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Q8N2R0

- OSR2_HUMAN

UniProt

Q8N2R0 - OSR2_HUMAN

Protein

Protein odd-skipped-related 2

Gene

OSR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. bone morphogenesis Source: UniProtKB
    2. cell differentiation Source: BHF-UCL
    3. chondrocyte differentiation Source: BHF-UCL
    4. embryo development Source: UniProtKB
    5. embryonic digit morphogenesis Source: BHF-UCL
    6. embryonic forelimb morphogenesis Source: BHF-UCL
    7. embryonic hindlimb morphogenesis Source: BHF-UCL
    8. embryonic skeletal joint development Source: BHF-UCL
    9. embryonic skeletal joint morphogenesis Source: BHF-UCL
    10. embryonic skeletal limb joint morphogenesis Source: BHF-UCL
    11. embryonic skeletal system morphogenesis Source: UniProtKB
    12. eyelid development in camera-type eye Source: UniProtKB
    13. head development Source: BHF-UCL
    14. mesonephros development Source: UniProtKB
    15. metanephros development Source: UniProtKB
    16. middle ear morphogenesis Source: UniProtKB
    17. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    18. odontogenesis Source: UniProtKB
    19. osteoblast proliferation Source: UniProtKB
    20. palate development Source: UniProtKB
    21. positive regulation of bone mineralization Source: BHF-UCL
    22. positive regulation of cell proliferation Source: UniProtKB
    23. positive regulation of epithelial cell proliferation Source: UniProtKB
    24. positive regulation of gastrulation Source: Ensembl
    25. positive regulation of gene expression Source: UniProtKB
    26. positive regulation of transcription, DNA-templated Source: UniProtKB
    27. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    28. pronephros development Source: Ensembl

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein odd-skipped-related 2
    Gene namesi
    Name:OSR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:15830. OSR2.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134924513.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Protein odd-skipped-related 2PRO_0000047007Add
    BLAST

    Proteomic databases

    PaxDbiQ8N2R0.
    PRIDEiQ8N2R0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8N2R0.
    BgeeiQ8N2R0.
    CleanExiHS_OSR2.
    GenevestigatoriQ8N2R0.

    Organism-specific databases

    HPAiHPA052425.

    Interactioni

    Protein-protein interaction databases

    BioGridi125467. 1 interaction.
    IntActiQ8N2R0. 1 interaction.
    STRINGi9606.ENSP00000297565.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N2R0.
    SMRiQ8N2R0. Positions 163-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri256 – 27823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri284 – 30623C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000013107.
    HOVERGENiHBG054398.
    InParanoidiQ8N2R0.
    KOiK09215.
    PhylomeDBiQ8N2R0.
    TreeFamiTF350876.

    Family and domain databases

    Gene3Di3.30.160.60. 5 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N2R0-1) [UniParc]FASTAAdd to Basket

    Also known as: OSR2A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH    50
    MNHWTLGYPN VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG 100
    AIAHVLPALH KDRPRFDFAN LAVAATQEDP PKMGDLSKLS PGLGSPISGL 150
    SKLTPDRKPS RGRLPSKTKK EFICKFCGRH FTKSYNLLIH ERTHTDERPY 200
    TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS RTLAVHKTLH 250
    MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR 300
    RHSLTHTPRQ DF 312
    Length:312
    Mass (Da):35,513
    Last modified:May 1, 2007 - v2
    Checksum:i312E5A688EFB88B6
    GO
    Isoform 2 (identifier: Q8N2R0-2) [UniParc]FASTAAdd to Basket

    Also known as: OSR2B

    The sequence of this isoform differs from the canonical sequence as follows:
         253-312: ESPHKCPTCG...SLTHTPRQDF → TSSPTAASSAAKCSGETVICGGTA

    Show »
    Length:276
    Mass (Da):30,573
    Checksum:i4782AC3D02F8F173
    GO
    Isoform 3 (identifier: Q8N2R0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MGLRAEEGKR...PSAPPASRKM

    Show »
    Length:433
    Mass (Da):48,771
    Checksum:iBFEB7D6DD5697B73
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321K → G in AAK74066. 1 PublicationCurated
    Sequence conflicti286 – 2861C → R in BAC11035. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MGLRAEEGKRKPPRSVRGEV SPSQGPLAQEDEARRLRSCT PACHPGKRGKGGHRARRQRS AWDLTTHPLTHRSQELRGAA ATEGFLYVLLSHWVFVGAPR PPASDSWKKGLVPSAPPASR KM in isoform 3. 1 PublicationVSP_054849
    Alternative sequencei253 – 31260ESPHK…PRQDF → TSSPTAASSAAKCSGETVIC GGTA in isoform 2. 3 PublicationsVSP_017121Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY038072 mRNA. Translation: AAK74066.1.
    AY038073 mRNA. Translation: AAK74067.1.
    AK074518 mRNA. Translation: BAC11035.1.
    AK291491 mRNA. Translation: BAF84180.1.
    AK304654 mRNA. Translation: BAG65429.1.
    AC016877 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW91785.1.
    BC016936 mRNA. Translation: AAH16936.1.
    CCDSiCCDS47901.1. [Q8N2R0-1]
    CCDS47902.1. [Q8N2R0-2]
    CCDS69520.1. [Q8N2R0-3]
    RefSeqiNP_001135934.1. NM_001142462.2. [Q8N2R0-1]
    NP_001273770.1. NM_001286841.1. [Q8N2R0-3]
    NP_443727.2. NM_053001.3. [Q8N2R0-2]
    XP_006716567.1. XM_006716504.1. [Q8N2R0-1]
    UniGeneiHs.253247.

    Genome annotation databases

    EnsembliENST00000297565; ENSP00000297565; ENSG00000164920. [Q8N2R0-1]
    ENST00000435298; ENSP00000402862; ENSG00000164920. [Q8N2R0-2]
    ENST00000457907; ENSP00000414657; ENSG00000164920. [Q8N2R0-3]
    ENST00000522510; ENSP00000430780; ENSG00000164920. [Q8N2R0-1]
    GeneIDi116039.
    KEGGihsa:116039.
    UCSCiuc003yiq.3. human. [Q8N2R0-2]
    uc003yir.3. human. [Q8N2R0-1]

    Polymorphism databases

    DMDMi146345473.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY038072 mRNA. Translation: AAK74066.1 .
    AY038073 mRNA. Translation: AAK74067.1 .
    AK074518 mRNA. Translation: BAC11035.1 .
    AK291491 mRNA. Translation: BAF84180.1 .
    AK304654 mRNA. Translation: BAG65429.1 .
    AC016877 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW91785.1 .
    BC016936 mRNA. Translation: AAH16936.1 .
    CCDSi CCDS47901.1. [Q8N2R0-1 ]
    CCDS47902.1. [Q8N2R0-2 ]
    CCDS69520.1. [Q8N2R0-3 ]
    RefSeqi NP_001135934.1. NM_001142462.2. [Q8N2R0-1 ]
    NP_001273770.1. NM_001286841.1. [Q8N2R0-3 ]
    NP_443727.2. NM_053001.3. [Q8N2R0-2 ]
    XP_006716567.1. XM_006716504.1. [Q8N2R0-1 ]
    UniGenei Hs.253247.

    3D structure databases

    ProteinModelPortali Q8N2R0.
    SMRi Q8N2R0. Positions 163-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125467. 1 interaction.
    IntActi Q8N2R0. 1 interaction.
    STRINGi 9606.ENSP00000297565.

    Polymorphism databases

    DMDMi 146345473.

    Proteomic databases

    PaxDbi Q8N2R0.
    PRIDEi Q8N2R0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297565 ; ENSP00000297565 ; ENSG00000164920 . [Q8N2R0-1 ]
    ENST00000435298 ; ENSP00000402862 ; ENSG00000164920 . [Q8N2R0-2 ]
    ENST00000457907 ; ENSP00000414657 ; ENSG00000164920 . [Q8N2R0-3 ]
    ENST00000522510 ; ENSP00000430780 ; ENSG00000164920 . [Q8N2R0-1 ]
    GeneIDi 116039.
    KEGGi hsa:116039.
    UCSCi uc003yiq.3. human. [Q8N2R0-2 ]
    uc003yir.3. human. [Q8N2R0-1 ]

    Organism-specific databases

    CTDi 116039.
    GeneCardsi GC08P099956.
    HGNCi HGNC:15830. OSR2.
    HPAi HPA052425.
    MIMi 611297. gene.
    neXtProti NX_Q8N2R0.
    PharmGKBi PA134924513.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000013107.
    HOVERGENi HBG054398.
    InParanoidi Q8N2R0.
    KOi K09215.
    PhylomeDBi Q8N2R0.
    TreeFami TF350876.

    Miscellaneous databases

    ChiTaRSi OSR2. human.
    GeneWikii OSR2_(gene).
    GenomeRNAii 116039.
    NextBioi 35477497.
    PROi Q8N2R0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N2R0.
    Bgeei Q8N2R0.
    CleanExi HS_OSR2.
    Genevestigatori Q8N2R0.

    Family and domain databases

    Gene3Di 3.30.160.60. 5 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the human OSR2 gene."
      Jiang R., Cho E.-S., Lan Y.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Embryo and Ovary.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.

    Entry informationi

    Entry nameiOSR2_HUMAN
    AccessioniPrimary (citable) accession number: Q8N2R0
    Secondary accession number(s): A8K626
    , B4E3B7, Q96AM6, Q96LB6, Q96LB7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3