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Q8N307

- MUC20_HUMAN

UniProt

Q8N307 - MUC20_HUMAN

Protein

Mucin-20

Gene

MUC20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.1 Publication

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. cellular protein metabolic process Source: Reactome
    3. hepatocyte growth factor receptor signaling pathway Source: Ensembl
    4. O-glycan processing Source: Reactome
    5. post-translational protein modification Source: Reactome
    6. protein homooligomerization Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucin-20
    Short name:
    MUC-20
    Gene namesi
    Name:MUC20
    Synonyms:KIAA1359
    ORF Names:UNQ2782/PRO7170
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:23282. MUC20.

    Subcellular locationi

    Secreted Curated. Apical cell membrane 1 Publication. Basolateral cell membrane 1 Publication. Cell projectionmicrovillus membrane 1 Publication

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. basal plasma membrane Source: MGI
    3. extracellular region Source: UniProtKB-SubCell
    4. Golgi lumen Source: Reactome
    5. microvillus membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134939730.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 709684Mucin-20PRO_0000317469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi616 – 6161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi622 – 6221N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8N307.
    PRIDEiQ8N307.

    PTM databases

    PhosphoSiteiQ8N307.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis.2 Publications

    Gene expression databases

    ArrayExpressiQ8N307.
    BgeeiQ8N307.
    CleanExiHS_MUC20.
    GenevestigatoriQ8N307.

    Interactioni

    Subunit structurei

    Interacts with MET; oligomerization increases affinity for MET.1 Publication

    Protein-protein interaction databases

    BioGridi128360. 2 interactions.
    IntActiQ8N307. 2 interactions.
    STRINGi9606.ENSP00000396774.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati173 – 1922011 PublicationAdd
    BLAST
    Repeati193 – 2111921 PublicationAdd
    BLAST
    Repeati212 – 2301931 PublicationAdd
    BLAST
    Repeati231 – 2491941 PublicationAdd
    BLAST
    Repeati250 – 2681951 PublicationAdd
    BLAST
    Repeati269 – 2871961 PublicationAdd
    BLAST
    Repeati288 – 3061971 PublicationAdd
    BLAST
    Repeati307 – 3251981 PublicationAdd
    BLAST
    Repeati326 – 3441991 PublicationAdd
    BLAST
    Repeati345 – 36319101 PublicationAdd
    BLAST
    Repeati364 – 38219111 PublicationAdd
    BLAST
    Repeati383 – 4001812; approximate1 PublicationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni173 – 40022812 X 20 AA approximate tandem repeats of S-S-E-S-S-A-S-S-D-S-P-H-P-V-I-T-P-S-R-AAdd
    BLAST
    Regioni450 – 656207Involved in oligomerizationAdd
    BLAST
    Regioni657 – 70953Interaction with METAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi173 – 389217Ser-richAdd
    BLAST
    Compositional biasi585 – 65268Thr-richAdd
    BLAST

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG84731.
    HOVERGENiHBG108160.
    OrthoDBiEOG7HXCS0.
    PhylomeDBiQ8N307.
    TreeFamiTF338458.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N307-1) [UniParc]FASTAAdd to Basket

    Also known as: hMUC20-L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGCLWGLALP LFFFCWEVGV SGSSAGPSTR RADTAMTTDD TEVPAMTLAP    50
    GHAALETQTL SAETSSRAST PAGPIPEAET RGAKRISPAR ETRSFTKTSP 100
    NFMVLIATSV ETSAASGSPE GAGMTTVQTI TGSDPREAIF DTLCTDDSSE 150
    EAKTLTMDIL TLAHTSTEAK GLSSESSASS DSPHPVITPS RASESSASSD 200
    GPHPVITPSR ASESSASSDG PHPVITPSRA SESSASSDGP HPVITPSRAS 250
    ESSASSDGPH PVITPSRASE SSASSDGPHP VITPSRASES SASSDGPHPV 300
    ITPSRASESS ASSDGPHPVI TPSRASESSA SSDGPHPVIT PSRASESSAS 350
    SDGLHPVITP SRASESSASS DGPHPVITPS RASESSASSD GPHPVITPSW 400
    SPGSDVTLLA EALVTVTNIE VINCSITEIE TTTSSIPGAS DTDLIPTEGV 450
    KASSTSDPPA LPDSTEAKPH ITEVTASAET LSTAGTTESA APDATVGTPL 500
    PTNSATEREV TAPGATTLSG ALVTVSRNPL EETSALSVET PSYVKVSGAA 550
    PVSIEAGSAV GKTTSFAGSS ASSYSPSEAA LKNFTPSETP TMDIATKGPF 600
    PTSRDPLPSV PPTTTNSSRG TNSTLAKITT SAKTTMKPPT ATPTTARTRP 650
    TTDVSAGENG GFLLLRLSVA SPEDLTDPRV AERLMQQLHR ELHAHAPHFQ 700
    VSLLRVRRG 709
    Length:709
    Mass (Da):71,982
    Last modified:January 11, 2011 - v3
    Checksum:iDD344A6014D39172
    GO
    Isoform 2 (identifier: Q8N307-3) [UniParc]FASTAAdd to Basket

    Also known as: hMUC20-S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-35: Missing.

    Show »
    Length:674
    Mass (Da):68,308
    Checksum:i2834A68A1250F5E1
    GO

    Sequence cautioni

    The sequence BAA92597.1 differs from that shown. Reason: Dubious isoform. Probable cloning artifact.
    The sequence AAQ88814.1 differs from that shown. Reason: Frameshift at position 638.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751I → V in AAH29267. (PubMed:15489334)Curated
    Sequence conflicti136 – 1361R → E in BAD06718. (PubMed:14565953)Curated
    Sequence conflicti136 – 1361R → E in BAD06720. (PubMed:14565953)Curated
    Sequence conflicti136 – 1361R → E in AAQ88814. (PubMed:12975309)Curated
    Sequence conflicti136 – 1361R → E in BAB55035. (PubMed:14702039)Curated
    Sequence conflicti136 – 1361R → E in AAH29267. (PubMed:15489334)Curated
    Sequence conflicti136 – 1361R → E in AAH44243. (PubMed:15489334)Curated
    Sequence conflicti182 – 1821S → G in BAD06718. (PubMed:14565953)Curated
    Sequence conflicti182 – 1821S → G in BAD06720. (PubMed:14565953)Curated
    Sequence conflicti182 – 1821S → G in AAQ88814. (PubMed:12975309)Curated
    Sequence conflicti182 – 1821S → G in BAB55035. (PubMed:14702039)Curated
    Sequence conflicti182 – 1821S → G in AAH29267. (PubMed:15489334)Curated
    Sequence conflicti182 – 1821S → G in AAH44243. (PubMed:15489334)Curated
    Sequence conflicti221 – 2211P → L in BAA92597. (PubMed:10718198)Curated
    Sequence conflicti407 – 4071T → A in BAB55035. (PubMed:14702039)Curated
    Sequence conflicti433 – 4331T → A in BAC11428. (PubMed:14702039)Curated
    Sequence conflicti444 – 4441L → P in AAH29267. (PubMed:15489334)Curated
    Sequence conflicti493 – 4931D → H in BAD06718. (PubMed:14565953)Curated
    Sequence conflicti493 – 4931D → H in BAD06720. (PubMed:14565953)Curated
    Sequence conflicti493 – 4931D → H in AAQ88814. (PubMed:12975309)Curated
    Sequence conflicti493 – 4931D → H in BAC11428. (PubMed:14702039)Curated
    Sequence conflicti493 – 4931D → H in AAH44243. (PubMed:15489334)Curated
    Sequence conflicti496 – 4961V → I in AAH29267. (PubMed:15489334)Curated
    Sequence conflicti505 – 5062AT → TI in AAH29267. (PubMed:15489334)Curated
    Sequence conflicti523 – 5275VTVSR → ATG in AAH29267. (PubMed:15489334)Curated
    Sequence conflicti592 – 5921M → T in AAH29267. (PubMed:15489334)Curated
    Sequence conflicti654 – 6541V → M in AAH29267. (PubMed:15489334)Curated

    Polymorphismi

    The region encoding the tandem repeats is highly polymorphic. Divergence of the number of tandem repeats was seen in different cDNA libraries.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31C → S.
    Corresponds to variant rs7627924 [ dbSNP | Ensembl ].
    VAR_038536
    Natural varianti18 – 181V → G.
    Corresponds to variant rs1811139 [ dbSNP | Ensembl ].
    VAR_038537
    Natural varianti130 – 376247Missing.
    VAR_054139Add
    BLAST
    Natural varianti184 – 354171Missing.
    VAR_054140Add
    BLAST
    Natural varianti203 – 354152Missing.
    VAR_054141Add
    BLAST
    Natural varianti241 – 354114Missing.1 Publication
    VAR_054142Add
    BLAST
    Natural varianti442 – 4421T → I.4 Publications
    Corresponds to variant rs2550232 [ dbSNP | Ensembl ].
    VAR_038538
    Natural varianti483 – 53351Missing.
    VAR_054143Add
    BLAST
    Natural varianti514 – 5141G → R.
    Corresponds to variant rs3828410 [ dbSNP | Ensembl ].
    VAR_056641
    Natural varianti590 – 5901P → L.1 Publication
    Corresponds to variant rs3828408 [ dbSNP | Ensembl ].
    VAR_038539
    Natural varianti666 – 6661R → W.
    Corresponds to variant rs11923495 [ dbSNP | Ensembl ].
    VAR_038540
    Natural varianti671 – 6711S → C.
    Corresponds to variant rs3762739 [ dbSNP | Ensembl ].
    VAR_038541

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3535Missing in isoform 2. 1 PublicationVSP_030980Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB098731 mRNA. Translation: BAD06718.1.
    AB098733 Genomic DNA. Translation: BAD06720.1.
    AY358449 mRNA. Translation: AAQ88814.1. Frameshift.
    AK027314 mRNA. Translation: BAB55035.1.
    AK075138 mRNA. Translation: BAC11428.1.
    AC069513 Genomic DNA. No translation available.
    BC029267 mRNA. Translation: AAH29267.1.
    BC044243 mRNA. Translation: AAH44243.1.
    AB037780 mRNA. Translation: BAA92597.1. Sequence problems.
    CCDSiCCDS63877.1. [Q8N307-1]
    RefSeqiNP_001269435.1. NM_001282506.1. [Q8N307-1]
    NP_001278762.1. NM_001291833.1.
    NP_065841.1. NM_020790.1.
    NP_689886.3. NM_152673.3.
    UniGeneiHs.308992.

    Genome annotation databases

    EnsembliENST00000445522; ENSP00000405629; ENSG00000176945. [Q8N307-3]
    ENST00000447234; ENSP00000414350; ENSG00000176945. [Q8N307-1]
    GeneIDi200958.
    KEGGihsa:200958.

    Polymorphism databases

    DMDMi317373415.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Mucin database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB098731 mRNA. Translation: BAD06718.1 .
    AB098733 Genomic DNA. Translation: BAD06720.1 .
    AY358449 mRNA. Translation: AAQ88814.1 . Frameshift.
    AK027314 mRNA. Translation: BAB55035.1 .
    AK075138 mRNA. Translation: BAC11428.1 .
    AC069513 Genomic DNA. No translation available.
    BC029267 mRNA. Translation: AAH29267.1 .
    BC044243 mRNA. Translation: AAH44243.1 .
    AB037780 mRNA. Translation: BAA92597.1 . Sequence problems.
    CCDSi CCDS63877.1. [Q8N307-1 ]
    RefSeqi NP_001269435.1. NM_001282506.1. [Q8N307-1 ]
    NP_001278762.1. NM_001291833.1.
    NP_065841.1. NM_020790.1.
    NP_689886.3. NM_152673.3.
    UniGenei Hs.308992.

    3D structure databases

    ProteinModelPortali Q8N307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128360. 2 interactions.
    IntActi Q8N307. 2 interactions.
    STRINGi 9606.ENSP00000396774.

    PTM databases

    PhosphoSitei Q8N307.

    Polymorphism databases

    DMDMi 317373415.

    Proteomic databases

    PaxDbi Q8N307.
    PRIDEi Q8N307.

    Protocols and materials databases

    DNASUi 200958.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000445522 ; ENSP00000405629 ; ENSG00000176945 . [Q8N307-3 ]
    ENST00000447234 ; ENSP00000414350 ; ENSG00000176945 . [Q8N307-1 ]
    GeneIDi 200958.
    KEGGi hsa:200958.

    Organism-specific databases

    CTDi 200958.
    GeneCardsi GC03P195447.
    HGNCi HGNC:23282. MUC20.
    MIMi 610360. gene.
    neXtProti NX_Q8N307.
    PharmGKBi PA134939730.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84731.
    HOVERGENi HBG108160.
    OrthoDBi EOG7HXCS0.
    PhylomeDBi Q8N307.
    TreeFami TF338458.

    Enzyme and pathway databases

    Reactomei REACT_115606. O-linked glycosylation of mucins.
    REACT_115835. Termination of O-glycan biosynthesis.

    Miscellaneous databases

    GeneWikii MUC20.
    NextBioi 90029.
    PROi Q8N307.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N307.
    Bgeei Q8N307.
    CleanExi HS_MUC20.
    Genevestigatori Q8N307.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up-regulated in injured kidney."
      Higuchi T., Orita T., Nakanishi S., Katsuya K., Watanabe H., Yamasaki Y., Waga I., Nanayama T., Yamamoto Y., Munger W., Sun H.-W., Falk R.J., Jennette J.C., Alcorta D.A., Li H., Yamamoto T., Saito Y., Nakamura M.
      J. Biol. Chem. 279:1968-1979(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS 184-HIS--LEU-354 DEL; 241-HIS--LEU-354 DEL AND ILE-442, POLYMORPHISM, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Kidney.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS 184-HIS--LEU-354 DEL AND ILE-442.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS 184-HIS--LEU-354 DEL; ILE-442 AND 483-THR--THR-533 DEL.
      Tissue: Embryo and Placenta.
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS 184-HIS--LEU-354 DEL; 203-HIS--LEU-354; DEL ILE-442 AND LEU-590.
      Tissue: Brain and Colon.
    6. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-638 (ISOFORM 1), VARIANT 241-HIS--LEU-354 DEL.
      Tissue: Brain.
    7. "MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met."
      Higuchi T., Orita T., Katsuya K., Yamasaki Y., Akiyama K., Li H., Yamamoto T., Saito Y., Nakamura M.
      Mol. Cell. Biol. 24:7456-7468(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MET.
    8. "Tandem repeats polymorphism of MUC20 is an independent factor for the progression of immunoglobulin A nephropathy."
      Li G., Zhang H., Lv J., Hou P., Wang H.
      Am. J. Nephrol. 26:43-49(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TANDEM REPEATS POLYMORPHISM.
    9. "Mucin gene expression in human male urogenital tract epithelia."
      Russo C.L., Spurr-Michaud S., Tisdale A., Pudney J., Anderson D., Gipson I.K.
      Hum. Reprod. 21:2783-2793(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiMUC20_HUMAN
    AccessioniPrimary (citable) accession number: Q8N307
    Secondary accession number(s): Q6UX97
    , Q76I83, Q76I85, Q86ST8, Q8NBY6, Q96KA1, Q9P2I8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3