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Q8N335

- GPD1L_HUMAN

UniProt

Q8N335 - GPD1L_HUMAN

Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

GPD1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.2 Publications

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431NADBy similarity
    Binding sitei99 – 991NADBy similarity
    Binding sitei122 – 1221SubstrateBy similarity
    Binding sitei155 – 1551NAD; via amide nitrogen1 Publication
    Active sitei206 – 2061Proton acceptor
    Binding sitei271 – 2711NADBy similarity
    Binding sitei298 – 2981NAD; via amide nitrogen1 Publication
    Binding sitei300 – 3001NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176NAD1 Publication

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    2. ion channel binding Source: BHF-UCL
    3. NAD binding Source: InterPro
    4. sodium channel regulator activity Source: BHF-UCL

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cellular lipid metabolic process Source: Reactome
    3. glycerol-3-phosphate catabolic process Source: InterPro
    4. glycerophospholipid biosynthetic process Source: Reactome
    5. NADH metabolic process Source: Ensembl
    6. NAD metabolic process Source: BHF-UCL
    7. negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
    8. negative regulation of protein kinase C signaling Source: BHF-UCL
    9. phosphatidic acid biosynthetic process Source: Reactome
    10. phospholipid metabolic process Source: Reactome
    11. positive regulation of protein localization to cell surface Source: BHF-UCL
    12. positive regulation of sodium ion transport Source: BHF-UCL
    13. regulation of heart rate Source: BHF-UCL
    14. regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
    15. regulation of ventricular cardiac muscle cell membrane depolarization Source: BHF-UCL
    16. small molecule metabolic process Source: Reactome
    17. triglyceride biosynthetic process Source: Reactome
    18. ventricular cardiac muscle cell action potential Source: BHF-UCL

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    ReactomeiREACT_1190. Triglyceride Biosynthesis.
    REACT_120906. Synthesis of PA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
    Short name:
    GPD1-L
    Gene namesi
    Name:GPD1L
    Synonyms:KIAA0089
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:28956. GPD1L.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Localized to the region of the plasma membrane.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. glycerol-3-phosphate dehydrogenase complex Source: InterPro
    4. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Brugada syndrome 2 (BRGDA2) [MIM:611777]: A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti280 – 2801A → V in BRGDA2; decreased enzymatic activity; affects SCN5A membrane expression; reduction of sodium current when coexpressed with SCN5A in HEK cells. 1 Publication
    VAR_044047
    Sudden infant death syndrome (SIDS) [MIM:272120]: SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831E → K in SIDS; decreased enzymatic activity and significant reduction of sodium current when coexpressed with SCN5A in HEK cells. 1 Publication
    VAR_044044
    Natural varianti124 – 1241I → V in SIDS; significant reduction of sodium current when coexpressed with SCN5A in HEK cells. 1 Publication
    Corresponds to variant rs72552293 [ dbSNP | Ensembl ].
    VAR_044045
    Natural varianti273 – 2731R → C in SIDS; significant reduction of sodium current when coexpressed with SCN5A in HEK cells. 1 Publication
    VAR_044046

    Keywords - Diseasei

    Brugada syndrome, Disease mutation

    Organism-specific databases

    MIMi272120. phenotype.
    611777. phenotype.
    Orphaneti130. Brugada syndrome.
    PharmGKBiPA134986345.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Glycerol-3-phosphate dehydrogenase 1-like proteinPRO_0000286511Add
    BLAST

    Proteomic databases

    MaxQBiQ8N335.
    PaxDbiQ8N335.
    PeptideAtlasiQ8N335.
    PRIDEiQ8N335.

    PTM databases

    PhosphoSiteiQ8N335.

    Expressioni

    Tissue specificityi

    Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.1 Publication

    Gene expression databases

    ArrayExpressiQ8N335.
    BgeeiQ8N335.
    CleanExiHS_GPD1L.
    GenevestigatoriQ8N335.

    Organism-specific databases

    HPAiHPA035284.

    Interactioni

    Subunit structurei

    Interacts with SCN5A.2 Publications

    Protein-protein interaction databases

    BioGridi116783. 3 interactions.
    STRINGi9606.ENSP00000282541.

    Structurei

    Secondary structure

    1
    351
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi8 – 114
    Helixi15 – 2814
    Beta strandi38 – 414
    Helixi52 – 598
    Turni63 – 653
    Beta strandi75 – 795
    Helixi81 – 855
    Beta strandi89 – 935
    Helixi97 – 993
    Helixi100 – 1078
    Beta strandi116 – 1194
    Beta strandi124 – 1274
    Beta strandi130 – 1334
    Helixi134 – 1429
    Beta strandi144 – 1529
    Helixi155 – 1595
    Beta strandi164 – 1696
    Helixi173 – 18311
    Beta strandi188 – 1947
    Helixi196 – 21823
    Helixi223 – 24422
    Beta strandi245 – 2473
    Helixi251 – 2544
    Turni257 – 2593
    Helixi260 – 26910
    Helixi271 – 28212
    Helixi286 – 2949
    Helixi301 – 31515
    Helixi318 – 3203
    Helixi322 – 33211
    Helixi339 – 3457

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PLAX-ray2.51A/B1-349[»]
    ProteinModelPortaliQ8N335.
    SMRiQ8N335. Positions 4-346.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8N335.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni271 – 2722Substrate binding

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0240.
    HOGENOMiHOG000246855.
    HOVERGENiHBG003669.
    InParanoidiQ8N335.
    KOiK00006.
    OMAiKIFCKGQ.
    PhylomeDBiQ8N335.
    TreeFamiTF300836.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8N335-1 [UniParc]FASTAAdd to Basket

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    MAAAPLKVCI VGSGNWGSAV AKIIGNNVKK LQKFASTVKM WVFEETVNGR    50
    KLTDIINNDH ENVKYLPGHK LPENVVAMSN LSEAVQDADL LVFVIPHQFI 100
    HRICDEITGR VPKKALGITL IKGIDEGPEG LKLISDIIRE KMGIDISVLM 150
    GANIANEVAA EKFCETTIGS KVMENGLLFK ELLQTPNFRI TVVDDADTVE 200
    LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF ARIFCKGQVS 250
    TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KEMLNGQKLQ 300
    GPQTSAEVYR ILKQKGLLDK FPLFTAVYQI CYESRPVQEM LSCLQSHPEH 350
    T 351
    Length:351
    Mass (Da):38,419
    Last modified:October 1, 2002 - v1
    Checksum:i74C3B27EEB41DE89
    GO

    Sequence cautioni

    The sequence BAA07648.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831E → K in SIDS; decreased enzymatic activity and significant reduction of sodium current when coexpressed with SCN5A in HEK cells. 1 Publication
    VAR_044044
    Natural varianti124 – 1241I → V in SIDS; significant reduction of sodium current when coexpressed with SCN5A in HEK cells. 1 Publication
    Corresponds to variant rs72552293 [ dbSNP | Ensembl ].
    VAR_044045
    Natural varianti178 – 1781L → F.
    Corresponds to variant rs35447795 [ dbSNP | Ensembl ].
    VAR_032114
    Natural varianti273 – 2731R → C in SIDS; significant reduction of sodium current when coexpressed with SCN5A in HEK cells. 1 Publication
    VAR_044046
    Natural varianti280 – 2801A → V in BRGDA2; decreased enzymatic activity; affects SCN5A membrane expression; reduction of sodium current when coexpressed with SCN5A in HEK cells. 1 Publication
    VAR_044047

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D42047 mRNA. Translation: BAA07648.1. Different initiation.
    AK292808 mRNA. Translation: BAF85497.1.
    CH471055 Genomic DNA. Translation: EAW64422.1.
    BC006168 mRNA. Translation: AAH06168.1.
    BC028726 mRNA. Translation: AAH28726.1.
    CCDSiCCDS33729.1.
    RefSeqiNP_055956.1. NM_015141.3.
    UniGeneiHs.82432.

    Genome annotation databases

    EnsembliENST00000282541; ENSP00000282541; ENSG00000152642.
    GeneIDi23171.
    KEGGihsa:23171.
    UCSCiuc003cew.3. human.

    Polymorphism databases

    DMDMi74750945.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D42047 mRNA. Translation: BAA07648.1 . Different initiation.
    AK292808 mRNA. Translation: BAF85497.1 .
    CH471055 Genomic DNA. Translation: EAW64422.1 .
    BC006168 mRNA. Translation: AAH06168.1 .
    BC028726 mRNA. Translation: AAH28726.1 .
    CCDSi CCDS33729.1.
    RefSeqi NP_055956.1. NM_015141.3.
    UniGenei Hs.82432.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PLA X-ray 2.51 A/B 1-349 [» ]
    ProteinModelPortali Q8N335.
    SMRi Q8N335. Positions 4-346.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116783. 3 interactions.
    STRINGi 9606.ENSP00000282541.

    PTM databases

    PhosphoSitei Q8N335.

    Polymorphism databases

    DMDMi 74750945.

    Proteomic databases

    MaxQBi Q8N335.
    PaxDbi Q8N335.
    PeptideAtlasi Q8N335.
    PRIDEi Q8N335.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282541 ; ENSP00000282541 ; ENSG00000152642 .
    GeneIDi 23171.
    KEGGi hsa:23171.
    UCSCi uc003cew.3. human.

    Organism-specific databases

    CTDi 23171.
    GeneCardsi GC03P032123.
    GeneReviewsi GPD1L.
    HGNCi HGNC:28956. GPD1L.
    HPAi HPA035284.
    MIMi 272120. phenotype.
    611777. phenotype.
    611778. gene.
    neXtProti NX_Q8N335.
    Orphaneti 130. Brugada syndrome.
    PharmGKBi PA134986345.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0240.
    HOGENOMi HOG000246855.
    HOVERGENi HBG003669.
    InParanoidi Q8N335.
    KOi K00006.
    OMAi KIFCKGQ.
    PhylomeDBi Q8N335.
    TreeFami TF300836.

    Enzyme and pathway databases

    Reactomei REACT_1190. Triglyceride Biosynthesis.
    REACT_120906. Synthesis of PA.

    Miscellaneous databases

    ChiTaRSi GPD1L. human.
    EvolutionaryTracei Q8N335.
    GenomeRNAii 23171.
    NextBioi 44579.
    PROi Q8N335.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N335.
    Bgeei Q8N335.
    CleanExi HS_GPD1L.
    Genevestigatori Q8N335.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
      DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Placenta.
    5. "GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A."
      Valdivia C.R., Ueda K., Ackerman M.J., Makielski J.C.
      Am. J. Physiol. 297:H1446-H1452(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CHARACTERIZATION OF VARIANTS LYS-83 AND VAL-280, INTERACTION WITH SCN5A.
    6. Cited for: FUNCTION, CHARACTERIZATION OF VARIANT VAL-280.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein."
      Structural genomics consortium (SGC)
      Submitted (MAY-2007) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 1-349 IN COMPLEX WITH NAD AND PHOSPHATE IONS.
    9. "Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome."
      Van Norstrand D.W., Valdivia C.R., Tester D.J., Ueda K., London B., Makielski J.C., Ackerman M.J.
      Circulation 116:2253-2259(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SIDS LYS-83; VAL-124 AND CYS-273, CHARACTERIZATION OF VARIANTS SIDS LYS-83; VAL-124 AND CYS-273.
    10. "Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias."
      London B., Michalec M., Mehdi H., Zhu X., Kerchner L., Sanyal S., Viswanathan P.C., Pfahnl A.E., Shang L.L., Madhusudanan M., Baty C.J., Lagana S., Aleong R., Gutmann R., Ackerman M.J., McNamara D.M., Weiss R., Dudley S.C. Jr.
      Circulation 116:2260-2268(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT BRGDA2 VAL-280, CHARACTERIZATION OF VARIANT BRGDA2 VAL-280.

    Entry informationi

    Entry nameiGPD1L_HUMAN
    AccessioniPrimary (citable) accession number: Q8N335
    Secondary accession number(s): A8K9U3, Q14702, Q9BRM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3