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Protein

PiggyBac transposable element-derived protein 3

Gene

PGBD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.1 Publication

Miscellaneous

PGBD3 gene is located within ERCC6 intron 5.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PiggyBac transposable element-derived protein 3
Gene namesi
Name:PGBD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000243251.5.
HGNCiHGNC:19400. PGBD3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2074.
267004.
OpenTargetsiENSG00000225830.
PharmGKBiPA134927747.

Polymorphism and mutation databases

DMDMi296439278.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880541 – 593PiggyBac transposable element-derived protein 3Add BLAST593

Proteomic databases

EPDiQ8N328.
MaxQBiQ8N328.
PaxDbiQ8N328.
PeptideAtlasiQ8N328.
PRIDEiQ8N328.

PTM databases

iPTMnetiQ8N328.
PhosphoSitePlusiQ8N328.

Expressioni

Tissue specificityi

Expressed in heart and oocytes, but not in granulosa cells (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000243251.
ExpressionAtlasiQ8N328. baseline and differential.
GenevisibleiQ8N328. HS.

Organism-specific databases

HPAiHPA025825.

Interactioni

Protein-protein interaction databases

BioGridi129356. 3 interactors.
IntActiQ8N328. 1 interactor.
STRINGi9606.ENSP00000387966.

Structurei

3D structure databases

ProteinModelPortaliQ8N328.
SMRiQ8N328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00590000083118.
HOGENOMiHOG000168721.
HOVERGENiHBG059393.
InParanoidiQ8N328.
OrthoDBiEOG091G05IL.
TreeFamiTF328011.

Family and domain databases

InterProiView protein in InterPro
IPR029526. PGBD.
PfamiView protein in Pfam
PF13843. DDE_Tnp_1_7. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform PGBD3 (identifier: Q8N328-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRTLSLHEI TDLLETDDSI EASAIVIQPP ENATAPVSDE ESGDEEGGTI
60 70 80 90 100
NNLPGSLLHT AAYLIQDGSD AESDSDDPSY APKDDSPDEV PSTFTVQQPP
110 120 130 140 150
PSRRRKMTKI LCKWKKADLT VQPVAGRVTA PPNDFFTVMR TPTEILELFL
160 170 180 190 200
DDEVIELIVK YSNLYACSKG VHLGLTSSEF KCFLGIIFLS GYVSVPRRRM
210 220 230 240 250
FWEQRTDVHN VLVSAAMRRD RFETIFSNLH VADNANLDPV DKFSKLRPLI
260 270 280 290 300
SKLNERCMKF VPNETYFSFD EFMVPYFGRH GCKQFIRGKP IRFGYKFWCG
310 320 330 340 350
ATCLGYICWF QPYQGKNPNT KHEEYGVGAS LVLQFSEALT EAHPGQYHFV
360 370 380 390 400
FNNFFTSIAL LDKLSSMGHQ ATGTVRKDHI DRVPLESDVA LKKKERGTFD
410 420 430 440 450
YRIDGKGNIV CRWNDNSVVT VASSGAGIHP LCLVSRYSQK LKKKIQVQQP
460 470 480 490 500
NMIKVYNQFM GGVDRADENI DKYRASIRGK KWYSSPLLFC FELVLQNAWQ
510 520 530 540 550
LHKTYDEKPV DFLEFRRRVV CHYLETHGHP PEPGQKGRPQ KRNIDSRYDG
560 570 580 590
INHVIVKQGK QTRCAECHKN TTFRCEKCDV ALHVKCSVEY HTE
Length:593
Mass (Da):67,595
Last modified:May 18, 2010 - v3
Checksum:iB2387127F9A9A369
GO
Isoform CSB-PGBD31 Publication (identifier: P0DP91-1) [UniParc] [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0DP91.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by an alternative splicing event that joins the first 5 exons of ERCC6 gene in frame to the entire PGBD3 coding region, which is located within ERCC6 intron 5. The resulting chimeric protein consists of the N-terminal 465 residues of ERCC6 tethered to the entire PGBD3 sequence.1 Publication
Length:1,061
Mass (Da):119,487
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032391382R → K2 PublicationsCorresponds to variant dbSNP:rs4253072Ensembl.1
Natural variantiVAR_035621415D → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_051274446Q → E. Corresponds to variant dbSNP:rs11101143Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074682 mRNA. Translation: BAG51986.1.
AL138760 Genomic DNA. No translation available.
BC028954 mRNA. Translation: AAH28954.2.
BC063690 mRNA. Translation: AAH63690.1.
CCDSiCCDS7230.1. [Q8N328-1]
RefSeqiNP_736609.2. NM_170753.3.
UniGeneiHs.49063.

Genome annotation databases

GeneIDi267004.
KEGGihsa:267004.
UCSCiuc057tet.1. human. [Q8N328-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPGBD3_HUMAN
AccessioniPrimary (citable) accession number: Q8N328
Secondary accession number(s): B3KQC4, Q5W0M0, Q6PIH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: October 25, 2017
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot