ID S35F6_HUMAN Reviewed; 371 AA. AC Q8N357; D6W543; Q53GK2; Q8NBX6; Q9NWX0; DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2002, sequence version 1. DT 27-MAR-2024, entry version 154. DE RecName: Full=Solute carrier family 35 member F6; DE AltName: Full=ANT2-binding protein; DE Short=ANT2BP; DE AltName: Full=Transport and Golgi organization 9 homolog; DE Flags: Precursor; GN Name=SLC35F6; Synonyms=C2orf18; ORFNames=UNQ3047/PRO9863; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Placenta; RX PubMed=16303743; DOI=10.1093/dnares/12.2.117; RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y., RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., RA Isogai T.; RT "Signal sequence and keyword trap in silico for selection of full-length RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA RT libraries."; RL DNA Res. 12:117-126(2005). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney; RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., RA Tanaka A., Yokoyama S.; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Blood; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [9] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the RT kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [11] RP FUNCTION, INTERACTION WITH SLC25A5, SUBCELLULAR LOCATION, AND TISSUE RP SPECIFICITY. RX PubMed=19154410; DOI=10.1111/j.1349-7006.2008.01058.x; RA Kashiwaya K., Hosokawa M., Eguchi H., Ohigashi H., Ishikawa O., RA Shinomura Y., Nakamura Y., Nakagawa H.; RT "Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of RT the key molecules involved in pancreatic carcinogenesis."; RL Cancer Sci. 100:457-464(2009). RN [12] RP REVIEW, AND SUBCELLULAR LOCATION. RX PubMed=20957757; DOI=10.1002/pmic.201000196; RA Schroeder B.A., Wrocklage C., Hasilik A., Saftig P.; RT "The proteome of lysosomes."; RL Proteomics 10:4053-4076(2010). RN [13] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Involved in the maintenance of mitochondrial membrane CC potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes CC pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as CC a nucleotide-sugar transporter. {ECO:0000269|PubMed:19154410}. CC -!- SUBUNIT: Interacts with SLC25A5. {ECO:0000269|PubMed:19154410}. CC -!- INTERACTION: CC Q8N357; Q13520: AQP6; NbExp=3; IntAct=EBI-713484, EBI-13059134; CC Q8N357; Q8N350-4: CBARP; NbExp=3; IntAct=EBI-713484, EBI-19051169; CC Q8N357; Q9HA82: CERS4; NbExp=3; IntAct=EBI-713484, EBI-2622997; CC Q8N357; P15328: FOLR1; NbExp=3; IntAct=EBI-713484, EBI-2556557; CC Q8N357; P48165: GJA8; NbExp=3; IntAct=EBI-713484, EBI-17458373; CC Q8N357; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-713484, EBI-13345167; CC Q8N357; P05141: SLC25A5; NbExp=2; IntAct=EBI-713484, EBI-355133; CC Q8N357; Q9NPL8: TIMMDC1; NbExp=3; IntAct=EBI-713484, EBI-6268651; CC Q8N357; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-713484, EBI-8638294; CC -!- SUBCELLULAR LOCATION: Mitochondrion. Lysosome membrane; Multi-pass CC membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in pancreatic ductal adenocarcinoma CC (PDAC) (at protein level). Strongly expressed in prostate and thyroid. CC Weakly expressed in lung, heart, liver and kidney. CC {ECO:0000269|PubMed:19154410}. CC -!- SIMILARITY: Belongs to the SLC35F solute transporter family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY358820; AAQ89179.1; -; mRNA. DR EMBL; AK000562; BAA91255.1; -; mRNA. DR EMBL; AK075164; BAC11445.1; -; mRNA. DR EMBL; CR457243; CAG33524.1; -; mRNA. DR EMBL; AK222929; BAD96649.1; -; mRNA. DR EMBL; AC011740; AAX93265.1; -; Genomic_DNA. DR EMBL; CH471053; EAX00673.1; -; Genomic_DNA. DR EMBL; CH471053; EAX00676.1; -; Genomic_DNA. DR EMBL; BC028081; AAH28081.1; -; mRNA. DR CCDS; CCDS1728.1; -. DR RefSeq; NP_060347.2; NM_017877.3. DR AlphaFoldDB; Q8N357; -. DR SMR; Q8N357; -. DR BioGRID; 120314; 99. DR IntAct; Q8N357; 46. DR MINT; Q8N357; -. DR STRING; 9606.ENSP00000345528; -. DR TCDB; 2.A.7.12.13; the drug/metabolite transporter (dmt) superfamily. DR GlyCosmos; Q8N357; 1 site, No reported glycans. DR GlyGen; Q8N357; 2 sites, 1 O-linked glycan (1 site). DR iPTMnet; Q8N357; -. DR PhosphoSitePlus; Q8N357; -. DR SwissPalm; Q8N357; -. DR BioMuta; SLC35F6; -. DR DMDM; 74728772; -. DR EPD; Q8N357; -. DR jPOST; Q8N357; -. DR MassIVE; Q8N357; -. DR MaxQB; Q8N357; -. DR PaxDb; 9606-ENSP00000345528; -. DR PeptideAtlas; Q8N357; -. DR ProteomicsDB; 71766; -. DR Pumba; Q8N357; -. DR Antibodypedia; 28001; 162 antibodies from 21 providers. DR DNASU; 54978; -. DR Ensembl; ENST00000344420.10; ENSP00000345528.5; ENSG00000213699.9. DR GeneID; 54978; -. DR KEGG; hsa:54978; -. DR MANE-Select; ENST00000344420.10; ENSP00000345528.5; NM_017877.4; NP_060347.2. DR UCSC; uc002rhp.2; human. DR AGR; HGNC:26055; -. DR CTD; 54978; -. DR DisGeNET; 54978; -. DR GeneCards; SLC35F6; -. DR HGNC; HGNC:26055; SLC35F6. DR HPA; ENSG00000213699; Low tissue specificity. DR MIM; 619667; gene. DR neXtProt; NX_Q8N357; -. DR OpenTargets; ENSG00000213699; -. DR PharmGKB; PA134913368; -. DR VEuPathDB; HostDB:ENSG00000213699; -. DR eggNOG; KOG3912; Eukaryota. DR GeneTree; ENSGT00390000017237; -. DR HOGENOM; CLU_025028_1_0_1; -. DR InParanoid; Q8N357; -. DR OMA; LWSKWQD; -. DR OrthoDB; 5483100at2759; -. DR PhylomeDB; Q8N357; -. DR TreeFam; TF105890; -. DR PathwayCommons; Q8N357; -. DR SignaLink; Q8N357; -. DR BioGRID-ORCS; 54978; 12 hits in 1161 CRISPR screens. DR ChiTaRS; SLC35F6; human. DR GeneWiki; C2orf18; -. DR GenomeRNAi; 54978; -. DR Pharos; Q8N357; Tbio. DR PRO; PR:Q8N357; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; Q8N357; Protein. DR Bgee; ENSG00000213699; Expressed in nipple and 182 other cell types or tissues. DR ExpressionAtlas; Q8N357; baseline and differential. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. DR GO; GO:0005765; C:lysosomal membrane; IDA:UniProtKB. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB. DR GO; GO:0005654; C:nucleoplasm; IDA:HPA. DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro. DR GO; GO:1901029; P:negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; IMP:UniProtKB. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:UniProtKB. DR InterPro; IPR009262; SLC35_F1/F2/F6. DR InterPro; IPR012404; UCP036436. DR PANTHER; PTHR13146:SF0; SOLUTE CARRIER FAMILY 35 MEMBER F6; 1. DR PANTHER; PTHR13146; UNCHARACTERIZED; 1. DR Pfam; PF06027; SLC35F; 1. DR PIRSF; PIRSF036436; UCP036436; 1. DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1. DR Genevisible; Q8N357; HS. PE 1: Evidence at protein level; KW Glycoprotein; Lysosome; Membrane; Mitochondrion; Phosphoprotein; KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. FT SIGNAL 1..18 FT /evidence="ECO:0000255" FT CHAIN 19..371 FT /note="Solute carrier family 35 member F6" FT /id="PRO_0000232514" FT TRANSMEM 48..68 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 89..109 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 117..137 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 140..160 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 176..196 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 216..236 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 261..281 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 295..312 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 317..336 FT /note="Helical" FT /evidence="ECO:0000255" FT DOMAIN 104..160 FT /note="EamA" FT REGION 352..371 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 365 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:18669648" FT CARBOHYD 110 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CONFLICT 107 FT /note="V -> A (in Ref. 5; BAD96649)" FT /evidence="ECO:0000305" FT CONFLICT 163 FT /note="L -> P (in Ref. 5; BAD96649)" FT /evidence="ECO:0000305" FT CONFLICT 215 FT /note="E -> K (in Ref. 2; BAA91255)" FT /evidence="ECO:0000305" FT CONFLICT 274 FT /note="A -> V (in Ref. 5; BAD96649)" FT /evidence="ECO:0000305" FT CONFLICT 295 FT /note="L -> S (in Ref. 3; BAC11445)" FT /evidence="ECO:0000305" SQ SEQUENCE 371 AA; 40214 MW; 225AFE41FA555B12 CRC64; MAWTKYQLFL AGLMLVTGSI NTLSAKWADN FMAEGCGGSK EHSFQHPFLQ AVGMFLGEFS CLAAFYLLRC RAAGQSDSSV DPQQPFNPLL FLPPALCDMT GTSLMYVALN MTSASSFQML RGAVIIFTGL FSVAFLGRRL VLSQWLGILA TIAGLVVVGL ADLLSKHDSQ HKLSEVITGD LLIIMAQIIV AIQMVLEEKF VYKHNVHPLR AVGTEGLFGF VILSLLLVPM YYIPAGSFSG NPRGTLEDAL DAFCQVGQQP LIAVALLGNI SSIAFFNFAG ISVTKELSAT TRMVLDSLRT VVIWALSLAL GWEAFHALQI LGFLILLIGT ALYNGLHRPL LGRLSRGRPL AEESEQERLL GGTRTPINDA S //