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Protein

Protein FAM43A

Gene

FAM43A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM43A
Gene namesi
Name:FAM43A
ORF Names:PP7298
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:26888. FAM43A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134950686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Protein FAM43APRO_0000187024Add
BLAST

Proteomic databases

PaxDbiQ8N2R8.
PRIDEiQ8N2R8.

PTM databases

PhosphoSiteiQ8N2R8.

Expressioni

Gene expression databases

BgeeiQ8N2R8.
CleanExiHS_FAM43A.
GenevestigatoriQ8N2R8.

Organism-specific databases

HPAiHPA048345.

Interactioni

Protein-protein interaction databases

BioGridi126288. 12 interactions.
STRINGi9606.ENSP00000371397.

Structurei

3D structure databases

ProteinModelPortaliQ8N2R8.
SMRiQ8N2R8. Positions 66-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM43 family.Curated

Phylogenomic databases

eggNOGiNOG237605.
GeneTreeiENSGT00510000047407.
HOGENOMiHOG000231650.
HOVERGENiHBG051535.
InParanoidiQ8N2R8.
OMAiYCVADAR.
OrthoDBiEOG7J4470.
PhylomeDBiQ8N2R8.
TreeFamiTF314159.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF14719. PID_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8N2R8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPWKKHKFE LLAEAPPRQA SKPKGYAVSL HYSALSSLAR ACPEGALSRV
60 70 80 90 100
GSMFRSKRKK LHITSEDPTY TVLYLGNATT IQARGDGCTD LAVGKIWSKS
110 120 130 140 150
EAGRQGTKMK LTVSAQGIRM VHAEERALRR PGHLYLLHRV TYCVADARLP
160 170 180 190 200
KVFAWVYRHE LKHKAVMLRC HAVLVSKPEK AQAMALLLYQ TSANALAEFK
210 220 230 240 250
RLKRRDDARH QQQELVGAHT IPLVPLRKLL LHGPCCYKPP VERSRSAPKL
260 270 280 290 300
GSITEDLLGE QLEQELQEEE EEEQPEGCPE EEENRAAEGD PAEEEAEAQR
310 320 330 340 350
ALVVAMHFEC GDLLDTLENG RGEALGGGGG SLGPGAGPPP LLLGSASDMK
360 370 380 390 400
AELSQLISDL GELSFGNDVR TLQADLRVTR LLSGDSTGSE SSIEGGGPDA
410 420
TSATAGDSSR QADGASADEP HSG
Length:423
Mass (Da):45,776
Last modified:August 16, 2004 - v2
Checksum:iAA70223F96B2729A
GO

Sequence cautioni

The sequence AAL55769.1 differs from that shown. Reason: Frameshift at position 246. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti305 – 3051A → V in BAC11027. (PubMed:14702039)Curated
Sequence conflicti351 – 3511A → V in AAL55769. (PubMed:15498874)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289585 mRNA. Translation: AAL55769.1. Frameshift.
AK074503 mRNA. Translation: BAC11027.1.
CH471052 Genomic DNA. Translation: EAW78033.1.
BC039689 mRNA. Translation: AAH39689.1.
BC064989 mRNA. Translation: AAH64989.1.
CCDSiCCDS33923.1.
RefSeqiNP_710157.2. NM_153690.4.
UniGeneiHs.435080.

Genome annotation databases

EnsembliENST00000329759; ENSP00000371397; ENSG00000185112.
GeneIDi131583.
KEGGihsa:131583.
UCSCiuc003fuj.3. human.

Polymorphism databases

DMDMi51316022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289585 mRNA. Translation: AAL55769.1. Frameshift.
AK074503 mRNA. Translation: BAC11027.1.
CH471052 Genomic DNA. Translation: EAW78033.1.
BC039689 mRNA. Translation: AAH39689.1.
BC064989 mRNA. Translation: AAH64989.1.
CCDSiCCDS33923.1.
RefSeqiNP_710157.2. NM_153690.4.
UniGeneiHs.435080.

3D structure databases

ProteinModelPortaliQ8N2R8.
SMRiQ8N2R8. Positions 66-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126288. 12 interactions.
STRINGi9606.ENSP00000371397.

PTM databases

PhosphoSiteiQ8N2R8.

Polymorphism databases

DMDMi51316022.

Proteomic databases

PaxDbiQ8N2R8.
PRIDEiQ8N2R8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329759; ENSP00000371397; ENSG00000185112.
GeneIDi131583.
KEGGihsa:131583.
UCSCiuc003fuj.3. human.

Organism-specific databases

CTDi131583.
GeneCardsiGC03P194406.
H-InvDBHIX0024294.
HGNCiHGNC:26888. FAM43A.
HPAiHPA048345.
neXtProtiNX_Q8N2R8.
PharmGKBiPA134950686.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG237605.
GeneTreeiENSGT00510000047407.
HOGENOMiHOG000231650.
HOVERGENiHBG051535.
InParanoidiQ8N2R8.
OMAiYCVADAR.
OrthoDBiEOG7J4470.
PhylomeDBiQ8N2R8.
TreeFamiTF314159.

Miscellaneous databases

ChiTaRSiFAM43A. human.
GeneWikiiFAM43A.
GenomeRNAii131583.
NextBioi82946.
PROiQ8N2R8.

Gene expression databases

BgeeiQ8N2R8.
CleanExiHS_FAM43A.
GenevestigatoriQ8N2R8.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF14719. PID_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Pancreas.

Entry informationi

Entry nameiFA43A_HUMAN
AccessioniPrimary (citable) accession number: Q8N2R8
Secondary accession number(s): A3KME2, Q8IXP4, Q8WZ07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.