Q8N3F9 (G137C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Integral membrane protein GPR137C

Alternative name(s):
Transmembrane 7 superfamily member 1-like 2 protein

Gene names

Name:	GPR137C
Synonyms:	TM7SF1L2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the GPR137 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Integral membrane protein GPR137C		PRO_0000304803
Regions
	Topological domain	1 – 48	48	Extracellular Potential
	Transmembrane	49 – 69	21	Helical; Potential
	Topological domain	70 – 83	14	Cytoplasmic Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Topological domain	105 – 120	16	Extracellular Potential
	Transmembrane	121 – 141	21	Helical; Potential
	Topological domain	142 – 167	26	Cytoplasmic Potential
	Transmembrane	168 – 188	21	Helical; Potential
	Topological domain	189 – 205	17	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Potential
	Topological domain	227 – 246	20	Cytoplasmic Potential
	Transmembrane	247 – 267	21	Helical; Potential
	Topological domain	268 – 300	33	Extracellular Potential
	Transmembrane	301 – 321	21	Helical; Potential
	Topological domain	322 – 429	108	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	285	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	248	1	V → I. Ref.3 Corresponds to variant rs762063 [ dbSNP | Ensembl ].		VAR_053880
Experimental info
	Sequence conflict	239	1	K → KITGSHSFLWLNSTPLC in CAD39035. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8N3F9 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: DD307DE80AF6B1C8	FASTA	429	47,075
	10 20 30 40 50 60 MRVSVPGPAA AAAPAAGREP STPGGGSGGG GAVAAASGAA VPGSVQLALS VLHALLYAAL 70 80 90 100 110 120 FAFAYLQLWR LLLYRERRLS YQSLCLFLCL LWAALRTTLF SAAFSLSGSL PLLRPPAHLH 130 140 150 160 170 180 FFPHWLLYCF PSCLQFSTLC LLNLYLAEVI CKVRCATELD RHKILLHLGF IMASLLFLVV 190 200 210 220 230 240 NLTCAMLVHG DVPENQLKWT VFVRALINDS LFILCAISLV CYICKITKMS SANVYLESKG 250 260 270 280 290 300 MSLCQTVVVG SVVILLYSSR ACYNLVVVTI SQDTLESPFN YGWDNLSDKA HVEDISGEEY 310 320 330 340 350 360 IVFGMVLFLW EHVPAWSVVL FFRAQRLNQN LAPAGMINSH SYSSRAYFFD NPRRYDSDDD 370 380 390 400 410 420 LPRLGSSREG SLPNSQSLGW YGTMTGCGSS SYTVTPHLNG PMTDTAPLLF TCSNLDLNNH HSLYVTPQN

References

[1]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-148.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 48-429, VARIANT ILE-248. Tissue: Melanoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL157971 Genomic DNA. No translation available. AY255590 mRNA. Translation: AAO85102.1. AL834372 mRNA. Translation: CAD39035.1.
IPI	IPI00855960.
RefSeq	NP_001093122.1. NM_001099652.1.
UniGene	Hs.416214.
3D structure databases
ProteinModelPortal	Q8N3F9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000315106.
Polymorphism databases
DMDM	158563844.
Proteomic databases
PaxDb	Q8N3F9.
PRIDE	Q8N3F9.
Protocols and materials databases
DNASU	283554.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321662; ENSP00000315106; ENSG00000180998.
GeneID	283554.
KEGG	hsa:283554.
UCSC	uc001wzt.4. human.
Organism-specific databases
CTD	283554.
GeneCards	GC14P053020.
H-InvDB	HIX0011659.
HGNC	HGNC:25445. GPR137C.
HPA	HPA030763.
neXtProt	NX_Q8N3F9.
PharmGKB	PA143485483.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG307093.
HOGENOM	HOG000286020.
HOVERGEN	HBG058911.
InParanoid	Q8N3F9.
OMA	LSDKAHV.
OrthoDB	EOG4H9XKT.
Gene expression databases
ArrayExpress	Q8N3F9.
Bgee	Q8N3F9.
CleanEx	HS_GPR137C.
Genevestigator	Q8N3F9.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	283554.
NextBio	94034.

Entry information

Entry name

G137C_HUMAN

Accession

Primary (citable) accession number: Q8N3F9
Secondary accession number(s): Q86SM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	April 3, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.