SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8N349

- OR2LD_HUMAN

UniProt

Q8N349 - OR2LD_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Olfactory receptor 2L13
Gene
OR2L13, OR2L14
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. protein binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2L13
Alternative name(s):
Olfactory receptor 2L14
Gene namesi
Name:OR2L13
Synonyms:OR2L14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:19578. OR2L13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Extracellular Reviewed prediction
Add
BLAST
Transmembranei25 – 4824Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini49 – 568Cytoplasmic Reviewed prediction
Transmembranei57 – 7822Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini79 – 9921Extracellular Reviewed prediction
Add
BLAST
Transmembranei100 – 11920Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini120 – 13819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei139 – 15719Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini158 – 19437Extracellular Reviewed prediction
Add
BLAST
Transmembranei195 – 21824Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini219 – 23517Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei236 – 25823Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini259 – 27113Extracellular Reviewed prediction
Add
BLAST
Transmembranei272 – 29120Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini292 – 31221Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982185.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2L13
PRO_0000150490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Glycosylationi20 – 201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 188 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8N349.
PRIDEiQ8N349.

PTM databases

PhosphoSiteiQ8N349.

Expressioni

Gene expression databases

BgeeiQ8N349.
CleanExiHS_OR2L13.
GenevestigatoriQ8N349.

Interactioni

Protein-protein interaction databases

BioGridi129891. 1 interaction.
STRINGi9606.ENSP00000350836.

Structurei

3D structure databases

ProteinModelPortaliQ8N349.
SMRiQ8N349. Positions 24-211.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44451.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8N349.
KOiK04257.
OMAiPKMVFNF.
OrthoDBiEOG7M0NRV.
PhylomeDBiQ8N349.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N349-1 [UniParc]FASTAAdd to Basket

« Hide

MEKWNHTSND FILLGLLPPN QTGIFLLCLI ILIFFLASVG NSAMIHLIHV    50
DPRLHTPMYF LLSQLSLMDL MYISTTVPKM AYNFLSGQKG ISFLGCGVQS 100
FFFLTMACSE GLLLTSMAYD RYLAICHSLY YPIRMSKMMC VKMIGGSWTL 150
GSINSLAHTV FALHIPYCRS RAIDHFFCDV PAMLLLACTD TWVYEYMVFV 200
STSLFLLFPF IGITSSCGRV LFAVYHMHSK EGRKKAFTTI STHLTVVIFY 250
YAPFVYTYLR PRNLRSPAED KILAVFYTIL TPMLNPIIYS LRNKEVLGAM 300
RRVFGIFSFL KE 312
Length:312
Mass (Da):35,634
Last modified:October 1, 2002 - v1
Checksum:i85AFE1D772F2A905
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561L → F.
Corresponds to variant rs12742561 [ dbSNP | Ensembl ].
VAR_053148
Natural varianti265 – 2651R → H.
Corresponds to variant rs45577033 [ dbSNP | Ensembl ].
VAR_062025

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513488 Genomic DNA. Translation: CAH70427.1.
BC028158 mRNA. Translation: AAH28158.1.
CCDSiCCDS1637.1.
RefSeqiNP_787107.1. NM_175911.2.
UniGeneiHs.372936.

Genome annotation databases

EnsembliENST00000358120; ENSP00000350836; ENSG00000196071.
ENST00000366478; ENSP00000355434; ENSG00000196071.
GeneIDi284521.
KEGGihsa:284521.
UCSCiuc001ids.3. human.

Polymorphism databases

DMDMi38372494.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513488 Genomic DNA. Translation: CAH70427.1 .
BC028158 mRNA. Translation: AAH28158.1 .
CCDSi CCDS1637.1.
RefSeqi NP_787107.1. NM_175911.2.
UniGenei Hs.372936.

3D structure databases

ProteinModelPortali Q8N349.
SMRi Q8N349. Positions 24-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129891. 1 interaction.
STRINGi 9606.ENSP00000350836.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8N349.

Polymorphism databases

DMDMi 38372494.

Proteomic databases

PaxDbi Q8N349.
PRIDEi Q8N349.

Protocols and materials databases

DNASUi 284521.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358120 ; ENSP00000350836 ; ENSG00000196071 .
ENST00000366478 ; ENSP00000355434 ; ENSG00000196071 .
GeneIDi 284521.
KEGGi hsa:284521.
UCSCi uc001ids.3. human.

Organism-specific databases

CTDi 284521.
GeneCardsi GC01P248100.
HGNCi HGNC:19578. OR2L13.
neXtProti NX_Q8N349.
PharmGKBi PA134982185.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44451.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8N349.
KOi K04257.
OMAi PKMVFNF.
OrthoDBi EOG7M0NRV.
PhylomeDBi Q8N349.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2L13.
GenomeRNAii 284521.
NextBioi 94937.
PROi Q8N349.

Gene expression databases

Bgeei Q8N349.
CleanExi HS_OR2L13.
Genevestigatori Q8N349.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiOR2LD_HUMAN
AccessioniPrimary (citable) accession number: Q8N349
Secondary accession number(s): Q5VUR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi