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Protein

Solute carrier family 35 member F6

Gene

SLC35F6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.1 Publication

GO - Biological processi

  • negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.12.13. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F6
Alternative name(s):
ANT2-binding protein
Short name:
ANT2BP
Transport and Golgi organization 9 homolog
Gene namesi
Name:SLC35F6
Synonyms:C2orf18
ORF Names:UNQ3047/PRO9863
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:26055. SLC35F6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Transmembranei295 – 312HelicalSequence analysisAdd BLAST18
Transmembranei317 – 336HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi54978.
OpenTargetsiENSG00000213699.
PharmGKBiPA134913368.

Polymorphism and mutation databases

BioMutaiSLC35F6.
DMDMi74728772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000023251419 – 371Solute carrier family 35 member F6Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Modified residuei365PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8N357.
MaxQBiQ8N357.
PaxDbiQ8N357.
PeptideAtlasiQ8N357.
PRIDEiQ8N357.

PTM databases

iPTMnetiQ8N357.
PhosphoSitePlusiQ8N357.
SwissPalmiQ8N357.

Expressioni

Tissue specificityi

Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney.1 Publication

Gene expression databases

BgeeiENSG00000213699.
CleanExiHS_C2orf18.
ExpressionAtlasiQ8N357. baseline and differential.
GenevisibleiQ8N357. HS.

Organism-specific databases

HPAiHPA034655.

Interactioni

Subunit structurei

Interacts with SLC25A5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC25A5P051412EBI-713484,EBI-355133

Protein-protein interaction databases

BioGridi120314. 31 interactors.
IntActiQ8N357. 35 interactors.
MINTiMINT-1383766.
STRINGi9606.ENSP00000345528.

Structurei

3D structure databases

ProteinModelPortaliQ8N357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 160EamAAdd BLAST57

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated
Contains 1 EamA domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3912. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00390000017237.
HOGENOMiHOG000210249.
HOVERGENiHBG057690.
InParanoidiQ8N357.
OMAiADNFVAQ.
OrthoDBiEOG091G0L5Q.
PhylomeDBiQ8N357.
TreeFamiTF105890.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
IPR012404. UCP036436.
[Graphical view]
PfamiPF06027. SLC35F. 1 hit.
[Graphical view]
PIRSFiPIRSF036436. UCP036436. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWTKYQLFL AGLMLVTGSI NTLSAKWADN FMAEGCGGSK EHSFQHPFLQ
60 70 80 90 100
AVGMFLGEFS CLAAFYLLRC RAAGQSDSSV DPQQPFNPLL FLPPALCDMT
110 120 130 140 150
GTSLMYVALN MTSASSFQML RGAVIIFTGL FSVAFLGRRL VLSQWLGILA
160 170 180 190 200
TIAGLVVVGL ADLLSKHDSQ HKLSEVITGD LLIIMAQIIV AIQMVLEEKF
210 220 230 240 250
VYKHNVHPLR AVGTEGLFGF VILSLLLVPM YYIPAGSFSG NPRGTLEDAL
260 270 280 290 300
DAFCQVGQQP LIAVALLGNI SSIAFFNFAG ISVTKELSAT TRMVLDSLRT
310 320 330 340 350
VVIWALSLAL GWEAFHALQI LGFLILLIGT ALYNGLHRPL LGRLSRGRPL
360 370
AEESEQERLL GGTRTPINDA S
Length:371
Mass (Da):40,214
Last modified:October 1, 2002 - v1
Checksum:i225AFE41FA555B12
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107V → A in BAD96649 (Ref. 5) Curated1
Sequence conflicti163L → P in BAD96649 (Ref. 5) Curated1
Sequence conflicti215E → K in BAA91255 (PubMed:14702039).Curated1
Sequence conflicti274A → V in BAD96649 (Ref. 5) Curated1
Sequence conflicti295L → S in BAC11445 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358820 mRNA. Translation: AAQ89179.1.
AK000562 mRNA. Translation: BAA91255.1.
AK075164 mRNA. Translation: BAC11445.1.
CR457243 mRNA. Translation: CAG33524.1.
AK222929 mRNA. Translation: BAD96649.1.
AC011740 Genomic DNA. Translation: AAX93265.1.
CH471053 Genomic DNA. Translation: EAX00673.1.
CH471053 Genomic DNA. Translation: EAX00676.1.
BC028081 mRNA. Translation: AAH28081.1.
CCDSiCCDS1728.1.
RefSeqiNP_060347.2. NM_017877.3.
UniGeneiHs.1594.
Hs.516034.

Genome annotation databases

EnsembliENST00000344420; ENSP00000345528; ENSG00000213699.
GeneIDi54978.
KEGGihsa:54978.
UCSCiuc002rhp.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358820 mRNA. Translation: AAQ89179.1.
AK000562 mRNA. Translation: BAA91255.1.
AK075164 mRNA. Translation: BAC11445.1.
CR457243 mRNA. Translation: CAG33524.1.
AK222929 mRNA. Translation: BAD96649.1.
AC011740 Genomic DNA. Translation: AAX93265.1.
CH471053 Genomic DNA. Translation: EAX00673.1.
CH471053 Genomic DNA. Translation: EAX00676.1.
BC028081 mRNA. Translation: AAH28081.1.
CCDSiCCDS1728.1.
RefSeqiNP_060347.2. NM_017877.3.
UniGeneiHs.1594.
Hs.516034.

3D structure databases

ProteinModelPortaliQ8N357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120314. 31 interactors.
IntActiQ8N357. 35 interactors.
MINTiMINT-1383766.
STRINGi9606.ENSP00000345528.

Protein family/group databases

TCDBi2.A.7.12.13. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ8N357.
PhosphoSitePlusiQ8N357.
SwissPalmiQ8N357.

Polymorphism and mutation databases

BioMutaiSLC35F6.
DMDMi74728772.

Proteomic databases

EPDiQ8N357.
MaxQBiQ8N357.
PaxDbiQ8N357.
PeptideAtlasiQ8N357.
PRIDEiQ8N357.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344420; ENSP00000345528; ENSG00000213699.
GeneIDi54978.
KEGGihsa:54978.
UCSCiuc002rhp.2. human.

Organism-specific databases

CTDi54978.
DisGeNETi54978.
GeneCardsiSLC35F6.
HGNCiHGNC:26055. SLC35F6.
HPAiHPA034655.
neXtProtiNX_Q8N357.
OpenTargetsiENSG00000213699.
PharmGKBiPA134913368.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3912. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00390000017237.
HOGENOMiHOG000210249.
HOVERGENiHBG057690.
InParanoidiQ8N357.
OMAiADNFVAQ.
OrthoDBiEOG091G0L5Q.
PhylomeDBiQ8N357.
TreeFamiTF105890.

Miscellaneous databases

GeneWikiiC2orf18.
GenomeRNAii54978.
PROiQ8N357.

Gene expression databases

BgeeiENSG00000213699.
CleanExiHS_C2orf18.
ExpressionAtlasiQ8N357. baseline and differential.
GenevisibleiQ8N357. HS.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
IPR012404. UCP036436.
[Graphical view]
PfamiPF06027. SLC35F. 1 hit.
[Graphical view]
PIRSFiPIRSF036436. UCP036436. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS35F6_HUMAN
AccessioniPrimary (citable) accession number: Q8N357
Secondary accession number(s): D6W543
, Q53GK2, Q8NBX6, Q9NWX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.