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Q8N2U0

- TM256_HUMAN

UniProt

Q8N2U0 - TM256_HUMAN

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Protein

Transmembrane protein 256

Gene

TMEM256

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 256
Gene namesi
Name:TMEM256
Synonyms:C17orf61
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:28618. TMEM256.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 11384Transmembrane protein 256PRO_0000287170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8N2U0.
PaxDbiQ8N2U0.
PRIDEiQ8N2U0.

PTM databases

PhosphoSiteiQ8N2U0.

Expressioni

Gene expression databases

BgeeiQ8N2U0.
CleanExiHS_C17orf61.
ExpressionAtlasiQ8N2U0. baseline and differential.
GenevestigatoriQ8N2U0.

Interactioni

Protein-protein interaction databases

BioGridi129054. 7 interactions.
IntActiQ8N2U0. 3 interactions.
STRINGi9606.ENSP00000301939.

Structurei

3D structure databases

ProteinModelPortaliQ8N2U0.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 6334ExtracellularSequence AnalysisAdd
BLAST
Topological domaini85 – 928CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8421HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM256 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257219.
GeneTreeiENSGT00390000000334.
HOGENOMiHOG000252654.
HOVERGENiHBG095157.
InParanoidiQ8N2U0.
OMAiGAHGFKN.
OrthoDBiEOG7VMP6D.
PhylomeDBiQ8N2U0.
TreeFamiTF300271.

Family and domain databases

InterProiIPR006696. DUF423.
[Graphical view]
PfamiPF04241. DUF423. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N2U0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGPAAAFRR LGALSGAAAL GFASYGAHGA QFPDAYGKEL FDKANKHHFL
60 70 80 90 100
HSLALLGVPH CRKPLWAGLL LASGTTLFCT SFYYQALSGD PSIQTLAPAG
110
GTLLLLGWLA LAL
Length:113
Mass (Da):11,742
Last modified:October 1, 2002 - v1
Checksum:i3184A3767F5ABB0E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC030270 mRNA. Translation: AAH30270.1.
CCDSiCCDS11102.1.
RefSeqiNP_689979.1. NM_152766.3.
UniGeneiHs.730789.

Genome annotation databases

EnsembliENST00000302422; ENSP00000301939; ENSG00000205544.
GeneIDi254863.
KEGGihsa:254863.
UCSCiuc002ggs.3. human.

Polymorphism databases

DMDMi74728725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC030270 mRNA. Translation: AAH30270.1 .
CCDSi CCDS11102.1.
RefSeqi NP_689979.1. NM_152766.3.
UniGenei Hs.730789.

3D structure databases

ProteinModelPortali Q8N2U0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129054. 7 interactions.
IntActi Q8N2U0. 3 interactions.
STRINGi 9606.ENSP00000301939.

PTM databases

PhosphoSitei Q8N2U0.

Polymorphism databases

DMDMi 74728725.

Proteomic databases

MaxQBi Q8N2U0.
PaxDbi Q8N2U0.
PRIDEi Q8N2U0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302422 ; ENSP00000301939 ; ENSG00000205544 .
GeneIDi 254863.
KEGGi hsa:254863.
UCSCi uc002ggs.3. human.

Organism-specific databases

CTDi 254863.
GeneCardsi GC17M007307.
HGNCi HGNC:28618. TMEM256.
neXtProti NX_Q8N2U0.
PharmGKBi PA142672244.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257219.
GeneTreei ENSGT00390000000334.
HOGENOMi HOG000252654.
HOVERGENi HBG095157.
InParanoidi Q8N2U0.
OMAi GAHGFKN.
OrthoDBi EOG7VMP6D.
PhylomeDBi Q8N2U0.
TreeFami TF300271.

Miscellaneous databases

GenomeRNAii 254863.
NextBioi 92403.

Gene expression databases

Bgeei Q8N2U0.
CleanExi HS_C17orf61.
ExpressionAtlasi Q8N2U0. baseline and differential.
Genevestigatori Q8N2U0.

Family and domain databases

InterProi IPR006696. DUF423.
[Graphical view ]
Pfami PF04241. DUF423. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiTM256_HUMAN
AccessioniPrimary (citable) accession number: Q8N2U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3