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Protein

Transmembrane protein 256

Gene

TMEM256

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31870-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 256
Gene namesi
Name:TMEM256
Synonyms:C17orf61
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28618. TMEM256.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 63ExtracellularSequence analysisAdd BLAST34
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 92CytoplasmicSequence analysis8
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205544.
PharmGKBiPA142672244.

Polymorphism and mutation databases

BioMutaiTMEM256.
DMDMi74728725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000028717030 – 113Transmembrane protein 256Add BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8N2U0.
MaxQBiQ8N2U0.
PaxDbiQ8N2U0.
PeptideAtlasiQ8N2U0.
PRIDEiQ8N2U0.
TopDownProteomicsiQ8N2U0.

PTM databases

iPTMnetiQ8N2U0.
PhosphoSitePlusiQ8N2U0.

Expressioni

Gene expression databases

BgeeiENSG00000205544.
CleanExiHS_C17orf61.
ExpressionAtlasiQ8N2U0. baseline and differential.
GenevisibleiQ8N2U0. HS.

Organism-specific databases

HPAiHPA062732.

Interactioni

Protein-protein interaction databases

BioGridi129054. 13 interactors.
IntActiQ8N2U0. 10 interactors.
STRINGi9606.ENSP00000301939.

Structurei

3D structure databases

ProteinModelPortaliQ8N2U0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM256 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3472. Eukaryota.
ENOG41125SJ. LUCA.
GeneTreeiENSGT00390000000334.
HOGENOMiHOG000252654.
HOVERGENiHBG095157.
InParanoidiQ8N2U0.
OMAiDWAAYLF.
OrthoDBiEOG091G16GE.
PhylomeDBiQ8N2U0.
TreeFamiTF300271.

Family and domain databases

InterProiIPR006696. DUF423.
[Graphical view]
PfamiPF04241. DUF423. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N2U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPAAAFRR LGALSGAAAL GFASYGAHGA QFPDAYGKEL FDKANKHHFL
60 70 80 90 100
HSLALLGVPH CRKPLWAGLL LASGTTLFCT SFYYQALSGD PSIQTLAPAG
110
GTLLLLGWLA LAL
Length:113
Mass (Da):11,742
Last modified:October 1, 2002 - v1
Checksum:i3184A3767F5ABB0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030270 mRNA. Translation: AAH30270.1.
CCDSiCCDS11102.1.
RefSeqiNP_689979.1. NM_152766.3.
UniGeneiHs.730789.

Genome annotation databases

EnsembliENST00000302422; ENSP00000301939; ENSG00000205544.
GeneIDi254863.
KEGGihsa:254863.
UCSCiuc002ggs.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030270 mRNA. Translation: AAH30270.1.
CCDSiCCDS11102.1.
RefSeqiNP_689979.1. NM_152766.3.
UniGeneiHs.730789.

3D structure databases

ProteinModelPortaliQ8N2U0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129054. 13 interactors.
IntActiQ8N2U0. 10 interactors.
STRINGi9606.ENSP00000301939.

PTM databases

iPTMnetiQ8N2U0.
PhosphoSitePlusiQ8N2U0.

Polymorphism and mutation databases

BioMutaiTMEM256.
DMDMi74728725.

Proteomic databases

EPDiQ8N2U0.
MaxQBiQ8N2U0.
PaxDbiQ8N2U0.
PeptideAtlasiQ8N2U0.
PRIDEiQ8N2U0.
TopDownProteomicsiQ8N2U0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302422; ENSP00000301939; ENSG00000205544.
GeneIDi254863.
KEGGihsa:254863.
UCSCiuc002ggs.4. human.

Organism-specific databases

CTDi254863.
GeneCardsiTMEM256.
HGNCiHGNC:28618. TMEM256.
HPAiHPA062732.
neXtProtiNX_Q8N2U0.
OpenTargetsiENSG00000205544.
PharmGKBiPA142672244.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3472. Eukaryota.
ENOG41125SJ. LUCA.
GeneTreeiENSGT00390000000334.
HOGENOMiHOG000252654.
HOVERGENiHBG095157.
InParanoidiQ8N2U0.
OMAiDWAAYLF.
OrthoDBiEOG091G16GE.
PhylomeDBiQ8N2U0.
TreeFamiTF300271.

Enzyme and pathway databases

BioCyciZFISH:G66-31870-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM256. human.
GenomeRNAii254863.
PROiQ8N2U0.

Gene expression databases

BgeeiENSG00000205544.
CleanExiHS_C17orf61.
ExpressionAtlasiQ8N2U0. baseline and differential.
GenevisibleiQ8N2U0. HS.

Family and domain databases

InterProiIPR006696. DUF423.
[Graphical view]
PfamiPF04241. DUF423. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM256_HUMAN
AccessioniPrimary (citable) accession number: Q8N2U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.