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Protein

Zinc finger protein 619

Gene

ZNF619

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri188 – 21023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 619
Gene namesi
Name:ZNF619
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:26910. ZNF619.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134889198.

Polymorphism and mutation databases

BioMutaiZNF619.
DMDMi74762517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Zinc finger protein 619PRO_0000234601Add
BLAST

Proteomic databases

EPDiQ8N2I2.
PaxDbiQ8N2I2.
PeptideAtlasiQ8N2I2.
PRIDEiQ8N2I2.

PTM databases

iPTMnetiQ8N2I2.
PhosphoSiteiQ8N2I2.

Expressioni

Gene expression databases

BgeeiQ8N2I2.
CleanExiHS_ZNF619.
ExpressionAtlasiQ8N2I2. baseline and differential.
GenevisibleiQ8N2I2. HS.

Organism-specific databases

HPAiHPA045094.

Interactioni

Protein-protein interaction databases

BioGridi130063. 1 interaction.
IntActiQ8N2I2. 1 interaction.
STRINGi9606.ENSP00000411132.

Structurei

3D structure databases

ProteinModelPortaliQ8N2I2.
SMRiQ8N2I2. Positions 170-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri188 – 21023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri216 – 23823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri244 – 26623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri440 – 46223C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123072.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N2I2.
KOiK09228.
OMAiAFRWNAS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N2I2.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2I2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGQPAPYAEG PIQGGDAGEL CKCDFLVSIS IPQTRSDIPA GARRSSMGPR
60 70 80 90 100
SLDTCWGRGP ERHVHRLECN GVIFTHRNLC LPGGKTKTEN EEKTAQLNIS
110 120 130 140 150
KESESHRLIV EGLLMDVPQH PDFKDRLEKS QLHDTGNKTK IGDCTDLTVQ
160 170 180 190 200
DHESSTTERE EIARKLEESS VSTHLITKQG FAKEQVFYKC GECGSYYNPH
210 220 230 240 250
SDFHLHQRVH TNEKPYTCKE CGKTFRYNSK LSRHQKIHTG EKPYSCEECG
260 270 280 290 300
QAFSQNSHLL QHQKLHGGQR PYECTDCGKT FSYNSKLIRH QRIHTGEKPF
310 320 330 340 350
KCKECGKAFS CSYDCIIHER IHNGEKPYEC KECGKSLSSN SVLIQHQRIH
360 370 380 390 400
TGEKPYECKE CGKAFHRSSV FLQHQRFHTG EQLYKCNECW KTFSCSSRFI
410 420 430 440 450
VHQRIHNGEK PYECQECGKT FSQKITLVQH QRVHTGEKPY ECKECGKAFR
460 470 480 490 500
WNASFIQHQK WHTRKKLING TGLSAVKPYC PCAILSPLPP QHTCSALAPP
510 520 530 540 550
GPPLSSSHAV VLPPSVPFFL LLPSSEKANP SPVQIAHFFQ DLAFPGKSSL
560
QSPNPLSHSL
Length:560
Mass (Da):63,322
Last modified:October 1, 2002 - v1
Checksum:iA65162901A812767
GO
Isoform 2 (identifier: Q8N2I2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MGQPAPYAEG...IFTHRNLCLP → MKPGVISHAP...GGEALRGMCT

Note: No experimental confirmation available.
Show »
Length:532
Mass (Da):60,138
Checksum:iBEB317A07AC9A93A
GO
Isoform 3 (identifier: Q8N2I2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MGQPAPYAEG...IFTHRNLCLP → MLQTVWFQGL...GGEALRGMCT

Note: Gene prediction based on EST data.
Show »
Length:576
Mass (Da):65,587
Checksum:i840970DA2F210408
GO
Isoform 4 (identifier: Q8N2I2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: MGQPAPYAEG...IFTHRNLCLP → MLQTVWFQGL...GGEALRGMCT

Note: Gene prediction based on EST data.
Show »
Length:616
Mass (Da):69,776
Checksum:iE8C80759E007D28E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282MGQPA…NLCLP → MKPGVISHAPDSVVPAAFPF PKPDLIFQLEQGEAAWGPDP WTLAGGEALRGMCT in isoform 2. 1 PublicationVSP_043080Add
BLAST
Alternative sequencei1 – 8282MGQPA…NLCLP → MLQTVWFQGLGRNLLFQEPV TFEDVAVYFTQNEWASLHPT QRALYREVMLENYANVTSLS AFPFPKPDLIFQLEQGEAAW GPDPWTLAGGEALRGMCT in isoform 3. CuratedVSP_055715Add
BLAST
Alternative sequencei1 – 8282MGQPA…NLCLP → MLQTVWFQGLGRNLLFQEPV TFEDVAVYFTQNEWASLHPT QRALYREVMLENYANVTSLY PTAGGFPLDTERTEKVPGAL SSFLPSSSSLELILALLPMS AFPFPKPDLIFQLEQGEAAW GPDPWTLAGGEALRGMCT in isoform 4. CuratedVSP_055716Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075245 mRNA. Translation: BAC11495.1.
AK304139 mRNA. Translation: BAG65033.1.
AC121754 Genomic DNA. No translation available.
CCDSiCCDS46801.1. [Q8N2I2-2]
CCDS46802.1. [Q8N2I2-4]
CCDS46803.1. [Q8N2I2-3]
RefSeqiNP_001138554.1. NM_001145082.2. [Q8N2I2-4]
NP_001138555.1. NM_001145083.1. [Q8N2I2-2]
NP_001138565.1. NM_001145093.2. [Q8N2I2-3]
UniGeneiHs.407159.

Genome annotation databases

EnsembliENST00000314686; ENSP00000322529; ENSG00000177873. [Q8N2I2-1]
ENST00000432264; ENSP00000388710; ENSG00000177873. [Q8N2I2-3]
ENST00000447116; ENSP00000411132; ENSG00000177873. [Q8N2I2-4]
ENST00000456778; ENSP00000397232; ENSG00000177873. [Q8N2I2-2]
ENST00000521353; ENSP00000430705; ENSG00000177873. [Q8N2I2-4]
GeneIDi285267.
KEGGihsa:285267.
UCSCiuc003ckj.4. human. [Q8N2I2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075245 mRNA. Translation: BAC11495.1.
AK304139 mRNA. Translation: BAG65033.1.
AC121754 Genomic DNA. No translation available.
CCDSiCCDS46801.1. [Q8N2I2-2]
CCDS46802.1. [Q8N2I2-4]
CCDS46803.1. [Q8N2I2-3]
RefSeqiNP_001138554.1. NM_001145082.2. [Q8N2I2-4]
NP_001138555.1. NM_001145083.1. [Q8N2I2-2]
NP_001138565.1. NM_001145093.2. [Q8N2I2-3]
UniGeneiHs.407159.

3D structure databases

ProteinModelPortaliQ8N2I2.
SMRiQ8N2I2. Positions 170-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130063. 1 interaction.
IntActiQ8N2I2. 1 interaction.
STRINGi9606.ENSP00000411132.

PTM databases

iPTMnetiQ8N2I2.
PhosphoSiteiQ8N2I2.

Polymorphism and mutation databases

BioMutaiZNF619.
DMDMi74762517.

Proteomic databases

EPDiQ8N2I2.
PaxDbiQ8N2I2.
PeptideAtlasiQ8N2I2.
PRIDEiQ8N2I2.

Protocols and materials databases

DNASUi285267.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314686; ENSP00000322529; ENSG00000177873. [Q8N2I2-1]
ENST00000432264; ENSP00000388710; ENSG00000177873. [Q8N2I2-3]
ENST00000447116; ENSP00000411132; ENSG00000177873. [Q8N2I2-4]
ENST00000456778; ENSP00000397232; ENSG00000177873. [Q8N2I2-2]
ENST00000521353; ENSP00000430705; ENSG00000177873. [Q8N2I2-4]
GeneIDi285267.
KEGGihsa:285267.
UCSCiuc003ckj.4. human. [Q8N2I2-1]

Organism-specific databases

CTDi285267.
GeneCardsiZNF619.
HGNCiHGNC:26910. ZNF619.
HPAiHPA045094.
neXtProtiNX_Q8N2I2.
PharmGKBiPA134889198.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123072.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8N2I2.
KOiK09228.
OMAiAFRWNAS.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8N2I2.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii285267.
PROiQ8N2I2.

Gene expression databases

BgeeiQ8N2I2.
CleanExiHS_ZNF619.
ExpressionAtlasiQ8N2I2. baseline and differential.
GenevisibleiQ8N2I2. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thyroid and Trachea.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN619_HUMAN
AccessioniPrimary (citable) accession number: Q8N2I2
Secondary accession number(s): B4E271
, C9JRN5, D4PHA2, E9PCD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.