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Q8N2N9

- AN36B_HUMAN

UniProt

Q8N2N9 - AN36B_HUMAN

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Protein

Ankyrin repeat domain-containing protein 36B

Gene

ANKRD36B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 36B
Alternative name(s):
CLL-associated antigen KW-1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:29333. ANKRD36B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13531353Ankyrin repeat domain-containing protein 36BPRO_0000243912Add
BLAST

Proteomic databases

PaxDbiQ8N2N9.
PRIDEiQ8N2N9.

PTM databases

PhosphoSiteiQ8N2N9.

Expressioni

Gene expression databases

CleanExiHS_ANKRD36B.
ExpressionAtlasiQ8N2N9. baseline and differential.
GenevestigatoriQ8N2N9.

Interactioni

Protein-protein interaction databases

IntActiQ8N2N9. 2 interactions.
STRINGi9606.ENSP00000258459.

Structurei

3D structure databases

ProteinModelPortaliQ8N2N9.
SMRiQ8N2N9. Positions 22-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati19 – 4830ANK 1Add
BLAST
Repeati52 – 8130ANK 2Add
BLAST
Repeati85 – 11430ANK 3Add
BLAST
Repeati118 – 14730ANK 4Add
BLAST
Repeati151 – 18030ANK 5Add
BLAST
Repeati184 – 21330ANK 6Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili731 – 76232Sequence AnalysisAdd
BLAST
Coiled coili821 – 90888Sequence AnalysisAdd
BLAST
Coiled coili937 – 1055119Sequence AnalysisAdd
BLAST
Coiled coili1119 – 1344226Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the ANKRD36 family.Curated
Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiCOG0666.
GeneTreeiENSGT00560000076605.
HOVERGENiHBG108636.
InParanoidiQ8N2N9.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8N2N9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERLCSDGFA FPHYYIKPYH LKRIHRAVLR GNLEKLKYLL LTYYDANKRD
60 70 80 90 100
RKERTALHLA CATGQPEMVH LLVSRRCELN LCDREDRTPL IKAVQLRQEA
110 120 130 140 150
CATLLLQNGA DPNITDVFGR TALHYAVYNE DTSMIEKLLS HGTNIEECSK
160 170 180 190 200
NEYQPLLLAV SRRKVKMVEF LLKKKANVNA IDYLGRSALI LAVTLGEKDI
210 220 230 240 250
VILLLQHNID VFSRDVYGKL AEDYASEAEN RVIFDLIYEY KRKRYEDLPI
260 270 280 290 300
NSNPVSPQKQ RAEKATSDDK DSVSNIATEI KEGPISGTVS SQKQPAEKAT
310 320 330 340 350
SDEKDSVSNI ATEIKEGQQS GTVSPQKQSA QKVIFKKKVS LLNIATRIMG
360 370 380 390 400
GGKSGTVSSQ KQPASKTASD KTDSALNTAT EIKDGLQCGT VSSQKQQALK
410 420 430 440 450
ATTDEEGSVS NIATEIKDGE KSGTVSSQKK PALKATSDEK DSFSNITREK
460 470 480 490 500
KDGEISRTVS SQKPPALKAT SVKEDSVLNI AREKKDGEKS RTVSFEQPPG
510 520 530 540 550
LKATRDEKDS LLNIARGKKD GEKTRRVSSH KQPSLKATSD KEDSVPNMAT
560 570 580 590 600
ETKDEQISGT VSCQKQPALK ATSDKKDSVS NIPTEIKDGQ QSGTVSSQKQ
610 620 630 640 650
PAWKATSVKK DSVSNIATEI KDGQIRGTVS SQRRPALKTT GDEKDSVSNI
660 670 680 690 700
AREIKDGEKS GTVSPQKQSA QKVIFKKKVS LLNIATRITG GGKSGTEYPE
710 720 730 740 750
NLRTLKATIE NKDSVLNTAT KMKEVQTSTP AEQDLEMASE GEQKRLEEYE
760 770 780 790 800
NNQPQVKNQI HSRDDLDDII QSSQTVSEDG DSLCCNCKNV ILLIDQHEMK
810 820 830 840 850
CKDCVHLLKI KNTFCLWKRL IKLKDNHCEQ LRVKIRKLKN KASVLQKRIS
860 870 880 890 900
EKEEIKSQLK HEILELEKEL CSLRFAIQQE KKKRRNVEEL HQKVREKLRI
910 920 930 940 950
TEEQYRIEAD VTKPIKPALK SAEVELKTGG NNSNQVSETD EKEDLLHENR
960 970 980 990 1000
LMQDEIARLR LEKDTIKNQN LEKKYLKDFE IVKRKHEDLQ KALKRNGETL
1010 1020 1030 1040 1050
AKTIACYSGQ LAALTDENTT LRSKLEKQRE SRQRLETEMQ SYRCRLNAAR
1060 1070 1080 1090 1100
CDHDQSHSSK RDQELAFQGT VDKCRHLQEN LNSHVLILSL QLSKAESKSR
1110 1120 1130 1140 1150
VLKTELHYTG EALKEKALVF EHVQSELKQK QSQMKDIEKM YKSGYNTMEK
1160 1170 1180 1190 1200
CIEKQERFCQ LKKQNMLLQQ QLDDARNKAD NQEKAILNIQ ARCDARVQNL
1210 1220 1230 1240 1250
QAECRKHRLL LEEDNKMLVN ELNHSKEKEC QYEKEKAERE VAVRQLQQKR
1260 1270 1280 1290 1300
DDVLNKGSAT KALLDASSRH CTYLENGMQD SRKKLDQMRS QFQEIQDQLT
1310 1320 1330 1340 1350
ATIRCTKEME GDTQKLEVEH VMMRKIIKKQ DDQIERLEKI LQHSSLMLQV

FES
Length:1,353
Mass (Da):153,582
Last modified:August 10, 2010 - v4
Checksum:iB5EEB358EBBC0BE4
GO
Isoform 2 (identifier: Q8N2N9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1292-1304: FQEIQDQLTATIR → VCMQLCTPTTVNL
     1305-1353: Missing.

Show »
Length:1,304
Mass (Da):147,586
Checksum:i734ECD8A794C395A
GO
Isoform 3 (identifier: Q8N2N9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1292-1292: F → A
     1293-1353: Missing.

Show »
Length:1,292
Mass (Da):146,252
Checksum:i44C7633F2DA1C333
GO
Isoform 4 (identifier: Q8N2N9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-239: IFDLIYE → VSSETTS
     240-1353: Missing.

Show »
Length:239
Mass (Da):27,341
Checksum:iB2484A3265820AE1
GO

Sequence cautioni

The sequence AAI25133.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI25134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL99915.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB15039.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB71081.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31R → C in BAC11066. (PubMed:14702039)Curated
Sequence conflicti117 – 1171V → F in BAC11066. (PubMed:14702039)Curated
Sequence conflicti884 – 8841R → K in AAH31883. (PubMed:15489334)Curated
Sequence conflicti884 – 8841R → K in AAH44844. (PubMed:15489334)Curated
Sequence conflicti1223 – 12231N → T in BAB71081. (PubMed:14702039)Curated
Sequence conflicti1310 – 13101E → D in BAB15039. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti483 – 4831E → G.
Corresponds to variant rs1839230 [ dbSNP | Ensembl ].
VAR_060687
Natural varianti496 – 4961E → D.
Corresponds to variant rs13001728 [ dbSNP | Ensembl ].
VAR_057818
Natural varianti534 – 5341S → A.
Corresponds to variant rs6761299 [ dbSNP | Ensembl ].
VAR_060688

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei233 – 2397IFDLIYE → VSSETTS in isoform 4. 2 PublicationsVSP_039666
Alternative sequencei240 – 13531114Missing in isoform 4. 2 PublicationsVSP_039667Add
BLAST
Alternative sequencei1292 – 130413FQEIQ…TATIR → VCMQLCTPTTVNL in isoform 2. 1 PublicationVSP_039668Add
BLAST
Alternative sequencei1292 – 12921F → A in isoform 3. 1 PublicationVSP_039669
Alternative sequencei1293 – 135361Missing in isoform 3. 1 PublicationVSP_039670Add
BLAST
Alternative sequencei1305 – 135349Missing in isoform 2. 1 PublicationVSP_039671Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC017099 Genomic DNA. No translation available.
BC031883 mRNA. Translation: AAH31883.1.
BC044844 mRNA. Translation: AAH44844.1.
BC071771 mRNA. No translation available.
BC125132 mRNA. Translation: AAI25133.1. Different initiation.
BC125133 mRNA. Translation: AAI25134.1. Different initiation.
AK024934 mRNA. Translation: BAB15039.1. Different initiation.
AK056042 mRNA. Translation: BAB71081.1. Different initiation.
AK074570 mRNA. Translation: BAC11066.1.
AF432208 mRNA. Translation: AAL99915.1. Different initiation.
CCDSiCCDS74543.1. [Q8N2N9-1]
RefSeqiNP_079466.3. NM_025190.3. [Q8N2N9-1]
XP_005264052.1. XM_005263995.2. [Q8N2N9-1]
XP_006712724.1. XM_006712661.1. [Q8N2N9-1]
UniGeneiHs.532921.

Genome annotation databases

EnsembliENST00000258459; ENSP00000481149; ENSG00000196912. [Q8N2N9-1]
ENST00000359901; ENSP00000477778; ENSG00000196912. [Q8N2N9-1]
ENST00000443455; ENSP00000482644; ENSG00000196912. [Q8N2N9-4]
ENST00000497329; ENSP00000481806; ENSG00000196912.
GeneIDi57730.
KEGGihsa:57730.
UCSCiuc010yvc.1. human. [Q8N2N9-1]

Polymorphism databases

DMDMi302393831.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC017099 Genomic DNA. No translation available.
BC031883 mRNA. Translation: AAH31883.1 .
BC044844 mRNA. Translation: AAH44844.1 .
BC071771 mRNA. No translation available.
BC125132 mRNA. Translation: AAI25133.1 . Different initiation.
BC125133 mRNA. Translation: AAI25134.1 . Different initiation.
AK024934 mRNA. Translation: BAB15039.1 . Different initiation.
AK056042 mRNA. Translation: BAB71081.1 . Different initiation.
AK074570 mRNA. Translation: BAC11066.1 .
AF432208 mRNA. Translation: AAL99915.1 . Different initiation.
CCDSi CCDS74543.1. [Q8N2N9-1 ]
RefSeqi NP_079466.3. NM_025190.3. [Q8N2N9-1 ]
XP_005264052.1. XM_005263995.2. [Q8N2N9-1 ]
XP_006712724.1. XM_006712661.1. [Q8N2N9-1 ]
UniGenei Hs.532921.

3D structure databases

ProteinModelPortali Q8N2N9.
SMRi Q8N2N9. Positions 22-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8N2N9. 2 interactions.
STRINGi 9606.ENSP00000258459.

PTM databases

PhosphoSitei Q8N2N9.

Polymorphism databases

DMDMi 302393831.

Proteomic databases

PaxDbi Q8N2N9.
PRIDEi Q8N2N9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258459 ; ENSP00000481149 ; ENSG00000196912 . [Q8N2N9-1 ]
ENST00000359901 ; ENSP00000477778 ; ENSG00000196912 . [Q8N2N9-1 ]
ENST00000443455 ; ENSP00000482644 ; ENSG00000196912 . [Q8N2N9-4 ]
ENST00000497329 ; ENSP00000481806 ; ENSG00000196912 .
GeneIDi 57730.
KEGGi hsa:57730.
UCSCi uc010yvc.1. human. [Q8N2N9-1 ]

Organism-specific databases

CTDi 57730.
GeneCardsi GC02M098108.
HGNCi HGNC:29333. ANKRD36B.
neXtProti NX_Q8N2N9.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
GeneTreei ENSGT00560000076605.
HOVERGENi HBG108636.
InParanoidi Q8N2N9.

Miscellaneous databases

ChiTaRSi ANKRD36B. human.
GenomeRNAii 57730.
NextBioi 64680.
PROi Q8N2N9.

Gene expression databases

CleanExi HS_ANKRD36B.
ExpressionAtlasi Q8N2N9. baseline and differential.
Genevestigatori Q8N2N9.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view ]
Pfami PF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view ]
SMARTi SM00248. ANK. 6 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 435-884 AND 1204-1353 (ISOFORM 1).
    Tissue: Brain, Prostate and Uterus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1165-1353 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1204-1353 (ISOFORM 1).
    Tissue: Embryo.
  4. "Identification of novel tumor antigens in CLL by SEREX: assessment of their potential as targets for immunotherapeutic approaches."
    Krackhardt A.M., Witzens M., Harig S., Hodi F.S., Zauls A.J., Chessia M., Barrett P., Gribben J.G.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1120-1353 (ISOFORM 2).

Entry informationi

Entry nameiAN36B_HUMAN
AccessioniPrimary (citable) accession number: Q8N2N9
Secondary accession number(s): Q08AK5
, Q6IPR0, Q6PI49, Q8IZM7, Q8TDH6, Q96N30, Q9H759
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 10, 2010
Last modified: November 26, 2014
This is version 83 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3