Q8N381 (Q8N381_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma) EMBL AAH21622.1

Gene names

Name:

PIK3R3 EMBL AAH21622.1

Organism

Homo sapiens (Human) EMBL AAH21622.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	461 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Kinase EMBL AAH21622.1 Transferase
Gene Ontology (GO)
Biological_process	regulation of phosphatidylinositol 3-kinase activity Inferred from electronic annotation. Source: GOC
Cellular_component	phosphatidylinositol 3-kinase complex Inferred from electronic annotation. Source: InterPro
Molecular_function	kinase activity Inferred from electronic annotation. Source: UniProtKB-KW phosphatidylinositol 3-kinase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8N381 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 303CBC2DEEEB5364	FASTA	461	54,404
	10 20 30 40 50 60 MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVP NGMKDSSVSL 70 80 90 100 110 120 QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY TLTLRKGGNN KLIKIYHRDG 130 140 150 160 170 180 KYGFSDPLTF NSVVELINHY HHESLAQYNP KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK 190 200 210 220 230 240 LQEYHSQYQE KSKEYDRLYE EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY 250 260 270 280 290 300 IERFRREGNE KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKNQALDNRE IDKKMNSIKP 310 320 330 340 350 360 DLIQLRKIRD QHLVWLNHKG VRQKRLNVWL GIKNEDAAEN YFINEEDENL PHYDEKTWFV 370 380 390 400 410 420 EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE VKHCVIYSTA RGYGFAEPYN 430 440 450 460 LYSSLKELVL HYQQTSLVQH NDSLNVRLAY PVHAQMPSLC R

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus EMBL AAH21622.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC021622 mRNA. Translation: AAH21622.1.
IPI	IPI00513745.
RefSeq	NP_001107644.1. NM_001114172.1. NP_003620.3. NM_003629.3.
UniGene	Hs.655387.
3D structure databases
HSSP	HSSP built from PDB template 2PNB based on UniProtKB P23727.
ProteinModelPortal	Q8N381.
SMR	Q8N381. Positions 57-331, 348-455.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N381. 2 interactions.
Protocols and materials databases
DNASU	8503.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8503.
KEGG	hsa:8503.
Organism-specific databases
CTD	8503.
PharmGKB	PA33314.
Phylogenomic databases
HOVERGEN	HBG082100.
KO	K02649.
Family and domain databases
Gene3D	3.30.505.10. 2 hits.
InterPro	IPR001720. PI3kinase_P85. IPR000980. SH2. [Graphical view]
PANTHER	PTHR10155. PTHR10155. 1 hit.
Pfam	PF00017. SH2. 2 hits. [Graphical view]
PRINTS	PR00678. PI3KINASEP85. PR00401. SH2DOMAIN.
SMART	SM00252. SH2. 2 hits. [Graphical view]
PROSITE	PS50001. SH2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	8503.
NextBio	31821.

Entry information

Entry name

Q8N381_HUMAN

Accession

Primary (citable) accession number: Q8N381

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.