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Protein

Neuroligin-1

Gene

NLGN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.By similarity

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: GO_Central
  2. cell adhesion molecule binding Source: BHF-UCL
  3. neurexin family protein binding Source: UniProtKB
  4. PDZ domain binding Source: UniProtKB
  5. protein dimerization activity Source: BHF-UCL
  6. receptor activity Source: BHF-UCL

GO - Biological processi

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering Source: BHF-UCL
  2. calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  3. cytoskeletal matrix organization at active zone Source: BHF-UCL
  4. establishment of protein localization Source: BHF-UCL
  5. heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
  6. metabolic process Source: GOC
  7. nervous system development Source: UniProtKB
  8. neurexin clustering Source: BHF-UCL
  9. neuronal signal transduction Source: BHF-UCL
  10. neuron cell-cell adhesion Source: BHF-UCL
  11. neuron projection development Source: CACAO
  12. N-methyl-D-aspartate receptor clustering Source: BHF-UCL
  13. positive regulation of circadian sleep/wake cycle, wakefulness Source: UniProtKB
  14. positive regulation of dendritic spine development Source: BHF-UCL
  15. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
  16. positive regulation of filopodium assembly Source: BHF-UCL
  17. positive regulation of intracellular signal transduction Source: BHF-UCL
  18. positive regulation of ruffle assembly Source: BHF-UCL
  19. positive regulation of synapse assembly Source: BHF-UCL
  20. positive regulation of synaptic transmission, GABAergic Source: BHF-UCL
  21. positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
  22. positive regulation of synaptic vesicle endocytosis Source: BHF-UCL
  23. positive regulation of synaptic vesicle exocytosis Source: BHF-UCL
  24. postsynaptic density protein 95 clustering Source: BHF-UCL
  25. postsynaptic membrane assembly Source: BHF-UCL
  26. presynaptic membrane assembly Source: BHF-UCL
  27. protein heterotetramerization Source: Ensembl
  28. protein homooligomerization Source: BHF-UCL
  29. protein localization to synapse Source: BHF-UCL
  30. protein targeting Source: UniProtKB
  31. receptor localization to synapse Source: BHF-UCL
  32. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
  33. regulation of neuron differentiation Source: UniProtKB
  34. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: BHF-UCL
  35. regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
  36. regulation of synaptic transmission Source: GO_Central
  37. rhythmic process Source: UniProtKB-KW
  38. synapse assembly Source: UniProtKB
  39. synaptic vesicle clustering Source: BHF-UCL
  40. synaptic vesicle targeting Source: UniProtKB
  41. terminal button organization Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Cell adhesion

Protein family/group databases

MEROPSiS09.994.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroligin-1
Gene namesi
Name:NLGN1
Synonyms:KIAA1070
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14291. NLGN1.

Subcellular locationi

  1. Cell membrane By similarity; Single-pass type I membrane protein By similarity
  2. Cell junctionsynapse By similarity
  3. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity

  4. Note: Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini46 – 694649ExtracellularSequence AnalysisAdd
BLAST
Transmembranei695 – 71521HelicalSequence AnalysisAdd
BLAST
Topological domaini716 – 840125CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell surface Source: BHF-UCL
  3. dendrite Source: BHF-UCL
  4. excitatory synapse Source: InterPro
  5. external side of plasma membrane Source: Ensembl
  6. filopodium tip Source: BHF-UCL
  7. integral component of plasma membrane Source: UniProtKB
  8. neuronal postsynaptic density Source: BHF-UCL
  9. N-methyl-D-aspartate selective glutamate receptor complex Source: Ensembl
  10. postsynaptic membrane Source: UniProtKB-KW
  11. synapse Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31647.

Polymorphism and mutation databases

DMDMi31076822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4545Sequence AnalysisAdd
BLAST
Chaini46 – 840795Neuroligin-1PRO_0000008640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...) (complex)By similarity
Disulfide bondi117 ↔ 153By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...) (complex)By similarity
Disulfide bondi339 ↔ 350By similarity
Glycosylationi340 – 3401N-linked (GlcNAc...) (complex)By similarity
Disulfide bondi509 ↔ 543By similarity
Glycosylationi544 – 5441N-linked (GlcNAc...)By similarity
Glycosylationi680 – 6801O-linked (GalNAc...)By similarity
Glycosylationi683 – 6831O-linked (GalNAc...)By similarity
Modified residuei779 – 7791PhosphotyrosineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8N2Q7.
PRIDEiQ8N2Q7.

PTM databases

PhosphoSiteiQ8N2Q7.

Expressioni

Tissue specificityi

Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

Gene expression databases

BgeeiQ8N2Q7.
CleanExiHS_NLGN1.
ExpressionAtlasiQ8N2Q7. baseline and differential.
GenevestigatoriQ8N2Q7.

Organism-specific databases

HPAiHPA006680.

Interactioni

Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3. Interacts with NLGN3. Interacts with AIP1 and PDZRN3 (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with GOPC.By similarity2 Publications

Protein-protein interaction databases

BioGridi116538. 8 interactions.
IntActiQ8N2Q7. 5 interactions.
MINTiMINT-1901478.
STRINGi9606.ENSP00000354541.

Structurei

3D structure databases

ProteinModelPortaliQ8N2Q7.
SMRiQ8N2Q7. Positions 52-628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2272.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000231424.
HOVERGENiHBG008839.
InParanoidiQ8N2Q7.
KOiK07378.
OrthoDBiEOG7RBZ7R.
PhylomeDBiQ8N2Q7.
TreeFamiTF326187.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Nlgn.
IPR030022. NLGN1.
[Graphical view]
PANTHERiPTHR11559:SF52. PTHR11559:SF52. 1 hit.
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2Q7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD
60 70 80 90 100
VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP
110 120 130 140 150
PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS
160 170 180 190 200
EDCLYLNIYV PTEDGPLTKK RDEATLNPPD TDIRDSGGPK PVMVYIHGGS
210 220 230 240 250
YMEGTGNLYD GSVLASYGNV IVITVNYRLG VLGFLSTGDQ AAKGNYGLLD
260 270 280 290 300
LIQALRWTSE NIGFFGGDPL RITVFGSGAG GSCVNLLTLS HYSEGNRWSN
310 320 330 340 350
STKGLFQRAI AQSGTALSSW AVSFQPAKYA RMLATKVGCN VSDTVELVEC
360 370 380 390 400
LQKKPYKELV DQDIQPARYH IAFGPVIDGD VIPDDPQILM EQGEFLNYDI
410 420 430 440 450
MLGVNQGEGL KFVENIVDSD DGISASDFDF AVSNFVDNLY GYPEGKDVLR
460 470 480 490 500
ETIKFMYTDW ADRHNPETRR KTLLALFTDH QWVAPAVATA DLHSNFGSPT
510 520 530 540 550
YFYAFYHHCQ TDQVPAWADA AHGDEVPYVL GIPMIGPTEL FPCNFSKNDV
560 570 580 590 600
MLSAVVMTYW TNFAKTGDPN QPVPQDTKFI HTKPNRFEEV AWTRYSQKDQ
610 620 630 640 650
LYLHIGLKPR VKEHYRANKV NLWLELVPHL HNLNDISQYT STTTKVPSTD
660 670 680 690 700
ITFRPTRKNS VPVTSAFPTA KQDDPKQQPS PFSVDQRDYS TELSVTIAVG
710 720 730 740 750
ASLLFLNILA FAALYYKKDK RRHDVHRRCS PQRTTTNDLT HAQEEEIMSL
760 770 780 790 800
QMKHTDLDHE CESIHPHEVV LRTACPPDYT LAMRRSPDDV PLMTPNTITM
810 820 830 840
IPNTIPGIQP LHTFNTFTGG QNNTLPHPHP HPHSHSTTRV

Note: No experimental confirmation available.

Length:840
Mass (Da):93,835
Last modified:May 23, 2003 - v2
Checksum:iA3FB21716F62DE29
GO
Isoform 2 (identifier: Q8N2Q7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-181: Missing.

Show »
Length:823
Mass (Da):92,000
Checksum:iEA93E8F9801CB8A8
GO

Sequence cautioni

The sequence BAA83022.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11039.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti711 – 7111F → L in BAC11039 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei165 – 18117Missing in isoform 2. 2 PublicationsVSP_007527Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028993 mRNA. Translation: BAA83022.2. Different initiation.
AC008082 Genomic DNA. No translation available.
AC008120 Genomic DNA. No translation available.
AC092923 Genomic DNA. No translation available.
AC092967 Genomic DNA. No translation available.
AC110871 Genomic DNA. No translation available.
AC131158 Genomic DNA. No translation available.
BC032555 mRNA. Translation: AAH32555.1.
AK074522 mRNA. Translation: BAC11039.1. Different initiation.
CCDSiCCDS3222.1. [Q8N2Q7-2]
RefSeqiNP_055747.1. NM_014932.3. [Q8N2Q7-2]
XP_005247291.1. XM_005247234.1. [Q8N2Q7-2]
XP_005247292.1. XM_005247235.2. [Q8N2Q7-2]
UniGeneiHs.478289.
Hs.732502.

Genome annotation databases

EnsembliENST00000361589; ENSP00000354541; ENSG00000169760. [Q8N2Q7-2]
ENST00000457714; ENSP00000392500; ENSG00000169760. [Q8N2Q7-2]
GeneIDi22871.
KEGGihsa:22871.
UCSCiuc003fio.1. human. [Q8N2Q7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028993 mRNA. Translation: BAA83022.2. Different initiation.
AC008082 Genomic DNA. No translation available.
AC008120 Genomic DNA. No translation available.
AC092923 Genomic DNA. No translation available.
AC092967 Genomic DNA. No translation available.
AC110871 Genomic DNA. No translation available.
AC131158 Genomic DNA. No translation available.
BC032555 mRNA. Translation: AAH32555.1.
AK074522 mRNA. Translation: BAC11039.1. Different initiation.
CCDSiCCDS3222.1. [Q8N2Q7-2]
RefSeqiNP_055747.1. NM_014932.3. [Q8N2Q7-2]
XP_005247291.1. XM_005247234.1. [Q8N2Q7-2]
XP_005247292.1. XM_005247235.2. [Q8N2Q7-2]
UniGeneiHs.478289.
Hs.732502.

3D structure databases

ProteinModelPortaliQ8N2Q7.
SMRiQ8N2Q7. Positions 52-628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116538. 8 interactions.
IntActiQ8N2Q7. 5 interactions.
MINTiMINT-1901478.
STRINGi9606.ENSP00000354541.

Protein family/group databases

MEROPSiS09.994.

PTM databases

PhosphoSiteiQ8N2Q7.

Polymorphism and mutation databases

DMDMi31076822.

Proteomic databases

PaxDbiQ8N2Q7.
PRIDEiQ8N2Q7.

Protocols and materials databases

DNASUi22871.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361589; ENSP00000354541; ENSG00000169760. [Q8N2Q7-2]
ENST00000457714; ENSP00000392500; ENSG00000169760. [Q8N2Q7-2]
GeneIDi22871.
KEGGihsa:22871.
UCSCiuc003fio.1. human. [Q8N2Q7-2]

Organism-specific databases

CTDi22871.
GeneCardsiGC03P173114.
HGNCiHGNC:14291. NLGN1.
HPAiHPA006680.
MIMi600568. gene.
neXtProtiNX_Q8N2Q7.
PharmGKBiPA31647.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2272.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000231424.
HOVERGENiHBG008839.
InParanoidiQ8N2Q7.
KOiK07378.
OrthoDBiEOG7RBZ7R.
PhylomeDBiQ8N2Q7.
TreeFamiTF326187.

Miscellaneous databases

ChiTaRSiNLGN1. human.
GeneWikiiNLGN1.
GenomeRNAii22871.
NextBioi43403.
PROiQ8N2Q7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N2Q7.
CleanExiHS_NLGN1.
ExpressionAtlasiQ8N2Q7. baseline and differential.
GenevestigatoriQ8N2Q7.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Nlgn.
IPR030022. NLGN1.
[Graphical view]
PANTHERiPTHR11559:SF52. PTHR11559:SF52. 1 hit.
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Duodenum.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 315-823.
    Tissue: Embryo.
  5. Cited for: INTERACTION WITH DLG4.
  6. "Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin."
    Li X., Zhang J., Cao Z., Wu J., Shi Y.
    Protein Sci. 15:2149-2158(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GOPC.
  7. "Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion."
    Suckow A.T., Comoletti D., Waldrop M.A., Mosedale M., Egodage S., Taylor P., Chessler S.D.
    Endocrinology 149:6006-6017(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  8. "The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions."
    Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B., Cera M.R., Mascia L., Bussolino F., Arese M.
    Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiNLGN1_HUMAN
AccessioniPrimary (citable) accession number: Q8N2Q7
Secondary accession number(s): Q9UPT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: April 29, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.