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Protein

Small vasohibin-binding protein

Gene

SVBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2.1 Publication

GO - Biological processi

  • negative regulation of endothelial cell migration Source: MGI
  • negative regulation of protein ubiquitination Source: MGI
  • protein secretion Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Small vasohibin-binding protein1 Publication
Alternative name(s):
Coiled coil domain-containing protein 23Imported
Gene namesi
Name:SVBP1 Publication
Synonyms:CCDC23Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29204. SVBP.

Subcellular locationi

  • Secreted By similarity

  • Note: Detected both intracellularly and extracellularly. Within cells, localizes mainly to the apical part of the cell.By similarity

GO - Cellular componenti

  • apical part of cell Source: MGI
  • extracellular region Source: UniProtKB-SubCell

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi374969.
OpenTargetsiENSG00000177868.
PharmGKBiPA142672181.

Polymorphism and mutation databases

BioMutaiCCDC23.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002336631 – 66Small vasohibin-binding proteinAdd BLAST66

Proteomic databases

EPDiQ8N300.
MaxQBiQ8N300.
PaxDbiQ8N300.
PeptideAtlasiQ8N300.
PRIDEiQ8N300.

PTM databases

iPTMnetiQ8N300.
PhosphoSitePlusiQ8N300.

Expressioni

Gene expression databases

BgeeiENSG00000177868.
CleanExiHS_CCDC23.
GenevisibleiQ8N300. HS.

Organism-specific databases

HPAiHPA008507.

Interactioni

Subunit structurei

Interacts with VASH1 and VASH2.1 Publication

Protein-protein interaction databases

BioGridi131942. 1 interactor.
STRINGi9606.ENSP00000361599.

Structurei

3D structure databases

ProteinModelPortaliQ8N300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 52Sequence analysisAdd BLAST48

Sequence similaritiesi

Belongs to the SVBP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J1TQ. Eukaryota.
ENOG410Y1K2. LUCA.
GeneTreeiENSGT00390000006113.
HOGENOMiHOG000231086.
HOVERGENiHBG080111.
InParanoidiQ8N300.
OMAiDRAKQKS.
OrthoDBiEOG091G15ZE.
PhylomeDBiQ8N300.
TreeFamiTF344015.

Family and domain databases

InterProiView protein in InterPro
IPR031378. SVBP.
PfamiView protein in Pfam
PF15674. CCDC23. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPPARKEKT KVKESVSRVE KAKQKSAQQE LKQRQRAEIY ALNRVMTELE
60
QQQFDEFCKQ MQPPGE
Length:66
Mass (Da):7,808
Last modified:October 1, 2002 - v1
Checksum:i9B128ABBF6ECD858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291356 mRNA. Translation: BAF84045.1.
AL512353, AC098484 Genomic DNA. Translation: CAH72714.1.
CH471059 Genomic DNA. Translation: EAX07134.1.
CH471059 Genomic DNA. Translation: EAX07135.1.
BC029427 mRNA. Translation: AAH29427.1.
CCDSiCCDS474.1.
RefSeqiNP_955374.1. NM_199342.3.
XP_016856715.1. XM_017001226.1.
UniGeneiHs.113919.

Genome annotation databases

EnsembliENST00000372521; ENSP00000361599; ENSG00000177868.
ENST00000372522; ENSP00000361600; ENSG00000177868.
GeneIDi374969.
KEGGihsa:374969.
UCSCiuc001cib.3. human.

Similar proteinsi

Entry informationi

Entry nameiSVBP_HUMAN
AccessioniPrimary (citable) accession number: Q8N300
Secondary accession number(s): A8K5P1, D3DPW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: August 30, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families