuei337Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8N3J3
MaxQBiQ8N3J3
PaxDbiQ8N3J3
PeptideAtlasiQ8N3J3
PRIDEiQ8N3J3

PTM databases

iPTMnetiQ8N3J3
PhosphoSitePlusiQ8N3J3

Expressioni

Gene expression databases

BgeeiENSG00000125319
CleanExiHS_C17orf53
GenevisibleiQ8N3J3 HS

Organism-specific databases

HPAiHPA023004
HPA023393
HPA024430

Interactioni

Protein-protein interaction databases

BioGridi122466, 9 interactors
IntActiQ8N3J3, 6 interactors
MINTiQ8N3J3
STRINGi9606.ENSP00000313500

Structurei

3D structure databases

ProteinModelPortaliQ8N3J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFHD Eukaryota
ENOG4111NPV LUCA
GeneTreeiENSGT00400000022305
HOGENOMiHOG000111931
HOVERGENiHBG099865
InParanoidiQ8N3J3
OMAiPNNLVHI
OrthoDBiEOG091G0GYK
PhylomeDBiQ8N3J3
TreeFamiTF331108

Family and domain databases

InterProiView protein in InterPro
IPR028045 DUF4539
PfamiView protein in Pfam
PF15072 DUF4539, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3J3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACSLQKLFA VEEEFEDEDF LSAVEDAENR FTGSLPVNAG RLRPVSSRPQ
60 70 80 90 100
ETVQAQSSRL LLLHPTAPSE ALGLPDLDLC LPASSTPSAD SRPSCIGAAP
110 120 130 140 150
LRPVSTSSSW IGNQRRVTVT EVLRETARPQ SSALHPLLTF ESQQQQVGGF
160 170 180 190 200
EGPEQDEFDK VLASMELEEP GMELECGVSS EAIPILPAQQ REGSVLAKKA
210 220 230 240 250
RVVDLSGSCQ KGPVPAIHKA GIMSAQDESL DPVIQCRTPR PPLRPGAVGH
260 270 280 290 300
LPVPTALTVP TQQLHWEVCP QRSPVQALQP LQAARGTIQS SPQNRFPCQP
310 320 330 340 350
FQSPSSWLSG KAHLPRPRTP NSSCSTPSRT SSGLFPRIPL QPQAPVSSIG
360 370 380 390 400
SPVGTPKGPQ GALQTPIVTN HLVQLVTAAS RTPQQPTHPS TRAKTRRFPG
410 420 430 440 450
PAGILPHQQS GRSLEDIMVS APQTPTHGAL AKFQTEIVAS SQASVEEDFG
460 470 480 490 500
RGPWLTMKST LGLDERDPSC FLCTYSIVMV LRKQAALKQL PRNKVPNMAV
510 520 530 540 550
MIKSLTRSTM DASVVFKDPT GEMQGTVHRL LLETCQNELK PGSVLLLKQI
560 570 580 590 600
GVFSPSLRNH YLNVTPNNLV HIYSPDSGDG SFLKPSQPFP KDSGSFQHDV
610 620 630 640
AAKPEEGFRT AQNLEAEASP EEELPEADDL DGLLSELPED FFCGTSS
Length:647
Mass (Da):69,771
Last modified:October 1, 2002 - v1
Checksum:i087F0413951BCD43
GO
Isoform 2 (identifier: Q8N3J3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-137: SSWIGNQRRVTVTEVLRETARPQSSALHPL → NCLNSSHSATPLGSLSATLHCSSTSASPSC
     138-647: Missing.

Note: No experimental confirmation available.
Show »
Length:137
Mass (Da):14,269
Checksum:iD59516006B13834D
GO
Isoform 3 (identifier: Q8N3J3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     409-484: Missing.
     592-597: DSGSFQ → MTWMDS
     598-647: Missing.

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):56,181
Checksum:i5614F5CA1893A33E
GO
Isoform 4 (identifier: Q8N3J3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     484-484: Missing.

Show »
Length:646
Mass (Da):69,643
Checksum:i6F984B89AA65B1C1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032393126T → P1 PublicationCorresponds to variant dbSNP:rs227584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025651108 – 137SSWIG…ALHPL → NCLNSSHSATPLGSLSATLH CSSTSASPSC in isoform 2. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_025652138 – 647Missing in isoform 2. 1 PublicationAdd BLAST510
Alternative sequenceiVSP_025653409 – 484Missing in isoform 3. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_047077484Missing in isoform 4. 1 Publication1
Alternative sequenceiVSP_025654592 – 597DSGSFQ → MTWMDS in isoform 3. 1 Publication6
Alternative sequenceiVSP_025655598 – 647Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291924 mRNA Translation: BAF84613.1
AK021656 mRNA Translation: BAB13867.1
AL834295 mRNA Translation: CAD38968.1
AC004596 Genomic DNA No translation available.
BC000121 mRNA Translation: AAH00121.1
CCDSiCCDS11477.1 [Q8N3J3-1]
CCDS59293.1 [Q8N3J3-4]
CCDS82136.1 [Q8N3J3-3]
RefSeqiNP_001164722.1, NM_001171251.2 [Q8N3J3-4]
NP_001308239.1, NM_001321310.1 [Q8N3J3-3]
NP_001308240.1, NM_001321311.1
NP_076937.2, NM_024032.4 [Q8N3J3-1]
UniGeneiHs.437059

Genome annotation databases

EnsembliENST00000245382; ENSP00000245382; ENSG00000125319 [Q8N3J3-3]
ENST00000319977; ENSP00000313500; ENSG00000125319 [Q8N3J3-1]
ENST00000585683; ENSP00000466618; ENSG00000125319 [Q8N3J3-4]
GeneIDi78995
KEGGihsa:78995
UCSCiuc002ifi.2 human [Q8N3J3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCQ053_HUMAN
AccessioniPrimary (citable) accession number: Q8N3J3
Secondary accession number(s): A8K7A9, Q9BWM9, Q9HAI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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