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Protein

Neuroligin-1

Gene

NLGN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biological rhythms, Cell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Protein family/group databases

ESTHERihuman-NLGN1. Neuroligin.
MEROPSiS09.994.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroligin-1
Gene namesi
Name:NLGN1
Synonyms:KIAA1070
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14291. NLGN1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini46 – 694ExtracellularSequence analysisAdd BLAST649
Transmembranei695 – 715HelicalSequence analysisAdd BLAST21
Topological domaini716 – 840CytoplasmicSequence analysisAdd BLAST125

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi22871.
OpenTargetsiENSG00000169760.
PharmGKBiPA31647.

Polymorphism and mutation databases

DMDMi31076822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 45Sequence analysisAdd BLAST45
ChainiPRO_000000864046 – 840Neuroligin-1Add BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...) (complex)By similarity1
Disulfide bondi117 ↔ 153By similarity
Glycosylationi300N-linked (GlcNAc...) (complex)By similarity1
Disulfide bondi339 ↔ 350By similarity
Glycosylationi340N-linked (GlcNAc...) (complex)By similarity1
Disulfide bondi509 ↔ 543By similarity
Glycosylationi544N-linked (GlcNAc...)By similarity1
Glycosylationi680O-linked (GalNAc...)By similarity1
Glycosylationi683O-linked (GalNAc...)By similarity1
Modified residuei730PhosphoserineBy similarity1
Modified residuei779PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8N2Q7.
PeptideAtlasiQ8N2Q7.
PRIDEiQ8N2Q7.

PTM databases

iPTMnetiQ8N2Q7.
PhosphoSitePlusiQ8N2Q7.

Expressioni

Tissue specificityi

Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

Gene expression databases

BgeeiENSG00000169760.
CleanExiHS_NLGN1.
ExpressionAtlasiQ8N2Q7. baseline and differential.
GenevisibleiQ8N2Q7. HS.

Organism-specific databases

HPAiHPA006680.

Interactioni

Subunit structurei

Interacts with NRXN1, NRXN2 and NRXN3. Interacts with NLGN3. Interacts with AIP1 and PDZRN3 (By similarity). Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with GOPC.By similarity2 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: BHF-UCL
  • neurexin family protein binding Source: UniProtKB
  • PDZ domain binding Source: UniProtKB
  • protein dimerization activity Source: BHF-UCL
  • scaffold protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi116538. 8 interactors.
IntActiQ8N2Q7. 5 interactors.
MINTiMINT-1901478.
STRINGi9606.ENSP00000354541.

Structurei

3D structure databases

ProteinModelPortaliQ8N2Q7.
SMRiQ8N2Q7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000231424.
HOVERGENiHBG008839.
InParanoidiQ8N2Q7.
KOiK07378.
OMAiKFVELIV.
OrthoDBiEOG091G0CHW.
PhylomeDBiQ8N2Q7.
TreeFamiTF326187.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Nlgn.
IPR030022. NLGN1.
[Graphical view]
PANTHERiPTHR11559:SF52. PTHR11559:SF52. 2 hits.
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2Q7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD
60 70 80 90 100
VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP
110 120 130 140 150
PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS
160 170 180 190 200
EDCLYLNIYV PTEDGPLTKK RDEATLNPPD TDIRDSGGPK PVMVYIHGGS
210 220 230 240 250
YMEGTGNLYD GSVLASYGNV IVITVNYRLG VLGFLSTGDQ AAKGNYGLLD
260 270 280 290 300
LIQALRWTSE NIGFFGGDPL RITVFGSGAG GSCVNLLTLS HYSEGNRWSN
310 320 330 340 350
STKGLFQRAI AQSGTALSSW AVSFQPAKYA RMLATKVGCN VSDTVELVEC
360 370 380 390 400
LQKKPYKELV DQDIQPARYH IAFGPVIDGD VIPDDPQILM EQGEFLNYDI
410 420 430 440 450
MLGVNQGEGL KFVENIVDSD DGISASDFDF AVSNFVDNLY GYPEGKDVLR
460 470 480 490 500
ETIKFMYTDW ADRHNPETRR KTLLALFTDH QWVAPAVATA DLHSNFGSPT
510 520 530 540 550
YFYAFYHHCQ TDQVPAWADA AHGDEVPYVL GIPMIGPTEL FPCNFSKNDV
560 570 580 590 600
MLSAVVMTYW TNFAKTGDPN QPVPQDTKFI HTKPNRFEEV AWTRYSQKDQ
610 620 630 640 650
LYLHIGLKPR VKEHYRANKV NLWLELVPHL HNLNDISQYT STTTKVPSTD
660 670 680 690 700
ITFRPTRKNS VPVTSAFPTA KQDDPKQQPS PFSVDQRDYS TELSVTIAVG
710 720 730 740 750
ASLLFLNILA FAALYYKKDK RRHDVHRRCS PQRTTTNDLT HAQEEEIMSL
760 770 780 790 800
QMKHTDLDHE CESIHPHEVV LRTACPPDYT LAMRRSPDDV PLMTPNTITM
810 820 830 840
IPNTIPGIQP LHTFNTFTGG QNNTLPHPHP HPHSHSTTRV
Note: No experimental confirmation available.
Length:840
Mass (Da):93,835
Last modified:May 23, 2003 - v2
Checksum:iA3FB21716F62DE29
GO
Isoform 2 (identifier: Q8N2Q7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-181: Missing.

Show »
Length:823
Mass (Da):92,000
Checksum:iEA93E8F9801CB8A8
GO

Sequence cautioni

The sequence BAA83022 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11039 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti711F → L in BAC11039 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007527165 – 181Missing in isoform 2. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028993 mRNA. Translation: BAA83022.2. Different initiation.
AC008082 Genomic DNA. No translation available.
AC008120 Genomic DNA. No translation available.
AC092923 Genomic DNA. No translation available.
AC092967 Genomic DNA. No translation available.
AC110871 Genomic DNA. No translation available.
AC131158 Genomic DNA. No translation available.
BC032555 mRNA. Translation: AAH32555.1.
AK074522 mRNA. Translation: BAC11039.1. Different initiation.
CCDSiCCDS3222.1. [Q8N2Q7-2]
RefSeqiNP_055747.1. NM_014932.3. [Q8N2Q7-2]
XP_005247291.1. XM_005247234.2. [Q8N2Q7-2]
XP_005247292.1. XM_005247235.3. [Q8N2Q7-2]
XP_016861387.1. XM_017005898.1. [Q8N2Q7-2]
XP_016861388.1. XM_017005899.1. [Q8N2Q7-2]
XP_016861389.1. XM_017005900.1. [Q8N2Q7-2]
XP_016861390.1. XM_017005901.1. [Q8N2Q7-2]
UniGeneiHs.478289.
Hs.732502.

Genome annotation databases

EnsembliENST00000361589; ENSP00000354541; ENSG00000169760. [Q8N2Q7-2]
ENST00000457714; ENSP00000392500; ENSG00000169760. [Q8N2Q7-2]
GeneIDi22871.
KEGGihsa:22871.
UCSCiuc003fio.3. human. [Q8N2Q7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028993 mRNA. Translation: BAA83022.2. Different initiation.
AC008082 Genomic DNA. No translation available.
AC008120 Genomic DNA. No translation available.
AC092923 Genomic DNA. No translation available.
AC092967 Genomic DNA. No translation available.
AC110871 Genomic DNA. No translation available.
AC131158 Genomic DNA. No translation available.
BC032555 mRNA. Translation: AAH32555.1.
AK074522 mRNA. Translation: BAC11039.1. Different initiation.
CCDSiCCDS3222.1. [Q8N2Q7-2]
RefSeqiNP_055747.1. NM_014932.3. [Q8N2Q7-2]
XP_005247291.1. XM_005247234.2. [Q8N2Q7-2]
XP_005247292.1. XM_005247235.3. [Q8N2Q7-2]
XP_016861387.1. XM_017005898.1. [Q8N2Q7-2]
XP_016861388.1. XM_017005899.1. [Q8N2Q7-2]
XP_016861389.1. XM_017005900.1. [Q8N2Q7-2]
XP_016861390.1. XM_017005901.1. [Q8N2Q7-2]
UniGeneiHs.478289.
Hs.732502.

3D structure databases

ProteinModelPortaliQ8N2Q7.
SMRiQ8N2Q7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116538. 8 interactors.
IntActiQ8N2Q7. 5 interactors.
MINTiMINT-1901478.
STRINGi9606.ENSP00000354541.

Protein family/group databases

ESTHERihuman-NLGN1. Neuroligin.
MEROPSiS09.994.

PTM databases

iPTMnetiQ8N2Q7.
PhosphoSitePlusiQ8N2Q7.

Polymorphism and mutation databases

DMDMi31076822.

Proteomic databases

PaxDbiQ8N2Q7.
PeptideAtlasiQ8N2Q7.
PRIDEiQ8N2Q7.

Protocols and materials databases

DNASUi22871.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361589; ENSP00000354541; ENSG00000169760. [Q8N2Q7-2]
ENST00000457714; ENSP00000392500; ENSG00000169760. [Q8N2Q7-2]
GeneIDi22871.
KEGGihsa:22871.
UCSCiuc003fio.3. human. [Q8N2Q7-1]

Organism-specific databases

CTDi22871.
DisGeNETi22871.
GeneCardsiNLGN1.
HGNCiHGNC:14291. NLGN1.
HPAiHPA006680.
MIMi600568. gene.
neXtProtiNX_Q8N2Q7.
OpenTargetsiENSG00000169760.
PharmGKBiPA31647.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1516. Eukaryota.
COG2272. LUCA.
GeneTreeiENSGT00760000118946.
HOGENOMiHOG000231424.
HOVERGENiHBG008839.
InParanoidiQ8N2Q7.
KOiK07378.
OMAiKFVELIV.
OrthoDBiEOG091G0CHW.
PhylomeDBiQ8N2Q7.
TreeFamiTF326187.

Enzyme and pathway databases

ReactomeiR-HSA-6794361. Interactions of neurexins and neuroligins at synapses.

Miscellaneous databases

ChiTaRSiNLGN1. human.
GeneWikiiNLGN1.
GenomeRNAii22871.
PROiQ8N2Q7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169760.
CleanExiHS_NLGN1.
ExpressionAtlasiQ8N2Q7. baseline and differential.
GenevisibleiQ8N2Q7. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019819. Carboxylesterase_B_CS.
IPR000460. Nlgn.
IPR030022. NLGN1.
[Graphical view]
PANTHERiPTHR11559:SF52. PTHR11559:SF52. 2 hits.
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
PRINTSiPR01090. NEUROLIGIN.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNLGN1_HUMAN
AccessioniPrimary (citable) accession number: Q8N2Q7
Secondary accession number(s): Q9UPT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: May 23, 2003
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.