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Protein

Protein SYS1 homolog

Gene

SYS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in protein trafficking. May serve as a receptor for ARFRP1.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SYS1 homolog
Gene namesi
Name:SYS1
Synonyms:C20orf169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16162. SYS1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence analysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei91 – 11121HelicalSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405119.

Polymorphism and mutation databases

BioMutaiSYS1.
DMDMi51316873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 156156Protein SYS1 homologPRO_0000213940Add
BLAST

Proteomic databases

EPDiQ8N2H4.
MaxQBiQ8N2H4.
PaxDbiQ8N2H4.
PRIDEiQ8N2H4.
TopDownProteomicsiQ8N2H4-1. [Q8N2H4-1]

PTM databases

iPTMnetiQ8N2H4.
PhosphoSiteiQ8N2H4.

Expressioni

Gene expression databases

BgeeiQ8N2H4.
ExpressionAtlasiQ8N2H4. baseline and differential.
GenevisibleiQ8N2H4. HS.

Organism-specific databases

HPAiHPA046716.

Interactioni

Subunit structurei

Interacts with ARFRP1.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000243918.

Structurei

3D structure databases

ProteinModelPortaliQ8N2H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SYS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4697. Eukaryota.
ENOG4111H59. LUCA.
GeneTreeiENSGT00390000004826.
HOGENOMiHOG000185908.
HOVERGENiHBG056907.
InParanoidiQ8N2H4.
OMAiIGCWIYN.
OrthoDBiEOG7MH10N.
PhylomeDBiQ8N2H4.
TreeFamiTF105875.

Family and domain databases

InterProiIPR016973. Integral_membrane_SYS1.
IPR019185. Integral_membrane_SYS1-rel.
[Graphical view]
PfamiPF09801. SYS1. 1 hit.
[Graphical view]
PIRSFiPIRSF031402. SYS1_homologue. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2H4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGQFRSYVW DPLLILSQIV LMQTVYYGSL GLWLALVDGL VRSSPSLDQM
60 70 80 90 100
FDAEILGFST PPGRLSMMSF ILNALTCALG LLYFIRRGKQ CLDFTVTVHF
110 120 130 140 150
FHLLGCWFYS SRFPSALTWW LVQAVCIALM AVIGEYLCMR TELKEIPLNS

APKSNV
Length:156
Mass (Da):17,615
Last modified:October 1, 2002 - v1
Checksum:i541FBB6326C9C0BB
GO
Isoform 2 (identifier: Q8N2H4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-156: Missing.

Note: No experimental confirmation available.
Show »
Length:76
Mass (Da):8,444
Checksum:iCDBBC2666CAC8B78
GO

Sequence cautioni

The sequence CAC39448.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei77 – 15680Missing in isoform 2. 1 PublicationVSP_044540Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591714 mRNA. Translation: CAC39448.1. Different initiation.
AK075264 mRNA. Translation: BAC11506.1.
AK172738 mRNA. No translation available.
AL021578 Genomic DNA. Translation: CAI21082.1.
CH471077 Genomic DNA. Translation: EAW75847.1.
CH471077 Genomic DNA. Translation: EAW75857.1.
BC048286 mRNA. Translation: AAH48286.1.
CCDSiCCDS13351.1. [Q8N2H4-1]
CCDS56192.1. [Q8N2H4-2]
RefSeqiNP_001093261.1. NM_001099791.2. [Q8N2H4-2]
NP_001184058.1. NM_001197129.1. [Q8N2H4-1]
NP_291020.1. NM_033542.3. [Q8N2H4-1]
UniGeneiHs.655055.
Hs.733183.

Genome annotation databases

EnsembliENST00000243918; ENSP00000243918; ENSG00000204070. [Q8N2H4-1]
ENST00000372727; ENSP00000361812; ENSG00000204070. [Q8N2H4-1]
ENST00000426004; ENSP00000416506; ENSG00000204070. [Q8N2H4-2]
GeneIDi90196.
KEGGihsa:90196.
UCSCiuc002xnv.4. human. [Q8N2H4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591714 mRNA. Translation: CAC39448.1. Different initiation.
AK075264 mRNA. Translation: BAC11506.1.
AK172738 mRNA. No translation available.
AL021578 Genomic DNA. Translation: CAI21082.1.
CH471077 Genomic DNA. Translation: EAW75847.1.
CH471077 Genomic DNA. Translation: EAW75857.1.
BC048286 mRNA. Translation: AAH48286.1.
CCDSiCCDS13351.1. [Q8N2H4-1]
CCDS56192.1. [Q8N2H4-2]
RefSeqiNP_001093261.1. NM_001099791.2. [Q8N2H4-2]
NP_001184058.1. NM_001197129.1. [Q8N2H4-1]
NP_291020.1. NM_033542.3. [Q8N2H4-1]
UniGeneiHs.655055.
Hs.733183.

3D structure databases

ProteinModelPortaliQ8N2H4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000243918.

PTM databases

iPTMnetiQ8N2H4.
PhosphoSiteiQ8N2H4.

Polymorphism and mutation databases

BioMutaiSYS1.
DMDMi51316873.

Proteomic databases

EPDiQ8N2H4.
MaxQBiQ8N2H4.
PaxDbiQ8N2H4.
PRIDEiQ8N2H4.
TopDownProteomicsiQ8N2H4-1. [Q8N2H4-1]

Protocols and materials databases

DNASUi90196.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243918; ENSP00000243918; ENSG00000204070. [Q8N2H4-1]
ENST00000372727; ENSP00000361812; ENSG00000204070. [Q8N2H4-1]
ENST00000426004; ENSP00000416506; ENSG00000204070. [Q8N2H4-2]
GeneIDi90196.
KEGGihsa:90196.
UCSCiuc002xnv.4. human. [Q8N2H4-1]

Organism-specific databases

CTDi90196.
GeneCardsiSYS1.
HGNCiHGNC:16162. SYS1.
HPAiHPA046716.
MIMi612979. gene.
neXtProtiNX_Q8N2H4.
PharmGKBiPA162405119.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4697. Eukaryota.
ENOG4111H59. LUCA.
GeneTreeiENSGT00390000004826.
HOGENOMiHOG000185908.
HOVERGENiHBG056907.
InParanoidiQ8N2H4.
OMAiIGCWIYN.
OrthoDBiEOG7MH10N.
PhylomeDBiQ8N2H4.
TreeFamiTF105875.

Miscellaneous databases

ChiTaRSiSYS1. human.
GenomeRNAii90196.
NextBioi76577.
PROiQ8N2H4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N2H4.
ExpressionAtlasiQ8N2H4. baseline and differential.
GenevisibleiQ8N2H4. HS.

Family and domain databases

InterProiIPR016973. Integral_membrane_SYS1.
IPR019185. Integral_membrane_SYS1-rel.
[Graphical view]
PfamiPF09801. SYS1. 1 hit.
[Graphical view]
PIRSFiPIRSF031402. SYS1_homologue. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Stavrides G.S., Huckle E.J., Deloukas P.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Embryo and Thyroid.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Blood.
  6. "Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p."
    Behnia R., Panic B., Whyte J.R.C., Munro S.
    Nat. Cell Biol. 6:405-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH ARFRP1.

Entry informationi

Entry nameiSYS1_HUMAN
AccessioniPrimary (citable) accession number: Q8N2H4
Secondary accession number(s): C9JFB3
, E1P620, Q5QPU7, Q96SD8, Q9BQZ2, Q9BQZ4, Q9H1F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.