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Protein

Ankyrin repeat domain-containing protein 36B

Gene

ANKRD36B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180253-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 36B
Alternative name(s):
CLL-associated antigen KW-1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29333. ANKRD36B.

Pathology & Biotechi

Organism-specific databases

DisGeNETi57730.
OpenTargetsiENSG00000196912.

Polymorphism and mutation databases

BioMutaiANKRD36B.
DMDMi302393831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002439121 – 1353Ankyrin repeat domain-containing protein 36BAdd BLAST1353

Proteomic databases

PeptideAtlasiQ8N2N9.
PRIDEiQ8N2N9.

PTM databases

iPTMnetiQ8N2N9.
PhosphoSitePlusiQ8N2N9.

Expressioni

Gene expression databases

CleanExiHS_ANKRD36B.
ExpressionAtlasiQ8N2N9. baseline and differential.
GenevisibleiQ8N2N9. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-2876112,EBI-10175124

Protein-protein interaction databases

BioGridi121750. 3 interactors.
IntActiQ8N2N9. 7 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8N2N9.
SMRiQ8N2N9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 48ANK 1Add BLAST30
Repeati52 – 81ANK 2Add BLAST30
Repeati85 – 114ANK 3Add BLAST30
Repeati118 – 147ANK 4Add BLAST30
Repeati151 – 180ANK 5Add BLAST30
Repeati184 – 213ANK 6Add BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili731 – 762Sequence analysisAdd BLAST32
Coiled coili821 – 908Sequence analysisAdd BLAST88
Coiled coili937 – 1055Sequence analysisAdd BLAST119
Coiled coili1119 – 1344Sequence analysisAdd BLAST226

Sequence similaritiesi

Belongs to the ANKRD36 family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00560000076605.
HOVERGENiHBG108636.
InParanoidiQ8N2N9.
OMAiLEMELKS.
OrthoDBiEOG091G01X9.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2N9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERLCSDGFA FPHYYIKPYH LKRIHRAVLR GNLEKLKYLL LTYYDANKRD
60 70 80 90 100
RKERTALHLA CATGQPEMVH LLVSRRCELN LCDREDRTPL IKAVQLRQEA
110 120 130 140 150
CATLLLQNGA DPNITDVFGR TALHYAVYNE DTSMIEKLLS HGTNIEECSK
160 170 180 190 200
NEYQPLLLAV SRRKVKMVEF LLKKKANVNA IDYLGRSALI LAVTLGEKDI
210 220 230 240 250
VILLLQHNID VFSRDVYGKL AEDYASEAEN RVIFDLIYEY KRKRYEDLPI
260 270 280 290 300
NSNPVSPQKQ RAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT
310 320 330 340 350
SDEKDSVSNI ATEIKEGQQS GTVSPQKQSA QKVIFKKKVS LLNIATRIMG
360 370 380 390 400
GGKSGTVSSQ KQPASKTASD KTDSALNTAT EIKDGLQCGT VSSQKQQALK
410 420 430 440 450
ATTDEEGSVS NIATEIKDGE KSGTVSSQKK PALKATSDEK DSFSNITREK
460 470 480 490 500
KDGEISRTVS SQKPPALKAT SVKEDSVLNI AREKKDGEKS RTVSFEQPPG
510 520 530 540 550
LKATRDEKDS LLNIARGKKD GEKTRRVSSH KQPSLKATSD KEDSVPNMAT
560 570 580 590 600
ETKDEQISGT VSCQKQPALK ATSDKKDSVS NIPTEIKDGQ QSGTVSSQKQ
610 620 630 640 650
PAWKATSVKK DSVSNIATEI KDGQIRGTVS SQRRPALKTT GDEKDSVSNI
660 670 680 690 700
AREIKDGEKS GTVSPQKQSA QKVIFKKKVS LLNIATRITG GGKSGTEYPE
710 720 730 740 750
NLRTLKATIE NKDSVLNTAT KMKEVQTSTP AEQDLEMASE GEQKRLEEYE
760 770 780 790 800
NNQPQVKNQI HSRDDLDDII QSSQTVSEDG DSLCCNCKNV ILLIDQHEMK
810 820 830 840 850
CKDCVHLLKI KNTFCLWKRL IKLKDNHCEQ LRVKIRKLKN KASVLQKRIS
860 870 880 890 900
EKEEIKSQLK HEILELEKEL CSLRFAIQQE KKKRRNVEEL HQKVREKLRI
910 920 930 940 950
TEEQYRIEAD VTKPIKPALK SAEVELKTGG NNSNQVSETD EKEDLLHENR
960 970 980 990 1000
LMQDEIARLR LEKDTIKNQN LEKKYLKDFE IVKRKHEDLQ KALKRNGETL
1010 1020 1030 1040 1050
AKTIACYSGQ LAALTDENTT LRSKLEKQRE SRQRLETEMQ SYRCRLNAAR
1060 1070 1080 1090 1100
CDHDQSHSSK RDQELAFQGT VDKCRHLQEN LNSHVLILSL QLSKAESKSR
1110 1120 1130 1140 1150
VLKTELHYTG EALKEKALVF EHVQSELKQK QSQMKDIEKM YKSGYNTMEK
1160 1170 1180 1190 1200
CIEKQERFCQ LKKQNMLLQQ QLDDARNKAD NQEKAILNIQ ARCDARVQNL
1210 1220 1230 1240 1250
QAECRKHRLL LEEDNKMLVN ELNHSKEKEC QYEKEKAERE VAVRQLQQKR
1260 1270 1280 1290 1300
DDVLNKGSAT KALLDASSRH CTYLENGMQD SRKKLDQMRS QFQEIQDQLT
1310 1320 1330 1340 1350
ATIRCTKEME GDTQKLEVEH VMMRKIIKKQ DDQIERLEKI LQHSSLMLQV

FES
Length:1,353
Mass (Da):153,582
Last modified:August 10, 2010 - v4
Checksum:iB5EEB358EBBC0BE4
GO
Isoform 2 (identifier: Q8N2N9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1292-1304: FQEIQDQLTATIR → VCMQLCTPTTVNL
     1305-1353: Missing.

Show »
Length:1,304
Mass (Da):147,586
Checksum:i734ECD8A794C395A
GO
Isoform 3 (identifier: Q8N2N9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1292-1292: F → A
     1293-1353: Missing.

Show »
Length:1,292
Mass (Da):146,252
Checksum:i44C7633F2DA1C333
GO
Isoform 4 (identifier: Q8N2N9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-239: IFDLIYE → VSSETTS
     240-1353: Missing.

Show »
Length:239
Mass (Da):27,341
Checksum:iB2484A3265820AE1
GO

Sequence cautioni

The sequence AAI25133 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI25134 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL99915 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB15039 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB71081 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → C in BAC11066 (PubMed:14702039).Curated1
Sequence conflicti117V → F in BAC11066 (PubMed:14702039).Curated1
Sequence conflicti884R → K in AAH31883 (PubMed:15489334).Curated1
Sequence conflicti884R → K in AAH44844 (PubMed:15489334).Curated1
Sequence conflicti1223N → T in BAB71081 (PubMed:14702039).Curated1
Sequence conflicti1310E → D in BAB15039 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060687483E → G.Corresponds to variant rs1839230dbSNPEnsembl.1
Natural variantiVAR_057818496E → D.Corresponds to variant rs13001728dbSNPEnsembl.1
Natural variantiVAR_060688534S → A.Corresponds to variant rs6761299dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039666233 – 239IFDLIYE → VSSETTS in isoform 4. 2 Publications7
Alternative sequenceiVSP_039667240 – 1353Missing in isoform 4. 2 PublicationsAdd BLAST1114
Alternative sequenceiVSP_0396681292 – 1304FQEIQ…TATIR → VCMQLCTPTTVNL in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_0396691292F → A in isoform 3. 1 Publication1
Alternative sequenceiVSP_0396701293 – 1353Missing in isoform 3. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_0396711305 – 1353Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC017099 Genomic DNA. No translation available.
BC031883 mRNA. Translation: AAH31883.1.
BC044844 mRNA. Translation: AAH44844.1.
BC071771 mRNA. No translation available.
BC125132 mRNA. Translation: AAI25133.1. Different initiation.
BC125133 mRNA. Translation: AAI25134.1. Different initiation.
AK024934 mRNA. Translation: BAB15039.1. Different initiation.
AK056042 mRNA. Translation: BAB71081.1. Different initiation.
AK074570 mRNA. Translation: BAC11066.1.
AF432208 mRNA. Translation: AAL99915.1. Different initiation.
CCDSiCCDS74543.1. [Q8N2N9-1]
RefSeqiNP_079466.3. NM_025190.3. [Q8N2N9-1]
XP_005264052.1. XM_005263995.4. [Q8N2N9-1]
XP_006712724.1. XM_006712661.1. [Q8N2N9-1]
UniGeneiHs.532921.

Genome annotation databases

EnsembliENST00000258459; ENSP00000481149; ENSG00000196912. [Q8N2N9-1]
ENST00000359901; ENSP00000477778; ENSG00000196912. [Q8N2N9-1]
ENST00000443455; ENSP00000482644; ENSG00000196912. [Q8N2N9-4]
GeneIDi57730.
KEGGihsa:57730.
UCSCiuc010fid.2. human. [Q8N2N9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC017099 Genomic DNA. No translation available.
BC031883 mRNA. Translation: AAH31883.1.
BC044844 mRNA. Translation: AAH44844.1.
BC071771 mRNA. No translation available.
BC125132 mRNA. Translation: AAI25133.1. Different initiation.
BC125133 mRNA. Translation: AAI25134.1. Different initiation.
AK024934 mRNA. Translation: BAB15039.1. Different initiation.
AK056042 mRNA. Translation: BAB71081.1. Different initiation.
AK074570 mRNA. Translation: BAC11066.1.
AF432208 mRNA. Translation: AAL99915.1. Different initiation.
CCDSiCCDS74543.1. [Q8N2N9-1]
RefSeqiNP_079466.3. NM_025190.3. [Q8N2N9-1]
XP_005264052.1. XM_005263995.4. [Q8N2N9-1]
XP_006712724.1. XM_006712661.1. [Q8N2N9-1]
UniGeneiHs.532921.

3D structure databases

ProteinModelPortaliQ8N2N9.
SMRiQ8N2N9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121750. 3 interactors.
IntActiQ8N2N9. 7 interactors.

PTM databases

iPTMnetiQ8N2N9.
PhosphoSitePlusiQ8N2N9.

Polymorphism and mutation databases

BioMutaiANKRD36B.
DMDMi302393831.

Proteomic databases

PeptideAtlasiQ8N2N9.
PRIDEiQ8N2N9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258459; ENSP00000481149; ENSG00000196912. [Q8N2N9-1]
ENST00000359901; ENSP00000477778; ENSG00000196912. [Q8N2N9-1]
ENST00000443455; ENSP00000482644; ENSG00000196912. [Q8N2N9-4]
GeneIDi57730.
KEGGihsa:57730.
UCSCiuc010fid.2. human. [Q8N2N9-1]

Organism-specific databases

CTDi57730.
DisGeNETi57730.
GeneCardsiANKRD36B.
HGNCiHGNC:29333. ANKRD36B.
neXtProtiNX_Q8N2N9.
OpenTargetsiENSG00000196912.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00560000076605.
HOVERGENiHBG108636.
InParanoidiQ8N2N9.
OMAiLEMELKS.
OrthoDBiEOG091G01X9.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180253-MONOMER.

Miscellaneous databases

ChiTaRSiANKRD36B. human.
GenomeRNAii57730.
PROiQ8N2N9.

Gene expression databases

CleanExiHS_ANKRD36B.
ExpressionAtlasiQ8N2N9. baseline and differential.
GenevisibleiQ8N2N9. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAN36B_HUMAN
AccessioniPrimary (citable) accession number: Q8N2N9
Secondary accession number(s): Q08AK5
, Q6IPR0, Q6PI49, Q8IZM7, Q8TDH6, Q96N30, Q9H759
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 10, 2010
Last modified: November 30, 2016
This is version 102 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.