CBARP

Functionⁱ

Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.By similarity

GO - Molecular functionⁱ

ion channel binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of calcium ion-dependent exocytosis Source: UniProtKB
negative regulation of calcium ion transmembrane transport Source: UniProtKB
negative regulation of voltage-gated calcium channel activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Voltage-dependent calcium channel beta subunit-associated regulatory proteinCurated
Gene namesⁱ	Name:CBARPImported Synonyms:C19orf26Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000099625.12.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28617. CBARP.
neXtProtⁱ	NX_Q8N350.

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 45	ExtracellularBy similarityAdd BLAST	45
Transmembraneⁱ	46 – 66	Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	67 – 705	CytoplasmicBy similarityAdd BLAST	639

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	255057.
Open Targets More...OpenTargetsⁱ	ENSG00000099625.
PharmGKBⁱ	PA134919853.

Polymorphism and mutation databases

BioMutaⁱ	DOS.
DMDMⁱ	73919246.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000079983	1 – 705	Voltage-dependent calcium channel beta subunit-associated regulatory proteinAdd BLAST		705

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	29	N-linked (GlcNAc...) asparagineBy similarity	1
Modified residueⁱ	299	PhosphoserineCombined sources	1
Modified residueⁱ	304	PhosphoserineCombined sources	1
Modified residueⁱ	507	PhosphoserineCombined sources	1
Modified residueⁱ	528	PhosphoserineCombined sources	1
Modified residueⁱ	621	PhosphoserineBy similarity	1
Modified residueⁱ	698	PhosphothreonineCombined sources	1
Modified residueⁱ	699	PhosphoserineCombined sources	1
Modified residueⁱ	703	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q8N350.
PeptideAtlas More...PeptideAtlasⁱ	Q8N350.
PRIDEⁱ	Q8N350.

PTM databases

iPTMnetⁱ	Q8N350.
PhosphoSitePlusⁱ	Q8N350.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000099625.
CleanExⁱ	HS_C19orf26.
ExpressionAtlasⁱ	Q8N350. baseline and differential.
Genevisibleⁱ	Q8N350. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012777.

HPAⁱ

HPA012777.

Interactionⁱ

Subunit structureⁱ

Interacts with voltage-dependent calcium channels CACNB1, CACNB2, CACNB3 and CACNB4 beta subunits; prevents their interaction with the CACNA1C alpha subunit thereby negatively regulating the activity of the corresponding calcium channels.By similarity

GO - Molecular functionⁱ

ion channel binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	129072. 9 interactors.
IntActⁱ	Q8N350. 2 interactors.
STRINGⁱ	9606.ENSP00000215376.

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	4 – 35	Thr-richPROSITE-ProRule annotationAdd BLAST		32

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009230.
HOGENOMⁱ	HOG000112250.
HOVERGENⁱ	HBG081461.
InParanoidⁱ	Q8N350.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0204.
TreeFamⁱ	TF331130.

Family and domain databases

InterProⁱ	View protein in InterPro IPR037658. CBARP.
PANTHERⁱ	PTHR28597. PTHR28597. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8N350-3) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPTATMATA ATTTTTTTAT VALTTSWDNA TGRPTAEPDP ILDNYVLLVV 
        60         70         80         90        100
VMSLFVGGTL VVLSGVLLLC KRCWDVHQRL NRAMEEAEKT TTTYLDNGTH 
       110        120        130        140        150
PAQDPDFRGE DPECQDAETE RFLSTSSTGR RVSFNEAALF EQSRKTQDKG 
       160        170        180        190        200
RRYTLTEGDF HHLKNARLTH LHLPPLKIVT IHECDSGEAS SATTPHPATS 
       210        220        230        240        250
PKATLAIFQP PGKALTGRSV GPSSALPGDP YNSAAGATDF AEISPSASSD 
       260        270        280        290        300
SGEGTSLDAG TRSTKAGGPG AAAGPGEAGP GSGAGTVLQF LTRLRRHASL 
       310        320        330        340        350
DGASPYFKVK KWKLEPSQRA ASLDTRGSPK RHHFQRQRAA SESTEQEEGD 
       360        370        380        390        400
APQEDFIQYI ARAGDAVAFP HPRPFLASPP PALGRLEAAE AAGGASPDSP 
       410        420        430        440        450
PERGAGSAGP EQQQPPLEPD AERDAGPEQA QTSYRDLWSL RASLELHAAA 
       460        470        480        490        500
SDHSSSGNDR DSVRSGDSSG SGSGGAAPAF PPPSPPAPRP KDGEARRLLQ 
       510        520        530        540        550
MDSGYASIEG RGAGDDTEPP AAPARPRSPR AWPRRPRRDY SIDEKTDALF 
       560        570        580        590        600
HEFLRHDPHF DDTPAAARHR ARAHPHARKQ WQRGRQHSDP GARAAPALAG 
       610        620        630        640        650
TPAPPAGAAR PARAPLRRGD SVDGPPDGRT LGGAGDDPAI PVIEEEPGGG 
       660        670        680        690        700
GCPGSGLCVL PSGSVLDKLA AGLDERLFPP RLAEPVVATP ALVAAAPTSP 

DHSPA

Note: Gene prediction based on EST data.

Length:705

Mass (Da):73,929

Last modified:March 16, 2016 - v3

Checksum:ⁱC116E348E8B7AD2B

GO

Isoform 2 (identifier: Q8N350-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
386-453: LEAAEAAGGA...LELHAAASDH → YFSVDGGARG...TRGGKQGETG
454-705: Missing.

« Hide

        10         20         30         40         50
MQPTATMATA ATTTTTTTAT VALTTSWDNA TGRPTAEPDP ILDNYVLLVV 
        60         70         80         90        100
VMSLFVGGTL VVLSGVLLLC KRCWDVHQRL NRAMEEAEKT TTTYLDNGTH 
       110        120        130        140        150
PAQDPDFRGE DPECQDAETE RFLSTSSTGR RVSFNEAALF EQSRKTQDKG 
       160        170        180        190        200
RRYTLTEGDF HHLKNARLTH LHLPPLKIVT IHECDSGEAS SATTPHPATS 
       210        220        230        240        250
PKATLAIFQP PGKALTGRSV GPSSALPGDP YNSAAGATDF AEISPSASSD 
       260        270        280        290        300
SGEGTSLDAG TRSTKAGGPG AAAGPGEAGP GSGAGTVLQF LTRLRRHASL 
       310        320        330        340        350
DGASPYFKVK KWKLEPSQRA ASLDTRGSPK RHHFQRQRAA SESTEQEEGD 
       360        370        380        390        400
APQEDFIQYI ARAGDAVAFP HPRPFLASPP PALGRYFSVD GGARGGPVGP 
       410        420        430        440        450
CPPSPPPRRP RERSPGPVDT RSPASSGKAP PRGGLTGATS PAWTRGGKQG 

ETG

Note: No experimental confirmation available.

Show »

Length:453

Mass (Da):47,719

Checksum:ⁱEDC4D167060D32CC

GO

Sequence cautionⁱ

The sequence AAC04305 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence AAH28156 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	256	S → L in AAH28156 (PubMed:15489334).Curated		1
Sequence conflictⁱ	371	H → R in AAH28156 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_058134	386 – 453	LEAAE…AASDH → YFSVDGGARGGPVGPCPPSP PPRRPRERSPGPVDTRSPAS SGKAPPRGGLTGATSPAWTR GGKQGETG in isoform 2. 1 PublicationAdd BLAST		68
Alternative sequenceⁱVSP_058135	454 – 705	Missing in isoform 2. 1 PublicationAdd BLAST		252

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004221 Genomic DNA. Translation: AAC04305.1. Sequence problems. BC028156 mRNA. Translation: AAH28156.1. Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12057.2. [Q8N350-4]
PIRⁱ	T00492.
NCBI Reference Sequences More...RefSeqⁱ	NP_689982.3. NM_152769.2. [Q8N350-4]
UniGeneⁱ	Hs.346575.

Genome annotation databases

Ensemblⁱ	ENST00000590083; ENSP00000465260; ENSG00000099625. [Q8N350-4]
GeneIDⁱ	255057.
KEGGⁱ	hsa:255057.
UCSC genome browser More...UCSCⁱ	uc002lrm.4. human. uc060qwp.1. human. [Q8N350-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8N350	UPI0007DC7E7E UPI00063ED3AC UPI0004F480D5 UPI00062AC81E F6QJ88 H0VDK7 A0A286XQT5 A0A1S3FNX8 Q8N350-4 UPI0007DC6613 +14	Homo sapiens (Human) Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Macaca mulatta (Rhesus macaque) Cavia porcellus (Guinea pig) Dipodomys ordii (Ord's kangaroo rat) Monodelphis domestica (Gray short-tailed opossum) Myotis lucifugus (Little brown bat) Felis catus (Cat) (Felis silvestris catus) And more	705	UniRef50_Q8N350	Cluster: Voltage-dependent calcium channel beta subunit-associated regulatory protein	25

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC004221 Genomic DNA. Translation: AAC04305.1. Sequence problems. BC028156 mRNA. Translation: AAH28156.1. Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12057.2. [Q8N350-4]
PIRⁱ	T00492.
NCBI Reference Sequences More...RefSeqⁱ	NP_689982.3. NM_152769.2. [Q8N350-4]
UniGeneⁱ	Hs.346575.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129072. 9 interactors.
IntActⁱ	Q8N350. 2 interactors.
STRINGⁱ	9606.ENSP00000215376.

PTM databases

iPTMnetⁱ	Q8N350.
PhosphoSitePlusⁱ	Q8N350.

Polymorphism and mutation databases

BioMutaⁱ	DOS.
DMDMⁱ	73919246.

Proteomic databases

PaxDbⁱ	Q8N350.
PeptideAtlas More...PeptideAtlasⁱ	Q8N350.
PRIDEⁱ	Q8N350.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	255057.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000590083; ENSP00000465260; ENSG00000099625. [Q8N350-4]
GeneIDⁱ	255057.
KEGGⁱ	hsa:255057.
UCSC genome browser More...UCSCⁱ	uc002lrm.4. human. uc060qwp.1. human. [Q8N350-3]

Organism-specific databases

CTDⁱ	255057.
DisGeNET More...DisGeNETⁱ	255057.
EuPathDBⁱ	HostDB:ENSG00000099625.12.
GeneCardsⁱ	CBARP.
H-InvDBⁱ	HIX0014574.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28617. CBARP.
Human Protein Atlas More...HPAⁱ	HPA012777.
neXtProtⁱ	NX_Q8N350.
Open Targets More...OpenTargetsⁱ	ENSG00000099625.
PharmGKBⁱ	PA134919853.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009230.
HOGENOMⁱ	HOG000112250.
HOVERGENⁱ	HBG081461.
InParanoidⁱ	Q8N350.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0204.
TreeFamⁱ	TF331130.

Miscellaneous databases

GenomeRNAiⁱ	255057.
Protein Ontology More...PROⁱ	PR:Q8N350.

Gene expression databases

Bgeeⁱ	ENSG00000099625.
CleanExⁱ	HS_C19orf26.
ExpressionAtlasⁱ	Q8N350. baseline and differential.
Genevisibleⁱ	Q8N350. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR037658. CBARP.
PANTHERⁱ	PTHR28597. PTHR28597. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CBARP_HUMAN
Accessionⁱ	Q8N350Primary (citable) accession number: Q8N350 Secondary accession number(s): K7EJP2, O43385
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	March 16, 2016
	Last modified:	February 28, 2018
	This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8N350 (CBARP_HUMAN)

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Voltage-dependent calcium channel beta subunit-associated regulatory protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ