Reviewed, UniProtKB/Swiss-Prot Q8N339 (MT1M_HUMAN)

Names and origin

Protein names

Recommended name:
    Metallothionein-1M
      Short name=MT-1M
Alternative name(s):
    Metallothionein-IM
      Short name=MT-IM

Gene names

Name:	MT1M
Synonyms:	MT1K

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Subunit structure	Monomer By similarity.
Domain	Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.
Sequence similarities	Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Cadmium Copper Metal-binding Metal-thiolate cluster Zinc
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	cadmium ion binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 61	61	Metallothionein-1M		PRO_0000223180
Regions
	Region	1 – 29	29	Beta
	Region	30 – 61	32	Alpha
Sites
	Metal binding	5	1	Cluster B
	Metal binding	7	1	Cluster B
	Metal binding	13	1	Cluster B
	Metal binding	15	1	Cluster B
	Metal binding	19	1	Cluster B
	Metal binding	21	1	Cluster B
	Metal binding	24	1	Cluster B
	Metal binding	26	1	Cluster B
	Metal binding	29	1	Cluster B
	Metal binding	33	1	Cluster A
	Metal binding	34	1	Cluster A
	Metal binding	36	1	Cluster A
	Metal binding	37	1	Cluster A
	Metal binding	41	1	Cluster A
	Metal binding	44	1	Cluster A
	Metal binding	48	1	Cluster A
	Metal binding	50	1	Cluster A
	Metal binding	57	1	Cluster A
	Metal binding	59	1	Cluster A
	Metal binding	60	1	Cluster A
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity
Natural variations
	Natural variant	20	1	T → K: dbSNP rs1827210. Ref.1 Ref.3		VAR_025310

Sequences

	Sequence		Length	Mass (Da)
	Q8N339-1 [UniParc]. Last modified February 7, 2006. Version 2. Checksum: 754753ED088411CE	FASTA	61	6,110
	10 20 30 40 50 60 MDPNCSCTTG VSCACTGSCT CKECKCTSCK KSCCSCCPVG CAKCAHGCVC KGTLENCSCC A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a new human cDNA homologous to monkey metallothionein." Li N.G., Yu L., Zhao S.Y. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-20.
[2]	"Cloning of a novel member of the MT gene family -- MT1M." Wang J., Yu L., Zhao S. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LYS-20. Tissue: Colon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF136177 mRNA. Translation: AAP97267.1. AF348671 Genomic DNA. Translation: AAL83902.1. BC028280 mRNA. Translation: AAH28280.1. BC103841 mRNA. Translation: AAI03842.1.
IPI	IPI00642651.
RefSeq	NP_789846.1.
UniGene	Hs.647370
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8N339.
Genome annotation databases
Ensembl	ENST00000379818; ENSP00000369146; ENSG00000205364; Homo sapiens. [Genome view]
GeneID	4499.
KEGG	hsa:4499.
UCSC	uc002ejn.1. human.
Organism-specific databases
CTD	4499.
GeneCards	GC16P055225.
HGNC	HGNC:14296. MT1M.
PharmGKB	PA142671312.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8N339.
InParanoid	Q8N339.
OMA	LENCSCC.
OrthoDB	EOG99W52G.
Gene expression databases
ArrayExpress	Q8N339.
Bgee	Q8N339.
CleanEx	HS_MT1M.
Genevestigator	Q8N339.
GermOnline	ENSG00000205364. Homo sapiens.
Family and domain databases
InterPro	IPR017854. Metallothionein_sfam. IPR003019. Metallothionein_sfam_euk. IPR000006. Metallothionein_vert. IPR018064. Metallothionein_vert_metal_BS. [Graphical view]
Gene3D	G3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
PANTHER	PTHR23299. Metallothionein_vert. 1 hit.
Pfam	PF00131. Metallothio. 1 hit. [Graphical view]
PRINTS	PR00860. MTVERTEBRATE.
PROSITE	PS00203. METALLOTHIONEIN_VRT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	17395.

Entry information

Entry name

MT1M_HUMAN

Accession

Primary (citable) accession number: Q8N339
Secondary accession number(s): Q8TDN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 7, 2006
Last sequence update:	February 7, 2006
Last modified:	December 15, 2009
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.