Q8N2N9 (AN36B_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 71.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ankyrin repeat domain-containing protein 36B Alternative name(s): CLL-associated antigen KW-1 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Reference proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 1353 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Sequence similarities | Belongs to the ANKRD36 family. Contains 6 ANK repeats. |
| Sequence caution | The sequence AAI25133.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI25134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAL99915.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB15039.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB71081.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | ANK repeat Coiled coil Repeat |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8N2N9-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8N2N9-2) The sequence of this isoform differs from the canonical sequence as follows: 1292-1304: FQEIQDQLTATIR → VCMQLCTPTTVNL 1305-1353: Missing. | ||||||
| Isoform 3 (identifier: Q8N2N9-3) The sequence of this isoform differs from the canonical sequence as follows: 1292-1292: F → A 1293-1353: Missing. | ||||||
| Isoform 4 (identifier: Q8N2N9-4) The sequence of this isoform differs from the canonical sequence as follows: 233-239: IFDLIYE → VSSETTS 240-1353: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1353 | 1353 | Ankyrin repeat domain-containing protein 36B | PRO_0000243912 | |||||
Regions | |||||||||
| Repeat | 19 – 48 | 30 | ANK 1 | ||||||
| Repeat | 52 – 81 | 30 | ANK 2 | ||||||
| Repeat | 85 – 114 | 30 | ANK 3 | ||||||
| Repeat | 118 – 147 | 30 | ANK 4 | ||||||
| Repeat | 151 – 180 | 30 | ANK 5 | ||||||
| Repeat | 184 – 213 | 30 | ANK 6 | ||||||
| Coiled coil | 731 – 762 | 32 | Potential | ||||||
| Coiled coil | 821 – 908 | 88 | Potential | ||||||
| Coiled coil | 937 – 1055 | 119 | Potential | ||||||
| Coiled coil | 1119 – 1344 | 226 | Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 233 – 239 | 7 | IFDLIYE → VSSETTS in isoform 4. | VSP_039666 | |||||
| Alternative sequence | 240 – 1353 | 1114 | Missing in isoform 4. | VSP_039667 | |||||
| Alternative sequence | 1292 – 1304 | 13 | FQEIQ…TATIR → VCMQLCTPTTVNL in isoform 2. | VSP_039668 | |||||
| Alternative sequence | 1292 | 1 | F → A in isoform 3. | VSP_039669 | |||||
| Alternative sequence | 1293 – 1353 | 61 | Missing in isoform 3. | VSP_039670 | |||||
| Alternative sequence | 1305 – 1353 | 49 | Missing in isoform 2. | VSP_039671 | |||||
| Natural variant | 483 | 1 | E → G. Corresponds to variant rs1839230 [ dbSNP | Ensembl ]. | VAR_060687 | |||||
| Natural variant | 496 | 1 | E → D. Corresponds to variant rs13001728 [ dbSNP | Ensembl ]. | VAR_057818 | |||||
| Natural variant | 534 | 1 | S → A. Corresponds to variant rs6761299 [ dbSNP | Ensembl ]. | VAR_060688 | |||||
Experimental info | |||||||||
| Sequence conflict | 3 | 1 | R → C in BAC11066. Ref.3 | ||||||
| Sequence conflict | 117 | 1 | V → F in BAC11066. Ref.3 | ||||||
| Sequence conflict | 884 | 1 | R → K in AAH31883. Ref.2 | ||||||
| Sequence conflict | 884 | 1 | R → K in AAH44844. Ref.2 | ||||||
| Sequence conflict | 1223 | 1 | N → T in BAB71081. Ref.3 | ||||||
| Sequence conflict | 1310 | 1 | E → D in BAB15039. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 435-884 AND 1204-1353 (ISOFORM 1). Tissue: Brain, Prostate and Uterus. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1165-1353 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1204-1353 (ISOFORM 1). Tissue: Embryo. |
| [4] | "Identification of novel tumor antigens in CLL by SEREX: Assessment of their potential as targets for immunotherapeutic approaches." Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M., Barrett P., Gribben J.G. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1120-1353 (ISOFORM 2). |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC017099 Genomic DNA. No translation available. BC031883 mRNA. Translation: AAH31883.1. BC044844 mRNA. Translation: AAH44844.1. BC071771 mRNA. No translation available. BC125132 mRNA. Translation: AAI25133.1. Different initiation. BC125133 mRNA. Translation: AAI25134.1. Different initiation. AK024934 mRNA. Translation: BAB15039.1. Different initiation. AK056042 mRNA. Translation: BAB71081.1. Different initiation. AK074570 mRNA. Translation: BAC11066.1. AF432208 mRNA. Translation: AAL99915.1. Different initiation. |
| IPI | IPI00186004. IPI00478632. IPI00893166. IPI00953306. |
| RefSeq | NP_079466.3. NM_025190.3. |
| UniGene | Hs.532921. |
3D structure databases | |
| ProteinModelPortal | Q8N2N9. |
| SMR | Q8N2N9. Positions 15-237. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q8N2N9. 2 interactions. |
| STRING | 9606.ENSP00000258459. |
PTM databases | |
| PhosphoSite | Q8N2N9. |
Polymorphism databases | |
| DMDM | 302393831. |
Proteomic databases | |
| PaxDb | Q8N2N9. |
| PRIDE | Q8N2N9. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 57730. |
| KEGG | hsa:57730. |
| UCSC | uc010yvc.1. human. |
Organism-specific databases | |
| CTD | 57730. |
| GeneCards | GC02M098108. |
| HGNC | HGNC:29333. ANKRD36B. |
| neXtProt | NX_Q8N2N9. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | COG0666. |
| HOVERGEN | HBG108636. |
| InParanoid | Q8N2N9. |
Gene expression databases | |
| CleanEx | HS_ANKRD36B. |
| Genevestigator | Q8N2N9. |
Family and domain databases | |
| Gene3D | 1.25.40.20. 1 hit. |
| InterPro | IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view] |
| Pfam | PF00023. Ank. 1 hit. PF12796. Ank_2. 2 hits. [Graphical view] |
| SMART | SM00248. ANK. 6 hits. [Graphical view] |
| SUPFAM | SSF48403. ANK. 1 hit. |
| PROSITE | PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 57730. |
| NextBio | 64680. |
Entry information
| Entry name | AN36B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8N2N9 Secondary accession number(s): Q08AK5 Q9H759 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with
