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Protein

Poly [ADP-ribose] polymerase 8

Gene

PARP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandNAD

Enzyme and pathway databases

ReactomeiR-HSA-197264 Nicotinamide salvaging

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 8 (EC:2.4.2.30)
Short name:
PARP-8
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 16
Short name:
ARTD16
Gene namesi
Name:PARP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000151883.16
HGNCiHGNC:26124 PARP8
neXtProtiNX_Q8N3A8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151883
PharmGKBiPA134903201

Chemistry databases

ChEMBLiCHEMBL3091262

Polymorphism and mutation databases

BioMutaiPARP8
DMDMi74714811

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524331 – 854Poly [ADP-ribose] polymerase 8Add BLAST854

Proteomic databases

EPDiQ8N3A8
MaxQBiQ8N3A8
PaxDbiQ8N3A8
PeptideAtlasiQ8N3A8
PRIDEiQ8N3A8
ProteomicsDBi71784
71785 [Q8N3A8-2]

PTM databases

iPTMnetiQ8N3A8
PhosphoSitePlusiQ8N3A8

Expressioni

Gene expression databases

BgeeiENSG00000151883
CleanExiHS_PARP8
ExpressionAtlasiQ8N3A8 baseline and differential
GenevisibleiQ8N3A8 HS

Organism-specific databases

HPAiHPA049183

Interactioni

Protein-protein interaction databases

BioGridi122793, 1 interactor
IntActiQ8N3A8, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8N3A8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini617 – 844PARP catalyticPROSITE-ProRule annotationAdd BLAST228

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi468 – 473Poly-Ser6

Phylogenomic databases

eggNOGiENOG410IE5T Eukaryota
ENOG410ZI9J LUCA
GeneTreeiENSGT00390000017707
HOGENOMiHOG000115451
HOVERGENiHBG057572
InParanoidiQ8N3A8
KOiK15258
OMAiDPNDPQM
OrthoDBiEOG091G02PT
PhylomeDBiQ8N3A8
TreeFamiTF323413

Family and domain databases

InterProiView protein in InterPro
IPR012317 Poly(ADP-ribose)pol_cat_dom
PfamiView protein in Pfam
PF00644 PARP, 1 hit
PROSITEiView protein in PROSITE
PS51059 PARP_CATALYTIC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3A8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGMCSRQERI QKDIDVVIQK SRAEKDCLFA DFRYSDSTFT FTYVGGPRSV
60 70 80 90 100
SYSVHVSEDY PDNTYVSSSE NDEDVLVTTE PIPVIFHRIA TELRKTNDIN
110 120 130 140 150
CCLSIKSKLQ KENGEESRQN STVEEDSEGD NDSEEFYYGG QVNYDGELHK
160 170 180 190 200
HPQLEADLSA VREIYGPHAV SLREYGAIDD VDIDLHIDVS FLDEEIAVAW
210 220 230 240 250
EVIRTEPIIV RLHCSLTQYL NGPVPTVDVF QISTKERFGL GHQLKKIMQT
260 270 280 290 300
FVTQQWKQSK EKSNCLHNKK LSEKKVKSPL HLFSTLRRSP SYPPPGCGKS
310 320 330 340 350
KSKLKSEQDG ISKTHKLLRR TCSSTVKTDD VCVTKSHRTF GRSLSSDPRA
360 370 380 390 400
EQAMTAIKSH KLLNRPCPAA VKSEECLTLK SHRLLTRSCS GDPRCEHNTN
410 420 430 440 450
LKPHKLLSRS YSSNLRMEEL YGLKNHKLLS KSYSSAPKSS KTELFKEPNA
460 470 480 490 500
EGRRLSLTSG LIGILTPSSS SSSQLAPNGA KCIPVRDRGF LVQTIEFAEQ
510 520 530 540 550
RIPVLNEYCV VCDEPHVFQN GPMLRPTVCE RELCVFAFQT LGVMNEAADE
560 570 580 590 600
IATGAQVVDL LVSMCRSALE SPRKVVIFEP YPSVVDPNDP QMLAFNPRKK
610 620 630 640 650
NYDRVMKALD SITSIREMTQ APYLEIKKQM DKQDPLAHPL LQWVISSNRS
660 670 680 690 700
HIVKLPVNRQ LKFMHTPHQF LLLSSPPAKE SNFRAAKKLF GSTFAFHGSH
710 720 730 740 750
IENWHSILRN GLVVASNTRL QLHGAMYGSG IYLSPMSSIS FGYSGMNKKQ
760 770 780 790 800
KVSAKDEPAS SSKSSNTSQS QKKGQQSQFL QSRNLKCIAL CEVITSSDLH
810 820 830 840 850
KHGEIWVVPN TDHVCTRFFF VYEDGQVGDA NINTQEGGIH KEILRVIGNQ

TATG
Length:854
Mass (Da):95,871
Last modified:October 1, 2002 - v1
Checksum:iD3287F5F46BA2B63
GO
Isoform 2 (identifier: Q8N3A8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-598: Missing.

Note: No experimental confirmation available.
Show »
Length:812
Mass (Da):91,158
Checksum:i968394B0E0897F42
GO

Sequence cautioni

The sequence AAI05790 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti849N → D in BAB15044 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035853777S → A in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020970557 – 598Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834477 mRNA Translation: CAD39136.1
BC075801 mRNA Translation: AAH75801.1
BC105789 mRNA Translation: AAI05790.1 Sequence problems.
AK024961 mRNA Translation: BAB15044.1
CCDSiCCDS3954.1 [Q8N3A8-1]
CCDS54849.1 [Q8N3A8-2]
RefSeqiNP_001171526.1, NM_001178055.1 [Q8N3A8-1]
NP_001171527.1, NM_001178056.1 [Q8N3A8-2]
NP_078891.2, NM_024615.3 [Q8N3A8-1]
XP_011541933.1, XM_011543631.2 [Q8N3A8-1]
XP_011541934.2, XM_011543632.2 [Q8N3A8-2]
UniGeneiHs.369581

Genome annotation databases

EnsembliENST00000281631; ENSP00000281631; ENSG00000151883 [Q8N3A8-1]
ENST00000505697; ENSP00000422217; ENSG00000151883 [Q8N3A8-1]
ENST00000514067; ENSP00000424814; ENSG00000151883 [Q8N3A8-2]
GeneIDi79668
KEGGihsa:79668
UCSCiuc003jon.5 human [Q8N3A8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPARP8_HUMAN
AccessioniPrimary (citable) accession number: Q8N3A8
Secondary accession number(s): Q3KRB7, Q6DHZ1, Q9H754
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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