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Protein

CLK4-associating serine/arginine rich protein

Gene

CLASRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
CLK4-associating serine/arginine rich protein
Alternative name(s):
Splicing factor, arginine/serine-rich 16
Suppressor of white-apricot homolog 2
Gene namesi
Name:CLASRP
Synonyms:SFRS16, SWAP2
ORF Names:UNQ2428/PRO4988
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17731. CLASRP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961731.

Polymorphism and mutation databases

BioMutaiCLASRP.
DMDMi226694202.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000819451 – 674CLK4-associating serine/arginine rich proteinAdd BLAST674

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei101PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei327PhosphothreonineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei573PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated in vitro by CLK4.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N2M8.
MaxQBiQ8N2M8.
PaxDbiQ8N2M8.
PeptideAtlasiQ8N2M8.
PRIDEiQ8N2M8.

PTM databases

iPTMnetiQ8N2M8.
PhosphoSitePlusiQ8N2M8.

Expressioni

Gene expression databases

BgeeiENSG00000104859.
CleanExiHS_SFRS16.
ExpressionAtlasiQ8N2M8. baseline and differential.
GenevisibleiQ8N2M8. HS.

Organism-specific databases

HPAiHPA060469.
HPA062455.

Interactioni

Subunit structurei

Probably interacts with CLK4.By similarity

Protein-protein interaction databases

BioGridi116302. 35 interactors.
IntActiQ8N2M8. 7 interactors.
MINTiMINT-1451947.
STRINGi9606.ENSP00000221455.

Structurei

3D structure databases

ProteinModelPortaliQ8N2M8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili585 – 647Sequence analysisAdd BLAST63

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi369 – 673Arg-richAdd BLAST305
Compositional biasi377 – 535Ser-richAdd BLAST159

Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2548. Eukaryota.
COG0303. LUCA.
HOGENOMiHOG000067785.
HOVERGENiHBG065901.
InParanoidiQ8N2M8.
KOiK13168.
PhylomeDBiQ8N2M8.
TreeFamiTF351621.

Family and domain databases

InterProiIPR019147. SWAP_N_domain.
[Graphical view]
PfamiPF09750. DRY_EERY. 1 hit.
[Graphical view]
SMARTiSM01141. DRY_EERY. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2M8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWHEARKHER KLRGMMVDYK KRAERRREYY EKIKKDPAQF LQVHGRACKV
60 70 80 90 100
HLDSAVALAA ESPVNMMPWQ GDTNNMIDRF DVRAHLDHIP DYTPPLLTTI
110 120 130 140 150
SPEQESDERK CNYERYRGLV QNDFAGISEE QCLYQIYIDE LYGGLQRPSE
160 170 180 190 200
DEKKKLAEKK ASIGYTYEDS TVAKVEKAAE KPEEEESAAE EESNSDEDEV
210 220 230 240 250
IPDIDVEVDV DELNQEQVAD LNKQATTYGM ADGDFVRMLR KDKEEAEAIK
260 270 280 290 300
HAKALEEEKA MYSGRRSRRQ RREFREKRLR GRKISPPSYA RRDSPTYDPY
310 320 330 340 350
KRSPSESSSE SRSRSRSPTP GREEKITFIT SFGGSDEEAA AAAAAAAASG
360 370 380 390 400
VTTGKPPAPP QPGGPAPGRN ASARRRSSSS SSSSSASRTS SSRSSSRSSS
410 420 430 440 450
RSRRGGGYYR SGRHARSRSR SWSRSRSRSR RYSRSRSRGR RHSGGGSRDG
460 470 480 490 500
HRYSRSPARR GGYGPRRRSR SRSHSGDRYR RGGRGLRHHS SSRSRSSWSL
510 520 530 540 550
SPSRSRSLTR SRSHSPSPSQ SRSRSRSRSQ SPSPSPAREK LTRPAASPAV
560 570 580 590 600
GEKLKKTEPA AGKETGAAKP KLTPQEKLKL RMQKALNRQF KADKKAAQEK
610 620 630 640 650
MIQQEHERQE REDELRAMAR KIRMKERERR EKEREEWERQ YSRQSRSPSP
660 670
RYSREYSSSR RRSRSRSRSP HYRH
Length:674
Mass (Da):77,161
Last modified:April 14, 2009 - v4
Checksum:i454F935EBDD96541
GO
Isoform 2 (identifier: Q8N2M8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-594: PKLTPQEKLKLRMQKALNRQFKADK → VTQADASGEAETEDAEGAEQAVQGG
     595-674: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
Show »
Length:594
Mass (Da):66,355
Checksum:i0886C8D42E4F88C1
GO
Isoform 3 (identifier: Q8N2M8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-103: Missing.

Show »
Length:612
Mass (Da):70,286
Checksum:i1D876098123C08C5
GO

Sequence cautioni

The sequence AAC82339 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAC82340 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH80554 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016809174K → E.4 PublicationsCorresponds to variant rs4803794dbSNPEnsembl.1
Natural variantiVAR_035490213L → S in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05571742 – 103Missing in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_013894570 – 594PKLTP…FKADK → VTQADASGEAETEDAEGAEQ AVQGG in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_013895595 – 674Missing in isoform 2. 1 PublicationAdd BLAST80

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042800 mRNA. Translation: AAC82339.1. Different initiation.
AF042810
, AF042802, AF042803, AF042804, AF042805, AF042806, AF042807, AF042808, AF042809 Genomic DNA. Translation: AAC82340.1. Different initiation.
AY358944 mRNA. Translation: AAQ89303.1.
AK293333 mRNA. Translation: BAG56849.1.
AC011489 Genomic DNA. No translation available.
BC080554 mRNA. Translation: AAH80554.1. Different initiation.
CCDSiCCDS12652.2. [Q8N2M8-1]
CCDS62710.1. [Q8N2M8-4]
RefSeqiNP_001265368.1. NM_001278439.1.
NP_008987.2. NM_007056.2.
UniGeneiHs.466917.

Genome annotation databases

EnsembliENST00000391952; ENSP00000375814; ENSG00000104859.
ENST00000391953; ENSP00000375815; ENSG00000104859.
GeneIDi11129.
KEGGihsa:11129.
UCSCiuc010xxh.3. human. [Q8N2M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042800 mRNA. Translation: AAC82339.1. Different initiation.
AF042810
, AF042802, AF042803, AF042804, AF042805, AF042806, AF042807, AF042808, AF042809 Genomic DNA. Translation: AAC82340.1. Different initiation.
AY358944 mRNA. Translation: AAQ89303.1.
AK293333 mRNA. Translation: BAG56849.1.
AC011489 Genomic DNA. No translation available.
BC080554 mRNA. Translation: AAH80554.1. Different initiation.
CCDSiCCDS12652.2. [Q8N2M8-1]
CCDS62710.1. [Q8N2M8-4]
RefSeqiNP_001265368.1. NM_001278439.1.
NP_008987.2. NM_007056.2.
UniGeneiHs.466917.

3D structure databases

ProteinModelPortaliQ8N2M8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116302. 35 interactors.
IntActiQ8N2M8. 7 interactors.
MINTiMINT-1451947.
STRINGi9606.ENSP00000221455.

PTM databases

iPTMnetiQ8N2M8.
PhosphoSitePlusiQ8N2M8.

Polymorphism and mutation databases

BioMutaiCLASRP.
DMDMi226694202.

Proteomic databases

EPDiQ8N2M8.
MaxQBiQ8N2M8.
PaxDbiQ8N2M8.
PeptideAtlasiQ8N2M8.
PRIDEiQ8N2M8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391952; ENSP00000375814; ENSG00000104859.
ENST00000391953; ENSP00000375815; ENSG00000104859.
GeneIDi11129.
KEGGihsa:11129.
UCSCiuc010xxh.3. human. [Q8N2M8-1]

Organism-specific databases

CTDi11129.
GeneCardsiCLASRP.
H-InvDBHIX0015221.
HGNCiHGNC:17731. CLASRP.
HPAiHPA060469.
HPA062455.
neXtProtiNX_Q8N2M8.
PharmGKBiPA134961731.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2548. Eukaryota.
COG0303. LUCA.
HOGENOMiHOG000067785.
HOVERGENiHBG065901.
InParanoidiQ8N2M8.
KOiK13168.
PhylomeDBiQ8N2M8.
TreeFamiTF351621.

Miscellaneous databases

ChiTaRSiCLASRP. human.
GeneWikiiSFRS16.
GenomeRNAii11129.
PROiQ8N2M8.

Gene expression databases

BgeeiENSG00000104859.
CleanExiHS_SFRS16.
ExpressionAtlasiQ8N2M8. baseline and differential.
GenevisibleiQ8N2M8. HS.

Family and domain databases

InterProiIPR019147. SWAP_N_domain.
[Graphical view]
PfamiPF09750. DRY_EERY. 1 hit.
[Graphical view]
SMARTiSM01141. DRY_EERY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLASR_HUMAN
AccessioniPrimary (citable) accession number: Q8N2M8
Secondary accession number(s): B4DDT8
, F8WAG9, O96026, Q6UW71, Q96DX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-16 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.