Q8N355 (Q8N355_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
IGL@ protein EMBL AAH28090.1

Gene names

Name:

IGL@ EMBL AAH28090.1

Organism

Homo sapiens (Human) EMBL AAH28090.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 4FQQ PDB 4HK0
Gene Ontology (GO)
None. [Check GOA]

Sequences

	Sequence		Length	Mass (Da)
	Q8N355 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: CC848CAEBA4A9D63	FASTA	234	24,793
	10 20 30 40 50 60 MAWTVLLLGL LSHCTGSVTS YVLTQPPSVS VAPGQTARIT CGGNNIGSKS VHWYQQKPGQ 70 80 90 100 110 120 APVLVVYDDS DRPSGIPERF SGSNSGNTAT LTISRVDAGD EADYYCQLWD SSSDHPVVFG 130 140 150 160 170 180 GGTKLTVLGQ PKAAPSVTLF PPSSEELQAN KATLVCLISD FYPGAVTVAW KADSSPVKAG 190 200 210 220 230 VETTTPSKQS NNKYAASSYL SLTPEQWKSH RSYSCQVTHE GSTVEKTVAP TECS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequences and three-dimensional modelling of the VH and VL domains of two human monoclonal antibodies specific for the D antigen of the human Rh-blood-group system." Hughes-Jones N.C., Bye J.M., Beale D., Coadwell J. Biochem. J. 268:135-140(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Structure and expression of the human immunoglobulin lambda genes." Vasicek T.J., Leder P. J. Exp. Med. 172:609-620(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain EMBL AAH28090.1.
[4]	"Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies." Mouquet H., Scharf L., Euler Z., Liu Y., Eden C., Scheid J.F., Halper-Stromberg A., Gnanapragasam P.N., Spencer D.I., Seaman M.S., Schuitemaker H., Feizi T., Nussenzweig M.C., Bjorkman P.J. Proc. Natl. Acad. Sci. U.S.A. 109:E3268-E3277(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 20-234.
[5]	"Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody." Schmidt A.G., Xu H., Khan A.R., O'Donnell T., Khurana S., King L.R., Manischewitz J., Golding H., Suphaphiphat P., Carfi A., Settembre E.C., Dormitzer P.R., Kepler T.B., Zhang R., Moody M.A., Haynes B.F., Liao H.X., Shaw D.E., Harrison S.C. Proc. Natl. Acad. Sci. U.S.A. 110:264-269(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 22-234.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BC028090 mRNA. Translation: AAH28090.1.

IPI

IPI00154742.

PIR

S09713.
S12441.
S30527.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4FQQ	X-ray	2.42	A/C/E/L	20-234	[»]
4HK0	X-ray	2.50	B/D	22-234	[»]

ProteinModelPortal

Q8N355.

SMR

Q8N355. Positions 21-234.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8N355. 4 interactions.

STRING

Q8N355.

Proteomic databases

PRIDE

Q8N355.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOGENOM

HOG000059537.

HOVERGEN

HBG018013.

Family and domain databases

Gene3D

2.60.40.10. 2 hits.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 2 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q8N355_HUMAN

Accession

Primary (citable) accession number: Q8N355

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.