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Q8N2R8 (FA43A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM43A
Gene names
Name:FAM43A
ORF Names:PP7298
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM43 family.

Sequence caution

The sequence AAL55769.1 differs from that shown. Reason: Frameshift at position 246.

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Protein FAM43A
PRO_0000187024

Experimental info

Sequence conflict3051A → V in BAC11027. Ref.2
Sequence conflict3511A → V in AAL55769. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8N2R8 [UniParc].

Last modified August 16, 2004. Version 2.
Checksum: AA70223F96B2729A

FASTA42345,776
        10         20         30         40         50         60 
MLPWKKHKFE LLAEAPPRQA SKPKGYAVSL HYSALSSLAR ACPEGALSRV GSMFRSKRKK 

        70         80         90        100        110        120 
LHITSEDPTY TVLYLGNATT IQARGDGCTD LAVGKIWSKS EAGRQGTKMK LTVSAQGIRM 

       130        140        150        160        170        180 
VHAEERALRR PGHLYLLHRV TYCVADARLP KVFAWVYRHE LKHKAVMLRC HAVLVSKPEK 

       190        200        210        220        230        240 
AQAMALLLYQ TSANALAEFK RLKRRDDARH QQQELVGAHT IPLVPLRKLL LHGPCCYKPP 

       250        260        270        280        290        300 
VERSRSAPKL GSITEDLLGE QLEQELQEEE EEEQPEGCPE EEENRAAEGD PAEEEAEAQR 

       310        320        330        340        350        360 
ALVVAMHFEC GDLLDTLENG RGEALGGGGG SLGPGAGPPP LLLGSASDMK AELSQLISDL 

       370        380        390        400        410        420 
GELSFGNDVR TLQADLRVTR LLSGDSTGSE SSIEGGGPDA TSATAGDSSR QADGASADEP 


HSG 

« Hide

References

[1]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF289585 mRNA. Translation: AAL55769.1. Frameshift.
AK074503 mRNA. Translation: BAC11027.1.
CH471052 Genomic DNA. Translation: EAW78033.1.
BC039689 mRNA. Translation: AAH39689.1.
BC064989 mRNA. Translation: AAH64989.1.
CCDSCCDS33923.1.
RefSeqNP_710157.2. NM_153690.4.
UniGeneHs.435080.

3D structure databases

ProteinModelPortalQ8N2R8.
SMRQ8N2R8. Positions 66-190.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000371397.

PTM databases

PhosphoSiteQ8N2R8.

Polymorphism databases

DMDM51316022.

Proteomic databases

PaxDbQ8N2R8.
PRIDEQ8N2R8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329759; ENSP00000371397; ENSG00000185112.
GeneID131583.
KEGGhsa:131583.
UCSCuc003fuj.3. human.

Organism-specific databases

CTD131583.
GeneCardsGC03P194406.
H-InvDBHIX0024294.
HGNCHGNC:26888. FAM43A.
HPAHPA048345.
neXtProtNX_Q8N2R8.
PharmGKBPA134950686.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237605.
HOGENOMHOG000231650.
HOVERGENHBG051535.
InParanoidQ8N2R8.
OMAYCVADAR.
OrthoDBEOG7J4470.
PhylomeDBQ8N2R8.
TreeFamTF314159.

Gene expression databases

BgeeQ8N2R8.
CleanExHS_FAM43A.
GenevestigatorQ8N2R8.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamPF14719. PID_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAM43A. human.
GeneWikiFAM43A.
GenomeRNAi131583.
NextBio82946.
PROQ8N2R8.

Entry information

Entry nameFA43A_HUMAN
AccessionPrimary (citable) accession number: Q8N2R8
Secondary accession number(s): A3KME2, Q8IXP4, Q8WZ07
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM