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Q8N2N9

- AN36B_HUMAN

UniProt

Q8N2N9 - AN36B_HUMAN

Protein

Ankyrin repeat domain-containing protein 36B

Gene

ANKRD36B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 4 (10 Aug 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ankyrin repeat domain-containing protein 36B
    Alternative name(s):
    CLL-associated antigen KW-1
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:29333. ANKRD36B.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13531353Ankyrin repeat domain-containing protein 36BPRO_0000243912Add
    BLAST

    Proteomic databases

    PaxDbiQ8N2N9.
    PRIDEiQ8N2N9.

    PTM databases

    PhosphoSiteiQ8N2N9.

    Expressioni

    Gene expression databases

    CleanExiHS_ANKRD36B.
    GenevestigatoriQ8N2N9.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8N2N9. 2 interactions.
    STRINGi9606.ENSP00000258459.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8N2N9.
    SMRiQ8N2N9. Positions 22-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati19 – 4830ANK 1Add
    BLAST
    Repeati52 – 8130ANK 2Add
    BLAST
    Repeati85 – 11430ANK 3Add
    BLAST
    Repeati118 – 14730ANK 4Add
    BLAST
    Repeati151 – 18030ANK 5Add
    BLAST
    Repeati184 – 21330ANK 6Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili731 – 76232Sequence AnalysisAdd
    BLAST
    Coiled coili821 – 90888Sequence AnalysisAdd
    BLAST
    Coiled coili937 – 1055119Sequence AnalysisAdd
    BLAST
    Coiled coili1119 – 1344226Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ANKRD36 family.Curated
    Contains 6 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOVERGENiHBG108636.
    InParanoidiQ8N2N9.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    [Graphical view]
    SMARTiSM00248. ANK. 6 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8N2N9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERLCSDGFA FPHYYIKPYH LKRIHRAVLR GNLEKLKYLL LTYYDANKRD     50
    RKERTALHLA CATGQPEMVH LLVSRRCELN LCDREDRTPL IKAVQLRQEA 100
    CATLLLQNGA DPNITDVFGR TALHYAVYNE DTSMIEKLLS HGTNIEECSK 150
    NEYQPLLLAV SRRKVKMVEF LLKKKANVNA IDYLGRSALI LAVTLGEKDI 200
    VILLLQHNID VFSRDVYGKL AEDYASEAEN RVIFDLIYEY KRKRYEDLPI 250
    NSNPVSPQKQ RAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT 300
    SDEKDSVSNI ATEIKEGQQS GTVSPQKQSA QKVIFKKKVS LLNIATRIMG 350
    GGKSGTVSSQ KQPASKTASD KTDSALNTAT EIKDGLQCGT VSSQKQQALK 400
    ATTDEEGSVS NIATEIKDGE KSGTVSSQKK PALKATSDEK DSFSNITREK 450
    KDGEISRTVS SQKPPALKAT SVKEDSVLNI AREKKDGEKS RTVSFEQPPG 500
    LKATRDEKDS LLNIARGKKD GEKTRRVSSH KQPSLKATSD KEDSVPNMAT 550
    ETKDEQISGT VSCQKQPALK ATSDKKDSVS NIPTEIKDGQ QSGTVSSQKQ 600
    PAWKATSVKK DSVSNIATEI KDGQIRGTVS SQRRPALKTT GDEKDSVSNI 650
    AREIKDGEKS GTVSPQKQSA QKVIFKKKVS LLNIATRITG GGKSGTEYPE 700
    NLRTLKATIE NKDSVLNTAT KMKEVQTSTP AEQDLEMASE GEQKRLEEYE 750
    NNQPQVKNQI HSRDDLDDII QSSQTVSEDG DSLCCNCKNV ILLIDQHEMK 800
    CKDCVHLLKI KNTFCLWKRL IKLKDNHCEQ LRVKIRKLKN KASVLQKRIS 850
    EKEEIKSQLK HEILELEKEL CSLRFAIQQE KKKRRNVEEL HQKVREKLRI 900
    TEEQYRIEAD VTKPIKPALK SAEVELKTGG NNSNQVSETD EKEDLLHENR 950
    LMQDEIARLR LEKDTIKNQN LEKKYLKDFE IVKRKHEDLQ KALKRNGETL 1000
    AKTIACYSGQ LAALTDENTT LRSKLEKQRE SRQRLETEMQ SYRCRLNAAR 1050
    CDHDQSHSSK RDQELAFQGT VDKCRHLQEN LNSHVLILSL QLSKAESKSR 1100
    VLKTELHYTG EALKEKALVF EHVQSELKQK QSQMKDIEKM YKSGYNTMEK 1150
    CIEKQERFCQ LKKQNMLLQQ QLDDARNKAD NQEKAILNIQ ARCDARVQNL 1200
    QAECRKHRLL LEEDNKMLVN ELNHSKEKEC QYEKEKAERE VAVRQLQQKR 1250
    DDVLNKGSAT KALLDASSRH CTYLENGMQD SRKKLDQMRS QFQEIQDQLT 1300
    ATIRCTKEME GDTQKLEVEH VMMRKIIKKQ DDQIERLEKI LQHSSLMLQV 1350
    FES 1353
    Length:1,353
    Mass (Da):153,582
    Last modified:August 10, 2010 - v4
    Checksum:iB5EEB358EBBC0BE4
    GO
    Isoform 2 (identifier: Q8N2N9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1292-1304: FQEIQDQLTATIR → VCMQLCTPTTVNL
         1305-1353: Missing.

    Show »
    Length:1,304
    Mass (Da):147,586
    Checksum:i734ECD8A794C395A
    GO
    Isoform 3 (identifier: Q8N2N9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1292-1292: F → A
         1293-1353: Missing.

    Show »
    Length:1,292
    Mass (Da):146,252
    Checksum:i44C7633F2DA1C333
    GO
    Isoform 4 (identifier: Q8N2N9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         233-239: IFDLIYE → VSSETTS
         240-1353: Missing.

    Show »
    Length:239
    Mass (Da):27,341
    Checksum:iB2484A3265820AE1
    GO

    Sequence cautioni

    The sequence AAI25133.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI25134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAL99915.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAB15039.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB71081.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31R → C in BAC11066. (PubMed:14702039)Curated
    Sequence conflicti117 – 1171V → F in BAC11066. (PubMed:14702039)Curated
    Sequence conflicti884 – 8841R → K in AAH31883. (PubMed:15489334)Curated
    Sequence conflicti884 – 8841R → K in AAH44844. (PubMed:15489334)Curated
    Sequence conflicti1223 – 12231N → T in BAB71081. (PubMed:14702039)Curated
    Sequence conflicti1310 – 13101E → D in BAB15039. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti483 – 4831E → G.
    Corresponds to variant rs1839230 [ dbSNP | Ensembl ].
    VAR_060687
    Natural varianti496 – 4961E → D.
    Corresponds to variant rs13001728 [ dbSNP | Ensembl ].
    VAR_057818
    Natural varianti534 – 5341S → A.
    Corresponds to variant rs6761299 [ dbSNP | Ensembl ].
    VAR_060688

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei233 – 2397IFDLIYE → VSSETTS in isoform 4. 2 PublicationsVSP_039666
    Alternative sequencei240 – 13531114Missing in isoform 4. 2 PublicationsVSP_039667Add
    BLAST
    Alternative sequencei1292 – 130413FQEIQ…TATIR → VCMQLCTPTTVNL in isoform 2. 1 PublicationVSP_039668Add
    BLAST
    Alternative sequencei1292 – 12921F → A in isoform 3. 1 PublicationVSP_039669
    Alternative sequencei1293 – 135361Missing in isoform 3. 1 PublicationVSP_039670Add
    BLAST
    Alternative sequencei1305 – 135349Missing in isoform 2. 1 PublicationVSP_039671Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC017099 Genomic DNA. No translation available.
    BC031883 mRNA. Translation: AAH31883.1.
    BC044844 mRNA. Translation: AAH44844.1.
    BC071771 mRNA. No translation available.
    BC125132 mRNA. Translation: AAI25133.1. Different initiation.
    BC125133 mRNA. Translation: AAI25134.1. Different initiation.
    AK024934 mRNA. Translation: BAB15039.1. Different initiation.
    AK056042 mRNA. Translation: BAB71081.1. Different initiation.
    AK074570 mRNA. Translation: BAC11066.1.
    AF432208 mRNA. Translation: AAL99915.1. Different initiation.
    RefSeqiNP_079466.3. NM_025190.3. [Q8N2N9-1]
    XP_005264052.1. XM_005263995.2. [Q8N2N9-1]
    XP_006712724.1. XM_006712661.1. [Q8N2N9-1]
    UniGeneiHs.532921.

    Genome annotation databases

    GeneIDi57730.
    KEGGihsa:57730.
    UCSCiuc010yvc.1. human. [Q8N2N9-1]

    Polymorphism databases

    DMDMi302393831.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC017099 Genomic DNA. No translation available.
    BC031883 mRNA. Translation: AAH31883.1 .
    BC044844 mRNA. Translation: AAH44844.1 .
    BC071771 mRNA. No translation available.
    BC125132 mRNA. Translation: AAI25133.1 . Different initiation.
    BC125133 mRNA. Translation: AAI25134.1 . Different initiation.
    AK024934 mRNA. Translation: BAB15039.1 . Different initiation.
    AK056042 mRNA. Translation: BAB71081.1 . Different initiation.
    AK074570 mRNA. Translation: BAC11066.1 .
    AF432208 mRNA. Translation: AAL99915.1 . Different initiation.
    RefSeqi NP_079466.3. NM_025190.3. [Q8N2N9-1 ]
    XP_005264052.1. XM_005263995.2. [Q8N2N9-1 ]
    XP_006712724.1. XM_006712661.1. [Q8N2N9-1 ]
    UniGenei Hs.532921.

    3D structure databases

    ProteinModelPortali Q8N2N9.
    SMRi Q8N2N9. Positions 22-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8N2N9. 2 interactions.
    STRINGi 9606.ENSP00000258459.

    PTM databases

    PhosphoSitei Q8N2N9.

    Polymorphism databases

    DMDMi 302393831.

    Proteomic databases

    PaxDbi Q8N2N9.
    PRIDEi Q8N2N9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 57730.
    KEGGi hsa:57730.
    UCSCi uc010yvc.1. human. [Q8N2N9-1 ]

    Organism-specific databases

    CTDi 57730.
    GeneCardsi GC02M098108.
    HGNCi HGNC:29333. ANKRD36B.
    neXtProti NX_Q8N2N9.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOVERGENi HBG108636.
    InParanoidi Q8N2N9.

    Miscellaneous databases

    GenomeRNAii 57730.
    NextBioi 64680.
    PROi Q8N2N9.

    Gene expression databases

    CleanExi HS_ANKRD36B.
    Genevestigatori Q8N2N9.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    [Graphical view ]
    SMARTi SM00248. ANK. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 435-884 AND 1204-1353 (ISOFORM 1).
      Tissue: Brain, Prostate and Uterus.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1165-1353 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1204-1353 (ISOFORM 1).
      Tissue: Embryo.
    4. "Identification of novel tumor antigens in CLL by SEREX: assessment of their potential as targets for immunotherapeutic approaches."
      Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M., Barrett P., Gribben J.G.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1120-1353 (ISOFORM 2).

    Entry informationi

    Entry nameiAN36B_HUMAN
    AccessioniPrimary (citable) accession number: Q8N2N9
    Secondary accession number(s): Q08AK5
    , Q6IPR0, Q6PI49, Q8IZM7, Q8TDH6, Q96N30, Q9H759
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 81 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3