Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 256

Gene

TMEM256

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 256
Gene namesi
Name:TMEM256
Synonyms:C17orf61
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000205544.3
HGNCiHGNC:28618 TMEM256
MIMi617779 gene
neXtProtiNX_Q8N2U0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 63ExtracellularSequence analysisAdd BLAST34
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 92CytoplasmicSequence analysis8
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205544
PharmGKBiPA142672244

Polymorphism and mutation databases

BioMutaiTMEM256
DMDMi74728725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000028717030 – 113Transmembrane protein 256Add BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8N2U0
MaxQBiQ8N2U0
PaxDbiQ8N2U0
PeptideAtlasiQ8N2U0
PRIDEiQ8N2U0
TopDownProteomicsiQ8N2U0

PTM databases

iPTMnetiQ8N2U0
PhosphoSitePlusiQ8N2U0

Expressioni

Gene expression databases

BgeeiENSG00000205544
CleanExiHS_C17orf61
ExpressionAtlasiQ8N2U0 baseline and differential
GenevisibleiQ8N2U0 HS

Organism-specific databases

HPAiHPA062732

Interactioni

Protein-protein interaction databases

BioGridi129054, 13 interactors
IntActiQ8N2U0, 10 interactors
STRINGi9606.ENSP00000301939

Structurei

3D structure databases

ProteinModelPortaliQ8N2U0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM256 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3472 Eukaryota
ENOG41125SJ LUCA
GeneTreeiENSGT00390000000334
HOGENOMiHOG000252654
HOVERGENiHBG095157
InParanoidiQ8N2U0
OMAiPSTKYPN
OrthoDBiEOG091G16GE
PhylomeDBiQ8N2U0
TreeFamiTF300271

Family and domain databases

InterProiView protein in InterPro
IPR006696 DUF423
PANTHERiPTHR43461 PTHR43461, 1 hit
PfamiView protein in Pfam
PF04241 DUF423, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8N2U0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPAAAFRR LGALSGAAAL GFASYGAHGA QFPDAYGKEL FDKANKHHFL
60 70 80 90 100
HSLALLGVPH CRKPLWAGLL LASGTTLFCT SFYYQALSGD PSIQTLAPAG
110
GTLLLLGWLA LAL
Length:113
Mass (Da):11,742
Last modified:October 1, 2002 - v1
Checksum:i3184A3767F5ABB0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC030270 mRNA Translation: AAH30270.1
CCDSiCCDS11102.1
RefSeqiNP_689979.1, NM_152766.3
UniGeneiHs.730789

Genome annotation databases

EnsembliENST00000302422; ENSP00000301939; ENSG00000205544
ENST00000639136; ENSP00000491711; ENSG00000283771
GeneIDi254863
KEGGihsa:254863
UCSCiuc002ggs.4 human

Similar proteinsi

Entry informationi

Entry nameiTM256_HUMAN
AccessioniPrimary (citable) accession number: Q8N2U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health