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Q8N3J2

- METL4_HUMAN

UniProt

Q8N3J2 - METL4_HUMAN

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Protein
Methyltransferase-like protein 4
Gene
METTL4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable methyltransferase By similarity.

GO - Molecular functioni

  1. methyltransferase activity Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. nucleobase-containing compound metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 4 (EC:2.1.1.-)
Gene namesi
Name:METTL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:24726. METTL4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916468.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Methyltransferase-like protein 4
PRO_0000251225Add
BLAST

Proteomic databases

PaxDbiQ8N3J2.
PRIDEiQ8N3J2.

PTM databases

PhosphoSiteiQ8N3J2.

Expressioni

Gene expression databases

ArrayExpressiQ8N3J2.
BgeeiQ8N3J2.
CleanExiHS_METTL4.
GenevestigatoriQ8N3J2.

Organism-specific databases

HPAiHPA040061.

Interactioni

Protein-protein interaction databases

BioGridi122334. 1 interaction.
STRINGi9606.ENSP00000320349.

Structurei

3D structure databases

ProteinModelPortaliQ8N3J2.

Family & Domainsi

Sequence similaritiesi

Belongs to the MT-A70-like family.

Phylogenomic databases

eggNOGiCOG4725.
HOGENOMiHOG000113569.
HOVERGENiHBG078120.
InParanoidiQ8N3J2.
OMAiLIVSVPC.
PhylomeDBiQ8N3J2.
TreeFamiTF314410.

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
PS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N3J2-1 [UniParc]FASTAAdd to Basket

« Hide

MSVVHQLSAG WLLDHLSFIN KINYQLHQHH EPCCRKKEFT TSVHFESLQM    50
DSVSSSGVCA AFIASDSSTK PENDDGGNYE MFTRKFVFRP ELFDVTKPYI 100
TPAVHKECQQ SNEKEDLMNG VKKEISISII GKKRKRCVVF NQGELDAMEY 150
HTKIRELILD GSLQLIQEGL KSGFLYPLFE KQDKGSKPIT LPLDACSLSE 200
LCEMAKHLPS LNEMEHQTLQ LVEEDTSVTE QDLFLRVVEN NSSFTKVITL 250
MGQKYLLPPK SSFLLSDISC MQPLLNYRKT FDVIVIDPPW QNKSVKRSNR 300
YSYLSPLQIQ QIPIPKLAAP NCLLVTWVTN RQKHLRFIKE ELYPSWSVEV 350
VAEWHWVKIT NSGEFVFPLD SPHKKPYEGL ILGRVQEKTA LPLRNADVNV 400
LPIPDHKLIV SVPCTLHSHK PPLAEVLKDY IKPDGEYLEL FARNLQPGWT 450
SWGNEVLKFQ HVDYFIAVES GS 472
Length:472
Mass (Da):54,041
Last modified:November 24, 2009 - v3
Checksum:i5A5D77484AF358D7
GO

Sequence cautioni

The sequence BAB15520.1 differs from that shown. Reason: Frameshift at position 343.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421S → F Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064731
Natural varianti163 – 1631L → F.
Corresponds to variant rs12606220 [ dbSNP | Ensembl ].
VAR_027670
Natural varianti230 – 2301E → D.
Corresponds to variant rs34143130 [ dbSNP | Ensembl ].
VAR_056159
Natural varianti310 – 3101Q → K.1 Publication
Corresponds to variant rs2677879 [ dbSNP | Ensembl ].
VAR_027671
Natural varianti468 – 4681V → L.3 Publications
Corresponds to variant rs8084295 [ dbSNP | Ensembl ].
VAR_027672

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531K → M in BAB15520. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP005136 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01698.1.
BC111020 mRNA. Translation: AAI11021.1.
BC136766 mRNA. Translation: AAI36767.1.
BC136767 mRNA. Translation: AAI36768.1.
AK026670 mRNA. Translation: BAB15520.1. Frameshift.
AL834296 mRNA. Translation: CAD38969.1.
CCDSiCCDS11826.1.
RefSeqiNP_073751.3. NM_022840.3.
UniGeneiHs.126888.

Genome annotation databases

EnsembliENST00000574538; ENSP00000458290; ENSG00000101574.
GeneIDi64863.
KEGGihsa:64863.
UCSCiuc002klh.4. human.

Polymorphism databases

DMDMi269849669.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP005136 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01698.1 .
BC111020 mRNA. Translation: AAI11021.1 .
BC136766 mRNA. Translation: AAI36767.1 .
BC136767 mRNA. Translation: AAI36768.1 .
AK026670 mRNA. Translation: BAB15520.1 . Frameshift.
AL834296 mRNA. Translation: CAD38969.1 .
CCDSi CCDS11826.1.
RefSeqi NP_073751.3. NM_022840.3.
UniGenei Hs.126888.

3D structure databases

ProteinModelPortali Q8N3J2.
ModBasei Search...

Protein-protein interaction databases

BioGridi 122334. 1 interaction.
STRINGi 9606.ENSP00000320349.

PTM databases

PhosphoSitei Q8N3J2.

Polymorphism databases

DMDMi 269849669.

Proteomic databases

PaxDbi Q8N3J2.
PRIDEi Q8N3J2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000574538 ; ENSP00000458290 ; ENSG00000101574 .
GeneIDi 64863.
KEGGi hsa:64863.
UCSCi uc002klh.4. human.

Organism-specific databases

CTDi 64863.
GeneCardsi GC18M002527.
H-InvDB HIX0014297.
HGNCi HGNC:24726. METTL4.
HPAi HPA040061.
neXtProti NX_Q8N3J2.
PharmGKBi PA134916468.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4725.
HOGENOMi HOG000113569.
HOVERGENi HBG078120.
InParanoidi Q8N3J2.
OMAi LIVSVPC.
PhylomeDBi Q8N3J2.
TreeFami TF314410.

Miscellaneous databases

GenomeRNAii 64863.
NextBioi 67019.
PROi Q8N3J2.

Gene expression databases

ArrayExpressi Q8N3J2.
Bgeei Q8N3J2.
CleanExi HS_METTL4.
Genevestigatori Q8N3J2.

Family and domain databases

InterProi IPR002052. DNA_methylase_N6_adenine_CS.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF05063. MT-A70. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51143. MT_A70. 1 hit.
PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-310 AND LEU-468.
    Tissue: Brain, Lung and Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-472, VARIANT LEU-468.
    Tissue: Lung.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-472, VARIANT LEU-468.
    Tissue: Melanoma.
  6. Cited for: VARIANT PHE-42.

Entry informationi

Entry nameiMETL4_HUMAN
AccessioniPrimary (citable) accession number: Q8N3J2
Secondary accession number(s): B2RNA1, Q2TAA7, Q9H5U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 24, 2009
Last modified: July 9, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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