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Q8N381

- Q8N381_HUMAN

UniProt

Q8N381 - Q8N381_HUMAN

Protein
Submitted name:

Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)

Gene

PIK3R3

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. kinase activity Source: UniProtKB-KW
    2. phosphatidylinositol 3-kinase regulator activity Source: InterPro

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Enzyme and pathway databases

    SignaLinkiQ8N381.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Phosphoinositide-3-kinase, regulatory subunit 3 (Gamma)Imported
    Gene namesi
    Name:PIK3R3Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. phosphatidylinositol 3-kinase complex Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33314.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8N381. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N381.
    SMRiQ8N381. Positions 57-331, 348-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG082100.
    KOiK02649.

    Family and domain databases

    Gene3Di3.30.505.10. 2 hits.
    InterProiIPR001720. PI3kinase_P85.
    IPR000980. SH2.
    [Graphical view]
    PANTHERiPTHR10155. PTHR10155. 1 hit.
    PfamiPF00017. SH2. 2 hits.
    [Graphical view]
    PRINTSiPR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTiSM00252. SH2. 2 hits.
    [Graphical view]
    SUPFAMiSSF55550. SSF55550. 2 hits.
    PROSITEiPS50001. SH2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N381-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVP    50
    NGMKDSSVSL QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY 100
    TLTLRKGGNN KLIKIYHRDG KYGFSDPLTF NSVVELINHY HHESLAQYNP 150
    KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK LQEYHSQYQE KSKEYDRLYE 200
    EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY IERFRREGNE 250
    KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKNQALDNRE IDKKMNSIKP 300
    DLIQLRKIRD QHLVWLNHKG VRQKRLNVWL GIKNEDAAEN YFINEEDENL 350
    PHYDEKTWFV EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE 400
    VKHCVIYSTA RGYGFAEPYN LYSSLKELVL HYQQTSLVQH NDSLNVRLAY 450
    PVHAQMPSLC R 461
    Length:461
    Mass (Da):54,404
    Last modified:October 1, 2002 - v1
    Checksum:i303CBC2DEEEB5364
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC021622 mRNA. Translation: AAH21622.1.
    RefSeqiNP_001107644.1. NM_001114172.1.
    NP_003620.3. NM_003629.3.
    UniGeneiHs.655387.

    Genome annotation databases

    GeneIDi8503.
    KEGGihsa:8503.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC021622 mRNA. Translation: AAH21622.1 .
    RefSeqi NP_001107644.1. NM_001114172.1.
    NP_003620.3. NM_003629.3.
    UniGenei Hs.655387.

    3D structure databases

    ProteinModelPortali Q8N381.
    SMRi Q8N381. Positions 57-331, 348-455.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8N381. 2 interactions.

    Protocols and materials databases

    DNASUi 8503.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8503.
    KEGGi hsa:8503.

    Organism-specific databases

    CTDi 8503.
    PharmGKBi PA33314.

    Phylogenomic databases

    HOVERGENi HBG082100.
    KOi K02649.

    Enzyme and pathway databases

    SignaLinki Q8N381.

    Miscellaneous databases

    GenomeRNAii 8503.
    NextBioi 31821.

    Family and domain databases

    Gene3Di 3.30.505.10. 2 hits.
    InterProi IPR001720. PI3kinase_P85.
    IPR000980. SH2.
    [Graphical view ]
    PANTHERi PTHR10155. PTHR10155. 1 hit.
    Pfami PF00017. SH2. 2 hits.
    [Graphical view ]
    PRINTSi PR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTi SM00252. SH2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55550. SSF55550. 2 hits.
    PROSITEi PS50001. SH2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: UterusImported.

    Entry informationi

    Entry nameiQ8N381_HUMAN
    AccessioniPrimary (citable) accession number: Q8N381
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.