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Protein

Integral membrane protein GPR137C

Gene

GPR137C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein GPR137C
Alternative name(s):
Transmembrane 7 superfamily member 1-like 2 protein
Gene namesi
Name:GPR137C
Synonyms:TM7SF1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:25445. GPR137C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 83CytoplasmicSequence analysisAdd BLAST14
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 120ExtracellularSequence analysisAdd BLAST16
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 167CytoplasmicSequence analysisAdd BLAST26
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 205ExtracellularSequence analysisAdd BLAST17
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 246CytoplasmicSequence analysisAdd BLAST20
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Topological domaini268 – 300ExtracellularSequence analysisAdd BLAST33
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 429CytoplasmicSequence analysisAdd BLAST108

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180998.
PharmGKBiPA143485483.

Polymorphism and mutation databases

BioMutaiGPR137C.
DMDMi158563844.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003048031 – 429Integral membrane protein GPR137CAdd BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N3F9.
PeptideAtlasiQ8N3F9.
PRIDEiQ8N3F9.

PTM databases

iPTMnetiQ8N3F9.
PhosphoSitePlusiQ8N3F9.

Expressioni

Gene expression databases

BgeeiENSG00000180998.
CleanExiHS_GPR137C.
ExpressionAtlasiQ8N3F9. baseline and differential.
GenevisibleiQ8N3F9. HS.

Organism-specific databases

HPAiHPA030763.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000315106.

Structurei

3D structure databases

ProteinModelPortaliQ8N3F9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPR137 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGBD. Eukaryota.
ENOG410XQNA. LUCA.
GeneTreeiENSGT00390000008320.
HOGENOMiHOG000286020.
HOVERGENiHBG058911.
InParanoidiQ8N3F9.
OMAiCAISLAC.
OrthoDBiEOG091G08XG.
PhylomeDBiQ8N3F9.
TreeFamiTF329003.

Family and domain databases

InterProiIPR029723. GPR137.
[Graphical view]
PANTHERiPTHR15146. PTHR15146. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N3F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVSVPGPAA AAAPAAGREP STPGGGSGGG GAVAAASGAA VPGSVQLALS
60 70 80 90 100
VLHALLYAAL FAFAYLQLWR LLLYRERRLS YQSLCLFLCL LWAALRTTLF
110 120 130 140 150
SAAFSLSGSL PLLRPPAHLH FFPHWLLYCF PSCLQFSTLC LLNLYLAEVI
160 170 180 190 200
CKVRCATELD RHKILLHLGF IMASLLFLVV NLTCAMLVHG DVPENQLKWT
210 220 230 240 250
VFVRALINDS LFILCAISLV CYICKITKMS SANVYLESKG MSLCQTVVVG
260 270 280 290 300
SVVILLYSSR ACYNLVVVTI SQDTLESPFN YGWDNLSDKA HVEDISGEEY
310 320 330 340 350
IVFGMVLFLW EHVPAWSVVL FFRAQRLNQN LAPAGMINSH SYSSRAYFFD
360 370 380 390 400
NPRRYDSDDD LPRLGSSREG SLPNSQSLGW YGTMTGCGSS SYTVTPHLNG
410 420
PMTDTAPLLF TCSNLDLNNH HSLYVTPQN
Length:429
Mass (Da):47,075
Last modified:September 11, 2007 - v2
Checksum:iDD307DE80AF6B1C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239K → KITGSHSFLWLNSTPLC in CAD39035 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053880248V → I.1 PublicationCorresponds to variant rs762063dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157971 Genomic DNA. No translation available.
AY255590 mRNA. Translation: AAO85102.1.
AL834372 mRNA. Translation: CAD39035.1.
CCDSiCCDS45106.1.
RefSeqiNP_001093122.1. NM_001099652.1.
UniGeneiHs.416214.

Genome annotation databases

EnsembliENST00000321662; ENSP00000315106; ENSG00000180998.
GeneIDi283554.
KEGGihsa:283554.
UCSCiuc001wzu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157971 Genomic DNA. No translation available.
AY255590 mRNA. Translation: AAO85102.1.
AL834372 mRNA. Translation: CAD39035.1.
CCDSiCCDS45106.1.
RefSeqiNP_001093122.1. NM_001099652.1.
UniGeneiHs.416214.

3D structure databases

ProteinModelPortaliQ8N3F9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000315106.

PTM databases

iPTMnetiQ8N3F9.
PhosphoSitePlusiQ8N3F9.

Polymorphism and mutation databases

BioMutaiGPR137C.
DMDMi158563844.

Proteomic databases

PaxDbiQ8N3F9.
PeptideAtlasiQ8N3F9.
PRIDEiQ8N3F9.

Protocols and materials databases

DNASUi283554.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321662; ENSP00000315106; ENSG00000180998.
GeneIDi283554.
KEGGihsa:283554.
UCSCiuc001wzu.4. human.

Organism-specific databases

CTDi283554.
GeneCardsiGPR137C.
H-InvDBHIX0011659.
HGNCiHGNC:25445. GPR137C.
HPAiHPA030763.
neXtProtiNX_Q8N3F9.
OpenTargetsiENSG00000180998.
PharmGKBiPA143485483.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGBD. Eukaryota.
ENOG410XQNA. LUCA.
GeneTreeiENSGT00390000008320.
HOGENOMiHOG000286020.
HOVERGENiHBG058911.
InParanoidiQ8N3F9.
OMAiCAISLAC.
OrthoDBiEOG091G08XG.
PhylomeDBiQ8N3F9.
TreeFamiTF329003.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180998-MONOMER.

Miscellaneous databases

GenomeRNAii283554.
PROiQ8N3F9.

Gene expression databases

BgeeiENSG00000180998.
CleanExiHS_GPR137C.
ExpressionAtlasiQ8N3F9. baseline and differential.
GenevisibleiQ8N3F9. HS.

Family and domain databases

InterProiIPR029723. GPR137.
[Graphical view]
PANTHERiPTHR15146. PTHR15146. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG137C_HUMAN
AccessioniPrimary (citable) accession number: Q8N3F9
Secondary accession number(s): Q86SM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.