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Q8N2R0 (OSR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein odd-skipped-related 2
Gene names
Name:OSR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the Odd C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbone morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

chondrocyte differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

embryo development

Inferred from sequence or structural similarity. Source: UniProtKB

embryonic digit morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic forelimb morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic hindlimb morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic skeletal joint development

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic skeletal joint morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic skeletal limb joint morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic skeletal system morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

eyelid development in camera-type eye

Inferred from sequence or structural similarity. Source: UniProtKB

head development

Inferred from sequence or structural similarity. Source: BHF-UCL

mesonephros development

Inferred from sequence or structural similarity. Source: UniProtKB

metanephros development

Inferred from sequence or structural similarity. Source: UniProtKB

middle ear morphogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: BHF-UCL

odontogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

osteoblast proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

palate development

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of bone mineralization

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of epithelial cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of gastrulation

Inferred from electronic annotation. Source: Ensembl

positive regulation of gene expression

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: UniProtKB

pronephros development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N2R0-1)

Also known as: OSR2A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N2R0-2)

Also known as: OSR2B;

The sequence of this isoform differs from the canonical sequence as follows:
     253-312: ESPHKCPTCG...SLTHTPRQDF → TSSPTAASSAAKCSGETVICGGTA

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Protein odd-skipped-related 2
PRO_0000047007

Regions

Zinc finger172 – 19423C2H2-type 1
Zinc finger200 – 22223C2H2-type 2
Zinc finger228 – 25023C2H2-type 3
Zinc finger256 – 27823C2H2-type 4
Zinc finger284 – 30623C2H2-type 5; degenerate

Natural variations

Alternative sequence253 – 31260ESPHK…PRQDF → TSSPTAASSAAKCSGETVIC GGTA in isoform 2.
VSP_017121

Experimental info

Sequence conflict1321K → G in AAK74066. Ref.1
Sequence conflict2861C → R in BAC11035. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (OSR2A) [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 312E5A688EFB88B6

FASTA31235,513
        10         20         30         40         50         60 
MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH MNHWTLGYPN 

        70         80         90        100        110        120 
VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG AIAHVLPALH KDRPRFDFAN 

       130        140        150        160        170        180 
LAVAATQEDP PKMGDLSKLS PGLGSPISGL SKLTPDRKPS RGRLPSKTKK EFICKFCGRH 

       190        200        210        220        230        240 
FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS 

       250        260        270        280        290        300 
RTLAVHKTLH MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR 

       310 
RHSLTHTPRQ DF 

« Hide

Isoform 2 (OSR2B) [UniParc].

Checksum: 4782AC3D02F8F173
Show »

FASTA27630,573

References

« Hide 'large scale' references
[1]"Isolation of the human OSR2 gene."
Jiang R., Cho E.-S., Lan Y.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Embryo and Ovary.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY038072 mRNA. Translation: AAK74066.1.
AY038073 mRNA. Translation: AAK74067.1.
AK074518 mRNA. Translation: BAC11035.1.
AK291491 mRNA. Translation: BAF84180.1.
CH471060 Genomic DNA. Translation: EAW91785.1.
BC016936 mRNA. Translation: AAH16936.1.
RefSeqNP_001135934.1. NM_001142462.2.
NP_001273770.1. NM_001286841.1.
NP_443727.2. NM_053001.3.
UniGeneHs.253247.

3D structure databases

ProteinModelPortalQ8N2R0.
SMRQ8N2R0. Positions 163-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125467. 1 interaction.
IntActQ8N2R0. 1 interaction.
STRING9606.ENSP00000297565.

Polymorphism databases

DMDM146345473.

Proteomic databases

PaxDbQ8N2R0.
PRIDEQ8N2R0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297565; ENSP00000297565; ENSG00000164920. [Q8N2R0-1]
ENST00000435298; ENSP00000402862; ENSG00000164920. [Q8N2R0-2]
ENST00000522510; ENSP00000430780; ENSG00000164920. [Q8N2R0-1]
GeneID116039.
KEGGhsa:116039.
UCSCuc003yiq.3. human. [Q8N2R0-2]
uc003yir.3. human. [Q8N2R0-1]

Organism-specific databases

CTD116039.
GeneCardsGC08P099956.
HGNCHGNC:15830. OSR2.
HPAHPA052425.
MIM611297. gene.
neXtProtNX_Q8N2R0.
PharmGKBPA134924513.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000013107.
HOVERGENHBG054398.
InParanoidQ8N2R0.
KOK09215.
PhylomeDBQ8N2R0.
TreeFamTF350876.

Gene expression databases

ArrayExpressQ8N2R0.
BgeeQ8N2R0.
CleanExHS_OSR2.
GenevestigatorQ8N2R0.

Family and domain databases

Gene3D3.30.160.60. 5 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSOSR2. human.
GeneWikiOSR2_(gene).
GenomeRNAi116039.
NextBio79729.
PROQ8N2R0.
SOURCESearch...

Entry information

Entry nameOSR2_HUMAN
AccessionPrimary (citable) accession number: Q8N2R0
Secondary accession number(s): A8K626 expand/collapse secondary AC list , Q96AM6, Q96LB6, Q96LB7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 1, 2007
Last modified: April 16, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM