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Protein

PiggyBac transposable element-derived protein 3

Gene

PGBD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-33238-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PiggyBac transposable element-derived protein 3
Gene namesi
Name:PGBD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:19400. PGBD3.

Pathology & Biotechi

Organism-specific databases

DisGeNETi267004.
OpenTargetsiENSG00000243251.
PharmGKBiPA134927747.

Polymorphism and mutation databases

DMDMi296439278.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880541 – 593PiggyBac transposable element-derived protein 3Add BLAST593

Proteomic databases

EPDiQ8N328.
MaxQBiQ8N328.
PaxDbiQ8N328.
PeptideAtlasiQ8N328.
PRIDEiQ8N328.

PTM databases

iPTMnetiQ8N328.
PhosphoSitePlusiQ8N328.

Expressioni

Gene expression databases

GenevisibleiQ8N328. HS.

Organism-specific databases

HPAiHPA025825.

Interactioni

Protein-protein interaction databases

BioGridi129356. 3 interactors.
IntActiQ8N328. 1 interactor.
STRINGi9606.ENSP00000387966.

Structurei

3D structure databases

ProteinModelPortaliQ8N328.
SMRiQ8N328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00530000063278.
HOGENOMiHOG000168721.
HOVERGENiHBG059393.
InParanoidiQ8N328.
OrthoDBiEOG091G05IL.
TreeFamiTF328011.

Family and domain databases

InterProiIPR029526. PGBD.
[Graphical view]
PfamiPF13843. DDE_Tnp_1_7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRTLSLHEI TDLLETDDSI EASAIVIQPP ENATAPVSDE ESGDEEGGTI
60 70 80 90 100
NNLPGSLLHT AAYLIQDGSD AESDSDDPSY APKDDSPDEV PSTFTVQQPP
110 120 130 140 150
PSRRRKMTKI LCKWKKADLT VQPVAGRVTA PPNDFFTVMR TPTEILELFL
160 170 180 190 200
DDEVIELIVK YSNLYACSKG VHLGLTSSEF KCFLGIIFLS GYVSVPRRRM
210 220 230 240 250
FWEQRTDVHN VLVSAAMRRD RFETIFSNLH VADNANLDPV DKFSKLRPLI
260 270 280 290 300
SKLNERCMKF VPNETYFSFD EFMVPYFGRH GCKQFIRGKP IRFGYKFWCG
310 320 330 340 350
ATCLGYICWF QPYQGKNPNT KHEEYGVGAS LVLQFSEALT EAHPGQYHFV
360 370 380 390 400
FNNFFTSIAL LDKLSSMGHQ ATGTVRKDHI DRVPLESDVA LKKKERGTFD
410 420 430 440 450
YRIDGKGNIV CRWNDNSVVT VASSGAGIHP LCLVSRYSQK LKKKIQVQQP
460 470 480 490 500
NMIKVYNQFM GGVDRADENI DKYRASIRGK KWYSSPLLFC FELVLQNAWQ
510 520 530 540 550
LHKTYDEKPV DFLEFRRRVV CHYLETHGHP PEPGQKGRPQ KRNIDSRYDG
560 570 580 590
INHVIVKQGK QTRCAECHKN TTFRCEKCDV ALHVKCSVEY HTE
Length:593
Mass (Da):67,595
Last modified:May 18, 2010 - v3
Checksum:iB2387127F9A9A369
GO

Sequence cautioni

The sequence AAH34479 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032391382R → K.2 PublicationsCorresponds to variant rs4253072dbSNPEnsembl.1
Natural variantiVAR_035621415D → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_051274446Q → E.Corresponds to variant rs11101143dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074682 mRNA. Translation: BAG51986.1.
AL138760 Genomic DNA. Translation: CAH70290.1.
BC028954 mRNA. Translation: AAH28954.2.
BC034479 mRNA. Translation: AAH34479.1. Different initiation.
BC063690 mRNA. Translation: AAH63690.1.
CCDSiCCDS7230.1.
RefSeqiNP_001263988.1. NM_001277059.1.
NP_736609.2. NM_170753.3.
UniGeneiHs.49063.

Genome annotation databases

EnsembliENST00000374127; ENSP00000363242; ENSG00000243251.
GeneIDi2074.
267004.
KEGGihsa:267004.
UCSCiuc057tet.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074682 mRNA. Translation: BAG51986.1.
AL138760 Genomic DNA. Translation: CAH70290.1.
BC028954 mRNA. Translation: AAH28954.2.
BC034479 mRNA. Translation: AAH34479.1. Different initiation.
BC063690 mRNA. Translation: AAH63690.1.
CCDSiCCDS7230.1.
RefSeqiNP_001263988.1. NM_001277059.1.
NP_736609.2. NM_170753.3.
UniGeneiHs.49063.

3D structure databases

ProteinModelPortaliQ8N328.
SMRiQ8N328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129356. 3 interactors.
IntActiQ8N328. 1 interactor.
STRINGi9606.ENSP00000387966.

PTM databases

iPTMnetiQ8N328.
PhosphoSitePlusiQ8N328.

Polymorphism and mutation databases

DMDMi296439278.

Proteomic databases

EPDiQ8N328.
MaxQBiQ8N328.
PaxDbiQ8N328.
PeptideAtlasiQ8N328.
PRIDEiQ8N328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374127; ENSP00000363242; ENSG00000243251.
GeneIDi2074.
267004.
KEGGihsa:267004.
UCSCiuc057tet.1. human.

Organism-specific databases

CTDi2074.
267004.
DisGeNETi267004.
GeneCardsiPGBD3.
HGNCiHGNC:19400. PGBD3.
HPAiHPA025825.
neXtProtiNX_Q8N328.
OpenTargetsiENSG00000243251.
PharmGKBiPA134927747.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHMN. Eukaryota.
ENOG410ZDPG. LUCA.
GeneTreeiENSGT00530000063278.
HOGENOMiHOG000168721.
HOVERGENiHBG059393.
InParanoidiQ8N328.
OrthoDBiEOG091G05IL.
TreeFamiTF328011.

Enzyme and pathway databases

BioCyciZFISH:G66-33238-MONOMER.

Miscellaneous databases

PROiQ8N328.

Gene expression databases

GenevisibleiQ8N328. HS.

Family and domain databases

InterProiIPR029526. PGBD.
[Graphical view]
PfamiPF13843. DDE_Tnp_1_7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGBD3_HUMAN
AccessioniPrimary (citable) accession number: Q8N328
Secondary accession number(s): B3KQC4, Q5W0M0, Q6PIH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.