ID   OSR2_HUMAN              Reviewed;         312 AA.
AC   Q8N2R0; A8K626; Q96AM6; Q96LB6; Q96LB7;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 2.
DT   03-NOV-2009, entry version 59.
DE   RecName: Full=Protein odd-skipped-related 2;
GN   Name=OSR2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA   Jiang R., Cho E.-S., Lan Y.;
RT   "Isolation of the human OSR2 gene.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Embryo, and Ovary;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=OSR2A;
CC         IsoId=Q8N2R0-1; Sequence=Displayed;
CC       Name=2; Synonyms=OSR2B;
CC         IsoId=Q8N2R0-2; Sequence=VSP_017121;
CC   -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 5 C2H2-type zinc fingers.
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DR   EMBL; AY038072; AAK74066.1; -; mRNA.
DR   EMBL; AY038073; AAK74067.1; -; mRNA.
DR   EMBL; AK074518; BAC11035.1; -; mRNA.
DR   EMBL; AK291491; BAF84180.1; -; mRNA.
DR   EMBL; CH471060; EAW91785.1; -; Genomic_DNA.
DR   EMBL; BC016936; AAH16936.1; -; mRNA.
DR   IPI; IPI00719002; -.
DR   IPI; IPI00943317; -.
DR   RefSeq; NP_001135934.1; -.
DR   RefSeq; NP_443727.2; -.
DR   UniGene; Hs.253247; -.
DR   HSSP; P07248; 2ADR.
DR   STRING; Q8N2R0; -.
DR   Ensembl; ENST00000297565; ENSP00000297565; ENSG00000164920; Homo sapiens.
DR   Ensembl; ENST00000435298; ENSP00000402862; ENSG00000164920; Homo sapiens.
DR   Ensembl; ENST00000457907; ENSP00000414657; ENSG00000164920; Homo sapiens.
DR   GeneID; 116039; -.
DR   KEGG; hsa:116039; -.
DR   UCSC; uc003yiq.1; human.
DR   UCSC; uc003yir.1; human.
DR   CTD; 116039; -.
DR   GeneCards; GC08P100025; -.
DR   HGNC; HGNC:15830; OSR2.
DR   MIM; 611297; gene.
DR   PharmGKB; PA28816; -.
DR   HOGENOM; Q8N2R0; -.
DR   HOVERGEN; Q8N2R0; -.
DR   OMA; VNTFPAA; -.
DR   NextBio; 79729; -.
DR   ArrayExpress; Q8N2R0; -.
DR   Bgee; Q8N2R0; -.
DR   CleanEx; HS_OSR2; -.
DR   Genevestigator; Q8N2R0; -.
DR   GermOnline; ENSG00000164920; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 1.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   ProDom; PD000003; Znf_C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Metal-binding; Nucleus; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    312       Protein odd-skipped-related 2.
FT                                /FTId=PRO_0000047007.
FT   ZN_FING     172    194       C2H2-type 1.
FT   ZN_FING     200    222       C2H2-type 2.
FT   ZN_FING     228    250       C2H2-type 3.
FT   ZN_FING     256    278       C2H2-type 4.
FT   ZN_FING     284    306       C2H2-type 5; degenerate.
FT   VAR_SEQ     253    312       ESPHKCPTCGRTFNQRSNLKTHLLTHTDIKPYSCEQCGKVF
FT                                RRNCDLRRHSLTHTPRQDF -> TSSPTAASSAAKCSGETV
FT                                ICGGTA (in isoform 2).
FT                                /FTId=VSP_017121.
FT   CONFLICT    132    132       K -> G (in Ref. 1; AAK74066).
FT   CONFLICT    286    286       C -> R (in Ref. 2; BAC11035).
SQ   SEQUENCE   312 AA;  35513 MW;  312E5A688EFB88B6 CRC64;
     MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH MNHWTLGYPN
     VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG AIAHVLPALH KDRPRFDFAN
     LAVAATQEDP PKMGDLSKLS PGLGSPISGL SKLTPDRKPS RGRLPSKTKK EFICKFCGRH
     FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS
     RTLAVHKTLH MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR
     RHSLTHTPRQ DF
//