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Q8N2N9 (AN36B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ankyrin repeat domain-containing protein 36B
Alternative name(s):
CLL-associated antigen KW-1
Gene names
Name:ANKRD36B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1353 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ANKRD36 family.

Contains 6 ANK repeats.

Sequence caution

The sequence AAI25133.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAI25134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAL99915.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAB15039.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB71081.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainANK repeat
Coiled coil
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8N2N9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8N2N9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1292-1304: FQEIQDQLTATIR → VCMQLCTPTTVNL
     1305-1353: Missing.
Isoform 3 (identifier: Q8N2N9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1292-1292: F → A
     1293-1353: Missing.
Isoform 4 (identifier: Q8N2N9-4)

The sequence of this isoform differs from the canonical sequence as follows:
     233-239: IFDLIYE → VSSETTS
     240-1353: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13531353Ankyrin repeat domain-containing protein 36B
PRO_0000243912

Regions

Repeat19 – 4830ANK 1
Repeat52 – 8130ANK 2
Repeat85 – 11430ANK 3
Repeat118 – 14730ANK 4
Repeat151 – 18030ANK 5
Repeat184 – 21330ANK 6
Coiled coil731 – 76232 Potential
Coiled coil821 – 90888 Potential
Coiled coil937 – 1055119 Potential
Coiled coil1119 – 1344226 Potential

Natural variations

Alternative sequence233 – 2397IFDLIYE → VSSETTS in isoform 4.
VSP_039666
Alternative sequence240 – 13531114Missing in isoform 4.
VSP_039667
Alternative sequence1292 – 130413FQEIQ…TATIR → VCMQLCTPTTVNL in isoform 2.
VSP_039668
Alternative sequence12921F → A in isoform 3.
VSP_039669
Alternative sequence1293 – 135361Missing in isoform 3.
VSP_039670
Alternative sequence1305 – 135349Missing in isoform 2.
VSP_039671
Natural variant4831E → G.
Corresponds to variant rs1839230 [ dbSNP | Ensembl ].
VAR_060687
Natural variant4961E → D.
Corresponds to variant rs13001728 [ dbSNP | Ensembl ].
VAR_057818
Natural variant5341S → A.
Corresponds to variant rs6761299 [ dbSNP | Ensembl ].
VAR_060688

Experimental info

Sequence conflict31R → C in BAC11066. Ref.3
Sequence conflict1171V → F in BAC11066. Ref.3
Sequence conflict8841R → K in AAH31883. Ref.2
Sequence conflict8841R → K in AAH44844. Ref.2
Sequence conflict12231N → T in BAB71081. Ref.3
Sequence conflict13101E → D in BAB15039. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 10, 2010. Version 4.
Checksum: B5EEB358EBBC0BE4

FASTA1,353153,582
        10         20         30         40         50         60 
MERLCSDGFA FPHYYIKPYH LKRIHRAVLR GNLEKLKYLL LTYYDANKRD RKERTALHLA 

        70         80         90        100        110        120 
CATGQPEMVH LLVSRRCELN LCDREDRTPL IKAVQLRQEA CATLLLQNGA DPNITDVFGR 

       130        140        150        160        170        180 
TALHYAVYNE DTSMIEKLLS HGTNIEECSK NEYQPLLLAV SRRKVKMVEF LLKKKANVNA 

       190        200        210        220        230        240 
IDYLGRSALI LAVTLGEKDI VILLLQHNID VFSRDVYGKL AEDYASEAEN RVIFDLIYEY 

       250        260        270        280        290        300 
KRKRYEDLPI NSNPVSPQKQ RAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT 

       310        320        330        340        350        360 
SDEKDSVSNI ATEIKEGQQS GTVSPQKQSA QKVIFKKKVS LLNIATRIMG GGKSGTVSSQ 

       370        380        390        400        410        420 
KQPASKTASD KTDSALNTAT EIKDGLQCGT VSSQKQQALK ATTDEEGSVS NIATEIKDGE 

       430        440        450        460        470        480 
KSGTVSSQKK PALKATSDEK DSFSNITREK KDGEISRTVS SQKPPALKAT SVKEDSVLNI 

       490        500        510        520        530        540 
AREKKDGEKS RTVSFEQPPG LKATRDEKDS LLNIARGKKD GEKTRRVSSH KQPSLKATSD 

       550        560        570        580        590        600 
KEDSVPNMAT ETKDEQISGT VSCQKQPALK ATSDKKDSVS NIPTEIKDGQ QSGTVSSQKQ 

       610        620        630        640        650        660 
PAWKATSVKK DSVSNIATEI KDGQIRGTVS SQRRPALKTT GDEKDSVSNI AREIKDGEKS 

       670        680        690        700        710        720 
GTVSPQKQSA QKVIFKKKVS LLNIATRITG GGKSGTEYPE NLRTLKATIE NKDSVLNTAT 

       730        740        750        760        770        780 
KMKEVQTSTP AEQDLEMASE GEQKRLEEYE NNQPQVKNQI HSRDDLDDII QSSQTVSEDG 

       790        800        810        820        830        840 
DSLCCNCKNV ILLIDQHEMK CKDCVHLLKI KNTFCLWKRL IKLKDNHCEQ LRVKIRKLKN 

       850        860        870        880        890        900 
KASVLQKRIS EKEEIKSQLK HEILELEKEL CSLRFAIQQE KKKRRNVEEL HQKVREKLRI 

       910        920        930        940        950        960 
TEEQYRIEAD VTKPIKPALK SAEVELKTGG NNSNQVSETD EKEDLLHENR LMQDEIARLR 

       970        980        990       1000       1010       1020 
LEKDTIKNQN LEKKYLKDFE IVKRKHEDLQ KALKRNGETL AKTIACYSGQ LAALTDENTT 

      1030       1040       1050       1060       1070       1080 
LRSKLEKQRE SRQRLETEMQ SYRCRLNAAR CDHDQSHSSK RDQELAFQGT VDKCRHLQEN 

      1090       1100       1110       1120       1130       1140 
LNSHVLILSL QLSKAESKSR VLKTELHYTG EALKEKALVF EHVQSELKQK QSQMKDIEKM 

      1150       1160       1170       1180       1190       1200 
YKSGYNTMEK CIEKQERFCQ LKKQNMLLQQ QLDDARNKAD NQEKAILNIQ ARCDARVQNL 

      1210       1220       1230       1240       1250       1260 
QAECRKHRLL LEEDNKMLVN ELNHSKEKEC QYEKEKAERE VAVRQLQQKR DDVLNKGSAT 

      1270       1280       1290       1300       1310       1320 
KALLDASSRH CTYLENGMQD SRKKLDQMRS QFQEIQDQLT ATIRCTKEME GDTQKLEVEH 

      1330       1340       1350 
VMMRKIIKKQ DDQIERLEKI LQHSSLMLQV FES 

« Hide

Isoform 2 [UniParc].

Checksum: 734ECD8A794C395A
Show »

FASTA1,304147,586
Isoform 3 [UniParc].

Checksum: 44C7633F2DA1C333
Show »

FASTA1,292146,252
Isoform 4 [UniParc].

Checksum: B2484A3265820AE1
Show »

FASTA23927,341

References

« Hide 'large scale' references
[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 435-884 AND 1204-1353 (ISOFORM 1).
Tissue: Brain, Prostate and Uterus.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1165-1353 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1204-1353 (ISOFORM 1).
Tissue: Embryo.
[4]"Identification of novel tumor antigens in CLL by SEREX: assessment of their potential as targets for immunotherapeutic approaches."
Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M., Barrett P., Gribben J.G.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1120-1353 (ISOFORM 2).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC017099 Genomic DNA. No translation available.
BC031883 mRNA. Translation: AAH31883.1.
BC044844 mRNA. Translation: AAH44844.1.
BC071771 mRNA. No translation available.
BC125132 mRNA. Translation: AAI25133.1. Different initiation.
BC125133 mRNA. Translation: AAI25134.1. Different initiation.
AK024934 mRNA. Translation: BAB15039.1. Different initiation.
AK056042 mRNA. Translation: BAB71081.1. Different initiation.
AK074570 mRNA. Translation: BAC11066.1.
AF432208 mRNA. Translation: AAL99915.1. Different initiation.
RefSeqNP_079466.3. NM_025190.3. [Q8N2N9-1]
XP_005264052.1. XM_005263995.2. [Q8N2N9-1]
XP_006712724.1. XM_006712661.1. [Q8N2N9-1]
UniGeneHs.532921.

3D structure databases

ProteinModelPortalQ8N2N9.
SMRQ8N2N9. Positions 22-247.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8N2N9. 2 interactions.
STRING9606.ENSP00000258459.

PTM databases

PhosphoSiteQ8N2N9.

Polymorphism databases

DMDM302393831.

Proteomic databases

PaxDbQ8N2N9.
PRIDEQ8N2N9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID57730.
KEGGhsa:57730.
UCSCuc010yvc.1. human. [Q8N2N9-1]

Organism-specific databases

CTD57730.
GeneCardsGC02M098108.
HGNCHGNC:29333. ANKRD36B.
neXtProtNX_Q8N2N9.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOVERGENHBG108636.
InParanoidQ8N2N9.

Gene expression databases

CleanExHS_ANKRD36B.
GenevestigatorQ8N2N9.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
SMARTSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57730.
NextBio64680.
PROQ8N2N9.

Entry information

Entry nameAN36B_HUMAN
AccessionPrimary (citable) accession number: Q8N2N9
Secondary accession number(s): Q08AK5 expand/collapse secondary AC list , Q6IPR0, Q6PI49, Q8IZM7, Q8TDH6, Q96N30, Q9H759
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 80 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM