ID   JMJD5_HUMAN             Reviewed;         416 AA.
AC   Q8N371; Q6VAK5; Q9H8B1;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   09-FEB-2010, entry version 48.
DE   RecName: Full=JmjC domain-containing protein 5;
DE   AltName: Full=Jumonji domain-containing protein 5;
GN   Name=JMJD5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Thyroid;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA   Li H., Yu R., Zheng G., Zhou G., Ke R., Shen C., Zhong G., Lin L.,
RA   Yang S.;
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N371-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N371-2; Sequence=VSP_026370;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Contains 1 JmjC domain.
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DR   EMBL; AK023860; BAB14706.1; -; mRNA.
DR   EMBL; AY345239; AAQ23080.1; -; mRNA.
DR   EMBL; BC027911; AAH27911.1; -; mRNA.
DR   IPI; IPI00296340; -.
DR   IPI; IPI00435577; -.
DR   RefSeq; NP_001138820.1; -.
DR   RefSeq; NP_079049.2; -.
DR   UniGene; Hs.145717; -.
DR   HSSP; Q9NWT6; 1MZF.
DR   SMR; Q8N371; 182-416.
DR   IntAct; Q8N371; 1.
DR   STRING; Q8N371; -.
DR   PRIDE; Q8N371; -.
DR   Ensembl; ENST00000286096; ENSP00000286096; ENSG00000155666; Homo sapiens.
DR   Ensembl; ENST00000441782; ENSP00000398410; ENSG00000155666; Homo sapiens.
DR   GeneID; 79831; -.
DR   KEGG; hsa:79831; -.
DR   UCSC; uc002doh.1; human.
DR   UCSC; uc010bxw.1; human.
DR   CTD; 79831; -.
DR   GeneCards; GC16P027123; -.
DR   HGNC; HGNC:25840; JMJD5.
DR   HPA; HPA026545; -.
DR   eggNOG; prNOG05246; -.
DR   HOVERGEN; Q8N371; -.
DR   InParanoid; Q8N371; -.
DR   OrthoDB; EOG9TB6X1; -.
DR   PhylomeDB; Q8N371; -.
DR   NextBio; 69473; -.
DR   ArrayExpress; Q8N371; -.
DR   Bgee; Q8N371; -.
DR   CleanEx; HS_JMJD5; -.
DR   Genevestigator; Q8N371; -.
DR   InterPro; IPR003347; TF_JmjC_AAH.
DR   SMART; SM00558; JmjC; 1.
DR   PROSITE; PS51184; JMJC; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Polymorphism.
FT   CHAIN         1    416       JmjC domain-containing protein 5.
FT                                /FTId=PRO_0000292010.
FT   DOMAIN      271    416       JmjC.
FT   VAR_SEQ     167    362       Missing (in isoform 2).
FT                                /FTId=VSP_026370.
FT   VARIANT     302    302       E -> D (in dbSNP:rs34445573).
FT                                /FTId=VAR_032928.
FT   CONFLICT     73     73       D -> G (in Ref. 1; BAB14706).
SQ   SEQUENCE   416 AA;  47270 MW;  18CE6D01E00ED5A4 CRC64;
     MAGDTHCPAE PLAREGTLWE ALRALLPHSK EDLKLDLGEK VERSVVTLLQ RATELFYEGR
     RDECLQSSEV ILDYSWEKLN TGTWQDVDKD WRRVYAIGCL LKALCLCQAP EDANTVAAAL
     RVCDMGLLMG AAILGDILLK VAAILQTHLP GKRPARGSLP EQPCTKKARA DHGLIPDVKL
     EKTVPRLHRP SLQHFREQFL VPGRPVILKG VADHWPCMQK WSLEYIQEIA GCRTVPVEVG
     SRYTDEEWSQ TLMTVNEFIS KYIVNEPRDV GYLAQHQLFD QIPELKQDIS IPDYCSLGDG
     EEEEITINAW FGPQGTISPL HQDPQQNFLV QVMGRKYIRL YSPQESGALY PHDTHLLHNT
     SQVDVENPDL EKFPKFAKAP FLSCILSPGE ILFIPVKYWH YVRALDLSFS VSFWWS
//