Reviewed,
UniProtKB/Swiss-Prot Q8N371 (JMJD5_HUMAN)
Last modified
November 3, 2009.
Version 44.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: JmjC domain-containing protein 5 Alternative name(s): Jumonji domain-containing protein 5 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 416 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8N371-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8N371-2) The sequence of this isoform differs from the canonical sequence as follows: 167-362: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 416 | 416 | JmjC domain-containing protein 5 | PRO_0000292010 | |||||
Regions | |||||||||
| Domain | 271 – 416 | 146 | JmjC | ||||||
Natural variations | |||||||||
| Alternative sequence | 167 – 362 | 196 | Missing in isoform 2. | VSP_026370 | |||||
| Natural variant | 302 | 1 | E → D: dbSNP rs34445573. | VAR_032928 | |||||
Experimental info | |||||||||
| Sequence conflict | 73 | 1 | D → G in BAB14706. Ref.1 | ||||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.  Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Thyroid. |
| [2] | Li H., Yu R., Zheng G., Zhou G., Ke R., Shen C., Zhong G., Lin L., Yang S. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AK023860 mRNA. Translation: BAB14706.1. AY345239 mRNA. Translation: AAQ23080.1. BC027911 mRNA. Translation: AAH27911.1. | |
| IPI | IPI00296340. IPI00435577. |
| RefSeq | NP_001138820.1. NP_079049.2. |
| UniGene | Hs.145717 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q8N371. 1 interaction. |
| STRING | Q8N371. |
Proteomic databases | |
| PRIDE | Q8N371. |
Genome annotation databases | |
| Ensembl | ENST00000286096; ENSP00000286096; ENSG00000155666; Homo sapiens. [Genome view] ENST00000380948; ENSP00000370335; ENSG00000155666; Homo sapiens. [Genome view] ENST00000441782; ENSP00000398410; ENSG00000155666; Homo sapiens. [Genome view] |
| GeneID | 79831. |
| KEGG | hsa:79831. |
| UCSC | uc002doh.1. human. uc010bxw.1. human. |
Organism-specific databases | |
| CTD | 79831. |
| GeneCards | GC16P027123. |
| HGNC | HGNC:25840. JMJD5. |
| HPA | HPA026545. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q8N371. |
| HOVERGEN | Q8N371. |
| OMA | KHWHYVR. |
Gene expression databases | |
| ArrayExpress | Q8N371. |
| Bgee | Q8N371. |
| CleanEx | HS_JMJD5. |
| Genevestigator | Q8N371. |
Family and domain databases | |
| InterPro | IPR003347. TF_JmjC_AAH. [Graphical view] |
| SMART | SM00558. JmjC. 1 hit. [Graphical view] |
| PROSITE | PS51184. JMJC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 69473. |
Entry information
| Entry name | JMJD5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N371 Secondary accession number(s): Q6VAK5, Q9H8B1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 16 Human chromosome 16: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |
