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Protein

Mucin-15

Gene

MUC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the cell adhesion to the extracellular matrix.

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-15
Short name:
MUC-15
Gene namesi
Name:MUC15
ORF Names:UNQ750/PRO1481
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14956. MUC15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 236213ExtracellularSequence analysisAdd
BLAST
Transmembranei237 – 25721HelicalSequence analysisAdd
BLAST
Topological domaini258 – 33477CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31313.

Polymorphism and mutation databases

BioMutaiMUC15.
DMDMi84028223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 334311Mucin-15PRO_0000019288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence analysis
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Highly glycosylated (N- and O-linked carbohydrates).By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N387.
PeptideAtlasiQ8N387.
PRIDEiQ8N387.

PTM databases

iPTMnetiQ8N387.
PhosphoSiteiQ8N387.

Expressioni

Tissue specificityi

Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, bone marrow, lymph node and lung.1 Publication

Gene expression databases

BgeeiENSG00000169550.
CleanExiHS_MUC15.
ExpressionAtlasiQ8N387. baseline and differential.
GenevisibleiQ8N387. HS.

Organism-specific databases

HPAiHPA026110.

Interactioni

Protein-protein interaction databases

BioGridi126813. 2 interactions.
STRINGi9606.ENSP00000416753.

Structurei

3D structure databases

ProteinModelPortaliQ8N387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IM00. Eukaryota.
ENOG41113G6. LUCA.
GeneTreeiENSGT00390000001698.
HOGENOMiHOG000231474.
HOVERGENiHBG052533.
InParanoidiQ8N387.
PhylomeDBiQ8N387.

Family and domain databases

InterProiIPR031371. Mucin-15.
[Graphical view]
PfamiPF15672. Mucin15. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N387-1) [UniParc]FASTAAdd to basket
Also known as: MUC15

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLALAKILLI STLFYSLLSG SHGKENQDIN TTQNIAEVFK TMENKPISLE
60 70 80 90 100
SEANLNSDKE NITTSNLKAS HSPPLNLPNN SHGITDFSSN SSAEHSLGSL
110 120 130 140 150
KPTSTISTSP PLIHSFVSKV PWNAPIADED LLPISAHPNA TPALSSENFT
160 170 180 190 200
WSLVNDTVKT PDNSSITVSI LSSEPTSPSV TPLIVEPSGW LTTNSDSFTG
210 220 230 240 250
FTPYQEKTTL QPTLKFTNNS KLFPNTSDPQ KENRNTGIVF GAILGAILGV
260 270 280 290 300
SLLTLVGYLL CGKRKTDSFS HRRLYDDRNE PVLRLDNAPE PYDVSFGNSS
310 320 330
YYNPTLNDSA MPESEENARD GIPMDDIPPL RTSV
Length:334
Mass (Da):36,294
Last modified:December 20, 2005 - v2
Checksum:i3CA38EEB40D533F1
GO
Isoform 2 (identifier: Q8N387-2) [UniParc]FASTAAdd to basket
Also known as: MUC15/S

The sequence of this isoform differs from the canonical sequence as follows:
     232-281: Missing.

Show »
Length:284
Mass (Da):30,762
Checksum:i1E906E2C2F7E45E5
GO

Sequence cautioni

The sequence AAH20912 differs from that shown. Reason: Erroneous termination at position 335. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431A → T in CAD45555 (PubMed:12047385).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191S → W.
Corresponds to variant rs293979 [ dbSNP | Ensembl ].
VAR_050452
Natural varianti184 – 1841I → T.
Corresponds to variant rs2292290 [ dbSNP | Ensembl ].
VAR_019376
Natural varianti202 – 2021T → I.2 Publications
Corresponds to variant rs15783 [ dbSNP | Ensembl ].
VAR_019377

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei232 – 28150Missing in isoform 2. 1 PublicationVSP_010825Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417818 mRNA. Translation: CAD10624.1.
AJ507429 mRNA. Translation: CAD45555.1.
AY358668 mRNA. Translation: AAQ89031.1.
AK128337 mRNA. Translation: BAG54662.1.
AC036114 Genomic DNA. No translation available.
BC020912 mRNA. Translation: AAH20912.2. Sequence problems.
BC058007 mRNA. Translation: AAH58007.1.
CCDSiCCDS7859.1. [Q8N387-1]
RefSeqiNP_001128563.1. NM_001135091.1.
NP_001128564.1. NM_001135092.1.
NP_663625.2. NM_145650.3. [Q8N387-1]
UniGeneiHs.407152.

Genome annotation databases

EnsembliENST00000455601; ENSP00000397339; ENSG00000169550. [Q8N387-1]
GeneIDi143662.
KEGGihsa:143662.
UCSCiuc001mqx.4. human. [Q8N387-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Mucin database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417818 mRNA. Translation: CAD10624.1.
AJ507429 mRNA. Translation: CAD45555.1.
AY358668 mRNA. Translation: AAQ89031.1.
AK128337 mRNA. Translation: BAG54662.1.
AC036114 Genomic DNA. No translation available.
BC020912 mRNA. Translation: AAH20912.2. Sequence problems.
BC058007 mRNA. Translation: AAH58007.1.
CCDSiCCDS7859.1. [Q8N387-1]
RefSeqiNP_001128563.1. NM_001135091.1.
NP_001128564.1. NM_001135092.1.
NP_663625.2. NM_145650.3. [Q8N387-1]
UniGeneiHs.407152.

3D structure databases

ProteinModelPortaliQ8N387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126813. 2 interactions.
STRINGi9606.ENSP00000416753.

PTM databases

iPTMnetiQ8N387.
PhosphoSiteiQ8N387.

Polymorphism and mutation databases

BioMutaiMUC15.
DMDMi84028223.

Proteomic databases

PaxDbiQ8N387.
PeptideAtlasiQ8N387.
PRIDEiQ8N387.

Protocols and materials databases

DNASUi143662.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000455601; ENSP00000397339; ENSG00000169550. [Q8N387-1]
GeneIDi143662.
KEGGihsa:143662.
UCSCiuc001mqx.4. human. [Q8N387-1]

Organism-specific databases

CTDi143662.
GeneCardsiMUC15.
HGNCiHGNC:14956. MUC15.
HPAiHPA026110.
MIMi608566. gene.
neXtProtiNX_Q8N387.
PharmGKBiPA31313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IM00. Eukaryota.
ENOG41113G6. LUCA.
GeneTreeiENSGT00390000001698.
HOGENOMiHOG000231474.
HOVERGENiHBG052533.
InParanoidiQ8N387.
PhylomeDBiQ8N387.

Enzyme and pathway databases

ReactomeiR-HSA-5083625. Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
R-HSA-5083632. Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
R-HSA-5083636. Defective GALNT12 causes colorectal cancer 1 (CRCS1).
R-HSA-913709. O-linked glycosylation of mucins.
R-HSA-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

GenomeRNAii143662.
PROiQ8N387.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169550.
CleanExiHS_MUC15.
ExpressionAtlasiQ8N387. baseline and differential.
GenevisibleiQ8N387. HS.

Family and domain databases

InterProiIPR031371. Mucin-15.
[Graphical view]
PfamiPF15672. Mucin15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUC15_HUMAN
AccessioniPrimary (citable) accession number: Q8N387
Secondary accession number(s): B3KY00
, E9PII6, F8W945, Q6UWS3, Q8IXI8, Q8WW41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.