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Protein

Leucine-rich repeat-containing protein 25

Gene

LRRC25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the activation of cells of innate and acquired immunity.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 25
Alternative name(s):
Monocyte and plasmacytoid-activated protein
Gene namesi
Name:LRRC25
Synonyms:MAPA
ORF Names:UNQ6169/PRO20174
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29806. LRRC25.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 165145ExtracellularSequence analysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST
Topological domaini187 – 305119CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134957834.

Polymorphism and mutation databases

BioMutaiLRRC25.
DMDMi47605902.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 305285Leucine-rich repeat-containing protein 25PRO_0000021613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence analysis
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence analysis
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence analysis
Modified residuei284 – 2841PhosphotyrosineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8N386.
PeptideAtlasiQ8N386.
PRIDEiQ8N386.

PTM databases

PhosphoSiteiQ8N386.
SwissPalmiQ8N386.

Expressioni

Tissue specificityi

Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus.1 Publication

Inductioni

Down-regulated in CD40-activated monocyte-derived dendritic cells.1 Publication

Gene expression databases

BgeeiQ8N386.
CleanExiHS_LRRC25.
GenevisibleiQ8N386. HS.

Organism-specific databases

HPAiHPA029459.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACDQ96AP02EBI-11304917,EBI-717666

Protein-protein interaction databases

BioGridi125983. 1 interaction.
IntActiQ8N386. 1 interaction.
STRINGi9606.ENSP00000340983.

Structurei

3D structure databases

ProteinModelPortaliQ8N386.
SMRiQ8N386. Positions 39-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati39 – 5921LRR 1Add
BLAST
Repeati62 – 8322LRR 2Add
BLAST
Repeati86 – 10722LRR 3Add
BLAST

Sequence similaritiesi

Contains 3 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J965. Eukaryota.
ENOG4111DR8. LUCA.
GeneTreeiENSGT00390000004001.
HOGENOMiHOG000237361.
HOVERGENiHBG052347.
InParanoidiQ8N386.
OMAiRRDNCSG.
OrthoDBiEOG7DJSMQ.
PhylomeDBiQ8N386.
TreeFamiTF337414.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N386-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGTLAWTLL LPLLLRESDS LEPSCTVSSA DVDWNAEFSA TCLNFSGLSL
60 70 80 90 100
SLPHNQSLRA SNVILLDLSG NGLRELPVTF FAHLQKLEVL NVLRNPLSRV
110 120 130 140 150
DGALAARCDL DLQADCNCAL ESWHDIRRDN CSGQKPLLCW DTTSSQHNLS
160 170 180 190 200
AFLEVSCAPG LASATIGAVV VSGCLLLGLA IAGPVLAWRL WRCRVARSRE
210 220 230 240 250
LNKPWAAQDG PKPGLGLQPR YGSRSAPKPQ VAVPSCPSTP DYENMFVGQP
260 270 280 290 300
AAEHQWDEQG AHPSEDNDFY INYKDIDLAS QPVYCNLQSL GQAPMDEEEY

VIPGH
Length:305
Mass (Da):33,179
Last modified:May 24, 2004 - v2
Checksum:iA2851B3B8F160294
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401A → V in BAC04548 (PubMed:14702039).Curated
Sequence conflicti82 – 821A → G in CAD19531 (PubMed:12384430).Curated
Sequence conflicti95 – 951N → S in BAC04548 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti234 – 2341P → T.
Corresponds to variant rs34439430 [ dbSNP | Ensembl ].
VAR_061677
Natural varianti294 – 2941P → S.2 Publications
Corresponds to variant rs6512265 [ dbSNP | Ensembl ].
VAR_051109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ422148 mRNA. Translation: CAD19531.1.
AY358151 mRNA. Translation: AAQ88518.1.
AK095435 mRNA. Translation: BAC04548.1.
BC071640 mRNA. Translation: AAH71640.1.
BC093842 mRNA. Translation: AAH93842.1.
CCDSiCCDS12377.1.
RefSeqiNP_660299.2. NM_145256.2.
XP_005259796.1. XM_005259739.2.
UniGeneiHs.332156.

Genome annotation databases

EnsembliENST00000339007; ENSP00000340983; ENSG00000175489.
ENST00000595840; ENSP00000472290; ENSG00000175489.
GeneIDi126364.
KEGGihsa:126364.
UCSCiuc002niw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ422148 mRNA. Translation: CAD19531.1.
AY358151 mRNA. Translation: AAQ88518.1.
AK095435 mRNA. Translation: BAC04548.1.
BC071640 mRNA. Translation: AAH71640.1.
BC093842 mRNA. Translation: AAH93842.1.
CCDSiCCDS12377.1.
RefSeqiNP_660299.2. NM_145256.2.
XP_005259796.1. XM_005259739.2.
UniGeneiHs.332156.

3D structure databases

ProteinModelPortaliQ8N386.
SMRiQ8N386. Positions 39-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125983. 1 interaction.
IntActiQ8N386. 1 interaction.
STRINGi9606.ENSP00000340983.

PTM databases

PhosphoSiteiQ8N386.
SwissPalmiQ8N386.

Polymorphism and mutation databases

BioMutaiLRRC25.
DMDMi47605902.

Proteomic databases

PaxDbiQ8N386.
PeptideAtlasiQ8N386.
PRIDEiQ8N386.

Protocols and materials databases

DNASUi126364.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339007; ENSP00000340983; ENSG00000175489.
ENST00000595840; ENSP00000472290; ENSG00000175489.
GeneIDi126364.
KEGGihsa:126364.
UCSCiuc002niw.4. human.

Organism-specific databases

CTDi126364.
GeneCardsiLRRC25.
HGNCiHGNC:29806. LRRC25.
HPAiHPA029459.
MIMi607518. gene.
neXtProtiNX_Q8N386.
PharmGKBiPA134957834.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J965. Eukaryota.
ENOG4111DR8. LUCA.
GeneTreeiENSGT00390000004001.
HOGENOMiHOG000237361.
HOVERGENiHBG052347.
InParanoidiQ8N386.
OMAiRRDNCSG.
OrthoDBiEOG7DJSMQ.
PhylomeDBiQ8N386.
TreeFamiTF337414.

Miscellaneous databases

ChiTaRSiLRRC25. human.
GenomeRNAii126364.
PROiQ8N386.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N386.
CleanExiHS_LRRC25.
GenevisibleiQ8N386. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Subtractive hybridization reveals the expression of immunoglobulin like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells."
    Rissoan M.-C., Duhen T., Bridon J.-M., Bendriss-Vermare N., Peronne C., de Saint-Vis B.M., Briere F., Bates E.E.M.
    Blood 100:3295-3303(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, VARIANT SER-294.
    Tissue: Plasmacytoid dendritic cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-294.
    Tissue: Blood, Heart and Lung.

Entry informationi

Entry nameiLRC25_HUMAN
AccessioniPrimary (citable) accession number: Q8N386
Secondary accession number(s): Q6IQ00, Q8N9A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 6, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.