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Q8N357

- S35F6_HUMAN

UniProt

Q8N357 - S35F6_HUMAN

Protein

Solute carrier family 35 member F6

Gene

SLC35F6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
    2. positive regulation of cell proliferation Source: UniProtKB
    3. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.7.12.13. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 35 member F6
    Alternative name(s):
    ANT2-binding protein
    Short name:
    ANT2BP
    Transport and Golgi organization 9 homolog
    Gene namesi
    Name:SLC35F6
    Synonyms:C2orf18
    ORF Names:UNQ3047/PRO9863
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:26055. SLC35F6.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosomal membrane Source: UniProtKB
    4. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Lysosome, Membrane, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134913368.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 371353Solute carrier family 35 member F6PRO_0000232514Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Modified residuei365 – 3651Phosphothreonine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8N357.
    PaxDbiQ8N357.
    PRIDEiQ8N357.

    PTM databases

    PhosphoSiteiQ8N357.

    Expressioni

    Tissue specificityi

    Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney.1 Publication

    Gene expression databases

    ArrayExpressiQ8N357.
    BgeeiQ8N357.
    CleanExiHS_C2orf18.
    GenevestigatoriQ8N357.

    Organism-specific databases

    HPAiHPA034655.

    Interactioni

    Subunit structurei

    Interacts with SLC25A5.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SLC25A5P051412EBI-713484,EBI-355133

    Protein-protein interaction databases

    BioGridi120314. 16 interactions.
    IntActiQ8N357. 17 interactions.
    MINTiMINT-1383766.
    STRINGi9606.ENSP00000345528.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N357.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 6821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31218HelicalSequence AnalysisAdd
    BLAST
    Transmembranei317 – 33620HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini104 – 16057EamAAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SLC35F solute transporter family.Curated
    Contains 1 EamA domain.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0697.
    HOGENOMiHOG000210249.
    HOVERGENiHBG057690.
    InParanoidiQ8N357.
    OMAiKYQDNQC.
    PhylomeDBiQ8N357.
    TreeFamiTF105890.

    Family and domain databases

    InterProiIPR009262. SLC35_F1/F2/F6.
    IPR012404. UCP036436.
    [Graphical view]
    PfamiPF06027. DUF914. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036436. UCP036436. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N357-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWTKYQLFL AGLMLVTGSI NTLSAKWADN FMAEGCGGSK EHSFQHPFLQ    50
    AVGMFLGEFS CLAAFYLLRC RAAGQSDSSV DPQQPFNPLL FLPPALCDMT 100
    GTSLMYVALN MTSASSFQML RGAVIIFTGL FSVAFLGRRL VLSQWLGILA 150
    TIAGLVVVGL ADLLSKHDSQ HKLSEVITGD LLIIMAQIIV AIQMVLEEKF 200
    VYKHNVHPLR AVGTEGLFGF VILSLLLVPM YYIPAGSFSG NPRGTLEDAL 250
    DAFCQVGQQP LIAVALLGNI SSIAFFNFAG ISVTKELSAT TRMVLDSLRT 300
    VVIWALSLAL GWEAFHALQI LGFLILLIGT ALYNGLHRPL LGRLSRGRPL 350
    AEESEQERLL GGTRTPINDA S 371
    Length:371
    Mass (Da):40,214
    Last modified:October 1, 2002 - v1
    Checksum:i225AFE41FA555B12
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti107 – 1071V → A in BAD96649. 1 PublicationCurated
    Sequence conflicti163 – 1631L → P in BAD96649. 1 PublicationCurated
    Sequence conflicti215 – 2151E → K in BAA91255. (PubMed:14702039)Curated
    Sequence conflicti274 – 2741A → V in BAD96649. 1 PublicationCurated
    Sequence conflicti295 – 2951L → S in BAC11445. (PubMed:16303743)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358820 mRNA. Translation: AAQ89179.1.
    AK000562 mRNA. Translation: BAA91255.1.
    AK075164 mRNA. Translation: BAC11445.1.
    CR457243 mRNA. Translation: CAG33524.1.
    AK222929 mRNA. Translation: BAD96649.1.
    AC011740 Genomic DNA. Translation: AAX93265.1.
    CH471053 Genomic DNA. Translation: EAX00673.1.
    CH471053 Genomic DNA. Translation: EAX00676.1.
    BC028081 mRNA. Translation: AAH28081.1.
    CCDSiCCDS1728.1.
    RefSeqiNP_060347.2. NM_017877.3.
    UniGeneiHs.1594.
    Hs.516034.

    Genome annotation databases

    EnsembliENST00000344420; ENSP00000345528; ENSG00000213699.
    GeneIDi54978.
    KEGGihsa:54978.
    UCSCiuc002rhp.1. human.

    Polymorphism databases

    DMDMi74728772.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358820 mRNA. Translation: AAQ89179.1 .
    AK000562 mRNA. Translation: BAA91255.1 .
    AK075164 mRNA. Translation: BAC11445.1 .
    CR457243 mRNA. Translation: CAG33524.1 .
    AK222929 mRNA. Translation: BAD96649.1 .
    AC011740 Genomic DNA. Translation: AAX93265.1 .
    CH471053 Genomic DNA. Translation: EAX00673.1 .
    CH471053 Genomic DNA. Translation: EAX00676.1 .
    BC028081 mRNA. Translation: AAH28081.1 .
    CCDSi CCDS1728.1.
    RefSeqi NP_060347.2. NM_017877.3.
    UniGenei Hs.1594.
    Hs.516034.

    3D structure databases

    ProteinModelPortali Q8N357.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120314. 16 interactions.
    IntActi Q8N357. 17 interactions.
    MINTi MINT-1383766.
    STRINGi 9606.ENSP00000345528.

    Protein family/group databases

    TCDBi 2.A.7.12.13. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q8N357.

    Polymorphism databases

    DMDMi 74728772.

    Proteomic databases

    MaxQBi Q8N357.
    PaxDbi Q8N357.
    PRIDEi Q8N357.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000344420 ; ENSP00000345528 ; ENSG00000213699 .
    GeneIDi 54978.
    KEGGi hsa:54978.
    UCSCi uc002rhp.1. human.

    Organism-specific databases

    CTDi 54978.
    GeneCardsi GC02P026989.
    HGNCi HGNC:26055. SLC35F6.
    HPAi HPA034655.
    neXtProti NX_Q8N357.
    PharmGKBi PA134913368.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0697.
    HOGENOMi HOG000210249.
    HOVERGENi HBG057690.
    InParanoidi Q8N357.
    OMAi KYQDNQC.
    PhylomeDBi Q8N357.
    TreeFami TF105890.

    Miscellaneous databases

    GeneWikii C2orf18.
    GenomeRNAii 54978.
    NextBioi 58238.

    Gene expression databases

    ArrayExpressi Q8N357.
    Bgeei Q8N357.
    CleanExi HS_C2orf18.
    Genevestigatori Q8N357.

    Family and domain databases

    InterProi IPR009262. SLC35_F1/F2/F6.
    IPR012404. UCP036436.
    [Graphical view ]
    Pfami PF06027. DUF914. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036436. UCP036436. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis."
      Kashiwaya K., Hosokawa M., Eguchi H., Ohigashi H., Ishikawa O., Shinomura Y., Nakamura Y., Nakagawa H.
      Cancer Sci. 100:457-464(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SLC25A5, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    12. Cited for: REVIEW, SUBCELLULAR LOCATION.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS35F6_HUMAN
    AccessioniPrimary (citable) accession number: Q8N357
    Secondary accession number(s): D6W543
    , Q53GK2, Q8NBX6, Q9NWX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3