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Protein

Circadian-associated transcriptional repressor

Gene

CIART

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity).By similarity

GO - Molecular functioni

  • core promoter sequence-specific DNA binding Source: UniProtKB
  • E-box binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159208-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Circadian-associated transcriptional repressor
Alternative name(s):
ChIP-derived repressor of network oscillator
Short name:
Chrono
Computationally highlighted repressor of the network oscillator
Gene namesi
Name:CIART
Synonyms:C1orf51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25200. CIART.

Subcellular locationi

  • Nucleus By similarity
  • NucleusPML body By similarity

  • Note: Co-localizes with the CLOCK-ARNTL/BMAL1 heterodimer in the PML body.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159208.
PharmGKBiPA134921053.

Polymorphism and mutation databases

BioMutaiC1orf51.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002511931 – 385Circadian-associated transcriptional repressorAdd BLAST385

Proteomic databases

PaxDbiQ8N365.
PRIDEiQ8N365.

PTM databases

iPTMnetiQ8N365.
PhosphoSitePlusiQ8N365.

Expressioni

Gene expression databases

BgeeiENSG00000159208.
CleanExiHS_C1orf51.
ExpressionAtlasiQ8N365. baseline and differential.
GenevisibleiQ8N365. HS.

Organism-specific databases

HPAiHPA027515.
HPA054349.

Interactioni

Subunit structurei

Interacts with PER2, CRY2, BHLHE41, HDAC1 and NR3C1 (By similarity). Interacts with ARNTL/BMAL1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DAB1O755533EBI-10265133,EBI-7875264

Protein-protein interaction databases

BioGridi127153. 6 interactors.
DIPiDIP-60822N.
IntActiQ8N365. 1 interactor.
STRINGi9606.ENSP00000290363.

Structurei

3D structure databases

ProteinModelPortaliQ8N365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 34Ser-richAdd BLAST32

Phylogenomic databases

eggNOGiENOG410IICF. Eukaryota.
ENOG410YK16. LUCA.
GeneTreeiENSGT00390000018360.
HOGENOMiHOG000236332.
HOVERGENiHBG058566.
InParanoidiQ8N365.
OMAiNSDFGFP.
OrthoDBiEOG091G088K.
PhylomeDBiQ8N365.
TreeFamiTF332541.

Family and domain databases

InterProiIPR031373. Ciart.
[Graphical view]
PfamiPF15673. Ciart. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N365-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSPSSVSSY SSYSLSSSFP TSPVNSDFGF PSDSEREDKG AHGPRPDTVG
60 70 80 90 100
QRGGSRPSPG PIRCRHRSKV SGNQHTPSHP KQRGSASPMA GSGAKRSRDG
110 120 130 140 150
ELETSLNTQG CTTEGDLLFA QKCKELQGFI PPLTDLLNGL KMGRFERGLS
160 170 180 190 200
SFQQSVAMDR IQRIVGVLQK PQMGERYLGT LLQVEGMLKT WFPQIAAQKS
210 220 230 240 250
SLGGGKHQLT KHFPSHHSDS AASSPASPME KMDQTQLGHL ALKPKQPWHL
260 270 280 290 300
TQWPAMNLTW IHTTPICNPP LSSPGTISFS HGPLGTGTGI GVILFLQHGV
310 320 330 340 350
QPFTHSAPTT PVPPTTASPV IPGEPMKLSG EGPRCYSLPV TLPSDWSYTL
360 370 380
SPPSLPTLAR KMTIGHREQQ RSHPPVAADA HLLNL
Length:385
Mass (Da):41,443
Last modified:October 1, 2002 - v1
Checksum:i3242FA7CA663493E
GO
Isoform 2 (identifier: Q8N365-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-123: C → D
     124-385: Missing.

Note: No experimental confirmation available.
Show »
Length:123
Mass (Da):12,982
Checksum:i0C8183FC432BCC38
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti187M → L in BAB71326 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020743123C → D in isoform 2. 1 Publication1
Alternative sequenceiVSP_020744124 – 385Missing in isoform 2. 1 PublicationAdd BLAST262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056960 mRNA. Translation: BAB71326.1.
AK098755 mRNA. Translation: BAC05404.1.
AK315397 mRNA. Translation: BAG37790.1.
AL138795 Genomic DNA. Translation: CAI22816.1.
CH471121 Genomic DNA. Translation: EAW53560.1.
CH471121 Genomic DNA. Translation: EAW53564.1.
BC027999 mRNA. Translation: AAH27999.1.
BC047238 mRNA. Translation: AAH47238.1.
CCDSiCCDS949.1. [Q8N365-1]
RefSeqiNP_001287767.1. NM_001300838.1. [Q8N365-1]
NP_001287769.1. NM_001300840.1.
NP_001287770.1. NM_001300841.1.
NP_653298.1. NM_144697.3. [Q8N365-1]
UniGeneiHs.54680.

Genome annotation databases

EnsembliENST00000290363; ENSP00000290363; ENSG00000159208. [Q8N365-1]
ENST00000369095; ENSP00000358091; ENSG00000159208. [Q8N365-1]
GeneIDi148523.
KEGGihsa:148523.
UCSCiuc001euh.4. human. [Q8N365-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056960 mRNA. Translation: BAB71326.1.
AK098755 mRNA. Translation: BAC05404.1.
AK315397 mRNA. Translation: BAG37790.1.
AL138795 Genomic DNA. Translation: CAI22816.1.
CH471121 Genomic DNA. Translation: EAW53560.1.
CH471121 Genomic DNA. Translation: EAW53564.1.
BC027999 mRNA. Translation: AAH27999.1.
BC047238 mRNA. Translation: AAH47238.1.
CCDSiCCDS949.1. [Q8N365-1]
RefSeqiNP_001287767.1. NM_001300838.1. [Q8N365-1]
NP_001287769.1. NM_001300840.1.
NP_001287770.1. NM_001300841.1.
NP_653298.1. NM_144697.3. [Q8N365-1]
UniGeneiHs.54680.

3D structure databases

ProteinModelPortaliQ8N365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127153. 6 interactors.
DIPiDIP-60822N.
IntActiQ8N365. 1 interactor.
STRINGi9606.ENSP00000290363.

PTM databases

iPTMnetiQ8N365.
PhosphoSitePlusiQ8N365.

Polymorphism and mutation databases

BioMutaiC1orf51.

Proteomic databases

PaxDbiQ8N365.
PRIDEiQ8N365.

Protocols and materials databases

DNASUi148523.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290363; ENSP00000290363; ENSG00000159208. [Q8N365-1]
ENST00000369095; ENSP00000358091; ENSG00000159208. [Q8N365-1]
GeneIDi148523.
KEGGihsa:148523.
UCSCiuc001euh.4. human. [Q8N365-1]

Organism-specific databases

CTDi148523.
GeneCardsiCIART.
HGNCiHGNC:25200. CIART.
HPAiHPA027515.
HPA054349.
MIMi615782. gene.
neXtProtiNX_Q8N365.
OpenTargetsiENSG00000159208.
PharmGKBiPA134921053.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IICF. Eukaryota.
ENOG410YK16. LUCA.
GeneTreeiENSGT00390000018360.
HOGENOMiHOG000236332.
HOVERGENiHBG058566.
InParanoidiQ8N365.
OMAiNSDFGFP.
OrthoDBiEOG091G088K.
PhylomeDBiQ8N365.
TreeFamiTF332541.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159208-MONOMER.

Miscellaneous databases

GenomeRNAii148523.
PROiQ8N365.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159208.
CleanExiHS_C1orf51.
ExpressionAtlasiQ8N365. baseline and differential.
GenevisibleiQ8N365. HS.

Family and domain databases

InterProiIPR031373. Ciart.
[Graphical view]
PfamiPF15673. Ciart. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCIART_HUMAN
AccessioniPrimary (citable) accession number: Q8N365
Secondary accession number(s): B2RD43
, D3DV01, Q8N795, Q96MG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.