Reviewed,
UniProtKB/Swiss-Prot Q8N2R0 (OSR2_HUMAN)
Last modified
January 19, 2010.
Version 62.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Protein odd-skipped-related 2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 312 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Nucleus Potential. |
| Sequence similarities | Belongs to the Odd C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing |
| Domain | Zinc-finger |
| Ligand | Metal-binding Zinc |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8N2R0-1) Also known as: OSR2A; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8N2R0-2) Also known as: OSR2B; The sequence of this isoform differs from the canonical sequence as follows: 253-312: ESPHKCPTCG...SLTHTPRQDF → TSSPTAASSAAKCSGETVICGGTA |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 312 | 312 | Protein odd-skipped-related 2 | PRO_0000047007 | |||||
Regions | |||||||||
| Zinc finger | 172 – 194 | 23 | C2H2-type 1 | ||||||
| Zinc finger | 200 – 222 | 23 | C2H2-type 2 | ||||||
| Zinc finger | 228 – 250 | 23 | C2H2-type 3 | ||||||
| Zinc finger | 256 – 278 | 23 | C2H2-type 4 | ||||||
| Zinc finger | 284 – 306 | 23 | C2H2-type 5; degenerate | ||||||
Natural variations | |||||||||
| Alternative sequence | 253 – 312 | 60 | ESPHK…PRQDF → TSSPTAASSAAKCSGETVIC GGTA in isoform 2. | VSP_017121 | |||||
Experimental info | |||||||||
| Sequence conflict | 132 | 1 | K → G in AAK74066. Ref.1 | ||||||
| Sequence conflict | 286 | 1 | C → R in BAC11035. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation of the human OSR2 gene." Jiang R., Cho E.-S., Lan Y. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Embryo and Ovary. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Kidney. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY038072 mRNA. Translation: AAK74066.1. AY038073 mRNA. Translation: AAK74067.1. AK074518 mRNA. Translation: BAC11035.1. AK291491 mRNA. Translation: BAF84180.1. CH471060 Genomic DNA. Translation: EAW91785.1. BC016936 mRNA. Translation: AAH16936.1. |
| IPI | IPI00719002. IPI00943317. |
| RefSeq | NP_001135934.1. NP_443727.2. |
| UniGene | Hs.253247 |
3D structure databases | |
| SMR | Q8N2R0. Positions 163-254, 169-307. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8N2R0. |
Genome annotation databases | |
| Ensembl | ENST00000297565; ENSP00000297565; ENSG00000164920; Homo sapiens. [Genome view] ENST00000457907; ENSP00000414657; ENSG00000164920; Homo sapiens. [Genome view] |
| GeneID | 116039. |
| KEGG | hsa:116039. |
| UCSC | uc003yiq.1. human. uc003yir.1. human. |
Organism-specific databases | |
| CTD | 116039. |
| GeneCards | GC08P100025. |
| HGNC | HGNC:15830. OSR2. |
| MIM | 611297. gene. |
| PharmGKB | PA28816. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG19573. |
| HOVERGEN | Q8N2R0. |
| InParanoid | Q8N2R0. |
| OrthoDB | EOG9F20NQ. |
| PhylomeDB | Q8N2R0. |
Gene expression databases | |
| ArrayExpress | Q8N2R0. |
| Bgee | Q8N2R0. |
| CleanEx | HS_OSR2. |
| Genevestigator | Q8N2R0. |
| GermOnline | ENSG00000164920. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view] |
| Gene3D | G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit. |
| Pfam | PF00096. zf-C2H2. 2 hits. [Graphical view] |
| SMART | SM00355. ZnF_C2H2. 5 hits. [Graphical view] |
| PROSITE | PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 79729. |
| SOURCE | Search... |
Entry information
| Entry name | OSR2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N2R0 Secondary accession number(s): A8K626 Q96LB7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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