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Q8N349 (OR2LD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2L13
Alternative name(s):
Olfactory receptor 2L14
Gene names
Name:OR2L13
Synonyms:OR2L14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 2L13
PRO_0000150490

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4824Helical; Name=1; Potential
Topological domain49 – 568Cytoplasmic Potential
Transmembrane57 – 7822Helical; Name=2; Potential
Topological domain79 – 9921Extracellular Potential
Transmembrane100 – 11920Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15719Helical; Name=4; Potential
Topological domain158 – 19437Extracellular Potential
Transmembrane195 – 21824Helical; Name=5; Potential
Topological domain219 – 23517Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29120Helical; Name=7; Potential
Topological domain292 – 31221Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation201N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 188 By similarity

Natural variations

Natural variant1561L → F.
Corresponds to variant rs12742561 [ dbSNP | Ensembl ].
VAR_053148
Natural variant2651R → H.
Corresponds to variant rs45577033 [ dbSNP | Ensembl ].
VAR_062025

Sequences

Sequence LengthMass (Da)Tools
Q8N349 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 85AFE1D772F2A905

FASTA31235,634
        10         20         30         40         50         60 
MEKWNHTSND FILLGLLPPN QTGIFLLCLI ILIFFLASVG NSAMIHLIHV DPRLHTPMYF 

        70         80         90        100        110        120 
LLSQLSLMDL MYISTTVPKM AYNFLSGQKG ISFLGCGVQS FFFLTMACSE GLLLTSMAYD 

       130        140        150        160        170        180 
RYLAICHSLY YPIRMSKMMC VKMIGGSWTL GSINSLAHTV FALHIPYCRS RAIDHFFCDV 

       190        200        210        220        230        240 
PAMLLLACTD TWVYEYMVFV STSLFLLFPF IGITSSCGRV LFAVYHMHSK EGRKKAFTTI 

       250        260        270        280        290        300 
STHLTVVIFY YAPFVYTYLR PRNLRSPAED KILAVFYTIL TPMLNPIIYS LRNKEVLGAM 

       310 
RRVFGIFSFL KE 

« Hide

References

[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL513488 Genomic DNA. Translation: CAH70427.1.
BC028158 mRNA. Translation: AAH28158.1.
CCDSCCDS1637.1.
RefSeqNP_787107.1. NM_175911.2.
UniGeneHs.372936.

3D structure databases

ProteinModelPortalQ8N349.
SMRQ8N349. Positions 24-211.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129891. 1 interaction.
STRING9606.ENSP00000350836.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8N349.

Polymorphism databases

DMDM38372494.

Proteomic databases

PaxDbQ8N349.
PRIDEQ8N349.

Protocols and materials databases

DNASU284521.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358120; ENSP00000350836; ENSG00000196071.
ENST00000366478; ENSP00000355434; ENSG00000196071.
GeneID284521.
KEGGhsa:284521.
UCSCuc001ids.3. human.

Organism-specific databases

CTD284521.
GeneCardsGC01P248100.
HGNCHGNC:19578. OR2L13.
neXtProtNX_Q8N349.
PharmGKBPA134982185.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44451.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8N349.
KOK04257.
OMAPKMVFNF.
OrthoDBEOG7M0NRV.
PhylomeDBQ8N349.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8N349.
CleanExHS_OR2L13.
GenevestigatorQ8N349.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2L13.
GenomeRNAi284521.
NextBio94937.
PROQ8N349.

Entry information

Entry nameOR2LD_HUMAN
AccessionPrimary (citable) accession number: Q8N349
Secondary accession number(s): Q5VUR5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries