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Protein

Voltage-dependent calcium channel beta subunit-associated regulatory protein

Gene

CBARP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subunits. Thereby, negatively regulates calcium channels activity at the plasma membrane and indirectly inhibits calcium-regulated exocytosis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent calcium channel beta subunit-associated regulatory proteinCurated
Gene namesi
Name:CBARPImported
Synonyms:C19orf26Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28617. CBARP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularBy similarityAdd BLAST45
Transmembranei46 – 66Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini67 – 705CytoplasmicBy similarityAdd BLAST639

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi255057.
OpenTargetsiENSG00000099625.
PharmGKBiPA134919853.

Polymorphism and mutation databases

BioMutaiDOS.
DMDMi73919246.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000799831 – 705Voltage-dependent calcium channel beta subunit-associated regulatory proteinAdd BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)By similarity1
Modified residuei299PhosphoserineCombined sources1
Modified residuei304PhosphoserineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei528PhosphoserineCombined sources1
Modified residuei621PhosphoserineBy similarity1
Modified residuei698PhosphothreonineCombined sources1
Modified residuei699PhosphoserineCombined sources1
Modified residuei703PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8N350.
PaxDbiK7EJP2.
PeptideAtlasiQ8N350.
PRIDEiQ8N350.

PTM databases

iPTMnetiQ8N350.
PhosphoSitePlusiQ8N350.

Expressioni

Gene expression databases

BgeeiENSG00000099625.
CleanExiHS_C19orf26.
ExpressionAtlasiQ8N350. baseline and differential.
GenevisibleiQ8N350. HS.

Organism-specific databases

HPAiHPA012777.

Interactioni

Subunit structurei

Interacts with voltage-dependent calcium channels CACNB1, CACNB2, CACNB3 and CACNB4 beta subunits; prevents their interaction with the CACNA1C alpha subunit thereby negatively regulating the activity of the corresponding calcium channels.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi129072. 8 interactors.
IntActiQ8N350. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8N350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 35Thr-richPROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000009230.
HOGENOMiHOG000112250.
HOVERGENiHBG081461.
InParanoidiQ8N350.
OrthoDBiEOG091G0204.
TreeFamiTF331130.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N350-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQPTATMATA ATTTTTTTAT VALTTSWDNA TGRPTAEPDP ILDNYVLLVV
60 70 80 90 100
VMSLFVGGTL VVLSGVLLLC KRCWDVHQRL NRAMEEAEKT TTTYLDNGTH
110 120 130 140 150
PAQDPDFRGE DPECQDAETE RFLSTSSTGR RVSFNEAALF EQSRKTQDKG
160 170 180 190 200
RRYTLTEGDF HHLKNARLTH LHLPPLKIVT IHECDSGEAS SATTPHPATS
210 220 230 240 250
PKATLAIFQP PGKALTGRSV GPSSALPGDP YNSAAGATDF AEISPSASSD
260 270 280 290 300
SGEGTSLDAG TRSTKAGGPG AAAGPGEAGP GSGAGTVLQF LTRLRRHASL
310 320 330 340 350
DGASPYFKVK KWKLEPSQRA ASLDTRGSPK RHHFQRQRAA SESTEQEEGD
360 370 380 390 400
APQEDFIQYI ARAGDAVAFP HPRPFLASPP PALGRLEAAE AAGGASPDSP
410 420 430 440 450
PERGAGSAGP EQQQPPLEPD AERDAGPEQA QTSYRDLWSL RASLELHAAA
460 470 480 490 500
SDHSSSGNDR DSVRSGDSSG SGSGGAAPAF PPPSPPAPRP KDGEARRLLQ
510 520 530 540 550
MDSGYASIEG RGAGDDTEPP AAPARPRSPR AWPRRPRRDY SIDEKTDALF
560 570 580 590 600
HEFLRHDPHF DDTPAAARHR ARAHPHARKQ WQRGRQHSDP GARAAPALAG
610 620 630 640 650
TPAPPAGAAR PARAPLRRGD SVDGPPDGRT LGGAGDDPAI PVIEEEPGGG
660 670 680 690 700
GCPGSGLCVL PSGSVLDKLA AGLDERLFPP RLAEPVVATP ALVAAAPTSP

DHSPA
Note: Gene prediction based on EST data.
Length:705
Mass (Da):73,929
Last modified:March 16, 2016 - v3
Checksum:iC116E348E8B7AD2B
GO
Isoform 2 (identifier: Q8N350-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-453: LEAAEAAGGA...LELHAAASDH → YFSVDGGARG...TRGGKQGETG
     454-705: Missing.

Note: No experimental confirmation available.
Show »
Length:453
Mass (Da):47,719
Checksum:iEDC4D167060D32CC
GO

Sequence cautioni

The sequence AAC04305 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH28156 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti256S → L in AAH28156 (PubMed:15489334).Curated1
Sequence conflicti371H → R in AAH28156 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058134386 – 453LEAAE…AASDH → YFSVDGGARGGPVGPCPPSP PPRRPRERSPGPVDTRSPAS SGKAPPRGGLTGATSPAWTR GGKQGETG in isoform 2. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_058135454 – 705Missing in isoform 2. 1 PublicationAdd BLAST252

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004221 Genomic DNA. Translation: AAC04305.1. Sequence problems.
BC028156 mRNA. Translation: AAH28156.1. Different initiation.
CCDSiCCDS12057.2. [Q8N350-4]
PIRiT00492.
RefSeqiNP_689982.3. NM_152769.2. [Q8N350-4]
UniGeneiHs.346575.

Genome annotation databases

EnsembliENST00000590083; ENSP00000465260; ENSG00000099625. [Q8N350-4]
GeneIDi255057.
KEGGihsa:255057.
UCSCiuc002lrm.4. human.
uc060qwp.1. human. [Q8N350-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004221 Genomic DNA. Translation: AAC04305.1. Sequence problems.
BC028156 mRNA. Translation: AAH28156.1. Different initiation.
CCDSiCCDS12057.2. [Q8N350-4]
PIRiT00492.
RefSeqiNP_689982.3. NM_152769.2. [Q8N350-4]
UniGeneiHs.346575.

3D structure databases

ProteinModelPortaliQ8N350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129072. 8 interactors.
IntActiQ8N350. 2 interactors.

PTM databases

iPTMnetiQ8N350.
PhosphoSitePlusiQ8N350.

Polymorphism and mutation databases

BioMutaiDOS.
DMDMi73919246.

Proteomic databases

EPDiQ8N350.
PaxDbiK7EJP2.
PeptideAtlasiQ8N350.
PRIDEiQ8N350.

Protocols and materials databases

DNASUi255057.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000590083; ENSP00000465260; ENSG00000099625. [Q8N350-4]
GeneIDi255057.
KEGGihsa:255057.
UCSCiuc002lrm.4. human.
uc060qwp.1. human. [Q8N350-3]

Organism-specific databases

CTDi255057.
DisGeNETi255057.
GeneCardsiC19orf26.
H-InvDBHIX0014574.
HGNCiHGNC:28617. CBARP.
HPAiHPA012777.
neXtProtiNX_Q8N350.
OpenTargetsiENSG00000099625.
PharmGKBiPA134919853.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000009230.
HOGENOMiHOG000112250.
HOVERGENiHBG081461.
InParanoidiQ8N350.
OrthoDBiEOG091G0204.
TreeFamiTF331130.

Miscellaneous databases

GenomeRNAii255057.
PROiQ8N350.

Gene expression databases

BgeeiENSG00000099625.
CleanExiHS_C19orf26.
ExpressionAtlasiQ8N350. baseline and differential.
GenevisibleiQ8N350. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCBARP_HUMAN
AccessioniPrimary (citable) accession number: Q8N350
Secondary accession number(s): K7EJP2, O43385
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 16, 2016
Last modified: November 2, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.