Q8N2R0 (OSR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein odd-skipped-related 2

Gene names

Name:

OSR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the Odd C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	bone morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB chondrocyte differentiation Inferred from sequence or structural similarity. Source: BHF-UCL embryonic digit morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL embryonic forelimb morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL embryonic hindlimb morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL embryonic skeletal limb joint morphogenesis Inferred from sequence or structural similarity. Source: BHF-UCL eyelid development in camera-type eye Inferred from sequence or structural similarity. Source: UniProtKB head development Inferred from sequence or structural similarity. Source: BHF-UCL mesonephros development Inferred from sequence or structural similarity. Source: UniProtKB metanephros development Inferred from sequence or structural similarity. Source: UniProtKB middle ear morphogenesis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: BHF-UCL odontogenesis Inferred from sequence or structural similarity. Source: UniProtKB osteoblast proliferation Inferred from sequence or structural similarity. Source: UniProtKB palate development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of bone mineralization Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of epithelial cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of gastrulation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: BHF-UCL pronephros development Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	sequence-specific DNA binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N2R0-1)

Also known as: OSR2A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N2R0-2)

Also known as: OSR2B;

The sequence of this isoform differs from the canonical sequence as follows:
     253-312: ESPHKCPTCG...SLTHTPRQDF → TSSPTAASSAAKCSGETVICGGTA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Protein odd-skipped-related 2		PRO_0000047007
Regions
	Zinc finger	172 – 194	23	C2H2-type 1
	Zinc finger	200 – 222	23	C2H2-type 2
	Zinc finger	228 – 250	23	C2H2-type 3
	Zinc finger	256 – 278	23	C2H2-type 4
	Zinc finger	284 – 306	23	C2H2-type 5; degenerate
Natural variations
	Alternative sequence	253 – 312	60	ESPHK…PRQDF → TSSPTAASSAAKCSGETVIC GGTA in isoform 2.		VSP_017121
Experimental info
	Sequence conflict	132	1	K → G in AAK74066. Ref.1
	Sequence conflict	286	1	C → R in BAC11035. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (OSR2A) [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 312E5A688EFB88B6	FASTA	312	35,513
	10 20 30 40 50 60 MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH MNHWTLGYPN 70 80 90 100 110 120 VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG AIAHVLPALH KDRPRFDFAN 130 140 150 160 170 180 LAVAATQEDP PKMGDLSKLS PGLGSPISGL SKLTPDRKPS RGRLPSKTKK EFICKFCGRH 190 200 210 220 230 240 FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS 250 260 270 280 290 300 RTLAVHKTLH MQESPHKCPT CGRTFNQRSN LKTHLLTHTD IKPYSCEQCG KVFRRNCDLR 310 RHSLTHTPRQ DF
	Isoform 2 (OSR2B) [UniParc]. Checksum: 4782AC3D02F8F173	FASTA	276	30,573
	10 20 30 40 50 60 MGSKALPAPI PLHPSLQLTN YSFLQAVNTF PATVDHLQGL YGLSAVQTMH MNHWTLGYPN 70 80 90 100 110 120 VHEITRSTIT EMAAAQGLVD ARFPFPALPF TTHLFHPKQG AIAHVLPALH KDRPRFDFAN 130 140 150 160 170 180 LAVAATQEDP PKMGDLSKLS PGLGSPISGL SKLTPDRKPS RGRLPSKTKK EFICKFCGRH 190 200 210 220 230 240 FTKSYNLLIH ERTHTDERPY TCDICHKAFR RQDHLRDHRY IHSKEKPFKC QECGKGFCQS 250 260 270 RTLAVHKTLH MQTSSPTAAS SAAKCSGETV ICGGTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of the human OSR2 gene." Jiang R., Cho E.-S., Lan Y. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Embryo and Ovary.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY038072 mRNA. Translation: AAK74066.1. AY038073 mRNA. Translation: AAK74067.1. AK074518 mRNA. Translation: BAC11035.1. AK291491 mRNA. Translation: BAF84180.1. CH471060 Genomic DNA. Translation: EAW91785.1. BC016936 mRNA. Translation: AAH16936.1.
IPI	IPI00719002. IPI00943317.
RefSeq	NP_001135934.1. NM_001142462.1. NP_443727.2. NM_053001.2.
UniGene	Hs.253247.
3D structure databases
ProteinModelPortal	Q8N2R0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N2R0. 1 interaction.
STRING	9606.ENSP00000297565.
Polymorphism databases
DMDM	146345473.
Proteomic databases
PaxDb	Q8N2R0.
PRIDE	Q8N2R0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297565; ENSP00000297565; ENSG00000164920. ENST00000435298; ENSP00000402862; ENSG00000164920. ENST00000522510; ENSP00000430780; ENSG00000164920.
GeneID	116039.
KEGG	hsa:116039.
UCSC	uc003yiq.3. human. uc003yir.3. human.
Organism-specific databases
CTD	116039.
GeneCards	GC08P099956.
HGNC	HGNC:15830. OSR2.
HPA	HPA052425.
MIM	611297. gene.
neXtProt	NX_Q8N2R0.
PharmGKB	PA134924513.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000013107.
HOVERGEN	HBG054398.
InParanoid	Q8N2R0.
KO	K09215.
OrthoDB	EOG46MBJW.
PhylomeDB	Q8N2R0.
Gene expression databases
ArrayExpress	Q8N2R0.
Bgee	Q8N2R0.
CleanEx	HS_OSR2.
Genevestigator	Q8N2R0.
GermOnline	ENSG00000164920. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 5 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 2 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	OSR2. human.
GenomeRNAi	116039.
NextBio	79729.
SOURCE	Search...

Entry information

Entry name

OSR2_HUMAN

Accession

Primary (citable) accession number: Q8N2R0
Secondary accession number(s): A8K626 , Q96AM6, Q96LB6, Q96LB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	May 1, 2007
Last modified:	May 1, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.