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Q8N2R0

- OSR2_HUMAN

UniProt

Q8N2R0 - OSR2_HUMAN

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Protein
Protein odd-skipped-related 2
Gene
OSR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1
Add
BLAST
Zinc fingeri200 – 22223C2H2-type 2
Add
BLAST
Zinc fingeri228 – 25023C2H2-type 3
Add
BLAST
Zinc fingeri256 – 27823C2H2-type 4
Add
BLAST
Zinc fingeri284 – 30623C2H2-type 5; degenerate
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  1. bone morphogenesis Source: UniProtKB
  2. cell differentiation Source: BHF-UCL
  3. chondrocyte differentiation Source: BHF-UCL
  4. embryo development Source: UniProtKB
  5. embryonic digit morphogenesis Source: BHF-UCL
  6. embryonic forelimb morphogenesis Source: BHF-UCL
  7. embryonic hindlimb morphogenesis Source: BHF-UCL
  8. embryonic skeletal joint development Source: BHF-UCL
  9. embryonic skeletal joint morphogenesis Source: BHF-UCL
  10. embryonic skeletal limb joint morphogenesis Source: BHF-UCL
  11. embryonic skeletal system morphogenesis Source: UniProtKB
  12. eyelid development in camera-type eye Source: UniProtKB
  13. head development Source: BHF-UCL
  14. mesonephros development Source: UniProtKB
  15. metanephros development Source: UniProtKB
  16. middle ear morphogenesis Source: UniProtKB
  17. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  18. odontogenesis Source: UniProtKB
  19. osteoblast proliferation Source: UniProtKB
  20. palate development Source: UniProtKB
  21. positive regulation of bone mineralization Source: BHF-UCL
  22. positive regulation of cell proliferation Source: UniProtKB
  23. positive regulation of epithelial cell proliferation Source: UniProtKB
  24. positive regulation of gastrulation Source: Ensembl
  25. positive regulation of gene expression Source: UniProtKB
  26. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  27. positive regulation of transcription, DNA-templated Source: UniProtKB
  28. pronephros development Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein odd-skipped-related 2
Gene namesi
Name:OSR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:15830. OSR2.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134924513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Protein odd-skipped-related 2
PRO_0000047007Add
BLAST

Proteomic databases

PaxDbiQ8N2R0.
PRIDEiQ8N2R0.

Expressioni

Gene expression databases

ArrayExpressiQ8N2R0.
BgeeiQ8N2R0.
CleanExiHS_OSR2.
GenevestigatoriQ8N2R0.

Organism-specific databases

HPAiHPA052425.

Interactioni

Protein-protein interaction databases

BioGridi125467. 1 interaction.
IntActiQ8N2R0. 1 interaction.
STRINGi9606.ENSP00000297565.

Structurei

3D structure databases

ProteinModelPortaliQ8N2R0.
SMRiQ8N2R0. Positions 163-312.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000013107.
HOVERGENiHBG054398.
InParanoidiQ8N2R0.
KOiK09215.
PhylomeDBiQ8N2R0.
TreeFamiTF350876.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N2R0-1) [UniParc]FASTAAdd to Basket

Also known as: OSR2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH    50
MNHWTLGYPN VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG 100
AIAHVLPALH KDRPRFDFAN LAVAATQEDP PKMGDLSKLS PGLGSPISGL 150
SKLTPDRKPS RGRLPSKTKK EFICKFCGRH FTKSYNLLIH ERTHTDERPY 200
TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS RTLAVHKTLH 250
MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR 300
RHSLTHTPRQ DF 312
Length:312
Mass (Da):35,513
Last modified:May 1, 2007 - v2
Checksum:i312E5A688EFB88B6
GO
Isoform 2 (identifier: Q8N2R0-2) [UniParc]FASTAAdd to Basket

Also known as: OSR2B

The sequence of this isoform differs from the canonical sequence as follows:
     253-312: ESPHKCPTCG...SLTHTPRQDF → TSSPTAASSAAKCSGETVICGGTA

Show »
Length:276
Mass (Da):30,573
Checksum:i4782AC3D02F8F173
GO
Isoform 3 (identifier: Q8N2R0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGLRAEEGKR...PSAPPASRKM

Show »
Length:433
Mass (Da):48,771
Checksum:iBFEB7D6DD5697B73
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MGLRAEEGKRKPPRSVRGEV SPSQGPLAQEDEARRLRSCT PACHPGKRGKGGHRARRQRS AWDLTTHPLTHRSQELRGAA ATEGFLYVLLSHWVFVGAPR PPASDSWKKGLVPSAPPASR KM in isoform 3.
VSP_054849
Alternative sequencei253 – 31260ESPHK…PRQDF → TSSPTAASSAAKCSGETVIC GGTA in isoform 2.
VSP_017121Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321K → G in AAK74066. 1 Publication
Sequence conflicti286 – 2861C → R in BAC11035. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY038072 mRNA. Translation: AAK74066.1.
AY038073 mRNA. Translation: AAK74067.1.
AK074518 mRNA. Translation: BAC11035.1.
AK291491 mRNA. Translation: BAF84180.1.
AK304654 mRNA. Translation: BAG65429.1.
AC016877 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91785.1.
BC016936 mRNA. Translation: AAH16936.1.
CCDSiCCDS47901.1. [Q8N2R0-1]
CCDS47902.1. [Q8N2R0-2]
CCDS69520.1. [Q8N2R0-3]
RefSeqiNP_001135934.1. NM_001142462.2. [Q8N2R0-1]
NP_001273770.1. NM_001286841.1. [Q8N2R0-3]
NP_443727.2. NM_053001.3. [Q8N2R0-2]
XP_006716567.1. XM_006716504.1. [Q8N2R0-1]
UniGeneiHs.253247.

Genome annotation databases

EnsembliENST00000297565; ENSP00000297565; ENSG00000164920. [Q8N2R0-1]
ENST00000435298; ENSP00000402862; ENSG00000164920. [Q8N2R0-2]
ENST00000457907; ENSP00000414657; ENSG00000164920.
ENST00000522510; ENSP00000430780; ENSG00000164920. [Q8N2R0-1]
GeneIDi116039.
KEGGihsa:116039.
UCSCiuc003yiq.3. human. [Q8N2R0-2]
uc003yir.3. human. [Q8N2R0-1]

Polymorphism databases

DMDMi146345473.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY038072 mRNA. Translation: AAK74066.1 .
AY038073 mRNA. Translation: AAK74067.1 .
AK074518 mRNA. Translation: BAC11035.1 .
AK291491 mRNA. Translation: BAF84180.1 .
AK304654 mRNA. Translation: BAG65429.1 .
AC016877 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91785.1 .
BC016936 mRNA. Translation: AAH16936.1 .
CCDSi CCDS47901.1. [Q8N2R0-1 ]
CCDS47902.1. [Q8N2R0-2 ]
CCDS69520.1. [Q8N2R0-3 ]
RefSeqi NP_001135934.1. NM_001142462.2. [Q8N2R0-1 ]
NP_001273770.1. NM_001286841.1. [Q8N2R0-3 ]
NP_443727.2. NM_053001.3. [Q8N2R0-2 ]
XP_006716567.1. XM_006716504.1. [Q8N2R0-1 ]
UniGenei Hs.253247.

3D structure databases

ProteinModelPortali Q8N2R0.
SMRi Q8N2R0. Positions 163-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125467. 1 interaction.
IntActi Q8N2R0. 1 interaction.
STRINGi 9606.ENSP00000297565.

Polymorphism databases

DMDMi 146345473.

Proteomic databases

PaxDbi Q8N2R0.
PRIDEi Q8N2R0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297565 ; ENSP00000297565 ; ENSG00000164920 . [Q8N2R0-1 ]
ENST00000435298 ; ENSP00000402862 ; ENSG00000164920 . [Q8N2R0-2 ]
ENST00000457907 ; ENSP00000414657 ; ENSG00000164920 .
ENST00000522510 ; ENSP00000430780 ; ENSG00000164920 . [Q8N2R0-1 ]
GeneIDi 116039.
KEGGi hsa:116039.
UCSCi uc003yiq.3. human. [Q8N2R0-2 ]
uc003yir.3. human. [Q8N2R0-1 ]

Organism-specific databases

CTDi 116039.
GeneCardsi GC08P099956.
HGNCi HGNC:15830. OSR2.
HPAi HPA052425.
MIMi 611297. gene.
neXtProti NX_Q8N2R0.
PharmGKBi PA134924513.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000013107.
HOVERGENi HBG054398.
InParanoidi Q8N2R0.
KOi K09215.
PhylomeDBi Q8N2R0.
TreeFami TF350876.

Miscellaneous databases

ChiTaRSi OSR2. human.
GeneWikii OSR2_(gene).
GenomeRNAii 116039.
NextBioi 35477497.
PROi Q8N2R0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8N2R0.
Bgeei Q8N2R0.
CleanExi HS_OSR2.
Genevestigatori Q8N2R0.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the human OSR2 gene."
    Jiang R., Cho E.-S., Lan Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Embryo and Ovary.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.

Entry informationi

Entry nameiOSR2_HUMAN
AccessioniPrimary (citable) accession number: Q8N2R0
Secondary accession number(s): A8K626
, B4E3B7, Q96AM6, Q96LB6, Q96LB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 1, 2007
Last modified: September 3, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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