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Protein

Mesoderm induction early response protein 2

Gene

MIER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mesoderm induction early response protein 2
Short name:
Mi-er2
Gene namesi
Name:MIER2
Synonyms:KIAA1193
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29210. MIER2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54531.
OpenTargetsiENSG00000105556.
PharmGKBiPA134925804.

Polymorphism and mutation databases

BioMutaiMIER2.
DMDMi74750947.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003136781 – 545Mesoderm induction early response protein 2Add BLAST545

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N344.
MaxQBiQ8N344.
PaxDbiQ8N344.
PeptideAtlasiQ8N344.
PRIDEiQ8N344.

PTM databases

iPTMnetiQ8N344.
PhosphoSitePlusiQ8N344.

Expressioni

Gene expression databases

BgeeiENSG00000105556.
CleanExiHS_MIER2.
ExpressionAtlasiQ8N344. baseline and differential.
GenevisibleiQ8N344. HS.

Organism-specific databases

HPAiHPA041439.
HPA043045.

Interactioni

Subunit structurei

Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.1 Publication

Protein-protein interaction databases

BioGridi120019. 31 interactors.
IntActiQ8N344. 5 interactors.
STRINGi9606.ENSP00000264819.

Structurei

3D structure databases

ProteinModelPortaliQ8N344.
SMRiQ8N344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 292ELM2PROSITE-ProRule annotationAdd BLAST98
Domaini297 – 349SANTPROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Contains 1 ELM2 domain.PROSITE-ProRule annotation
Contains 1 SANT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4329. Eukaryota.
ENOG410Y9DJ. LUCA.
GeneTreeiENSGT00510000046482.
HOGENOMiHOG000015798.
HOVERGENiHBG052923.
InParanoidiQ8N344.
OMAiWDPNILP.
OrthoDBiEOG091G0BKH.
PhylomeDBiQ8N344.
TreeFamiTF106453.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEASSLGRQ SPRVVSCLEH SLCPGEPGLQ TTAVVSMGSG DHQFNLAEIL
60 70 80 90 100
SQNYSVRGEC EEASRCPDKP KEELEKDFIS QSNDMPFDEL LALYGYEASD
110 120 130 140 150
PISDRESEGG DVAPNLPDMT LDKEQIAKDL LSGEEEEETQ SSADDLTPSV
160 170 180 190 200
TSHEASDLFP NRSGSRFLAD EDREPGSSAS SDTEEDSLPA NKCKKEIMVG
210 220 230 240 250
PQFQADLSNL HLNRHCEKIY ENEDQLLWDP SVLPEREVEE FLYRAVKRRW
260 270 280 290 300
HEMAGPQLPE GEAVKDSEQA LYELVKCNFN VEEALRRLRF NVKVIRDGLC
310 320 330 340 350
AWSEEECRNF EHGFRVHGKN FHLIQANKVR TRSVGECVEY YYLWKKSERY
360 370 380 390 400
DYFAQQTRLG RRKYVPSGTT DADQDLDGSD PDGPGRPRPE QDTLTGMRTD
410 420 430 440 450
PLSVDGTAGG LDEPGVASDG LPSSEPGPCS FQQLDESPAV PLSHRPPALA
460 470 480 490 500
DPASYQPAVT APEPDASPRL AVDFALPKEL PLISSHVDLS GDPEETVAPA
510 520 530 540
QVALSVTEFG LIGIGDVNPF LAAHPTCPAP GLHSEPLSHC NVMTC
Length:545
Mass (Da):59,944
Last modified:July 5, 2004 - v2
Checksum:i891526F8094F18D8
GO

Sequence cautioni

The sequence BAA86507 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03769568D → N.Corresponds to variant rs7507468dbSNPEnsembl.1
Natural variantiVAR_037696104D → N.Corresponds to variant rs10421231dbSNPEnsembl.1
Natural variantiVAR_037697464P → S.Corresponds to variant rs34129568dbSNPEnsembl.1
Natural variantiVAR_037698485S → G.Corresponds to variant rs35042658dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028203 mRNA. Translation: AAH28203.2.
AB033019 mRNA. Translation: BAA86507.2. Sequence problems.
CCDSiCCDS32855.1.
RefSeqiNP_060020.1. NM_017550.2.
UniGeneiHs.101891.

Genome annotation databases

EnsembliENST00000264819; ENSP00000264819; ENSG00000105556.
GeneIDi54531.
KEGGihsa:54531.
UCSCiuc002lok.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028203 mRNA. Translation: AAH28203.2.
AB033019 mRNA. Translation: BAA86507.2. Sequence problems.
CCDSiCCDS32855.1.
RefSeqiNP_060020.1. NM_017550.2.
UniGeneiHs.101891.

3D structure databases

ProteinModelPortaliQ8N344.
SMRiQ8N344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120019. 31 interactors.
IntActiQ8N344. 5 interactors.
STRINGi9606.ENSP00000264819.

PTM databases

iPTMnetiQ8N344.
PhosphoSitePlusiQ8N344.

Polymorphism and mutation databases

BioMutaiMIER2.
DMDMi74750947.

Proteomic databases

EPDiQ8N344.
MaxQBiQ8N344.
PaxDbiQ8N344.
PeptideAtlasiQ8N344.
PRIDEiQ8N344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264819; ENSP00000264819; ENSG00000105556.
GeneIDi54531.
KEGGihsa:54531.
UCSCiuc002lok.1. human.

Organism-specific databases

CTDi54531.
DisGeNETi54531.
GeneCardsiMIER2.
H-InvDBHIX0014549.
HGNCiHGNC:29210. MIER2.
HPAiHPA041439.
HPA043045.
neXtProtiNX_Q8N344.
OpenTargetsiENSG00000105556.
PharmGKBiPA134925804.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4329. Eukaryota.
ENOG410Y9DJ. LUCA.
GeneTreeiENSGT00510000046482.
HOGENOMiHOG000015798.
HOVERGENiHBG052923.
InParanoidiQ8N344.
OMAiWDPNILP.
OrthoDBiEOG091G0BKH.
PhylomeDBiQ8N344.
TreeFamiTF106453.

Miscellaneous databases

ChiTaRSiMIER2. human.
GenomeRNAii54531.
PROiQ8N344.

Gene expression databases

BgeeiENSG00000105556.
CleanExiHS_MIER2.
ExpressionAtlasiQ8N344. baseline and differential.
GenevisibleiQ8N344. HS.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIER2_HUMAN
AccessioniPrimary (citable) accession number: Q8N344
Secondary accession number(s): Q9ULM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.