Reviewed, UniProtKB/Swiss-Prot Q8N2Z9 (CENPS_HUMAN)

Names and origin

Protein names

Recommended name:
    Centromere protein S
      Short name=CENP-S
Alternative name(s):
    Apoptosis-inducing TAF9-like domain-containing protein 1

Gene names

Name:	APITD1
Synonyms:	CENPS

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
Subunit structure	Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU.
Subcellular location	Nucleus. Centromere. Note= Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Tissue specificity	Ubiquitously expressed.
Sequence similarities	Belongs to the TAF9 family.

Ontologies

Keywords
Cellular component	Centromere Chromosomal protein Nucleus
Coding sequence diversity	Alternative splicing
Gene Ontology (GO)
Cellular component	chromosome, centromeric region Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N2Z9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N2Z9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     91-138: SLLKYITDKS...AEAGVVESEN → SLHMQEAAGI...FFWKTFSSCK

Notes: No experimental confirmation available.

Isoform 3 (identifier: Q8N2Z9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     70-77: RHAKRTTI → SICRKRQE
     78-138: Missing.

Notes: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	Centromere protein S		PRO_0000249477
Natural variations
	Alternative sequence	70 – 77	8	RHAKRTTI → SICRKRQE in isoform 3.		VSP_020432
	Alternative sequence	78 – 138	61	Missing in isoform 3.		VSP_020433
	Alternative sequence	91 – 138	48	SLLKY…VESEN → SLHMQEAAGIRKSSLLTFLA WWFEWTSQASAGPLIGEEAR EVARRQEGAPPQQSARRDRM PCRNFFWKTFSSCK in isoform 2.		VSP_020434

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: CBCD22CDDE213D87	FASTA	138	15,893
	10 20 30 40 50 60 MEEEAETEEQ QRFSYQQRLK AAVHYTVGCL CEEVALDKEM QFSKQTIAAI SELTFRQCEN 70 80 90 100 110 120 FAKDLEMFAR HAKRTTINTE DVKLLARRSN SLLKYITDKS EEIAQINLER KAQKKKKSED 130 GSKNSRQPAE AGVVESEN
	Isoform 2 [UniParc]. Checksum: 389682C41252426A		164	19,048
	10 20 30 40 50 60 MEEEAETEEQ QRFSYQQRLK AAVHYTVGCL CEEVALDKEM QFSKQTIAAI SELTFRQCEN 70 80 90 100 110 120 FAKDLEMFAR HAKRTTINTE DVKLLARRSN SLHMQEAAGI RKSSLLTFLA WWFEWTSQAS 130 140 150 160 AGPLIGEEAR EVARRQEGAP PQQSARRDRM PCRNFFWKTF SSCK
	Isoform 3 [UniParc]. Checksum: 447AD9A2366361C1		77	9,074
	10 20 30 40 50 60 MEEEAETEEQ QRFSYQQRLK AAVHYTVGCL CEEVALDKEM QFSKQTIAAI SELTFRQCEN 70 FAKDLEMFAS ICRKRQE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Cai Q., Guo J.H., Yu L. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[4]	"A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma tumours." Krona C., Ejeskaer K., Caren H., Abel F., Sjoeberg R.-M., Martinsson T. Br. J. Cancer 91:1119-1130(2004) [PubMed: 15328517] [Abstract] Cited for: TISSUE SPECIFICITY.
[5]	"The human CENP-A centromeric nucleosome-associated complex." Foltz D.R., Jansen L.E.T., Black B.E., Bailey A.O., Yates J.R. III, Cleveland D.W. Nat. Cell Biol. 8:458-469(2006) [PubMed: 16622419] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE CENPA-CAD COMPLEX WITH CENPI; CENPK; CENPL; CENPO; CENPP CENPQ AND CENPR.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF516753 mRNA. Translation: AAM61954.1. AF521016 mRNA. Translation: AAM70482.1. AL139424, AL354956 Genomic DNA. Translation: CAI95756.1. AL354956, AL139424 Genomic DNA. Translation: CAI19200.1. AL139424, AL354956 Genomic DNA. Translation: CAI95757.1. AL354956, AL139424 Genomic DNA. Translation: CAI19201.1. AL139424, AL354956 Genomic DNA. Translation: CAI95755.1. AL354956, AL139424 Genomic DNA. Translation: CAI19199.1. BC029430 mRNA. Translation: AAH29430.1.
RefSeq	NP_940946.1. NP_954988.1. NP_954992.1.
UniGene	Hs.412311
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q8N2Z9.
Genome annotation databases
Ensembl	ENSG00000175279. Homo sapiens. [Contig view]
GeneID	378708.
KEGG	hsa:378708.
NMPDR	fig|9606.3.peg.250.
Organism-specific databases
HGNC	HGNC:23163. APITD1.
MIM	609130. gene.
PharmGKB	PA134861614.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q8N2Z9.
Gene expression databases
ArrayExpress	Q8N2Z9.
GermOnline	ENSG00000175279. Homo sapiens.
Family and domain databases
BLOCKS	Search...
ProtoNet	Search...
Other Resources
NextBio	100737.
SOURCE	Search...

Entry information

Entry name

CENPS_HUMAN

Accession

Primary (citable) accession number: Q8N2Z9
Secondary accession number(s): Q8NFE5, Q8NFG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	October 1, 2002
Last modified:	November 4, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)