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Q8N357

- S35F6_HUMAN

UniProt

Q8N357 - S35F6_HUMAN

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Protein
Solute carrier family 35 member F6
Gene
SLC35F6, C2orf18, UNQ3047/PRO9863
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
  2. positive regulation of cell proliferation Source: UniProtKB
  3. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.12.13. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F6
Alternative name(s):
ANT2-binding protein
Short name:
ANT2BP
Transport and Golgi organization 9 homolog
Gene namesi
Name:SLC35F6
Synonyms:C2orf18
ORF Names:UNQ3047/PRO9863
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:26055. SLC35F6.

Subcellular locationi

Mitochondrion. Lysosome membrane; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei48 – 6821Helical; Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Reviewed prediction
Add
BLAST
Transmembranei117 – 13721Helical; Reviewed prediction
Add
BLAST
Transmembranei140 – 16021Helical; Reviewed prediction
Add
BLAST
Transmembranei176 – 19621Helical; Reviewed prediction
Add
BLAST
Transmembranei216 – 23621Helical; Reviewed prediction
Add
BLAST
Transmembranei261 – 28121Helical; Reviewed prediction
Add
BLAST
Transmembranei295 – 31218Helical; Reviewed prediction
Add
BLAST
Transmembranei317 – 33620Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosomal membrane Source: UniProtKB
  4. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134913368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 371353Solute carrier family 35 member F6
PRO_0000232514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Modified residuei365 – 3651Phosphothreonine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8N357.
PaxDbiQ8N357.
PRIDEiQ8N357.

PTM databases

PhosphoSiteiQ8N357.

Expressioni

Tissue specificityi

Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney.1 Publication

Gene expression databases

ArrayExpressiQ8N357.
BgeeiQ8N357.
CleanExiHS_C2orf18.
GenevestigatoriQ8N357.

Organism-specific databases

HPAiHPA034655.

Interactioni

Subunit structurei

Interacts with SLC25A5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC25A5P051412EBI-713484,EBI-355133

Protein-protein interaction databases

BioGridi120314. 16 interactions.
IntActiQ8N357. 17 interactions.
MINTiMINT-1383766.
STRINGi9606.ENSP00000345528.

Structurei

3D structure databases

ProteinModelPortaliQ8N357.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 16057EamA
Add
BLAST

Sequence similaritiesi

Contains 1 EamA domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
HOGENOMiHOG000210249.
HOVERGENiHBG057690.
InParanoidiQ8N357.
OMAiKYQDNQC.
PhylomeDBiQ8N357.
TreeFamiTF105890.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
IPR012404. UCP036436.
[Graphical view]
PfamiPF06027. DUF914. 1 hit.
[Graphical view]
PIRSFiPIRSF036436. UCP036436. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N357-1 [UniParc]FASTAAdd to Basket

« Hide

MAWTKYQLFL AGLMLVTGSI NTLSAKWADN FMAEGCGGSK EHSFQHPFLQ    50
AVGMFLGEFS CLAAFYLLRC RAAGQSDSSV DPQQPFNPLL FLPPALCDMT 100
GTSLMYVALN MTSASSFQML RGAVIIFTGL FSVAFLGRRL VLSQWLGILA 150
TIAGLVVVGL ADLLSKHDSQ HKLSEVITGD LLIIMAQIIV AIQMVLEEKF 200
VYKHNVHPLR AVGTEGLFGF VILSLLLVPM YYIPAGSFSG NPRGTLEDAL 250
DAFCQVGQQP LIAVALLGNI SSIAFFNFAG ISVTKELSAT TRMVLDSLRT 300
VVIWALSLAL GWEAFHALQI LGFLILLIGT ALYNGLHRPL LGRLSRGRPL 350
AEESEQERLL GGTRTPINDA S 371
Length:371
Mass (Da):40,214
Last modified:October 1, 2002 - v1
Checksum:i225AFE41FA555B12
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071V → A in BAD96649. 1 Publication
Sequence conflicti163 – 1631L → P in BAD96649. 1 Publication
Sequence conflicti215 – 2151E → K in BAA91255. 1 Publication
Sequence conflicti274 – 2741A → V in BAD96649. 1 Publication
Sequence conflicti295 – 2951L → S in BAC11445. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358820 mRNA. Translation: AAQ89179.1.
AK000562 mRNA. Translation: BAA91255.1.
AK075164 mRNA. Translation: BAC11445.1.
CR457243 mRNA. Translation: CAG33524.1.
AK222929 mRNA. Translation: BAD96649.1.
AC011740 Genomic DNA. Translation: AAX93265.1.
CH471053 Genomic DNA. Translation: EAX00673.1.
CH471053 Genomic DNA. Translation: EAX00676.1.
BC028081 mRNA. Translation: AAH28081.1.
CCDSiCCDS1728.1.
RefSeqiNP_060347.2. NM_017877.3.
UniGeneiHs.1594.
Hs.516034.

Genome annotation databases

EnsembliENST00000344420; ENSP00000345528; ENSG00000213699.
GeneIDi54978.
KEGGihsa:54978.
UCSCiuc002rhp.1. human.

Polymorphism databases

DMDMi74728772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358820 mRNA. Translation: AAQ89179.1 .
AK000562 mRNA. Translation: BAA91255.1 .
AK075164 mRNA. Translation: BAC11445.1 .
CR457243 mRNA. Translation: CAG33524.1 .
AK222929 mRNA. Translation: BAD96649.1 .
AC011740 Genomic DNA. Translation: AAX93265.1 .
CH471053 Genomic DNA. Translation: EAX00673.1 .
CH471053 Genomic DNA. Translation: EAX00676.1 .
BC028081 mRNA. Translation: AAH28081.1 .
CCDSi CCDS1728.1.
RefSeqi NP_060347.2. NM_017877.3.
UniGenei Hs.1594.
Hs.516034.

3D structure databases

ProteinModelPortali Q8N357.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120314. 16 interactions.
IntActi Q8N357. 17 interactions.
MINTi MINT-1383766.
STRINGi 9606.ENSP00000345528.

Protein family/group databases

TCDBi 2.A.7.12.13. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSitei Q8N357.

Polymorphism databases

DMDMi 74728772.

Proteomic databases

MaxQBi Q8N357.
PaxDbi Q8N357.
PRIDEi Q8N357.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000344420 ; ENSP00000345528 ; ENSG00000213699 .
GeneIDi 54978.
KEGGi hsa:54978.
UCSCi uc002rhp.1. human.

Organism-specific databases

CTDi 54978.
GeneCardsi GC02P026989.
HGNCi HGNC:26055. SLC35F6.
HPAi HPA034655.
neXtProti NX_Q8N357.
PharmGKBi PA134913368.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0697.
HOGENOMi HOG000210249.
HOVERGENi HBG057690.
InParanoidi Q8N357.
OMAi KYQDNQC.
PhylomeDBi Q8N357.
TreeFami TF105890.

Miscellaneous databases

GeneWikii C2orf18.
GenomeRNAii 54978.
NextBioi 58238.

Gene expression databases

ArrayExpressi Q8N357.
Bgeei Q8N357.
CleanExi HS_C2orf18.
Genevestigatori Q8N357.

Family and domain databases

InterProi IPR009262. SLC35_F1/F2/F6.
IPR012404. UCP036436.
[Graphical view ]
Pfami PF06027. DUF914. 1 hit.
[Graphical view ]
PIRSFi PIRSF036436. UCP036436. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-365, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as one of the key molecules involved in pancreatic carcinogenesis."
    Kashiwaya K., Hosokawa M., Eguchi H., Ohigashi H., Ishikawa O., Shinomura Y., Nakamura Y., Nakagawa H.
    Cancer Sci. 100:457-464(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SLC25A5, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  12. Cited for: REVIEW, SUBCELLULAR LOCATION.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS35F6_HUMAN
AccessioniPrimary (citable) accession number: Q8N357
Secondary accession number(s): D6W543
, Q53GK2, Q8NBX6, Q9NWX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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