ID   Q8N2W7_HUMAN            Unreviewed;       413 AA.
AC   Q8N2W7;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Chordin {ECO:0000256|ARBA:ARBA00016968};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAH29879.1};
RN   [1] {ECO:0000313|EMBL:AAH29879.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AAH29879.1};
RA   Strausberg R.;
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC029879; AAH29879.1; -; mRNA.
DR   RefSeq; NP_001291401.1; NM_001304472.1.
DR   RefSeq; NP_001291402.1; NM_001304473.1.
DR   RefSeq; NP_001291403.1; NM_001304474.1.
DR   RefSeq; NP_003732.2; NM_003741.3.
DR   AlphaFoldDB; Q8N2W7; -.
DR   PeptideAtlas; Q8N2W7; -.
DR   DNASU; 8646; -.
DR   GeneID; 8646; -.
DR   KEGG; hsa:8646; -.
DR   CTD; 8646; -.
DR   OrthoDB; 3039493at2759; -.
DR   BioGRID-ORCS; 8646; 17 hits in 1146 CRISPR screens.
DR   GenomeRNAi; 8646; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   Gene3D; 6.20.200.20; -; 2.
DR   InterPro; IPR010895; CHRD.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR46526; CHORDIN; 1.
DR   PANTHER; PTHR46526:SF1; CHORDIN; 1.
DR   Pfam; PF07452; CHRD; 1.
DR   Pfam; PF00093; VWC; 2.
DR   SMART; SM00754; CHRD; 1.
DR   SMART; SM00214; VWC; 3.
DR   SUPFAM; SSF57603; FnI-like domain; 3.
DR   PROSITE; PS50933; CHRD; 1.
DR   PROSITE; PS01208; VWFC_1; 2.
DR   PROSITE; PS50184; VWFC_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473, ECO:0000256|PROSITE-
KW   ProRule:PRU00230}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          1..108
FT                   /note="CHRD"
FT                   /evidence="ECO:0000259|PROSITE:PS50933"
FT   DOMAIN          161..221
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   REGION          133..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..155
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAH29879.1"
SQ   SEQUENCE   413 AA;  43822 MW;  FCED20584BEE0E06 CRC64;
     VLPPVKSQAA GHAWLSLDTH CHLHYEVLLA GLGGSEQGTV TAHLLGPPGT PGPRRLLKGF
     YGSEAQGVVK DLEPELLRHL AKGMASLMIT TKGSPRGELR GQVHIANQCE VGGLRLEAAG
     AEGVRALGAP DTASAAPPVV PGLPALAPAK PGGPGRPRDP NTCFFEGQQR PHGARWAPNY
     DPLCSLCTCQ RRTVICDPVV CPPPSCPHPV QAPDQCCPVC PEKQDVRDLP GLPRSRDPGE
     GCYFDGDRSW RAAGTRWHPV VPPFGLIKCA VCTCKGGTGE VHCEKVQCPR LACAQPVRVN
     PTDCCKQCPV GSGAHPQLGD PMQADGPRGC RFAGQWFPES QSWHPSVPPF GEMSCITCRC
     GAGVPHCERD DCSLPLSCGS GKESRCCSRC TAHRRPAPET RTDPELEKEA EGS
//