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Q8N349

- OR2LD_HUMAN

UniProt

Q8N349 - OR2LD_HUMAN

Protein

Olfactory receptor 2L13

Gene

OR2L13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro
    3. protein binding Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2L13
    Alternative name(s):
    Olfactory receptor 2L14
    Gene namesi
    Name:OR2L13
    Synonyms:OR2L14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:19578. OR2L13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134982185.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 2L13PRO_0000150490Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi20 – 201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8N349.
    PRIDEiQ8N349.

    PTM databases

    PhosphoSiteiQ8N349.

    Expressioni

    Gene expression databases

    BgeeiQ8N349.
    CleanExiHS_OR2L13.
    GenevestigatoriQ8N349.

    Interactioni

    Protein-protein interaction databases

    BioGridi129891. 1 interaction.
    STRINGi9606.ENSP00000350836.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N349.
    SMRiQ8N349. Positions 24-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44451.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8N349.
    KOiK04257.
    OMAiPKMVFNF.
    OrthoDBiEOG7M0NRV.
    PhylomeDBiQ8N349.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N349-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKWNHTSND FILLGLLPPN QTGIFLLCLI ILIFFLASVG NSAMIHLIHV    50
    DPRLHTPMYF LLSQLSLMDL MYISTTVPKM AYNFLSGQKG ISFLGCGVQS 100
    FFFLTMACSE GLLLTSMAYD RYLAICHSLY YPIRMSKMMC VKMIGGSWTL 150
    GSINSLAHTV FALHIPYCRS RAIDHFFCDV PAMLLLACTD TWVYEYMVFV 200
    STSLFLLFPF IGITSSCGRV LFAVYHMHSK EGRKKAFTTI STHLTVVIFY 250
    YAPFVYTYLR PRNLRSPAED KILAVFYTIL TPMLNPIIYS LRNKEVLGAM 300
    RRVFGIFSFL KE 312
    Length:312
    Mass (Da):35,634
    Last modified:October 1, 2002 - v1
    Checksum:i85AFE1D772F2A905
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti156 – 1561L → F.
    Corresponds to variant rs12742561 [ dbSNP | Ensembl ].
    VAR_053148
    Natural varianti265 – 2651R → H.
    Corresponds to variant rs45577033 [ dbSNP | Ensembl ].
    VAR_062025

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513488 Genomic DNA. Translation: CAH70427.1.
    BC028158 mRNA. Translation: AAH28158.1.
    CCDSiCCDS1637.1.
    RefSeqiNP_787107.1. NM_175911.2.
    UniGeneiHs.372936.

    Genome annotation databases

    EnsembliENST00000358120; ENSP00000350836; ENSG00000196071.
    ENST00000366478; ENSP00000355434; ENSG00000196071.
    GeneIDi284521.
    KEGGihsa:284521.
    UCSCiuc001ids.3. human.

    Polymorphism databases

    DMDMi38372494.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513488 Genomic DNA. Translation: CAH70427.1 .
    BC028158 mRNA. Translation: AAH28158.1 .
    CCDSi CCDS1637.1.
    RefSeqi NP_787107.1. NM_175911.2.
    UniGenei Hs.372936.

    3D structure databases

    ProteinModelPortali Q8N349.
    SMRi Q8N349. Positions 24-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129891. 1 interaction.
    STRINGi 9606.ENSP00000350836.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8N349.

    Polymorphism databases

    DMDMi 38372494.

    Proteomic databases

    PaxDbi Q8N349.
    PRIDEi Q8N349.

    Protocols and materials databases

    DNASUi 284521.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358120 ; ENSP00000350836 ; ENSG00000196071 .
    ENST00000366478 ; ENSP00000355434 ; ENSG00000196071 .
    GeneIDi 284521.
    KEGGi hsa:284521.
    UCSCi uc001ids.3. human.

    Organism-specific databases

    CTDi 284521.
    GeneCardsi GC01P248100.
    HGNCi HGNC:19578. OR2L13.
    neXtProti NX_Q8N349.
    PharmGKBi PA134982185.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44451.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8N349.
    KOi K04257.
    OMAi PKMVFNF.
    OrthoDBi EOG7M0NRV.
    PhylomeDBi Q8N349.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2L13.
    GenomeRNAii 284521.
    NextBioi 94937.
    PROi Q8N349.

    Gene expression databases

    Bgeei Q8N349.
    CleanExi HS_OR2L13.
    Genevestigatori Q8N349.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiOR2LD_HUMAN
    AccessioniPrimary (citable) accession number: Q8N349
    Secondary accession number(s): Q5VUR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3