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Protein

Methyltransferase-like protein 4

Gene

METTL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. nucleobase-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 4 (EC:2.1.1.-)
Gene namesi
Name:METTL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:24726. METTL4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916468.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Methyltransferase-like protein 4PRO_0000251225Add
BLAST

Proteomic databases

PaxDbiQ8N3J2.
PRIDEiQ8N3J2.

PTM databases

PhosphoSiteiQ8N3J2.

Expressioni

Gene expression databases

BgeeiQ8N3J2.
CleanExiHS_METTL4.
ExpressionAtlasiQ8N3J2. baseline and differential.
GenevestigatoriQ8N3J2.

Organism-specific databases

HPAiHPA040061.

Interactioni

Protein-protein interaction databases

BioGridi122334. 1 interaction.
STRINGi9606.ENSP00000320349.

Structurei

3D structure databases

ProteinModelPortaliQ8N3J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MT-A70-like family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG4725.
GeneTreeiENSGT00390000016237.
HOGENOMiHOG000113569.
HOVERGENiHBG078120.
InParanoidiQ8N3J2.
OMAiLIVSVPC.
PhylomeDBiQ8N3J2.
TreeFamiTF314410.

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
PS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N3J2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVVHQLSAG WLLDHLSFIN KINYQLHQHH EPCCRKKEFT TSVHFESLQM
60 70 80 90 100
DSVSSSGVCA AFIASDSSTK PENDDGGNYE MFTRKFVFRP ELFDVTKPYI
110 120 130 140 150
TPAVHKECQQ SNEKEDLMNG VKKEISISII GKKRKRCVVF NQGELDAMEY
160 170 180 190 200
HTKIRELILD GSLQLIQEGL KSGFLYPLFE KQDKGSKPIT LPLDACSLSE
210 220 230 240 250
LCEMAKHLPS LNEMEHQTLQ LVEEDTSVTE QDLFLRVVEN NSSFTKVITL
260 270 280 290 300
MGQKYLLPPK SSFLLSDISC MQPLLNYRKT FDVIVIDPPW QNKSVKRSNR
310 320 330 340 350
YSYLSPLQIQ QIPIPKLAAP NCLLVTWVTN RQKHLRFIKE ELYPSWSVEV
360 370 380 390 400
VAEWHWVKIT NSGEFVFPLD SPHKKPYEGL ILGRVQEKTA LPLRNADVNV
410 420 430 440 450
LPIPDHKLIV SVPCTLHSHK PPLAEVLKDY IKPDGEYLEL FARNLQPGWT
460 470
SWGNEVLKFQ HVDYFIAVES GS
Length:472
Mass (Da):54,041
Last modified:November 24, 2009 - v3
Checksum:i5A5D77484AF358D7
GO

Sequence cautioni

The sequence BAB15520.1 differs from that shown. Reason: Frameshift at position 343. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531K → M in BAB15520. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421S → F Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064731
Natural varianti163 – 1631L → F.
Corresponds to variant rs12606220 [ dbSNP | Ensembl ].
VAR_027670
Natural varianti230 – 2301E → D.
Corresponds to variant rs34143130 [ dbSNP | Ensembl ].
VAR_056159
Natural varianti310 – 3101Q → K.1 Publication
Corresponds to variant rs2677879 [ dbSNP | Ensembl ].
VAR_027671
Natural varianti468 – 4681V → L.3 Publications
Corresponds to variant rs8084295 [ dbSNP | Ensembl ].
VAR_027672

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005136 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01698.1.
BC111020 mRNA. Translation: AAI11021.1.
BC136766 mRNA. Translation: AAI36767.1.
BC136767 mRNA. Translation: AAI36768.1.
AK026670 mRNA. Translation: BAB15520.1. Frameshift.
AL834296 mRNA. Translation: CAD38969.1.
CCDSiCCDS11826.1.
RefSeqiNP_073751.3. NM_022840.3.
UniGeneiHs.126888.

Genome annotation databases

EnsembliENST00000574538; ENSP00000458290; ENSG00000101574.
GeneIDi64863.
KEGGihsa:64863.
UCSCiuc002klh.4. human.

Polymorphism databases

DMDMi269849669.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005136 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01698.1.
BC111020 mRNA. Translation: AAI11021.1.
BC136766 mRNA. Translation: AAI36767.1.
BC136767 mRNA. Translation: AAI36768.1.
AK026670 mRNA. Translation: BAB15520.1. Frameshift.
AL834296 mRNA. Translation: CAD38969.1.
CCDSiCCDS11826.1.
RefSeqiNP_073751.3. NM_022840.3.
UniGeneiHs.126888.

3D structure databases

ProteinModelPortaliQ8N3J2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122334. 1 interaction.
STRINGi9606.ENSP00000320349.

PTM databases

PhosphoSiteiQ8N3J2.

Polymorphism databases

DMDMi269849669.

Proteomic databases

PaxDbiQ8N3J2.
PRIDEiQ8N3J2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000574538; ENSP00000458290; ENSG00000101574.
GeneIDi64863.
KEGGihsa:64863.
UCSCiuc002klh.4. human.

Organism-specific databases

CTDi64863.
GeneCardsiGC18M002527.
H-InvDBHIX0014297.
HGNCiHGNC:24726. METTL4.
HPAiHPA040061.
neXtProtiNX_Q8N3J2.
PharmGKBiPA134916468.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG4725.
GeneTreeiENSGT00390000016237.
HOGENOMiHOG000113569.
HOVERGENiHBG078120.
InParanoidiQ8N3J2.
OMAiLIVSVPC.
PhylomeDBiQ8N3J2.
TreeFamiTF314410.

Miscellaneous databases

ChiTaRSiMETTL4. human.
GenomeRNAii64863.
NextBioi67019.
PROiQ8N3J2.

Gene expression databases

BgeeiQ8N3J2.
CleanExiHS_METTL4.
ExpressionAtlasiQ8N3J2. baseline and differential.
GenevestigatoriQ8N3J2.

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
PS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-310 AND LEU-468.
    Tissue: Brain, Lung and Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-472, VARIANT LEU-468.
    Tissue: Lung.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-472, VARIANT LEU-468.
    Tissue: Melanoma.
  6. Cited for: VARIANT PHE-42.

Entry informationi

Entry nameiMETL4_HUMAN
AccessioniPrimary (citable) accession number: Q8N3J2
Secondary accession number(s): B2RNA1, Q2TAA7, Q9H5U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 24, 2009
Last modified: January 7, 2015
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.