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Protein

Methyltransferase-like protein 4

Gene

METTL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 4 (EC:2.1.1.-)
Gene namesi
Name:METTL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000101574.14
HGNCiHGNC:24726 METTL4
neXtProtiNX_Q8N3J2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi64863
OpenTargetsiENSG00000101574
PharmGKBiPA134916468

Polymorphism and mutation databases

BioMutaiMETTL4
DMDMi269849669

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512251 – 472Methyltransferase-like protein 4Add BLAST472

Proteomic databases

PaxDbiQ8N3J2
PeptideAtlasiQ8N3J2
PRIDEiQ8N3J2

PTM databases

iPTMnetiQ8N3J2
PhosphoSitePlusiQ8N3J2

Expressioni

Gene expression databases

BgeeiENSG00000101574
CleanExiHS_METTL4
ExpressionAtlasiQ8N3J2 baseline and differential
GenevisibleiQ8N3J2 HS

Organism-specific databases

HPAiHPA040061

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000458290

Structurei

3D structure databases

ProteinModelPortaliQ8N3J2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MT-A70-like family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2356 Eukaryota
ENOG410Y4SI LUCA
GeneTreeiENSGT00390000016237
HOGENOMiHOG000113569
HOVERGENiHBG078120
InParanoidiQ8N3J2
OMAiLSDISCM
OrthoDBiEOG091G0FJ4
PhylomeDBiQ8N3J2
TreeFamiTF314410

Family and domain databases

InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR007757 MT-A70-like
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF05063 MT-A70, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51143 MT_A70, 1 hit
PS00092 N6_MTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8N3J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVHQLSAG WLLDHLSFIN KINYQLHQHH EPCCRKKEFT TSVHFESLQM
60 70 80 90 100
DSVSSSGVCA AFIASDSSTK PENDDGGNYE MFTRKFVFRP ELFDVTKPYI
110 120 130 140 150
TPAVHKECQQ SNEKEDLMNG VKKEISISII GKKRKRCVVF NQGELDAMEY
160 170 180 190 200
HTKIRELILD GSLQLIQEGL KSGFLYPLFE KQDKGSKPIT LPLDACSLSE
210 220 230 240 250
LCEMAKHLPS LNEMEHQTLQ LVEEDTSVTE QDLFLRVVEN NSSFTKVITL
260 270 280 290 300
MGQKYLLPPK SSFLLSDISC MQPLLNYRKT FDVIVIDPPW QNKSVKRSNR
310 320 330 340 350
YSYLSPLQIQ QIPIPKLAAP NCLLVTWVTN RQKHLRFIKE ELYPSWSVEV
360 370 380 390 400
VAEWHWVKIT NSGEFVFPLD SPHKKPYEGL ILGRVQEKTA LPLRNADVNV
410 420 430 440 450
LPIPDHKLIV SVPCTLHSHK PPLAEVLKDY IKPDGEYLEL FARNLQPGWT
460 470
SWGNEVLKFQ HVDYFIAVES GS
Length:472
Mass (Da):54,041
Last modified:November 24, 2009 - v3
Checksum:i5A5D77484AF358D7
GO

Sequence cautioni

The sequence BAB15520 differs from that shown. Reason: Frameshift at position 343.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153K → M in BAB15520 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06473142S → F Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_027670163L → F. Corresponds to variant dbSNP:rs12606220Ensembl.1
Natural variantiVAR_056159230E → D. Corresponds to variant dbSNP:rs34143130Ensembl.1
Natural variantiVAR_027671310Q → K1 PublicationCorresponds to variant dbSNP:rs2677879Ensembl.1
Natural variantiVAR_027672468V → L3 PublicationsCorresponds to variant dbSNP:rs8084295Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP005136 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01698.1
BC111020 mRNA Translation: AAI11021.1
BC136766 mRNA Translation: AAI36767.1
BC136767 mRNA Translation: AAI36768.1
AK026670 mRNA Translation: BAB15520.1 Frameshift.
AL834296 mRNA Translation: CAD38969.1
CCDSiCCDS11826.1
RefSeqiNP_073751.3, NM_022840.4
UniGeneiHs.126888

Genome annotation databases

EnsembliENST00000574538; ENSP00000458290; ENSG00000101574
GeneIDi64863
KEGGihsa:64863
UCSCiuc002klh.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMETL4_HUMAN
AccessioniPrimary (citable) accession number: Q8N3J2
Secondary accession number(s): B2RNA1, Q2TAA7, Q9H5U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 24, 2009
Last modified: January 31, 2018
This is version 115 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health