Reviewed,
UniProtKB/Swiss-Prot Q8N3J2 (METL4_HUMAN)
Last modified
June 16, 2009.
Version 47.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Methyltransferase-like protein 4 EC=2.1.1.- | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 472 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Probable methyltransferase By similarity. |
| Sequence similarities | Belongs to the MT-A70-like family. |
| Sequence caution | The sequence BAB15520.1 differs from that shown. Reason: Frameshift at position 343. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| Molecular function | Methyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | methylation Inferred from electronic annotation. Source: InterPro nucleobase, nucleoside, nucleotide and nucleic acid metabolic processInferred from electronic annotation. Source: InterPro |
| Molecular function | methyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 472 | 472 | Methyltransferase-like protein 4 | PRO_0000251225 | |||||
Natural variations | |||||||||
| Natural variant | 163 | 1 | L → F: dbSNP rs12606220. | VAR_027670 | |||||
| Natural variant | 230 | 1 | E → D: dbSNP rs34143130. | VAR_056159 | |||||
| Natural variant | 310 | 1 | K → Q: dbSNP rs2677879. Ref.1 Ref.2 Ref.3 | VAR_027671 | |||||
| Natural variant | 468 | 1 | L → V: dbSNP rs8084295. | VAR_027672 | |||||
Experimental info | |||||||||
| Sequence conflict | 153 | 1 | K → M in BAB15520. Ref.2 | ||||||
Sequences
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References
| [1] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLN-310. Tissue: Lung. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.  Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-472, VARIANT GLN-310. Tissue: Lung. |
| [3] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-472, VARIANT GLN-310. Tissue: Melanoma. |
Cross-references
Sequence databases | |
|---|---|
| BC111020 mRNA. Translation: AAI11021.1. AK026670 mRNA. Translation: BAB15520.1. Frameshift. AL834296 mRNA. Translation: CAD38969.1. | |
| IPI | IPI00394998. |
| RefSeq | NP_073751.3. |
| UniGene | Hs.126888 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q8N3J2. |
Genome annotation databases | |
| Ensembl | ENSG00000101574. Homo sapiens. [Contig view] |
| GeneID | 64863. |
| KEGG | hsa:64863. |
Organism-specific databases | |
| GeneCards | GC18M002527. |
| HGNC | HGNC:24726. METTL4. |
| PharmGKB | PA134916468. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q8N3J2. |
Gene expression databases | |
| ArrayExpress | Q8N3J2. |
| Bgee | Q8N3J2. |
| CleanEx | HS_METTL4. |
| GermOnline | ENSG00000101574. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR007757. MT-A70. IPR002052. N6_adenine_Mtase_CS. [Graphical view] |
| Pfam | PF05063. MT-A70. 1 hit. [Graphical view] |
| PROSITE | PS51143. MT_A70. 1 hit. PS00092. N6_MTASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 67019. |
Entry information
| Entry name | METL4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N3J2 Secondary accession number(s): Q2TAA7, Q9H5U9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 18 Human chromosome 18: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |
