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Q8N357 (S35F6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 35 member F6
Alternative name(s):
ANT2-binding protein
Short name=ANT2BP
Transport and Golgi organization 9 homolog
Gene names
Name:SLC35F6
Synonyms:C2orf18
ORF Names:UNQ3047/PRO9863
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter. Ref.11

Subunit structure

Interacts with SLC25A5. Ref.11

Subcellular location

Mitochondrion. Lysosome membrane; Multi-pass membrane protein Ref.11 Ref.12.

Tissue specificity

Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney. Ref.11

Sequence similarities

Belongs to the SLC35F solute transporter family.

Contains 1 EamA domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SLC25A5P051412EBI-713484,EBI-355133

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 371353Solute carrier family 35 member F6
PRO_0000232514

Regions

Transmembrane48 – 6821Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane216 – 23621Helical; Potential
Transmembrane261 – 28121Helical; Potential
Transmembrane295 – 31218Helical; Potential
Transmembrane317 – 33620Helical; Potential
Domain104 – 16057EamA

Amino acid modifications

Modified residue3651Phosphothreonine Ref.10
Glycosylation1101N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1071V → A in BAD96649. Ref.5
Sequence conflict1631L → P in BAD96649. Ref.5
Sequence conflict2151E → K in BAA91255. Ref.2
Sequence conflict2741A → V in BAD96649. Ref.5
Sequence conflict2951L → S in BAC11445. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8N357 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 225AFE41FA555B12

FASTA37140,214
        10         20         30         40         50         60 
MAWTKYQLFL AGLMLVTGSI NTLSAKWADN FMAEGCGGSK EHSFQHPFLQ AVGMFLGEFS 

        70         80         90        100        110        120 
CLAAFYLLRC RAAGQSDSSV DPQQPFNPLL FLPPALCDMT GTSLMYVALN MTSASSFQML 

       130        140        150        160        170        180 
RGAVIIFTGL FSVAFLGRRL VLSQWLGILA TIAGLVVVGL ADLLSKHDSQ HKLSEVITGD 

       190        200        210        220        230        240 
LLIIMAQIIV AIQMVLEEKF VYKHNVHPLR AVGTEGLFGF VILSLLLVPM YYIPAGSFSG 

       250        260        270        280        290        300 
NPRGTLEDAL DAFCQVGQQP LIAVALLGNI SSIAFFNFAG ISVTKELSAT TRMVLDSLRT 

       310        320        330        340        350        360 
VVIWALSLAL GWEAFHALQI LGFLILLIGT ALYNGLHRPL LGRLSRGRPL AEESEQERLL 

       370 
GGTRTPINDA S 

« Hide

References

« Hide 'large scale' references
[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[6]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
[9]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis."
Kashiwaya K., Hosokawa M., Eguchi H., Ohigashi H., Ishikawa O., Shinomura Y., Nakamura Y., Nakagawa H.
Cancer Sci. 100:457-464(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH SLC25A5, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[12]"The proteome of lysosomes."
Schroeder B.A., Wrocklage C., Hasilik A., Saftig P.
Proteomics 10:4053-4076(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW, SUBCELLULAR LOCATION.
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358820 mRNA. Translation: AAQ89179.1.
AK000562 mRNA. Translation: BAA91255.1.
AK075164 mRNA. Translation: BAC11445.1.
CR457243 mRNA. Translation: CAG33524.1.
AK222929 mRNA. Translation: BAD96649.1.
AC011740 Genomic DNA. Translation: AAX93265.1.
CH471053 Genomic DNA. Translation: EAX00673.1.
CH471053 Genomic DNA. Translation: EAX00676.1.
BC028081 mRNA. Translation: AAH28081.1.
RefSeqNP_060347.2. NM_017877.3.
UniGeneHs.1594.
Hs.516034.

3D structure databases

ProteinModelPortalQ8N357.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120314. 16 interactions.
IntActQ8N357. 17 interactions.
MINTMINT-1383766.
STRING9606.ENSP00000345528.

Protein family/group databases

TCDB2.A.7.12.13. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ8N357.

Polymorphism databases

DMDM74728772.

Proteomic databases

PaxDbQ8N357.
PRIDEQ8N357.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344420; ENSP00000345528; ENSG00000213699.
GeneID54978.
KEGGhsa:54978.
UCSCuc002rhp.1. human.

Organism-specific databases

CTD54978.
GeneCardsGC02P026989.
HGNCHGNC:26055. SLC35F6.
HPAHPA034655.
neXtProtNX_Q8N357.
PharmGKBPA134913368.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0697.
HOGENOMHOG000210249.
HOVERGENHBG057690.
InParanoidQ8N357.
OMAKYQDNQC.
PhylomeDBQ8N357.
TreeFamTF105890.

Gene expression databases

ArrayExpressQ8N357.
BgeeQ8N357.
CleanExHS_C2orf18.
GenevestigatorQ8N357.

Family and domain databases

InterProIPR009262. SLC35_F1/F2/F6.
IPR012404. UCP036436.
[Graphical view]
PfamPF06027. DUF914. 1 hit.
[Graphical view]
PIRSFPIRSF036436. UCP036436. 1 hit.
ProtoNetSearch...

Other

GeneWikiC2orf18.
GenomeRNAi54978.
NextBio58238.

Entry information

Entry nameS35F6_HUMAN
AccessionPrimary (citable) accession number: Q8N357
Secondary accession number(s): D6W543 expand/collapse secondary AC list , Q53GK2, Q8NBX6, Q9NWX0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM