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Protein

Poly [ADP-ribose] polymerase 8

Gene

PARP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciZFISH:HS14395-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 8 (EC:2.4.2.30)
Short name:
PARP-8
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 16
Short name:
ARTD16
Gene namesi
Name:PARP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:26124. PARP8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151883.
PharmGKBiPA134903201.

Chemistry databases

ChEMBLiCHEMBL3091262.

Polymorphism and mutation databases

BioMutaiPARP8.
DMDMi74714811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524331 – 854Poly [ADP-ribose] polymerase 8Add BLAST854

Proteomic databases

EPDiQ8N3A8.
MaxQBiQ8N3A8.
PaxDbiQ8N3A8.
PeptideAtlasiQ8N3A8.
PRIDEiQ8N3A8.

PTM databases

iPTMnetiQ8N3A8.
PhosphoSitePlusiQ8N3A8.

Expressioni

Gene expression databases

BgeeiENSG00000151883.
CleanExiHS_PARP8.
ExpressionAtlasiQ8N3A8. baseline and differential.
GenevisibleiQ8N3A8. HS.

Organism-specific databases

HPAiHPA049183.

Interactioni

Protein-protein interaction databases

BioGridi122793. 1 interactor.
IntActiQ8N3A8. 2 interactors.
MINTiMINT-4713423.
STRINGi9606.ENSP00000281631.

Structurei

3D structure databases

ProteinModelPortaliQ8N3A8.
SMRiQ8N3A8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini617 – 844PARP catalyticPROSITE-ProRule annotationAdd BLAST228

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi468 – 473Poly-Ser6

Sequence similaritiesi

Contains 1 PARP catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IE5T. Eukaryota.
ENOG410ZI9J. LUCA.
GeneTreeiENSGT00390000017707.
HOGENOMiHOG000115451.
HOVERGENiHBG057572.
InParanoidiQ8N3A8.
KOiK15258.
OMAiPDLHKHG.
OrthoDBiEOG091G02PT.
PhylomeDBiQ8N3A8.
TreeFamiTF323413.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N3A8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGMCSRQERI QKDIDVVIQK SRAEKDCLFA DFRYSDSTFT FTYVGGPRSV
60 70 80 90 100
SYSVHVSEDY PDNTYVSSSE NDEDVLVTTE PIPVIFHRIA TELRKTNDIN
110 120 130 140 150
CCLSIKSKLQ KENGEESRQN STVEEDSEGD NDSEEFYYGG QVNYDGELHK
160 170 180 190 200
HPQLEADLSA VREIYGPHAV SLREYGAIDD VDIDLHIDVS FLDEEIAVAW
210 220 230 240 250
EVIRTEPIIV RLHCSLTQYL NGPVPTVDVF QISTKERFGL GHQLKKIMQT
260 270 280 290 300
FVTQQWKQSK EKSNCLHNKK LSEKKVKSPL HLFSTLRRSP SYPPPGCGKS
310 320 330 340 350
KSKLKSEQDG ISKTHKLLRR TCSSTVKTDD VCVTKSHRTF GRSLSSDPRA
360 370 380 390 400
EQAMTAIKSH KLLNRPCPAA VKSEECLTLK SHRLLTRSCS GDPRCEHNTN
410 420 430 440 450
LKPHKLLSRS YSSNLRMEEL YGLKNHKLLS KSYSSAPKSS KTELFKEPNA
460 470 480 490 500
EGRRLSLTSG LIGILTPSSS SSSQLAPNGA KCIPVRDRGF LVQTIEFAEQ
510 520 530 540 550
RIPVLNEYCV VCDEPHVFQN GPMLRPTVCE RELCVFAFQT LGVMNEAADE
560 570 580 590 600
IATGAQVVDL LVSMCRSALE SPRKVVIFEP YPSVVDPNDP QMLAFNPRKK
610 620 630 640 650
NYDRVMKALD SITSIREMTQ APYLEIKKQM DKQDPLAHPL LQWVISSNRS
660 670 680 690 700
HIVKLPVNRQ LKFMHTPHQF LLLSSPPAKE SNFRAAKKLF GSTFAFHGSH
710 720 730 740 750
IENWHSILRN GLVVASNTRL QLHGAMYGSG IYLSPMSSIS FGYSGMNKKQ
760 770 780 790 800
KVSAKDEPAS SSKSSNTSQS QKKGQQSQFL QSRNLKCIAL CEVITSSDLH
810 820 830 840 850
KHGEIWVVPN TDHVCTRFFF VYEDGQVGDA NINTQEGGIH KEILRVIGNQ

TATG
Length:854
Mass (Da):95,871
Last modified:October 1, 2002 - v1
Checksum:iD3287F5F46BA2B63
GO
Isoform 2 (identifier: Q8N3A8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-598: Missing.

Note: No experimental confirmation available.
Show »
Length:812
Mass (Da):91,158
Checksum:i968394B0E0897F42
GO

Sequence cautioni

The sequence AAI05790 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti849N → D in BAB15044 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035853777S → A in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020970557 – 598Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834477 mRNA. Translation: CAD39136.1.
BC075801 mRNA. Translation: AAH75801.1.
BC105789 mRNA. Translation: AAI05790.1. Sequence problems.
AK024961 mRNA. Translation: BAB15044.1.
CCDSiCCDS3954.1. [Q8N3A8-1]
CCDS54849.1. [Q8N3A8-2]
RefSeqiNP_001171526.1. NM_001178055.1. [Q8N3A8-1]
NP_001171527.1. NM_001178056.1. [Q8N3A8-2]
NP_078891.2. NM_024615.3. [Q8N3A8-1]
XP_011541933.1. XM_011543631.2. [Q8N3A8-1]
XP_011541934.2. XM_011543632.2. [Q8N3A8-2]
UniGeneiHs.369581.

Genome annotation databases

EnsembliENST00000281631; ENSP00000281631; ENSG00000151883. [Q8N3A8-1]
ENST00000505697; ENSP00000422217; ENSG00000151883. [Q8N3A8-1]
ENST00000514067; ENSP00000424814; ENSG00000151883. [Q8N3A8-2]
GeneIDi79668.
KEGGihsa:79668.
UCSCiuc003jon.5. human. [Q8N3A8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834477 mRNA. Translation: CAD39136.1.
BC075801 mRNA. Translation: AAH75801.1.
BC105789 mRNA. Translation: AAI05790.1. Sequence problems.
AK024961 mRNA. Translation: BAB15044.1.
CCDSiCCDS3954.1. [Q8N3A8-1]
CCDS54849.1. [Q8N3A8-2]
RefSeqiNP_001171526.1. NM_001178055.1. [Q8N3A8-1]
NP_001171527.1. NM_001178056.1. [Q8N3A8-2]
NP_078891.2. NM_024615.3. [Q8N3A8-1]
XP_011541933.1. XM_011543631.2. [Q8N3A8-1]
XP_011541934.2. XM_011543632.2. [Q8N3A8-2]
UniGeneiHs.369581.

3D structure databases

ProteinModelPortaliQ8N3A8.
SMRiQ8N3A8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122793. 1 interactor.
IntActiQ8N3A8. 2 interactors.
MINTiMINT-4713423.
STRINGi9606.ENSP00000281631.

Chemistry databases

ChEMBLiCHEMBL3091262.

PTM databases

iPTMnetiQ8N3A8.
PhosphoSitePlusiQ8N3A8.

Polymorphism and mutation databases

BioMutaiPARP8.
DMDMi74714811.

Proteomic databases

EPDiQ8N3A8.
MaxQBiQ8N3A8.
PaxDbiQ8N3A8.
PeptideAtlasiQ8N3A8.
PRIDEiQ8N3A8.

Protocols and materials databases

DNASUi79668.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281631; ENSP00000281631; ENSG00000151883. [Q8N3A8-1]
ENST00000505697; ENSP00000422217; ENSG00000151883. [Q8N3A8-1]
ENST00000514067; ENSP00000424814; ENSG00000151883. [Q8N3A8-2]
GeneIDi79668.
KEGGihsa:79668.
UCSCiuc003jon.5. human. [Q8N3A8-1]

Organism-specific databases

CTDi79668.
GeneCardsiPARP8.
H-InvDBHIX0018354.
HIX0121007.
HIX0160161.
HGNCiHGNC:26124. PARP8.
HPAiHPA049183.
neXtProtiNX_Q8N3A8.
OpenTargetsiENSG00000151883.
PharmGKBiPA134903201.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE5T. Eukaryota.
ENOG410ZI9J. LUCA.
GeneTreeiENSGT00390000017707.
HOGENOMiHOG000115451.
HOVERGENiHBG057572.
InParanoidiQ8N3A8.
KOiK15258.
OMAiPDLHKHG.
OrthoDBiEOG091G02PT.
PhylomeDBiQ8N3A8.
TreeFamiTF323413.

Enzyme and pathway databases

BioCyciZFISH:HS14395-MONOMER.

Miscellaneous databases

ChiTaRSiPARP8. human.
GeneWikiiPARP8.
GenomeRNAii79668.
PROiQ8N3A8.

Gene expression databases

BgeeiENSG00000151883.
CleanExiHS_PARP8.
ExpressionAtlasiQ8N3A8. baseline and differential.
GenevisibleiQ8N3A8. HS.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF00644. PARP. 1 hit.
[Graphical view]
PROSITEiPS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPARP8_HUMAN
AccessioniPrimary (citable) accession number: Q8N3A8
Secondary accession number(s): Q3KRB7, Q6DHZ1, Q9H754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.