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Q8N2R8

- FA43A_HUMAN

UniProt

Q8N2R8 - FA43A_HUMAN

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Protein

Protein FAM43A

Gene
FAM43A, PP7298
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM43A
Gene namesi
Name:FAM43A
ORF Names:PP7298
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:26888. FAM43A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Protein FAM43APRO_0000187024Add
BLAST

Proteomic databases

PaxDbiQ8N2R8.
PRIDEiQ8N2R8.

PTM databases

PhosphoSiteiQ8N2R8.

Expressioni

Gene expression databases

BgeeiQ8N2R8.
CleanExiHS_FAM43A.
GenevestigatoriQ8N2R8.

Organism-specific databases

HPAiHPA048345.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371397.

Structurei

3D structure databases

ProteinModelPortaliQ8N2R8.
SMRiQ8N2R8. Positions 66-190.

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM43 family.

Phylogenomic databases

eggNOGiNOG237605.
HOGENOMiHOG000231650.
HOVERGENiHBG051535.
InParanoidiQ8N2R8.
OMAiYCVADAR.
OrthoDBiEOG7J4470.
PhylomeDBiQ8N2R8.
TreeFamiTF314159.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF14719. PID_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N2R8-1 [UniParc]FASTAAdd to Basket

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MLPWKKHKFE LLAEAPPRQA SKPKGYAVSL HYSALSSLAR ACPEGALSRV    50
GSMFRSKRKK LHITSEDPTY TVLYLGNATT IQARGDGCTD LAVGKIWSKS 100
EAGRQGTKMK LTVSAQGIRM VHAEERALRR PGHLYLLHRV TYCVADARLP 150
KVFAWVYRHE LKHKAVMLRC HAVLVSKPEK AQAMALLLYQ TSANALAEFK 200
RLKRRDDARH QQQELVGAHT IPLVPLRKLL LHGPCCYKPP VERSRSAPKL 250
GSITEDLLGE QLEQELQEEE EEEQPEGCPE EEENRAAEGD PAEEEAEAQR 300
ALVVAMHFEC GDLLDTLENG RGEALGGGGG SLGPGAGPPP LLLGSASDMK 350
AELSQLISDL GELSFGNDVR TLQADLRVTR LLSGDSTGSE SSIEGGGPDA 400
TSATAGDSSR QADGASADEP HSG 423
Length:423
Mass (Da):45,776
Last modified:August 16, 2004 - v2
Checksum:iAA70223F96B2729A
GO

Sequence cautioni

The sequence AAL55769.1 differs from that shown. Reason: Frameshift at position 246.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti305 – 3051A → V in BAC11027. 1 Publication
Sequence conflicti351 – 3511A → V in AAL55769. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF289585 mRNA. Translation: AAL55769.1. Frameshift.
AK074503 mRNA. Translation: BAC11027.1.
CH471052 Genomic DNA. Translation: EAW78033.1.
BC039689 mRNA. Translation: AAH39689.1.
BC064989 mRNA. Translation: AAH64989.1.
CCDSiCCDS33923.1.
RefSeqiNP_710157.2. NM_153690.4.
UniGeneiHs.435080.

Genome annotation databases

EnsembliENST00000329759; ENSP00000371397; ENSG00000185112.
GeneIDi131583.
KEGGihsa:131583.
UCSCiuc003fuj.3. human.

Polymorphism databases

DMDMi51316022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF289585 mRNA. Translation: AAL55769.1 . Frameshift.
AK074503 mRNA. Translation: BAC11027.1 .
CH471052 Genomic DNA. Translation: EAW78033.1 .
BC039689 mRNA. Translation: AAH39689.1 .
BC064989 mRNA. Translation: AAH64989.1 .
CCDSi CCDS33923.1.
RefSeqi NP_710157.2. NM_153690.4.
UniGenei Hs.435080.

3D structure databases

ProteinModelPortali Q8N2R8.
SMRi Q8N2R8. Positions 66-190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000371397.

PTM databases

PhosphoSitei Q8N2R8.

Polymorphism databases

DMDMi 51316022.

Proteomic databases

PaxDbi Q8N2R8.
PRIDEi Q8N2R8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329759 ; ENSP00000371397 ; ENSG00000185112 .
GeneIDi 131583.
KEGGi hsa:131583.
UCSCi uc003fuj.3. human.

Organism-specific databases

CTDi 131583.
GeneCardsi GC03P194406.
H-InvDB HIX0024294.
HGNCi HGNC:26888. FAM43A.
HPAi HPA048345.
neXtProti NX_Q8N2R8.
PharmGKBi PA134950686.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237605.
HOGENOMi HOG000231650.
HOVERGENi HBG051535.
InParanoidi Q8N2R8.
OMAi YCVADAR.
OrthoDBi EOG7J4470.
PhylomeDBi Q8N2R8.
TreeFami TF314159.

Miscellaneous databases

ChiTaRSi FAM43A. human.
GeneWikii FAM43A.
GenomeRNAii 131583.
NextBioi 82946.
PROi Q8N2R8.

Gene expression databases

Bgeei Q8N2R8.
CleanExi HS_FAM43A.
Genevestigatori Q8N2R8.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view ]
Pfami PF14719. PID_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Pancreas.

Entry informationi

Entry nameiFA43A_HUMAN
AccessioniPrimary (citable) accession number: Q8N2R8
Secondary accession number(s): A3KME2, Q8IXP4, Q8WZ07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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