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Protein

Small vasohibin-binding protein

Gene

SVBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2.1 Publication

GO - Biological processi

  • negative regulation of endothelial cell migration Source: MGI
  • negative regulation of protein ubiquitination Source: MGI
  • protein secretion Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Small vasohibin-binding protein1 Publication
Alternative name(s):
Coiled coil domain-containing protein 23Imported
Gene namesi
Name:SVBP1 Publication
Synonyms:CCDC23Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29204. SVBP.

Subcellular locationi

  • Secreted By similarity

  • Note: Detected both intracellularly and extracellularly. Within cells, localizes mainly to the apical part of the cell.By similarity

GO - Cellular componenti

  • apical part of cell Source: MGI
  • extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672181.

Polymorphism and mutation databases

BioMutaiCCDC23.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Small vasohibin-binding proteinPRO_0000233663Add
BLAST

Proteomic databases

MaxQBiQ8N300.
PaxDbiQ8N300.
PRIDEiQ8N300.

PTM databases

PhosphoSiteiQ8N300.

Expressioni

Gene expression databases

BgeeiQ8N300.
CleanExiHS_CCDC23.
GenevisibleiQ8N300. HS.

Organism-specific databases

HPAiHPA008507.

Interactioni

Subunit structurei

Interacts with VASH1 and VASH2.1 Publication

Protein-protein interaction databases

BioGridi131942. 1 interaction.
STRINGi9606.ENSP00000361599.

Structurei

3D structure databases

ProteinModelPortaliQ8N300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili5 – 5248Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SVBP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J1TQ. Eukaryota.
ENOG410Y1K2. LUCA.
GeneTreeiENSGT00390000006113.
HOGENOMiHOG000231086.
HOVERGENiHBG080111.
InParanoidiQ8N300.
OMAiDRAKQKS.
OrthoDBiEOG7RBZCB.
PhylomeDBiQ8N300.
TreeFamiTF344015.

Family and domain databases

InterProiIPR031378. SVBP.
[Graphical view]
PfamiPF15674. CCDC23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPPARKEKT KVKESVSRVE KAKQKSAQQE LKQRQRAEIY ALNRVMTELE
60
QQQFDEFCKQ MQPPGE
Length:66
Mass (Da):7,808
Last modified:October 1, 2002 - v1
Checksum:i9B128ABBF6ECD858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291356 mRNA. Translation: BAF84045.1.
AL512353, AC098484 Genomic DNA. Translation: CAH72714.1.
CH471059 Genomic DNA. Translation: EAX07134.1.
CH471059 Genomic DNA. Translation: EAX07135.1.
BC029427 mRNA. Translation: AAH29427.1.
CCDSiCCDS474.1.
RefSeqiNP_955374.1. NM_199342.3.
UniGeneiHs.113919.

Genome annotation databases

EnsembliENST00000372521; ENSP00000361599; ENSG00000177868.
ENST00000372522; ENSP00000361600; ENSG00000177868.
GeneIDi374969.
KEGGihsa:374969.
UCSCiuc001cib.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291356 mRNA. Translation: BAF84045.1.
AL512353, AC098484 Genomic DNA. Translation: CAH72714.1.
CH471059 Genomic DNA. Translation: EAX07134.1.
CH471059 Genomic DNA. Translation: EAX07135.1.
BC029427 mRNA. Translation: AAH29427.1.
CCDSiCCDS474.1.
RefSeqiNP_955374.1. NM_199342.3.
UniGeneiHs.113919.

3D structure databases

ProteinModelPortaliQ8N300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131942. 1 interaction.
STRINGi9606.ENSP00000361599.

PTM databases

PhosphoSiteiQ8N300.

Polymorphism and mutation databases

BioMutaiCCDC23.

Proteomic databases

MaxQBiQ8N300.
PaxDbiQ8N300.
PRIDEiQ8N300.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372521; ENSP00000361599; ENSG00000177868.
ENST00000372522; ENSP00000361600; ENSG00000177868.
GeneIDi374969.
KEGGihsa:374969.
UCSCiuc001cib.3. human.

Organism-specific databases

CTDi374969.
GeneCardsiCCDC23.
HGNCiHGNC:29204. SVBP.
HPAiHPA008507.
neXtProtiNX_Q8N300.
PharmGKBiPA142672181.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1TQ. Eukaryota.
ENOG410Y1K2. LUCA.
GeneTreeiENSGT00390000006113.
HOGENOMiHOG000231086.
HOVERGENiHBG080111.
InParanoidiQ8N300.
OMAiDRAKQKS.
OrthoDBiEOG7RBZCB.
PhylomeDBiQ8N300.
TreeFamiTF344015.

Miscellaneous databases

ChiTaRSiCCDC23. human.
GenomeRNAii374969.
NextBioi100352.
PROiQ8N300.

Gene expression databases

BgeeiQ8N300.
CleanExiHS_CCDC23.
GenevisibleiQ8N300. HS.

Family and domain databases

InterProiIPR031378. SVBP.
[Graphical view]
PfamiPF15674. CCDC23. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Tissue: Brain.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion."
    Suzuki Y., Kobayashi M., Miyashita H., Ohta H., Sonoda H., Sato Y.
    J. Cell Sci. 123:3094-3101(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH VASH1 AND VASH2.

Entry informationi

Entry nameiSVBP_HUMAN
AccessioniPrimary (citable) accession number: Q8N300
Secondary accession number(s): A8K5P1, D3DPW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.