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Protein
Submitted name:

Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)

Gene

PIK3R3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, Transferase

Enzyme and pathway databases

SignaLinkiQ8N381.

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)Imported
Gene namesi
Name:PIK3R3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33314.

PTM / Processingi

Proteomic databases

PaxDbiQ8N381.
PeptideAtlasiQ8N381.
PRIDEiQ8N381.

Expressioni

Gene expression databases

GenevisibleiQ8N381. HS.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ8N381. 5 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8N381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 160SH2InterPro annotationAdd BLAST96
Domaini358 – 452SH2InterPro annotationAdd BLAST95

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili181 – 208Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4637. Eukaryota.
ENOG410XP6R. LUCA.
HOVERGENiHBG082100.
KOiK02649.

Family and domain databases

CDDicd09930. SH2_cSH2_p85_like. 1 hit.
cd09942. SH2_nSH2_p85_like. 1 hit.
Gene3Di3.30.505.10. 2 hits.
InterProiView protein in InterPro
IPR032498. PI3K_P85_iSH2.
IPR035020. PI3kinase_P85_cSH2.
IPR035022. PI3kinase_P85_nSH2.
IPR001720. PI3kinase_P85_p55.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiView protein in Pfam
PF16454. PI3K_P85_iSH2. 1 hit.
PF00017. SH2. 2 hits.
PRINTSiPR00401. SH2DOMAIN.
SMARTiView protein in SMART
SM00252. SH2. 2 hits.
SUPFAMiSSF55550. SSF55550. 2 hits.
PROSITEiView protein in PROSITE
PS50001. SH2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8N381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVP
60 70 80 90 100
NGMKDSSVSL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY
110 120 130 140 150
TLTLRKGGNN KLIKIYHRDG KYGFSDPLTF NSVVELINHY HHESLAQYNP
160 170 180 190 200
KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK LQEYHSQYQE KSKEYDRLYE
210 220 230 240 250
EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY IERFRREGNE
260 270 280 290 300
KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKNQALDNRE IDKKMNSIKP
310 320 330 340 350
DLIQLRKIRD QHLVWLNHKG VRQKRLNVWL GIKNEDAAEN YFINEEDENL
360 370 380 390 400
PHYDEKTWFV EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE
410 420 430 440 450
VKHCVIYSTA RGYGFAEPYN LYSSLKELVL HYQQTSLVQH NDSLNVRLAY
460
PVHAQMPSLC R
Length:461
Mass (Da):54,404
Last modified:October 1, 2002 - v1
Checksum:i303CBC2DEEEB5364
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021622 mRNA. Translation: AAH21622.1.
RefSeqiNP_001107644.1. NM_001114172.1.
NP_001290358.1. NM_001303429.1.
NP_003620.3. NM_003629.3.
UniGeneiHs.655387.

Genome annotation databases

GeneIDi8503.
KEGGihsa:8503.

Similar proteinsi

Entry informationi

Entry nameiQ8N381_HUMAN
AccessioniPrimary (citable) accession number: Q8N381
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.