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Q8N2R8

- FA43A_HUMAN

UniProt

Q8N2R8 - FA43A_HUMAN

Protein

Protein FAM43A

Gene

FAM43A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (16 Aug 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM43A
    Gene namesi
    Name:FAM43A
    ORF Names:PP7298
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:26888. FAM43A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134950686.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Protein FAM43APRO_0000187024Add
    BLAST

    Proteomic databases

    PaxDbiQ8N2R8.
    PRIDEiQ8N2R8.

    PTM databases

    PhosphoSiteiQ8N2R8.

    Expressioni

    Gene expression databases

    BgeeiQ8N2R8.
    CleanExiHS_FAM43A.
    GenevestigatoriQ8N2R8.

    Organism-specific databases

    HPAiHPA048345.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000371397.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N2R8.
    SMRiQ8N2R8. Positions 66-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM43 family.Curated

    Phylogenomic databases

    eggNOGiNOG237605.
    HOGENOMiHOG000231650.
    HOVERGENiHBG051535.
    InParanoidiQ8N2R8.
    OMAiYCVADAR.
    OrthoDBiEOG7J4470.
    PhylomeDBiQ8N2R8.
    TreeFamiTF314159.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view]
    PfamiPF14719. PID_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8N2R8-1 [UniParc]FASTAAdd to Basket

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    MLPWKKHKFE LLAEAPPRQA SKPKGYAVSL HYSALSSLAR ACPEGALSRV    50
    GSMFRSKRKK LHITSEDPTY TVLYLGNATT IQARGDGCTD LAVGKIWSKS 100
    EAGRQGTKMK LTVSAQGIRM VHAEERALRR PGHLYLLHRV TYCVADARLP 150
    KVFAWVYRHE LKHKAVMLRC HAVLVSKPEK AQAMALLLYQ TSANALAEFK 200
    RLKRRDDARH QQQELVGAHT IPLVPLRKLL LHGPCCYKPP VERSRSAPKL 250
    GSITEDLLGE QLEQELQEEE EEEQPEGCPE EEENRAAEGD PAEEEAEAQR 300
    ALVVAMHFEC GDLLDTLENG RGEALGGGGG SLGPGAGPPP LLLGSASDMK 350
    AELSQLISDL GELSFGNDVR TLQADLRVTR LLSGDSTGSE SSIEGGGPDA 400
    TSATAGDSSR QADGASADEP HSG 423
    Length:423
    Mass (Da):45,776
    Last modified:August 16, 2004 - v2
    Checksum:iAA70223F96B2729A
    GO

    Sequence cautioni

    The sequence AAL55769.1 differs from that shown. Reason: Frameshift at position 246.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti305 – 3051A → V in BAC11027. (PubMed:14702039)Curated
    Sequence conflicti351 – 3511A → V in AAL55769. (PubMed:15498874)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289585 mRNA. Translation: AAL55769.1. Frameshift.
    AK074503 mRNA. Translation: BAC11027.1.
    CH471052 Genomic DNA. Translation: EAW78033.1.
    BC039689 mRNA. Translation: AAH39689.1.
    BC064989 mRNA. Translation: AAH64989.1.
    CCDSiCCDS33923.1.
    RefSeqiNP_710157.2. NM_153690.4.
    UniGeneiHs.435080.

    Genome annotation databases

    EnsembliENST00000329759; ENSP00000371397; ENSG00000185112.
    GeneIDi131583.
    KEGGihsa:131583.
    UCSCiuc003fuj.3. human.

    Polymorphism databases

    DMDMi51316022.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF289585 mRNA. Translation: AAL55769.1 . Frameshift.
    AK074503 mRNA. Translation: BAC11027.1 .
    CH471052 Genomic DNA. Translation: EAW78033.1 .
    BC039689 mRNA. Translation: AAH39689.1 .
    BC064989 mRNA. Translation: AAH64989.1 .
    CCDSi CCDS33923.1.
    RefSeqi NP_710157.2. NM_153690.4.
    UniGenei Hs.435080.

    3D structure databases

    ProteinModelPortali Q8N2R8.
    SMRi Q8N2R8. Positions 66-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000371397.

    PTM databases

    PhosphoSitei Q8N2R8.

    Polymorphism databases

    DMDMi 51316022.

    Proteomic databases

    PaxDbi Q8N2R8.
    PRIDEi Q8N2R8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329759 ; ENSP00000371397 ; ENSG00000185112 .
    GeneIDi 131583.
    KEGGi hsa:131583.
    UCSCi uc003fuj.3. human.

    Organism-specific databases

    CTDi 131583.
    GeneCardsi GC03P194406.
    H-InvDB HIX0024294.
    HGNCi HGNC:26888. FAM43A.
    HPAi HPA048345.
    neXtProti NX_Q8N2R8.
    PharmGKBi PA134950686.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237605.
    HOGENOMi HOG000231650.
    HOVERGENi HBG051535.
    InParanoidi Q8N2R8.
    OMAi YCVADAR.
    OrthoDBi EOG7J4470.
    PhylomeDBi Q8N2R8.
    TreeFami TF314159.

    Miscellaneous databases

    ChiTaRSi FAM43A. human.
    GeneWikii FAM43A.
    GenomeRNAii 131583.
    NextBioi 82946.
    PROi Q8N2R8.

    Gene expression databases

    Bgeei Q8N2R8.
    CleanExi HS_FAM43A.
    Genevestigatori Q8N2R8.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view ]
    Pfami PF14719. PID_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye and Pancreas.

    Entry informationi

    Entry nameiFA43A_HUMAN
    AccessioniPrimary (citable) accession number: Q8N2R8
    Secondary accession number(s): A3KME2, Q8IXP4, Q8WZ07
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3