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Q8N2U0

- TM256_HUMAN

UniProt

Q8N2U0 - TM256_HUMAN

Protein

Transmembrane protein 256

Gene

TMEM256

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 256
    Gene namesi
    Name:TMEM256
    Synonyms:C17orf61
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:28618. TMEM256.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672244.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 11384Transmembrane protein 256PRO_0000287170Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei43 – 431N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8N2U0.
    PaxDbiQ8N2U0.
    PRIDEiQ8N2U0.

    PTM databases

    PhosphoSiteiQ8N2U0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N2U0.
    BgeeiQ8N2U0.
    CleanExiHS_C17orf61.
    GenevestigatoriQ8N2U0.

    Interactioni

    Protein-protein interaction databases

    BioGridi129054. 7 interactions.
    IntActiQ8N2U0. 3 interactions.
    STRINGi9606.ENSP00000301939.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N2U0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 6334ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini85 – 928CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM256 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG257219.
    HOGENOMiHOG000252654.
    HOVERGENiHBG095157.
    InParanoidiQ8N2U0.
    OMAiGAHGFKN.
    OrthoDBiEOG7VMP6D.
    PhylomeDBiQ8N2U0.
    TreeFamiTF300271.

    Family and domain databases

    InterProiIPR006696. DUF423.
    [Graphical view]
    PfamiPF04241. DUF423. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8N2U0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPAAAFRR LGALSGAAAL GFASYGAHGA QFPDAYGKEL FDKANKHHFL    50
    HSLALLGVPH CRKPLWAGLL LASGTTLFCT SFYYQALSGD PSIQTLAPAG 100
    GTLLLLGWLA LAL 113
    Length:113
    Mass (Da):11,742
    Last modified:October 1, 2002 - v1
    Checksum:i3184A3767F5ABB0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC030270 mRNA. Translation: AAH30270.1.
    CCDSiCCDS11102.1.
    RefSeqiNP_689979.1. NM_152766.3.
    UniGeneiHs.730789.

    Genome annotation databases

    EnsembliENST00000302422; ENSP00000301939; ENSG00000205544.
    GeneIDi254863.
    KEGGihsa:254863.
    UCSCiuc002ggs.3. human.

    Polymorphism databases

    DMDMi74728725.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC030270 mRNA. Translation: AAH30270.1 .
    CCDSi CCDS11102.1.
    RefSeqi NP_689979.1. NM_152766.3.
    UniGenei Hs.730789.

    3D structure databases

    ProteinModelPortali Q8N2U0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129054. 7 interactions.
    IntActi Q8N2U0. 3 interactions.
    STRINGi 9606.ENSP00000301939.

    PTM databases

    PhosphoSitei Q8N2U0.

    Polymorphism databases

    DMDMi 74728725.

    Proteomic databases

    MaxQBi Q8N2U0.
    PaxDbi Q8N2U0.
    PRIDEi Q8N2U0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302422 ; ENSP00000301939 ; ENSG00000205544 .
    GeneIDi 254863.
    KEGGi hsa:254863.
    UCSCi uc002ggs.3. human.

    Organism-specific databases

    CTDi 254863.
    GeneCardsi GC17M007307.
    HGNCi HGNC:28618. TMEM256.
    neXtProti NX_Q8N2U0.
    PharmGKBi PA142672244.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG257219.
    HOGENOMi HOG000252654.
    HOVERGENi HBG095157.
    InParanoidi Q8N2U0.
    OMAi GAHGFKN.
    OrthoDBi EOG7VMP6D.
    PhylomeDBi Q8N2U0.
    TreeFami TF300271.

    Miscellaneous databases

    GenomeRNAii 254863.
    NextBioi 92403.

    Gene expression databases

    ArrayExpressi Q8N2U0.
    Bgeei Q8N2U0.
    CleanExi HS_C17orf61.
    Genevestigatori Q8N2U0.

    Family and domain databases

    InterProi IPR006696. DUF423.
    [Graphical view ]
    Pfami PF04241. DUF423. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiTM256_HUMAN
    AccessioniPrimary (citable) accession number: Q8N2U0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3