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Protein

Metallothionein-1M

Gene

MT1M

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi5 – 51Divalent metal cation; cluster B
Metal bindingi7 – 71Divalent metal cation; cluster B
Metal bindingi13 – 131Divalent metal cation; cluster B
Metal bindingi15 – 151Divalent metal cation; cluster B
Metal bindingi19 – 191Divalent metal cation; cluster B
Metal bindingi21 – 211Divalent metal cation; cluster B
Metal bindingi24 – 241Divalent metal cation; cluster B
Metal bindingi26 – 261Divalent metal cation; cluster B
Metal bindingi29 – 291Divalent metal cation; cluster B
Metal bindingi33 – 331Divalent metal cation; cluster A
Metal bindingi34 – 341Divalent metal cation; cluster A
Metal bindingi36 – 361Divalent metal cation; cluster A
Metal bindingi37 – 371Divalent metal cation; cluster A
Metal bindingi41 – 411Divalent metal cation; cluster A
Metal bindingi44 – 441Divalent metal cation; cluster A
Metal bindingi48 – 481Divalent metal cation; cluster A
Metal bindingi50 – 501Divalent metal cation; cluster A
Metal bindingi57 – 571Divalent metal cation; cluster A
Metal bindingi59 – 591Divalent metal cation; cluster A
Metal bindingi60 – 601Divalent metal cation; cluster A

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Cadmium, Copper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231. Metallothioneins bind metals.

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1M
Short name:
MT-1M
Alternative name(s):
Metallothionein-IM
Short name:
MT-IM
Gene namesi
Name:MT1M
Synonyms:MT1K
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14296. MT1M.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671312.

Polymorphism and mutation databases

BioMutaiMT1M.
DMDMi88913543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6161Metallothionein-1MPRO_0000223180Add
BLAST

Proteomic databases

EPDiQ8N339.
PaxDbiQ8N339.
PRIDEiQ8N339.

PTM databases

iPTMnetiQ8N339.

Expressioni

Gene expression databases

BgeeiQ8N339.
CleanExiHS_MT1M.
ExpressionAtlasiQ8N339. baseline and differential.
GenevisibleiQ8N339. HS.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi110605. 2 interactions.
IntActiQ8N339. 1 interaction.
STRINGi9606.ENSP00000369146.

Structurei

3D structure databases

ProteinModelPortaliQ8N339.
SMRiQ8N339. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929BetaAdd
BLAST
Regioni30 – 6132AlphaAdd
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000236262.
HOVERGENiHBG009063.
InParanoidiQ8N339.
KOiK14739.
OMAiMCASSCK.
OrthoDBiEOG7PZS1X.
PhylomeDBiQ8N339.
TreeFamiTF336054.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCTTG VSCACTGSCT CKECKCTSCK KSCCSCCPVG CAKCAHGCVC
60
KGTLENCSCC A
Length:61
Mass (Da):6,110
Last modified:February 7, 2006 - v2
Checksum:i754753ED088411CE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201T → K.2 Publications
Corresponds to variant rs1827210 [ dbSNP | Ensembl ].
VAR_025310

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136177 mRNA. Translation: AAP97267.1.
AF348671 Genomic DNA. Translation: AAL83902.1.
BC028280 mRNA. Translation: AAH28280.1.
BC103841 mRNA. Translation: AAI03842.1.
CCDSiCCDS42166.1.
RefSeqiNP_789846.1. NM_176870.2.
UniGeneiHs.647370.

Genome annotation databases

EnsembliENST00000379818; ENSP00000369146; ENSG00000205364.
GeneIDi4499.
KEGGihsa:4499.
UCSCiuc002ejn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF136177 mRNA. Translation: AAP97267.1.
AF348671 Genomic DNA. Translation: AAL83902.1.
BC028280 mRNA. Translation: AAH28280.1.
BC103841 mRNA. Translation: AAI03842.1.
CCDSiCCDS42166.1.
RefSeqiNP_789846.1. NM_176870.2.
UniGeneiHs.647370.

3D structure databases

ProteinModelPortaliQ8N339.
SMRiQ8N339. Positions 1-61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110605. 2 interactions.
IntActiQ8N339. 1 interaction.
STRINGi9606.ENSP00000369146.

PTM databases

iPTMnetiQ8N339.

Polymorphism and mutation databases

BioMutaiMT1M.
DMDMi88913543.

Proteomic databases

EPDiQ8N339.
PaxDbiQ8N339.
PRIDEiQ8N339.

Protocols and materials databases

DNASUi4499.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379818; ENSP00000369146; ENSG00000205364.
GeneIDi4499.
KEGGihsa:4499.
UCSCiuc002ejn.4. human.

Organism-specific databases

CTDi4499.
GeneCardsiMT1M.
HGNCiHGNC:14296. MT1M.
MIMi156357. gene.
neXtProtiNX_Q8N339.
PharmGKBiPA142671312.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000236262.
HOVERGENiHBG009063.
InParanoidiQ8N339.
KOiK14739.
OMAiMCASSCK.
OrthoDBiEOG7PZS1X.
PhylomeDBiQ8N339.
TreeFamiTF336054.

Enzyme and pathway databases

ReactomeiR-HSA-5661231. Metallothioneins bind metals.

Miscellaneous databases

GeneWikiiMT1M.
GenomeRNAii4499.
PROiQ8N339.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N339.
CleanExiHS_MT1M.
ExpressionAtlasiQ8N339. baseline and differential.
GenevisibleiQ8N339. HS.

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR003019. Metalthion.
IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new human cDNA homologous to monkey metallothionein."
    Li N.G., Yu L., Zhao S.Y.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-20.
  2. "Cloning of a novel member of the MT gene family -- MT1M."
    Wang J., Yu L., Zhao S.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-20.
    Tissue: Colon.

Entry informationi

Entry nameiMT1M_HUMAN
AccessioniPrimary (citable) accession number: Q8N339
Secondary accession number(s): Q8TDN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 7, 2006
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Metallothioneins
    Classification of metallothioneins and list of entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.