Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8N3J2

- METL4_HUMAN

UniProt

Q8N3J2 - METL4_HUMAN

Protein

Methyltransferase-like protein 4

Gene

METTL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 3 (24 Nov 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable methyltransferase.By similarity

    GO - Molecular functioni

    1. methyltransferase activity Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. nucleobase-containing compound metabolic process Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methyltransferase-like protein 4 (EC:2.1.1.-)
    Gene namesi
    Name:METTL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:24726. METTL4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134916468.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Methyltransferase-like protein 4PRO_0000251225Add
    BLAST

    Proteomic databases

    PaxDbiQ8N3J2.
    PRIDEiQ8N3J2.

    PTM databases

    PhosphoSiteiQ8N3J2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N3J2.
    BgeeiQ8N3J2.
    CleanExiHS_METTL4.
    GenevestigatoriQ8N3J2.

    Organism-specific databases

    HPAiHPA040061.

    Interactioni

    Protein-protein interaction databases

    BioGridi122334. 1 interaction.
    STRINGi9606.ENSP00000320349.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N3J2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MT-A70-like family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG4725.
    HOGENOMiHOG000113569.
    HOVERGENiHBG078120.
    InParanoidiQ8N3J2.
    OMAiLIVSVPC.
    PhylomeDBiQ8N3J2.
    TreeFamiTF314410.

    Family and domain databases

    InterProiIPR002052. DNA_methylase_N6_adenine_CS.
    IPR007757. MT-A70-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF05063. MT-A70. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51143. MT_A70. 1 hit.
    PS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N3J2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVVHQLSAG WLLDHLSFIN KINYQLHQHH EPCCRKKEFT TSVHFESLQM    50
    DSVSSSGVCA AFIASDSSTK PENDDGGNYE MFTRKFVFRP ELFDVTKPYI 100
    TPAVHKECQQ SNEKEDLMNG VKKEISISII GKKRKRCVVF NQGELDAMEY 150
    HTKIRELILD GSLQLIQEGL KSGFLYPLFE KQDKGSKPIT LPLDACSLSE 200
    LCEMAKHLPS LNEMEHQTLQ LVEEDTSVTE QDLFLRVVEN NSSFTKVITL 250
    MGQKYLLPPK SSFLLSDISC MQPLLNYRKT FDVIVIDPPW QNKSVKRSNR 300
    YSYLSPLQIQ QIPIPKLAAP NCLLVTWVTN RQKHLRFIKE ELYPSWSVEV 350
    VAEWHWVKIT NSGEFVFPLD SPHKKPYEGL ILGRVQEKTA LPLRNADVNV 400
    LPIPDHKLIV SVPCTLHSHK PPLAEVLKDY IKPDGEYLEL FARNLQPGWT 450
    SWGNEVLKFQ HVDYFIAVES GS 472
    Length:472
    Mass (Da):54,041
    Last modified:November 24, 2009 - v3
    Checksum:i5A5D77484AF358D7
    GO

    Sequence cautioni

    The sequence BAB15520.1 differs from that shown. Reason: Frameshift at position 343.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti153 – 1531K → M in BAB15520. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421S → F Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
    VAR_064731
    Natural varianti163 – 1631L → F.
    Corresponds to variant rs12606220 [ dbSNP | Ensembl ].
    VAR_027670
    Natural varianti230 – 2301E → D.
    Corresponds to variant rs34143130 [ dbSNP | Ensembl ].
    VAR_056159
    Natural varianti310 – 3101Q → K.1 Publication
    Corresponds to variant rs2677879 [ dbSNP | Ensembl ].
    VAR_027671
    Natural varianti468 – 4681V → L.3 Publications
    Corresponds to variant rs8084295 [ dbSNP | Ensembl ].
    VAR_027672

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP005136 Genomic DNA. No translation available.
    CH471113 Genomic DNA. Translation: EAX01698.1.
    BC111020 mRNA. Translation: AAI11021.1.
    BC136766 mRNA. Translation: AAI36767.1.
    BC136767 mRNA. Translation: AAI36768.1.
    AK026670 mRNA. Translation: BAB15520.1. Frameshift.
    AL834296 mRNA. Translation: CAD38969.1.
    CCDSiCCDS11826.1.
    RefSeqiNP_073751.3. NM_022840.3.
    UniGeneiHs.126888.

    Genome annotation databases

    EnsembliENST00000574538; ENSP00000458290; ENSG00000101574.
    GeneIDi64863.
    KEGGihsa:64863.
    UCSCiuc002klh.4. human.

    Polymorphism databases

    DMDMi269849669.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP005136 Genomic DNA. No translation available.
    CH471113 Genomic DNA. Translation: EAX01698.1 .
    BC111020 mRNA. Translation: AAI11021.1 .
    BC136766 mRNA. Translation: AAI36767.1 .
    BC136767 mRNA. Translation: AAI36768.1 .
    AK026670 mRNA. Translation: BAB15520.1 . Frameshift.
    AL834296 mRNA. Translation: CAD38969.1 .
    CCDSi CCDS11826.1.
    RefSeqi NP_073751.3. NM_022840.3.
    UniGenei Hs.126888.

    3D structure databases

    ProteinModelPortali Q8N3J2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122334. 1 interaction.
    STRINGi 9606.ENSP00000320349.

    PTM databases

    PhosphoSitei Q8N3J2.

    Polymorphism databases

    DMDMi 269849669.

    Proteomic databases

    PaxDbi Q8N3J2.
    PRIDEi Q8N3J2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000574538 ; ENSP00000458290 ; ENSG00000101574 .
    GeneIDi 64863.
    KEGGi hsa:64863.
    UCSCi uc002klh.4. human.

    Organism-specific databases

    CTDi 64863.
    GeneCardsi GC18M002527.
    H-InvDB HIX0014297.
    HGNCi HGNC:24726. METTL4.
    HPAi HPA040061.
    neXtProti NX_Q8N3J2.
    PharmGKBi PA134916468.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4725.
    HOGENOMi HOG000113569.
    HOVERGENi HBG078120.
    InParanoidi Q8N3J2.
    OMAi LIVSVPC.
    PhylomeDBi Q8N3J2.
    TreeFami TF314410.

    Miscellaneous databases

    GenomeRNAii 64863.
    NextBioi 67019.
    PROi Q8N3J2.

    Gene expression databases

    ArrayExpressi Q8N3J2.
    Bgeei Q8N3J2.
    CleanExi HS_METTL4.
    Genevestigatori Q8N3J2.

    Family and domain databases

    InterProi IPR002052. DNA_methylase_N6_adenine_CS.
    IPR007757. MT-A70-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF05063. MT-A70. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51143. MT_A70. 1 hit.
    PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS LYS-310 AND LEU-468.
      Tissue: Brain, Lung and Testis.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-472, VARIANT LEU-468.
      Tissue: Lung.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-472, VARIANT LEU-468.
      Tissue: Melanoma.
    6. Cited for: VARIANT PHE-42.

    Entry informationi

    Entry nameiMETL4_HUMAN
    AccessioniPrimary (citable) accession number: Q8N3J2
    Secondary accession number(s): B2RNA1, Q2TAA7, Q9H5U9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 90 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3