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Q8N2N9

- AN36B_HUMAN

UniProt

Q8N2N9 - AN36B_HUMAN

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Protein
Ankyrin repeat domain-containing protein 36B
Gene
ANKRD36B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 36B
Alternative name(s):
CLL-associated antigen KW-1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:29333. ANKRD36B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13531353Ankyrin repeat domain-containing protein 36B
PRO_0000243912Add
BLAST

Proteomic databases

PaxDbiQ8N2N9.
PRIDEiQ8N2N9.

PTM databases

PhosphoSiteiQ8N2N9.

Expressioni

Gene expression databases

CleanExiHS_ANKRD36B.
GenevestigatoriQ8N2N9.

Interactioni

Protein-protein interaction databases

IntActiQ8N2N9. 2 interactions.
STRINGi9606.ENSP00000258459.

Structurei

3D structure databases

ProteinModelPortaliQ8N2N9.
SMRiQ8N2N9. Positions 22-247.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati19 – 4830ANK 1
Add
BLAST
Repeati52 – 8130ANK 2
Add
BLAST
Repeati85 – 11430ANK 3
Add
BLAST
Repeati118 – 14730ANK 4
Add
BLAST
Repeati151 – 18030ANK 5
Add
BLAST
Repeati184 – 21330ANK 6
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili731 – 76232 Reviewed prediction
Add
BLAST
Coiled coili821 – 90888 Reviewed prediction
Add
BLAST
Coiled coili937 – 1055119 Reviewed prediction
Add
BLAST
Coiled coili1119 – 1344226 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the ANKRD36 family.
Contains 6 ANK repeats.

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
HOVERGENiHBG108636.
InParanoidiQ8N2N9.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N2N9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MERLCSDGFA FPHYYIKPYH LKRIHRAVLR GNLEKLKYLL LTYYDANKRD     50
RKERTALHLA CATGQPEMVH LLVSRRCELN LCDREDRTPL IKAVQLRQEA 100
CATLLLQNGA DPNITDVFGR TALHYAVYNE DTSMIEKLLS HGTNIEECSK 150
NEYQPLLLAV SRRKVKMVEF LLKKKANVNA IDYLGRSALI LAVTLGEKDI 200
VILLLQHNID VFSRDVYGKL AEDYASEAEN RVIFDLIYEY KRKRYEDLPI 250
NSNPVSPQKQ RAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT 300
SDEKDSVSNI ATEIKEGQQS GTVSPQKQSA QKVIFKKKVS LLNIATRIMG 350
GGKSGTVSSQ KQPASKTASD KTDSALNTAT EIKDGLQCGT VSSQKQQALK 400
ATTDEEGSVS NIATEIKDGE KSGTVSSQKK PALKATSDEK DSFSNITREK 450
KDGEISRTVS SQKPPALKAT SVKEDSVLNI AREKKDGEKS RTVSFEQPPG 500
LKATRDEKDS LLNIARGKKD GEKTRRVSSH KQPSLKATSD KEDSVPNMAT 550
ETKDEQISGT VSCQKQPALK ATSDKKDSVS NIPTEIKDGQ QSGTVSSQKQ 600
PAWKATSVKK DSVSNIATEI KDGQIRGTVS SQRRPALKTT GDEKDSVSNI 650
AREIKDGEKS GTVSPQKQSA QKVIFKKKVS LLNIATRITG GGKSGTEYPE 700
NLRTLKATIE NKDSVLNTAT KMKEVQTSTP AEQDLEMASE GEQKRLEEYE 750
NNQPQVKNQI HSRDDLDDII QSSQTVSEDG DSLCCNCKNV ILLIDQHEMK 800
CKDCVHLLKI KNTFCLWKRL IKLKDNHCEQ LRVKIRKLKN KASVLQKRIS 850
EKEEIKSQLK HEILELEKEL CSLRFAIQQE KKKRRNVEEL HQKVREKLRI 900
TEEQYRIEAD VTKPIKPALK SAEVELKTGG NNSNQVSETD EKEDLLHENR 950
LMQDEIARLR LEKDTIKNQN LEKKYLKDFE IVKRKHEDLQ KALKRNGETL 1000
AKTIACYSGQ LAALTDENTT LRSKLEKQRE SRQRLETEMQ SYRCRLNAAR 1050
CDHDQSHSSK RDQELAFQGT VDKCRHLQEN LNSHVLILSL QLSKAESKSR 1100
VLKTELHYTG EALKEKALVF EHVQSELKQK QSQMKDIEKM YKSGYNTMEK 1150
CIEKQERFCQ LKKQNMLLQQ QLDDARNKAD NQEKAILNIQ ARCDARVQNL 1200
QAECRKHRLL LEEDNKMLVN ELNHSKEKEC QYEKEKAERE VAVRQLQQKR 1250
DDVLNKGSAT KALLDASSRH CTYLENGMQD SRKKLDQMRS QFQEIQDQLT 1300
ATIRCTKEME GDTQKLEVEH VMMRKIIKKQ DDQIERLEKI LQHSSLMLQV 1350
FES 1353
Length:1,353
Mass (Da):153,582
Last modified:August 10, 2010 - v4
Checksum:iB5EEB358EBBC0BE4
GO
Isoform 2 (identifier: Q8N2N9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1292-1304: FQEIQDQLTATIR → VCMQLCTPTTVNL
     1305-1353: Missing.

Show »
Length:1,304
Mass (Da):147,586
Checksum:i734ECD8A794C395A
GO
Isoform 3 (identifier: Q8N2N9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1292-1292: F → A
     1293-1353: Missing.

Show »
Length:1,292
Mass (Da):146,252
Checksum:i44C7633F2DA1C333
GO
Isoform 4 (identifier: Q8N2N9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-239: IFDLIYE → VSSETTS
     240-1353: Missing.

Show »
Length:239
Mass (Da):27,341
Checksum:iB2484A3265820AE1
GO

Sequence cautioni

The sequence AAI25133.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAI25134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAL99915.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAB15039.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB71081.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti483 – 4831E → G.
Corresponds to variant rs1839230 [ dbSNP | Ensembl ].
VAR_060687
Natural varianti496 – 4961E → D.
Corresponds to variant rs13001728 [ dbSNP | Ensembl ].
VAR_057818
Natural varianti534 – 5341S → A.
Corresponds to variant rs6761299 [ dbSNP | Ensembl ].
VAR_060688

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei233 – 2397IFDLIYE → VSSETTS in isoform 4.
VSP_039666
Alternative sequencei240 – 13531114Missing in isoform 4.
VSP_039667Add
BLAST
Alternative sequencei1292 – 130413FQEIQ…TATIR → VCMQLCTPTTVNL in isoform 2.
VSP_039668Add
BLAST
Alternative sequencei1292 – 12921F → A in isoform 3.
VSP_039669
Alternative sequencei1293 – 135361Missing in isoform 3.
VSP_039670Add
BLAST
Alternative sequencei1305 – 135349Missing in isoform 2.
VSP_039671Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31R → C in BAC11066. 1 Publication
Sequence conflicti117 – 1171V → F in BAC11066. 1 Publication
Sequence conflicti884 – 8841R → K in AAH31883. 1 Publication
Sequence conflicti884 – 8841R → K in AAH44844. 1 Publication
Sequence conflicti1223 – 12231N → T in BAB71081. 1 Publication
Sequence conflicti1310 – 13101E → D in BAB15039. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC017099 Genomic DNA. No translation available.
BC031883 mRNA. Translation: AAH31883.1.
BC044844 mRNA. Translation: AAH44844.1.
BC071771 mRNA. No translation available.
BC125132 mRNA. Translation: AAI25133.1. Different initiation.
BC125133 mRNA. Translation: AAI25134.1. Different initiation.
AK024934 mRNA. Translation: BAB15039.1. Different initiation.
AK056042 mRNA. Translation: BAB71081.1. Different initiation.
AK074570 mRNA. Translation: BAC11066.1.
AF432208 mRNA. Translation: AAL99915.1. Different initiation.
RefSeqiNP_079466.3. NM_025190.3. [Q8N2N9-1]
XP_005264052.1. XM_005263995.2. [Q8N2N9-1]
XP_006712724.1. XM_006712661.1. [Q8N2N9-1]
UniGeneiHs.532921.

Genome annotation databases

GeneIDi57730.
KEGGihsa:57730.
UCSCiuc010yvc.1. human. [Q8N2N9-1]

Polymorphism databases

DMDMi302393831.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC017099 Genomic DNA. No translation available.
BC031883 mRNA. Translation: AAH31883.1 .
BC044844 mRNA. Translation: AAH44844.1 .
BC071771 mRNA. No translation available.
BC125132 mRNA. Translation: AAI25133.1 . Different initiation.
BC125133 mRNA. Translation: AAI25134.1 . Different initiation.
AK024934 mRNA. Translation: BAB15039.1 . Different initiation.
AK056042 mRNA. Translation: BAB71081.1 . Different initiation.
AK074570 mRNA. Translation: BAC11066.1 .
AF432208 mRNA. Translation: AAL99915.1 . Different initiation.
RefSeqi NP_079466.3. NM_025190.3. [Q8N2N9-1 ]
XP_005264052.1. XM_005263995.2. [Q8N2N9-1 ]
XP_006712724.1. XM_006712661.1. [Q8N2N9-1 ]
UniGenei Hs.532921.

3D structure databases

ProteinModelPortali Q8N2N9.
SMRi Q8N2N9. Positions 22-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8N2N9. 2 interactions.
STRINGi 9606.ENSP00000258459.

PTM databases

PhosphoSitei Q8N2N9.

Polymorphism databases

DMDMi 302393831.

Proteomic databases

PaxDbi Q8N2N9.
PRIDEi Q8N2N9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 57730.
KEGGi hsa:57730.
UCSCi uc010yvc.1. human. [Q8N2N9-1 ]

Organism-specific databases

CTDi 57730.
GeneCardsi GC02M098108.
HGNCi HGNC:29333. ANKRD36B.
neXtProti NX_Q8N2N9.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
HOVERGENi HBG108636.
InParanoidi Q8N2N9.

Miscellaneous databases

GenomeRNAii 57730.
NextBioi 64680.
PROi Q8N2N9.

Gene expression databases

CleanExi HS_ANKRD36B.
Genevestigatori Q8N2N9.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view ]
SMARTi SM00248. ANK. 6 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 435-884 AND 1204-1353 (ISOFORM 1).
    Tissue: Brain, Prostate and Uterus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1165-1353 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1204-1353 (ISOFORM 1).
    Tissue: Embryo.
  4. "Identification of novel tumor antigens in CLL by SEREX: assessment of their potential as targets for immunotherapeutic approaches."
    Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M., Barrett P., Gribben J.G.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1120-1353 (ISOFORM 2).

Entry informationi

Entry nameiAN36B_HUMAN
AccessioniPrimary (citable) accession number: Q8N2N9
Secondary accession number(s): Q08AK5
, Q6IPR0, Q6PI49, Q8IZM7, Q8TDH6, Q96N30, Q9H759
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 10, 2010
Last modified: June 11, 2014
This is version 80 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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