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Protein

NXPE family member 1

Gene

NXPE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
NXPE family member 1
Alternative name(s):
Protein FAM55A
Gene namesi
Name:NXPE1
Synonyms:FAM55A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28527. NXPE1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910690.

Polymorphism and mutation databases

DMDMi160014059.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 547526NXPE family member 1PRO_0000307930Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence analysis
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8N323.
PRIDEiQ8N323.

PTM databases

iPTMnetiQ8N323.
PhosphoSiteiQ8N323.

Expressioni

Gene expression databases

BgeeiQ8N323.
ExpressionAtlasiQ8N323. baseline and differential.
GenevisibleiQ8N323. HS.

Organism-specific databases

HPAiHPA049133.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000251921.

Structurei

3D structure databases

ProteinModelPortaliQ8N323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NXPE family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF0E. Eukaryota.
ENOG410YBMF. LUCA.
GeneTreeiENSGT00530000062893.
HOGENOMiHOG000048706.
HOVERGENiHBG004824.
InParanoidiQ8N323.
OMAiCEYLDNR.
OrthoDBiEOG71ZP16.
PhylomeDBiQ8N323.
TreeFamiTF329555.

Family and domain databases

InterProiIPR014756. Ig_E-set.
IPR026845. NXPH/NXPE.
[Graphical view]
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N323-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSNTMLQKT LLILISFSVV TWMIFIISQN FTKLWSALNL SISVHYWNNS
60 70 80 90 100
AKSLFPKTSL IPLKPLTETE LRIKEIIEKL DQQIPPRPFT HVNTTTSATH
110 120 130 140 150
STATILNPRD TYCRGDQLDI LLEVRDHLGQ RKQYGGDFLR ARMSSPALTA
160 170 180 190 200
GASGKVMDFN NGTYLVSFTL FWEGQVSLSL LLIHPSEGAS ALWRARNQGY
210 220 230 240 250
DKIIFKGKFV NGTSHVFTEC GLTLNSNAEL CEYLDDRDQE AFYCMKPQHM
260 270 280 290 300
PCEALTYMTT RNREVSYLTD KENSLFHRSK VGVEMMKDRK HIDVTNCNKR
310 320 330 340 350
EKIEETCQVG MKPPVPGGYT LQGKWITTFC NQVQLDTIKI NGCLKGKLIY
360 370 380 390 400
LLGDSTLRQW IYYFPKVVKT LKFFDLHETG IFKKHLLLDA ERHTQIQWKK
410 420 430 440 450
HSYPFVTFQL YSLIDHDYIP REIDRLSGDK NTAIVITFGQ HFRPFPIDIF
460 470 480 490 500
IRRAIGVQKA IERLFLRSPA TKVIIKTENI REMHIETERF GDFHGYIHYL
510 520 530 540
IMKDIFKDLN VGIIDAWDMT IAYGTDTIHP PDHVIGNQIN MFLNYIC
Length:547
Mass (Da):63,178
Last modified:October 23, 2007 - v2
Checksum:iE4BA67FFD78F94AA
GO
Isoform 2 (identifier: Q8N323-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Show »
Length:405
Mass (Da):46,866
Checksum:iBD8B6D93A038BD6E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti491 – 4911G → V in AAH29049 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti353 – 3531G → R.
Corresponds to variant rs10891692 [ dbSNP | Ensembl ].
VAR_036712
Natural varianti423 – 4231I → T.
Corresponds to variant rs34993124 [ dbSNP | Ensembl ].
VAR_036713

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 142142Missing in isoform 2. 1 PublicationVSP_028872Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020549 Genomic DNA. No translation available.
EF444977 Genomic DNA. Translation: ACA05991.1.
CH471065 Genomic DNA. Translation: EAW67252.1.
BC029049 mRNA. Translation: AAH29049.1.
CCDSiCCDS8372.1. [Q8N323-2]
RefSeqiNP_689528.2. NM_152315.3. [Q8N323-2]
XP_011540896.1. XM_011542594.1. [Q8N323-1]
XP_011540897.1. XM_011542595.1. [Q8N323-1]
XP_011540898.1. XM_011542596.1. [Q8N323-1]
XP_011540899.1. XM_011542597.1. [Q8N323-1]
XP_011540900.1. XM_011542598.1. [Q8N323-1]
XP_011540901.1. XM_011542599.1. [Q8N323-1]
UniGeneiHs.721328.
Hs.735553.

Genome annotation databases

EnsembliENST00000251921; ENSP00000251921; ENSG00000095110. [Q8N323-2]
ENST00000424269; ENSP00000411690; ENSG00000095110. [Q8N323-1]
GeneIDi120400.
KEGGihsa:120400.
UCSCiuc001ppa.5. human. [Q8N323-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020549 Genomic DNA. No translation available.
EF444977 Genomic DNA. Translation: ACA05991.1.
CH471065 Genomic DNA. Translation: EAW67252.1.
BC029049 mRNA. Translation: AAH29049.1.
CCDSiCCDS8372.1. [Q8N323-2]
RefSeqiNP_689528.2. NM_152315.3. [Q8N323-2]
XP_011540896.1. XM_011542594.1. [Q8N323-1]
XP_011540897.1. XM_011542595.1. [Q8N323-1]
XP_011540898.1. XM_011542596.1. [Q8N323-1]
XP_011540899.1. XM_011542597.1. [Q8N323-1]
XP_011540900.1. XM_011542598.1. [Q8N323-1]
XP_011540901.1. XM_011542599.1. [Q8N323-1]
UniGeneiHs.721328.
Hs.735553.

3D structure databases

ProteinModelPortaliQ8N323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000251921.

PTM databases

iPTMnetiQ8N323.
PhosphoSiteiQ8N323.

Polymorphism and mutation databases

DMDMi160014059.

Proteomic databases

PaxDbiQ8N323.
PRIDEiQ8N323.

Protocols and materials databases

DNASUi120400.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251921; ENSP00000251921; ENSG00000095110. [Q8N323-2]
ENST00000424269; ENSP00000411690; ENSG00000095110. [Q8N323-1]
GeneIDi120400.
KEGGihsa:120400.
UCSCiuc001ppa.5. human. [Q8N323-1]

Organism-specific databases

CTDi120400.
GeneCardsiNXPE1.
HGNCiHGNC:28527. NXPE1.
HPAiHPA049133.
neXtProtiNX_Q8N323.
PharmGKBiPA134910690.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF0E. Eukaryota.
ENOG410YBMF. LUCA.
GeneTreeiENSGT00530000062893.
HOGENOMiHOG000048706.
HOVERGENiHBG004824.
InParanoidiQ8N323.
OMAiCEYLDNR.
OrthoDBiEOG71ZP16.
PhylomeDBiQ8N323.
TreeFamiTF329555.

Miscellaneous databases

GenomeRNAii120400.
PROiQ8N323.

Gene expression databases

BgeeiQ8N323.
ExpressionAtlasiQ8N323. baseline and differential.
GenevisibleiQ8N323. HS.

Family and domain databases

InterProiIPR014756. Ig_E-set.
IPR026845. NXPH/NXPE.
[Graphical view]
PfamiPF06312. Neurexophilin. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Colon.

Entry informationi

Entry nameiNXPE1_HUMAN
AccessioniPrimary (citable) accession number: Q8N323
Secondary accession number(s): B0YJ13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 8, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.