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Protein

Protein FAM19A2

Gene

FAM19A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM19A2
Alternative name(s):
Chemokine-like protein TAFA-2
Gene namesi
Name:FAM19A2
Synonyms:TAFA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000198673.10.
HGNCiHGNC:21589. FAM19A2.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi338811.
OpenTargetsiENSG00000198673.
PharmGKBiPA134974674.

Polymorphism and mutation databases

BioMutaiFAM19A2.
DMDMi74714846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004272331 – 131Protein FAM19A2Add BLAST101

Proteomic databases

MaxQBiQ8N3H0.
PaxDbiQ8N3H0.
PeptideAtlasiQ8N3H0.
PRIDEiQ8N3H0.

PTM databases

PhosphoSitePlusiQ8N3H0.

Expressioni

Tissue specificityi

Brain-specific.1 Publication

Gene expression databases

BgeeiENSG00000198673.
CleanExiHS_FAM19A2.
ExpressionAtlasiQ8N3H0. baseline and differential.
GenevisibleiQ8N3H0. HS.

Interactioni

Protein-protein interaction databases

BioGridi130801. 43 interactors.
STRINGi9606.ENSP00000393987.

Structurei

3D structure databases

ProteinModelPortaliQ8N3H0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM19/TAFA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXED. Eukaryota.
ENOG410YKC5. LUCA.
GeneTreeiENSGT00390000001768.
HOGENOMiHOG000236302.
HOVERGENiHBG081496.
InParanoidiQ8N3H0.
OMAiNHRGPTV.
OrthoDBiEOG091G0TKK.
PhylomeDBiQ8N3H0.
TreeFamiTF331749.

Family and domain databases

InterProiView protein in InterPro
IPR020350. Chemokine-like_FAM19A2.
PfamiView protein in Pfam
PF12020. TAFA. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD298472. Chemokine-like_2FAM19A2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3H0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKRYLQKAT KGKLLIIIFI VTLWGKVVSS ANHHKAHHVK TGTCEVVALH
60 70 80 90 100
RCCNKNKIEE RSQTVKCSCF PGQVAGTTRA APSCVDASIV EQKWWCHMQP
110 120 130
CLEGEECKVL PDRKGWSCSS GNKVKTTRVT H
Length:131
Mass (Da):14,620
Last modified:October 1, 2002 - v1
Checksum:i6D7E0DB2E59965E4
GO
Isoform 2 (identifier: Q8N3H0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: No experimental confirmation available.
Show »
Length:34
Mass (Da):3,805
Checksum:i0F19A30E62C3F9D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52C → Y in AAH28403 (PubMed:15489334).Curated1
Sequence conflicti67C → Y in AAH28403 (PubMed:15489334).Curated1
Sequence conflicti129 – 131VTH → ANV in CAH18220 (PubMed:17974005).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0160661 – 97Missing in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY325115 mRNA. Translation: AAP92407.1.
AK123580 mRNA. Translation: BAG53916.1.
AL834160 mRNA. Translation: CAD38865.1.
CR749367 mRNA. Translation: CAH18220.1.
CH471054 Genomic DNA. Translation: EAW97100.1.
BC028403 mRNA. Translation: AAH28403.1.
BC040286 mRNA. Translation: AAH40286.1.
CCDSiCCDS8962.1. [Q8N3H0-1]
RefSeqiNP_848634.1. NM_178539.4. [Q8N3H0-1]
XP_006719433.1. XM_006719370.2. [Q8N3H0-1]
XP_011536574.1. XM_011538272.1. [Q8N3H0-1]
XP_011536576.1. XM_011538274.1. [Q8N3H0-1]
UniGeneiHs.269745.
Hs.602099.
Hs.604626.

Genome annotation databases

EnsembliENST00000416284; ENSP00000393987; ENSG00000198673. [Q8N3H0-1]
ENST00000550003; ENSP00000449457; ENSG00000198673. [Q8N3H0-2]
ENST00000551619; ENSP00000447305; ENSG00000198673. [Q8N3H0-1]
GeneIDi338811.
KEGGihsa:338811.
UCSCiuc001sqw.4. human. [Q8N3H0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiF19A2_HUMAN
AccessioniPrimary (citable) accession number: Q8N3H0
Secondary accession number(s): B3KVV4
, Q4G0R9, Q68DK0, Q6GTX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families