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Protein

Zinc finger protein 786

Gene

ZNF786

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri192 – 20918C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri649 – 67022C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri676 – 69823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri704 – 72623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri732 – 75423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 786
Gene namesi
Name:ZNF786
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21806. ZNF786.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410468.

Polymorphism and mutation databases

BioMutaiZNF786.
DMDMi296453058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 782782Zinc finger protein 786PRO_0000293694Add
BLAST

Proteomic databases

EPDiQ8N393.
PaxDbiQ8N393.
PRIDEiQ8N393.

PTM databases

iPTMnetiQ8N393.
PhosphoSiteiQ8N393.

Expressioni

Gene expression databases

BgeeiENSG00000197362.
CleanExiHS_ZNF786.
ExpressionAtlasiQ8N393. baseline and differential.
GenevisibleiQ8N393. HS.

Organism-specific databases

HPAiHPA021518.
HPA053459.

Interactioni

Protein-protein interaction databases

BioGridi126445. 6 interactions.
MINTiMINT-2810215.
STRINGi9606.ENSP00000417470.

Structurei

3D structure databases

ProteinModelPortaliQ8N393.
SMRiQ8N393. Positions 190-759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 8072KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri192 – 20918C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri565 – 58723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri593 – 61523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri649 – 67022C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri676 – 69823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri704 – 72623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri732 – 75423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111009.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N393.
KOiK09228.
OMAiQCKLREH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N393.
TreeFamiTF326846.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N393-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPPRLPLT FEDVAIYFSE QEWQDLEAWQ KELYKHVMRS NYETLVSLDD
60 70 80 90 100
GLPKPELISW IEHGGEPFRK WRESQKSGNI ICSSVDMHFD PGFEEQLFWG
110 120 130 140 150
SQQAMNSGKT KSHFQLDPES QCSFGSFVSF RPDQGITLGS PQRHDARAPP
160 170 180 190 200
PLACGPSEST LKEGIPGPRN LDLPGLWDVP AWESTQHPWP VCGESCWENN
210 220 230 240 250
HLVMHQRGHS KDRTRRAWEK FNKRAETQMP WSSPRVQRHF RCGVCGKSFR
260 270 280 290 300
RKLCLLRHLA AHTGRGPFRN ADGEMCFRHE LTHPSHRLPQ QGEKPAQCTP
310 320 330 340 350
CGKRSLPVDS TQARRCQHSR EGPASWREGR GASSSVHSGQ KPGSRLPQEG
360 370 380 390 400
NSHQEGDTEA LQHGAEGPCS CSECGERSPM SARLASPCRA HTGEKPFQCA
410 420 430 440 450
HCTKRFRLRR LLQVHQHAHG GERPFSCRKC GKGFAKQCKL TEHIRVHSGE
460 470 480 490 500
KPFRCAKCGR NFRQRGQLLR HQRLHTDEKP FQCPECGLSF RLESMLRAHR
510 520 530 540 550
LRHGGERPFS CSECGRGFTH QCKLREHLRV HSGERPFQCL KCDKRFRLKG
560 570 580 590 600
ILKAHQHTHS KERPFSCGEC GKGFTRQSKL TEHLRVHSGE RPFQCPECNR
610 620 630 640 650
SFRLKGQLLS HQRLHTGERP FQCPECDKRY RVKADMKAHQ LLHSGEMPFS
660 670 680 690 700
CECGKGFVKH SKLIEHIRTH TGEKPFQCPK CDKSFRLKAQ LLSHQGLHTG
710 720 730 740 750
ERPFHCPECD KNFRERGHML RHQRIHRPER PFACGDCGKG FIYKSKLAEH
760 770 780
IRVHTKSCPA PNELDIKKRL SQLFAMIEAD WS
Length:782
Mass (Da):89,815
Last modified:May 18, 2010 - v2
Checksum:i9BDB1B88B5759F76
GO
Isoform 2 (identifier: Q8N393-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Note: No experimental confirmation available.
Show »
Length:745
Mass (Da):85,295
Checksum:i8A24C7CC9C94A6E4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti503 – 5031H → Q in CAD39166 (PubMed:17974005).Curated
Sequence conflicti714 – 7141R → W in CAD39166 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3737Missing in isoform 2. 1 PublicationVSP_055971Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297472 mRNA. Translation: BAG59893.1.
AL834510 mRNA. Translation: CAD39166.1.
AACC02000041 Genomic DNA. Translation: EAL24426.1.
AC073422 Genomic DNA. No translation available.
BC128392 mRNA. Translation: AAI28393.1.
CCDSiCCDS47738.1. [Q8N393-1]
RefSeqiNP_689624.2. NM_152411.3. [Q8N393-1]
UniGeneiHs.729572.

Genome annotation databases

EnsembliENST00000491431; ENSP00000417470; ENSG00000197362. [Q8N393-1]
GeneIDi136051.
KEGGihsa:136051.
UCSCiuc003wfh.3. human. [Q8N393-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297472 mRNA. Translation: BAG59893.1.
AL834510 mRNA. Translation: CAD39166.1.
AACC02000041 Genomic DNA. Translation: EAL24426.1.
AC073422 Genomic DNA. No translation available.
BC128392 mRNA. Translation: AAI28393.1.
CCDSiCCDS47738.1. [Q8N393-1]
RefSeqiNP_689624.2. NM_152411.3. [Q8N393-1]
UniGeneiHs.729572.

3D structure databases

ProteinModelPortaliQ8N393.
SMRiQ8N393. Positions 190-759.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126445. 6 interactions.
MINTiMINT-2810215.
STRINGi9606.ENSP00000417470.

PTM databases

iPTMnetiQ8N393.
PhosphoSiteiQ8N393.

Polymorphism and mutation databases

BioMutaiZNF786.
DMDMi296453058.

Proteomic databases

EPDiQ8N393.
PaxDbiQ8N393.
PRIDEiQ8N393.

Protocols and materials databases

DNASUi136051.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000491431; ENSP00000417470; ENSG00000197362. [Q8N393-1]
GeneIDi136051.
KEGGihsa:136051.
UCSCiuc003wfh.3. human. [Q8N393-1]

Organism-specific databases

CTDi136051.
GeneCardsiZNF786.
HGNCiHGNC:21806. ZNF786.
HPAiHPA021518.
HPA053459.
neXtProtiNX_Q8N393.
PharmGKBiPA162410468.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000111009.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N393.
KOiK09228.
OMAiQCKLREH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8N393.
TreeFamiTF326846.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF786. human.
GenomeRNAii136051.
PROiQ8N393.

Gene expression databases

BgeeiENSG00000197362.
CleanExiHS_ZNF786.
ExpressionAtlasiQ8N393. baseline and differential.
GenevisibleiQ8N393. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN786_HUMAN
AccessioniPrimary (citable) accession number: Q8N393
Secondary accession number(s): A1A568, B4DMI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.