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Protein

Protein odd-skipped-related 2

Gene

OSR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 2
Gene namesi
Name:OSR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164920.9
HGNCiHGNC:15830 OSR2
MIMi611297 gene
neXtProtiNX_Q8N2R0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi116039
OpenTargetsiENSG00000164920
PharmGKBiPA134924513

Polymorphism and mutation databases

DMDMi146345473

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470071 – 312Protein odd-skipped-related 2Add BLAST312

Proteomic databases

MaxQBiQ8N2R0
PaxDbiQ8N2R0
PeptideAtlasiQ8N2R0
PRIDEiQ8N2R0

PTM databases

iPTMnetiQ8N2R0
PhosphoSitePlusiQ8N2R0

Expressioni

Gene expression databases

BgeeiENSG00000164920
CleanExiHS_OSR2
ExpressionAtlasiQ8N2R0 baseline and differential
GenevisibleiQ8N2R0 HS

Organism-specific databases

HPAiHPA052425
HPA063486

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PSMA3P257883EBI-5660512,EBI-348380

Protein-protein interaction databases

BioGridi125467, 2 interactors
IntActiQ8N2R0, 3 interactors
STRINGi9606.ENSP00000297565

Structurei

3D structure databases

ProteinModelPortaliQ8N2R0
SMRiQ8N2R0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00880000137939
HOGENOMiHOG000013107
HOVERGENiHBG054398
InParanoidiQ8N2R0
KOiK09215
OrthoDBiEOG091G0LRE
PhylomeDBiQ8N2R0
TreeFamiTF350876

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2R0-1) [UniParc]FASTAAdd to basket
Also known as: OSR2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH
60 70 80 90 100
MNHWTLGYPN VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG
110 120 130 140 150
AIAHVLPALH KDRPRFDFAN LAVAATQEDP PKMGDLSKLS PGLGSPISGL
160 170 180 190 200
SKLTPDRKPS RGRLPSKTKK EFICKFCGRH FTKSYNLLIH ERTHTDERPY
210 220 230 240 250
TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS RTLAVHKTLH
260 270 280 290 300
MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR
310
RHSLTHTPRQ DF
Length:312
Mass (Da):35,513
Last modified:May 1, 2007 - v2
Checksum:i312E5A688EFB88B6
GO
Isoform 2 (identifier: Q8N2R0-2) [UniParc]FASTAAdd to basket
Also known as: OSR2B

The sequence of this isoform differs from the canonical sequence as follows:
     253-312: ESPHKCPTCG...SLTHTPRQDF → TSSPTAASSAAKCSGETVICGGTA

Show »
Length:276
Mass (Da):30,573
Checksum:i4782AC3D02F8F173
GO
Isoform 3 (identifier: Q8N2R0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGLRAEEGKR...PSAPPASRKM

Show »
Length:433
Mass (Da):48,771
Checksum:iBFEB7D6DD5697B73
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132K → G in AAK74066 (Ref. 1) Curated1
Sequence conflicti286C → R in BAC11035 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0548491M → MGLRAEEGKRKPPRSVRGEV SPSQGPLAQEDEARRLRSCT PACHPGKRGKGGHRARRQRS AWDLTTHPLTHRSQELRGAA ATEGFLYVLLSHWVFVGAPR PPASDSWKKGLVPSAPPASR KM in isoform 3. 1 Publication1
Alternative sequenceiVSP_017121253 – 312ESPHK…PRQDF → TSSPTAASSAAKCSGETVIC GGTA in isoform 2. 3 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038072 mRNA Translation: AAK74066.1
AY038073 mRNA Translation: AAK74067.1
AK074518 mRNA Translation: BAC11035.1
AK291491 mRNA Translation: BAF84180.1
AK304654 mRNA Translation: BAG65429.1
AC016877 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91785.1
BC016936 mRNA Translation: AAH16936.1
CCDSiCCDS47901.1 [Q8N2R0-1]
CCDS47902.1 [Q8N2R0-2]
CCDS69520.1 [Q8N2R0-3]
RefSeqiNP_001135934.1, NM_001142462.2 [Q8N2R0-1]
NP_001273770.1, NM_001286841.1 [Q8N2R0-3]
NP_443727.2, NM_053001.3 [Q8N2R0-2]
XP_011515129.1, XM_011516827.2 [Q8N2R0-1]
XP_016868507.1, XM_017013018.1 [Q8N2R0-1]
UniGeneiHs.253247

Genome annotation databases

EnsembliENST00000297565; ENSP00000297565; ENSG00000164920 [Q8N2R0-1]
ENST00000435298; ENSP00000402862; ENSG00000164920 [Q8N2R0-2]
ENST00000457907; ENSP00000414657; ENSG00000164920 [Q8N2R0-3]
ENST00000522510; ENSP00000430780; ENSG00000164920 [Q8N2R0-1]
GeneIDi116039
KEGGihsa:116039
UCSCiuc003yiq.5 human [Q8N2R0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiOSR2_HUMAN
AccessioniPrimary (citable) accession number: Q8N2R0
Secondary accession number(s): A8K626
, B4E3B7, Q96AM6, Q96LB6, Q96LB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 1, 2007
Last modified: March 28, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health