UniProtKB - Q8N350 (CBARP_HUMAN)
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Protein
Voltage-dependent calcium channel beta subunit-associated regulatory protein
Gene
CBARP
Organism
Homo sapiens (Human)
Status
Functioni
Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.By similarity
GO - Molecular functioni
- ion channel binding Source: UniProtKB
GO - Biological processi
- negative regulation of calcium ion-dependent exocytosis Source: UniProtKB
- negative regulation of calcium ion transmembrane transport Source: UniProtKB
- negative regulation of voltage-gated calcium channel activity Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent calcium channel beta subunit-associated regulatory proteinCurated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000099625.12. |
HGNCi | HGNC:28617. CBARP. |
neXtProti | NX_Q8N350. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 45 | ExtracellularBy similarityAdd BLAST | 45 | |
Transmembranei | 46 – 66 | Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 67 – 705 | CytoplasmicBy similarityAdd BLAST | 639 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 255057. |
OpenTargetsi | ENSG00000099625. |
PharmGKBi | PA134919853. |
Polymorphism and mutation databases
BioMutai | DOS. |
DMDMi | 73919246. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000079983 | 1 – 705 | Voltage-dependent calcium channel beta subunit-associated regulatory proteinAdd BLAST | 705 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Modified residuei | 299 | PhosphoserineCombined sources | 1 | |
Modified residuei | 304 | PhosphoserineCombined sources | 1 | |
Modified residuei | 507 | PhosphoserineCombined sources | 1 | |
Modified residuei | 528 | PhosphoserineCombined sources | 1 | |
Modified residuei | 621 | PhosphoserineBy similarity | 1 | |
Modified residuei | 698 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 699 | PhosphoserineCombined sources | 1 | |
Modified residuei | 703 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q8N350. |
PeptideAtlasi | Q8N350. |
PRIDEi | Q8N350. |
PTM databases
iPTMneti | Q8N350. |
PhosphoSitePlusi | Q8N350. |
Expressioni
Gene expression databases
Bgeei | ENSG00000099625. |
CleanExi | HS_C19orf26. |
ExpressionAtlasi | Q8N350. baseline and differential. |
Genevisiblei | Q8N350. HS. |
Organism-specific databases
HPAi | HPA012777. |
Interactioni
Subunit structurei
Interacts with voltage-dependent calcium channels CACNB1, CACNB2, CACNB3 and CACNB4 beta subunits; prevents their interaction with the CACNA1C alpha subunit thereby negatively regulating the activity of the corresponding calcium channels.By similarity
GO - Molecular functioni
- ion channel binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 129072. 9 interactors. |
IntActi | Q8N350. 2 interactors. |
STRINGi | 9606.ENSP00000215376. |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 4 – 35 | Thr-richPROSITE-ProRule annotationAdd BLAST | 32 |
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00390000009230. |
HOGENOMi | HOG000112250. |
HOVERGENi | HBG081461. |
InParanoidi | Q8N350. |
OrthoDBi | EOG091G0204. |
TreeFami | TF331130. |
Family and domain databases
InterProi | View protein in InterPro IPR037658. CBARP. |
PANTHERi | PTHR28597. PTHR28597. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8N350-3) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MQPTATMATA ATTTTTTTAT VALTTSWDNA TGRPTAEPDP ILDNYVLLVV
60 70 80 90 100
VMSLFVGGTL VVLSGVLLLC KRCWDVHQRL NRAMEEAEKT TTTYLDNGTH
110 120 130 140 150
PAQDPDFRGE DPECQDAETE RFLSTSSTGR RVSFNEAALF EQSRKTQDKG
160 170 180 190 200
RRYTLTEGDF HHLKNARLTH LHLPPLKIVT IHECDSGEAS SATTPHPATS
210 220 230 240 250
PKATLAIFQP PGKALTGRSV GPSSALPGDP YNSAAGATDF AEISPSASSD
260 270 280 290 300
SGEGTSLDAG TRSTKAGGPG AAAGPGEAGP GSGAGTVLQF LTRLRRHASL
310 320 330 340 350
DGASPYFKVK KWKLEPSQRA ASLDTRGSPK RHHFQRQRAA SESTEQEEGD
360 370 380 390 400
APQEDFIQYI ARAGDAVAFP HPRPFLASPP PALGRLEAAE AAGGASPDSP
410 420 430 440 450
PERGAGSAGP EQQQPPLEPD AERDAGPEQA QTSYRDLWSL RASLELHAAA
460 470 480 490 500
SDHSSSGNDR DSVRSGDSSG SGSGGAAPAF PPPSPPAPRP KDGEARRLLQ
510 520 530 540 550
MDSGYASIEG RGAGDDTEPP AAPARPRSPR AWPRRPRRDY SIDEKTDALF
560 570 580 590 600
HEFLRHDPHF DDTPAAARHR ARAHPHARKQ WQRGRQHSDP GARAAPALAG
610 620 630 640 650
TPAPPAGAAR PARAPLRRGD SVDGPPDGRT LGGAGDDPAI PVIEEEPGGG
660 670 680 690 700
GCPGSGLCVL PSGSVLDKLA AGLDERLFPP RLAEPVVATP ALVAAAPTSP
DHSPA
Note: Gene prediction based on EST data.
Sequence cautioni
The sequence AAC04305 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH28156 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 256 | S → L in AAH28156 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 371 | H → R in AAH28156 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_058134 | 386 – 453 | LEAAE…AASDH → YFSVDGGARGGPVGPCPPSP PPRRPRERSPGPVDTRSPAS SGKAPPRGGLTGATSPAWTR GGKQGETG in isoform 2. 1 PublicationAdd BLAST | 68 | |
Alternative sequenceiVSP_058135 | 454 – 705 | Missing in isoform 2. 1 PublicationAdd BLAST | 252 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC004221 Genomic DNA. Translation: AAC04305.1. Sequence problems. BC028156 mRNA. Translation: AAH28156.1. Different initiation. |
CCDSi | CCDS12057.2. [Q8N350-4] |
PIRi | T00492. |
RefSeqi | NP_689982.3. NM_152769.2. [Q8N350-4] |
UniGenei | Hs.346575. |
Genome annotation databases
Ensembli | ENST00000590083; ENSP00000465260; ENSG00000099625. [Q8N350-4] |
GeneIDi | 255057. |
KEGGi | hsa:255057. |
UCSCi | uc002lrm.4. human. uc060qwp.1. human. [Q8N350-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | CBARP_HUMAN | |
Accessioni | Q8N350Primary (citable) accession number: Q8N350 Secondary accession number(s): K7EJP2, O43385 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | March 16, 2016 | |
Last modified: | February 28, 2018 | |
This is version 116 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |