Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8N2Q7

- NLGN1_HUMAN

UniProt

Q8N2Q7 - NLGN1_HUMAN

Protein

Neuroligin-1

Gene

NLGN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (23 May 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses By similarity.By similarity

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: BHF-UCL
    2. neurexin family protein binding Source: UniProtKB
    3. PDZ domain binding Source: UniProt
    4. protein dimerization activity Source: BHF-UCL
    5. receptor activity Source: BHF-UCL

    GO - Biological processi

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering Source: BHF-UCL
    2. calcium-dependent cell-cell adhesion Source: UniProtKB
    3. cytoskeletal matrix organization at active zone Source: BHF-UCL
    4. establishment of protein localization Source: BHF-UCL
    5. heterophilic cell-cell adhesion Source: BHF-UCL
    6. nervous system development Source: UniProtKB
    7. neurexin clustering Source: BHF-UCL
    8. neuronal signal transduction Source: BHF-UCL
    9. neuron cell-cell adhesion Source: BHF-UCL
    10. N-methyl-D-aspartate receptor clustering Source: BHF-UCL
    11. positive regulation of dendritic spine development Source: BHF-UCL
    12. positive regulation of excitatory postsynaptic membrane potential Source: BHF-UCL
    13. positive regulation of filopodium assembly Source: BHF-UCL
    14. positive regulation of intracellular signal transduction Source: BHF-UCL
    15. positive regulation of ruffle assembly Source: BHF-UCL
    16. positive regulation of synapse assembly Source: BHF-UCL
    17. positive regulation of synaptic transmission, GABAergic Source: BHF-UCL
    18. positive regulation of synaptic transmission, glutamatergic Source: BHF-UCL
    19. positive regulation of synaptic vesicle endocytosis Source: BHF-UCL
    20. positive regulation of synaptic vesicle exocytosis Source: BHF-UCL
    21. postsynaptic density protein 95 clustering Source: BHF-UCL
    22. postsynaptic membrane assembly Source: BHF-UCL
    23. presynaptic membrane assembly Source: BHF-UCL
    24. protein heterotetramerization Source: Ensembl
    25. protein homooligomerization Source: BHF-UCL
    26. protein localization to synapse Source: BHF-UCL
    27. protein targeting Source: UniProtKB
    28. receptor localization to synapse Source: BHF-UCL
    29. regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Source: BHF-UCL
    30. regulation of neuron differentiation Source: UniProtKB
    31. regulation of N-methyl-D-aspartate selective glutamate receptor activity Source: BHF-UCL
    32. regulation of respiratory gaseous exchange by neurological system process Source: Ensembl
    33. synapse assembly Source: UniProtKB
    34. synaptic vesicle clustering Source: BHF-UCL
    35. synaptic vesicle targeting Source: UniProtKB
    36. terminal button organization Source: BHF-UCL

    Keywords - Biological processi

    Cell adhesion

    Protein family/group databases

    MEROPSiS09.994.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuroligin-1
    Gene namesi
    Name:NLGN1
    Synonyms:KIAA1070
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:14291. NLGN1.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Cell junctionsynapse By similarity. Cell junctionsynapsepostsynaptic cell membranepostsynaptic density By similarity
    Note: Enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. Detected at dendritic spines. Colocalized with DLG4/PSD-95 and GRIN1/NMDAR1 By similarity.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cell surface Source: BHF-UCL
    3. dendrite Source: BHF-UCL
    4. external side of plasma membrane Source: Ensembl
    5. filopodium tip Source: BHF-UCL
    6. integral component of plasma membrane Source: UniProtKB
    7. neuronal postsynaptic density Source: BHF-UCL
    8. N-methyl-D-aspartate selective glutamate receptor complex Source: Ensembl
    9. postsynaptic membrane Source: UniProtKB-KW
    10. synapse Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31647.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4545Sequence AnalysisAdd
    BLAST
    Chaini46 – 840795Neuroligin-1PRO_0000008640Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi109 – 1091N-linked (GlcNAc...) (complex)By similarity
    Disulfide bondi117 ↔ 153By similarity
    Glycosylationi300 – 3001N-linked (GlcNAc...) (complex)By similarity
    Disulfide bondi339 ↔ 350By similarity
    Glycosylationi340 – 3401N-linked (GlcNAc...) (complex)By similarity
    Disulfide bondi509 ↔ 543By similarity
    Glycosylationi544 – 5441N-linked (GlcNAc...)By similarity
    Glycosylationi680 – 6801O-linked (GalNAc...)By similarity
    Glycosylationi683 – 6831O-linked (GalNAc...)By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8N2Q7.
    PRIDEiQ8N2Q7.

    PTM databases

    PhosphoSiteiQ8N2Q7.

    Expressioni

    Tissue specificityi

    Expressed in the blood vessel walls (at protein level). Detected in brain, and at lower levels in pancreas islet beta cells.2 Publications

    Gene expression databases

    ArrayExpressiQ8N2Q7.
    BgeeiQ8N2Q7.
    CleanExiHS_NLGN1.
    GenevestigatoriQ8N2Q7.

    Organism-specific databases

    HPAiHPA006680.

    Interactioni

    Subunit structurei

    Interacts with NRXN1, NRXN2 and NRXN3. Interacts with NLGN3. Interacts with AIP1 and PDZRN3 By similarity. Interacts (via its C-terminus) with DLG4/PSD-95 (via PDZ domain 3). Interacts with GOPC.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi116538. 6 interactions.
    IntActiQ8N2Q7. 4 interactions.
    MINTiMINT-1901478.
    STRINGi9606.ENSP00000354541.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N2Q7.
    SMRiQ8N2Q7. Positions 52-628.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini46 – 694649ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini716 – 840125CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei695 – 71521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2272.
    HOGENOMiHOG000231424.
    HOVERGENiHBG008839.
    InParanoidiQ8N2Q7.
    KOiK07378.
    OrthoDBiEOG7RBZ7R.
    PhylomeDBiQ8N2Q7.
    TreeFamiTF326187.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019819. Carboxylesterase_B_CS.
    IPR000460. Neuroligin.
    [Graphical view]
    PfamiPF00135. COesterase. 1 hit.
    [Graphical view]
    PRINTSiPR01090. NEUROLIGIN.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N2Q7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD    50
    VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP 100
    PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS 150
    EDCLYLNIYV PTEDGPLTKK RDEATLNPPD TDIRDSGGPK PVMVYIHGGS 200
    YMEGTGNLYD GSVLASYGNV IVITVNYRLG VLGFLSTGDQ AAKGNYGLLD 250
    LIQALRWTSE NIGFFGGDPL RITVFGSGAG GSCVNLLTLS HYSEGNRWSN 300
    STKGLFQRAI AQSGTALSSW AVSFQPAKYA RMLATKVGCN VSDTVELVEC 350
    LQKKPYKELV DQDIQPARYH IAFGPVIDGD VIPDDPQILM EQGEFLNYDI 400
    MLGVNQGEGL KFVENIVDSD DGISASDFDF AVSNFVDNLY GYPEGKDVLR 450
    ETIKFMYTDW ADRHNPETRR KTLLALFTDH QWVAPAVATA DLHSNFGSPT 500
    YFYAFYHHCQ TDQVPAWADA AHGDEVPYVL GIPMIGPTEL FPCNFSKNDV 550
    MLSAVVMTYW TNFAKTGDPN QPVPQDTKFI HTKPNRFEEV AWTRYSQKDQ 600
    LYLHIGLKPR VKEHYRANKV NLWLELVPHL HNLNDISQYT STTTKVPSTD 650
    ITFRPTRKNS VPVTSAFPTA KQDDPKQQPS PFSVDQRDYS TELSVTIAVG 700
    ASLLFLNILA FAALYYKKDK RRHDVHRRCS PQRTTTNDLT HAQEEEIMSL 750
    QMKHTDLDHE CESIHPHEVV LRTACPPDYT LAMRRSPDDV PLMTPNTITM 800
    IPNTIPGIQP LHTFNTFTGG QNNTLPHPHP HPHSHSTTRV 840

    Note: No experimental confirmation available.

    Length:840
    Mass (Da):93,835
    Last modified:May 23, 2003 - v2
    Checksum:iA3FB21716F62DE29
    GO
    Isoform 2 (identifier: Q8N2Q7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         165-181: Missing.

    Show »
    Length:823
    Mass (Da):92,000
    Checksum:iEA93E8F9801CB8A8
    GO

    Sequence cautioni

    The sequence BAA83022.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAC11039.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti711 – 7111F → L in BAC11039. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei165 – 18117Missing in isoform 2. 2 PublicationsVSP_007527Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028993 mRNA. Translation: BAA83022.2. Different initiation.
    AC008082 Genomic DNA. No translation available.
    AC008120 Genomic DNA. No translation available.
    AC092923 Genomic DNA. No translation available.
    AC092967 Genomic DNA. No translation available.
    AC110871 Genomic DNA. No translation available.
    AC131158 Genomic DNA. No translation available.
    BC032555 mRNA. Translation: AAH32555.1.
    AK074522 mRNA. Translation: BAC11039.1. Different initiation.
    CCDSiCCDS3222.1. [Q8N2Q7-2]
    RefSeqiNP_055747.1. NM_014932.3. [Q8N2Q7-2]
    XP_005247291.1. XM_005247234.1. [Q8N2Q7-2]
    XP_005247292.1. XM_005247235.1. [Q8N2Q7-2]
    UniGeneiHs.478289.
    Hs.732502.

    Genome annotation databases

    EnsembliENST00000361589; ENSP00000354541; ENSG00000169760. [Q8N2Q7-2]
    ENST00000457714; ENSP00000392500; ENSG00000169760. [Q8N2Q7-2]
    GeneIDi22871.
    KEGGihsa:22871.
    UCSCiuc003fio.1. human. [Q8N2Q7-2]

    Polymorphism databases

    DMDMi31076822.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028993 mRNA. Translation: BAA83022.2 . Different initiation.
    AC008082 Genomic DNA. No translation available.
    AC008120 Genomic DNA. No translation available.
    AC092923 Genomic DNA. No translation available.
    AC092967 Genomic DNA. No translation available.
    AC110871 Genomic DNA. No translation available.
    AC131158 Genomic DNA. No translation available.
    BC032555 mRNA. Translation: AAH32555.1 .
    AK074522 mRNA. Translation: BAC11039.1 . Different initiation.
    CCDSi CCDS3222.1. [Q8N2Q7-2 ]
    RefSeqi NP_055747.1. NM_014932.3. [Q8N2Q7-2 ]
    XP_005247291.1. XM_005247234.1. [Q8N2Q7-2 ]
    XP_005247292.1. XM_005247235.1. [Q8N2Q7-2 ]
    UniGenei Hs.478289.
    Hs.732502.

    3D structure databases

    ProteinModelPortali Q8N2Q7.
    SMRi Q8N2Q7. Positions 52-628.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116538. 6 interactions.
    IntActi Q8N2Q7. 4 interactions.
    MINTi MINT-1901478.
    STRINGi 9606.ENSP00000354541.

    Protein family/group databases

    MEROPSi S09.994.

    PTM databases

    PhosphoSitei Q8N2Q7.

    Polymorphism databases

    DMDMi 31076822.

    Proteomic databases

    PaxDbi Q8N2Q7.
    PRIDEi Q8N2Q7.

    Protocols and materials databases

    DNASUi 22871.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361589 ; ENSP00000354541 ; ENSG00000169760 . [Q8N2Q7-2 ]
    ENST00000457714 ; ENSP00000392500 ; ENSG00000169760 . [Q8N2Q7-2 ]
    GeneIDi 22871.
    KEGGi hsa:22871.
    UCSCi uc003fio.1. human. [Q8N2Q7-2 ]

    Organism-specific databases

    CTDi 22871.
    GeneCardsi GC03P173114.
    HGNCi HGNC:14291. NLGN1.
    HPAi HPA006680.
    MIMi 600568. gene.
    neXtProti NX_Q8N2Q7.
    PharmGKBi PA31647.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2272.
    HOGENOMi HOG000231424.
    HOVERGENi HBG008839.
    InParanoidi Q8N2Q7.
    KOi K07378.
    OrthoDBi EOG7RBZ7R.
    PhylomeDBi Q8N2Q7.
    TreeFami TF326187.

    Miscellaneous databases

    ChiTaRSi NLGN1. human.
    GeneWikii NLGN1.
    GenomeRNAii 22871.
    NextBioi 43403.
    PROi Q8N2Q7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8N2Q7.
    Bgeei Q8N2Q7.
    CleanExi HS_NLGN1.
    Genevestigatori Q8N2Q7.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR002018. CarbesteraseB.
    IPR019819. Carboxylesterase_B_CS.
    IPR000460. Neuroligin.
    [Graphical view ]
    Pfami PF00135. COesterase. 1 hit.
    [Graphical view ]
    PRINTSi PR01090. NEUROLIGIN.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00941. CARBOXYLESTERASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Duodenum.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 315-823.
      Tissue: Embryo.
    5. Cited for: INTERACTION WITH DLG4.
    6. "Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin."
      Li X., Zhang J., Cao Z., Wu J., Shi Y.
      Protein Sci. 15:2149-2158(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GOPC.
    7. "Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion."
      Suckow A.T., Comoletti D., Waldrop M.A., Mosedale M., Egodage S., Taylor P., Chessler S.D.
      Endocrinology 149:6006-6017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    8. "The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions."
      Bottos A., Destro E., Rissone A., Graziano S., Cordara G., Assenzio B., Cera M.R., Mascia L., Bussolino F., Arese M.
      Proc. Natl. Acad. Sci. U.S.A. 106:20782-20787(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiNLGN1_HUMAN
    AccessioniPrimary (citable) accession number: Q8N2Q7
    Secondary accession number(s): Q9UPT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 23, 2003
    Last sequence update: May 23, 2003
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3