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Protein

Iporin

Gene

RUSC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Iporin
Alternative name(s):
Interacting protein of Rab1
RUN and SH3 domain-containing protein 2
Gene namesi
Name:RUSC2
Synonyms:KIAA0375
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23625. RUSC2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic vesicle Source: UniProtKB
  • cytosol Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134956488.

Polymorphism and mutation databases

BioMutaiRUSC2.
DMDMi317373513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15161516IporinPRO_0000097534Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei536 – 5361PhosphoserineCombined sources
Modified residuei543 – 5431PhosphoserineCombined sources
Modified residuei559 – 5591PhosphoserineCombined sources
Modified residuei656 – 6561PhosphoserineCombined sources
Modified residuei781 – 7811PhosphoserineCombined sources
Modified residuei1368 – 13681PhosphoserineCombined sources
Modified residuei1380 – 13801PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8N2Y8.
PaxDbiQ8N2Y8.
PeptideAtlasiQ8N2Y8.
PRIDEiQ8N2Y8.

PTM databases

iPTMnetiQ8N2Y8.
PhosphoSiteiQ8N2Y8.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in brain and testis.1 Publication

Gene expression databases

BgeeiENSG00000198853.
CleanExiHS_RUSC2.
GenevisibleiQ8N2Y8. HS.

Organism-specific databases

HPAiHPA021297.

Interactioni

Subunit structurei

Interacts with active RAB1A and RAB1B, and with GOLGA2.1 Publication

GO - Molecular functioni

  • Rab GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115187. 18 interactions.
IntActiQ8N2Y8. 20 interactions.
MINTiMINT-1343754.
STRINGi9606.ENSP00000355177.

Structurei

3D structure databases

ProteinModelPortaliQ8N2Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1031 – 1175145RUNPROSITE-ProRule annotationAdd
BLAST
Domaini1447 – 150660SH3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1239 – 124911Poly-GluAdd
BLAST

Domaini

The RUN domain is required for the interaction with RAB1A and RAB1B.

Sequence similaritiesi

Contains 1 RUN domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiENOG410IFB8. Eukaryota.
ENOG410XPGW. LUCA.
GeneTreeiENSGT00840000129820.
HOGENOMiHOG000133098.
HOVERGENiHBG059413.
InParanoidiQ8N2Y8.
OMAiNCRLNGQ.
OrthoDBiEOG091G0LEE.
PhylomeDBiQ8N2Y8.
TreeFamiTF332235.

Family and domain databases

InterProiIPR004012. Run_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF02759. RUN. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N2Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPPKLTGE TLIVHHIPLV HCQVPDRQCC GGAGGGGGST RPNPFCPPEL
60 70 80 90 100
GITQPDQDLG QADSLLFSSL HSTPGGTARS IDSTKSRSRD GRGPGAPKRH
110 120 130 140 150
NPFLLQEGVG EPGLGDLYDD SIGDSATQQS FHLHGTGQPN FHLSSFQLPP
160 170 180 190 200
SGPRVGRPWG TTRSRAGVVE GQEQEPVMTL DTQQCGTSHC CRPELEAETM
210 220 230 240 250
ELDECGGPGG SGSGGGASDT SGFSFDQEWK LSSDESPRNP GCSGSGDQHC
260 270 280 290 300
RCSSTSSQSE AADQSMGYVS DSSCNSSDGV LVTFSTLYNK MHGTPRANLN
310 320 330 340 350
SAPQSCSDSS FCSHSDPGAF YLDLQPSPFE SKMSYESHHP ESGGREGGYG
360 370 380 390 400
CPHASSPELD ANCNSYRPHC EPCPAVADLT ACFQSQARLV VATQNYYKLV
410 420 430 440 450
TCDLSSQSSP SPAGSSITSC SEEHTKISPP PGPGPDPGPS QPSEYYLFQK
460 470 480 490 500
PEVQPEEQEA VSSSTQAAAA VGPTVLEGQV YTNTSPPNLS TGRQRSRSYD
510 520 530 540 550
RSLQRSPPVR LGSLERMLSC PVRLSEGPAA MAGPGSPPRR VTSFAELAKG
560 570 580 590 600
RKKTGGSGSP PLRVSVGDSS QEFSPIQEAQ QDRGAPLDEG TCCSHSLPPM
610 620 630 640 650
PLGPGMDLLG PDPSPPWSTQ VCQGPHSSEM PPAGLRATGQ GPLAQLMDPG
660 670 680 690 700
PALPGSPANS HTQRDARARA DGGGTESRPV LRYSKEQRPT TLPIQPFVFQ
710 720 730 740 750
HHFPKQLAKA RALHSLSQLY SLSGCSRTQQ PAPLAAPAAQ VSVPAPSGEP
760 770 780 790 800
QASTPRATGR GARKAGSEPE TSRPSPLGSY SPIRSVGPFG PSTDSSASTS
810 820 830 840 850
CSPPPEQPTA TESLPPWSHS CPSAVRPATS QQPQKEDQKI LTLTEYRLHG
860 870 880 890 900
TGSLPPLGSW RSGLSRAESL ARGGGEGSMA TRPSNANHLS PQALKWREYR
910 920 930 940 950
RKNPLGPPGL SGSLDRRSQE ARLARRNPIF EFPGSLSAAS HLNCRLNGQA
960 970 980 990 1000
VKPLPLTCPD FQDPFSLTEK PPAEFCLSPD GSSEAISIDL LQKKGLVKAV
1010 1020 1030 1040 1050
NIAVDLIVAH FGTSRDPGVK AKLGNSSVSP NVGHLVLKYL CPAVRAVLED
1060 1070 1080 1090 1100
GLKAFVLDVI IGQRKNMPWS VVEASTQLGP STKVLHGLYN KVSQFPELTS
1110 1120 1130 1140 1150
HTMRFNAFIL GLLNIRSLEF WFNHLYNHED IIQTHYQPWG FLSAAHTVCP
1160 1170 1180 1190 1200
GLFEELLLLL QPLALLPFSL DLLFQHRLLQ SGQQQRQHKE LLRVSQDLLL
1210 1220 1230 1240 1250
SAHSTLQLAR ARGQEGPGDV DRAAQGERVK GVGASEGGEE EEEEEETEEV
1260 1270 1280 1290 1300
AEAAGGSGRA RWARGGQAGW WYQLMQSSQV YIDGSIEGSR FPRGSSNSSS
1310 1320 1330 1340 1350
EKKKGAGGGG PPQAPPPREG VVEGAEACPA SEEALGRERG WPFWMGSPPD
1360 1370 1380 1390 1400
SVLAELRRSR EREGPAASPA ENEEGASEPS PGGIKWGHLF GSRKAQREAR
1410 1420 1430 1440 1450
PTNRLPSDWL SLDKSMFQLV AQTVGSRREP EPKESLQEPH SPALPSSPPC
1460 1470 1480 1490 1500
EVQALCHHLA TGPGQLSFHK GDILRVLGRA GGDWLRCSRG PDSGLVPLAY
1510
VTLTPTPSPT PGSSQN
Length:1,516
Mass (Da):161,225
Last modified:January 11, 2011 - v3
Checksum:iE96E1180A1E18CF8
GO

Sequence cautioni

The sequence BAA20830 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731T → A.3 Publications
Corresponds to variant rs1535422 [ dbSNP | Ensembl ].
VAR_034653
Natural varianti654 – 6541P → L.
Corresponds to variant rs3750427 [ dbSNP | Ensembl ].
VAR_034654

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002373 mRNA. Translation: BAA20830.2. Different initiation.
AL133476 Genomic DNA. Translation: CAH70650.1.
CH471071 Genomic DNA. Translation: EAW58377.1.
BC029647 mRNA. Translation: AAH29647.1.
BC064843 mRNA. Translation: AAH64843.1.
BC082245 mRNA. Translation: AAH82245.1.
BC132766 mRNA. Translation: AAI32767.1.
BC132770 mRNA. Translation: AAI32771.1.
BC146654 mRNA. Translation: AAI46655.1.
BC150262 mRNA. Translation: AAI50263.1.
CCDSiCCDS35008.1.
RefSeqiNP_001129471.1. NM_001135999.1.
NP_055621.1. NM_014806.3.
UniGeneiHs.493796.

Genome annotation databases

EnsembliENST00000361226; ENSP00000355177; ENSG00000198853.
ENST00000455600; ENSP00000393922; ENSG00000198853.
GeneIDi9853.
KEGGihsa:9853.
UCSCiuc003zww.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002373 mRNA. Translation: BAA20830.2. Different initiation.
AL133476 Genomic DNA. Translation: CAH70650.1.
CH471071 Genomic DNA. Translation: EAW58377.1.
BC029647 mRNA. Translation: AAH29647.1.
BC064843 mRNA. Translation: AAH64843.1.
BC082245 mRNA. Translation: AAH82245.1.
BC132766 mRNA. Translation: AAI32767.1.
BC132770 mRNA. Translation: AAI32771.1.
BC146654 mRNA. Translation: AAI46655.1.
BC150262 mRNA. Translation: AAI50263.1.
CCDSiCCDS35008.1.
RefSeqiNP_001129471.1. NM_001135999.1.
NP_055621.1. NM_014806.3.
UniGeneiHs.493796.

3D structure databases

ProteinModelPortaliQ8N2Y8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115187. 18 interactions.
IntActiQ8N2Y8. 20 interactions.
MINTiMINT-1343754.
STRINGi9606.ENSP00000355177.

PTM databases

iPTMnetiQ8N2Y8.
PhosphoSiteiQ8N2Y8.

Polymorphism and mutation databases

BioMutaiRUSC2.
DMDMi317373513.

Proteomic databases

MaxQBiQ8N2Y8.
PaxDbiQ8N2Y8.
PeptideAtlasiQ8N2Y8.
PRIDEiQ8N2Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361226; ENSP00000355177; ENSG00000198853.
ENST00000455600; ENSP00000393922; ENSG00000198853.
GeneIDi9853.
KEGGihsa:9853.
UCSCiuc003zww.4. human.

Organism-specific databases

CTDi9853.
GeneCardsiRUSC2.
HGNCiHGNC:23625. RUSC2.
HPAiHPA021297.
MIMi611053. gene.
neXtProtiNX_Q8N2Y8.
PharmGKBiPA134956488.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFB8. Eukaryota.
ENOG410XPGW. LUCA.
GeneTreeiENSGT00840000129820.
HOGENOMiHOG000133098.
HOVERGENiHBG059413.
InParanoidiQ8N2Y8.
OMAiNCRLNGQ.
OrthoDBiEOG091G0LEE.
PhylomeDBiQ8N2Y8.
TreeFamiTF332235.

Miscellaneous databases

ChiTaRSiRUSC2. human.
GenomeRNAii9853.
PROiQ8N2Y8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198853.
CleanExiHS_RUSC2.
GenevisibleiQ8N2Y8. HS.

Family and domain databases

InterProiIPR004012. Run_dom.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF02759. RUN. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRUSC2_HUMAN
AccessioniPrimary (citable) accession number: Q8N2Y8
Secondary accession number(s): A2RU62
, A7E2A9, O15080, Q5W134, Q641Q6, Q6P1W7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.