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Protein

Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

Gene

PYROXD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probable oxidoreductase.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 7134FADSequence analysisAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC:1.-.-.-)
Gene namesi
Name:PYROXD2
Synonyms:C10orf33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23517. PYROXD2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165549043.

Polymorphism and mutation databases

BioMutaiPYROXD2.
DMDMi109820933.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2PRO_0000244071Add
BLAST

Proteomic databases

MaxQBiQ8N2H3.
PaxDbiQ8N2H3.
PRIDEiQ8N2H3.

PTM databases

iPTMnetiQ8N2H3.
PhosphoSiteiQ8N2H3.

Expressioni

Gene expression databases

BgeeiQ8N2H3.
CleanExiHS_C10orf33.
GenevisibleiQ8N2H3. HS.

Organism-specific databases

HPAiHPA037566.
HPA037567.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-3919450,EBI-743771

Protein-protein interaction databases

BioGridi124263. 3 interactions.
IntActiQ8N2H3. 3 interactions.
MINTiMINT-8247423.
STRINGi9606.ENSP00000359607.

Structurei

3D structure databases

ProteinModelPortaliQ8N2H3.
SMRiQ8N2H3. Positions 29-72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4254. Eukaryota.
COG1233. LUCA.
GeneTreeiENSGT00390000011684.
HOGENOMiHOG000238954.
InParanoidiQ8N2H3.
OMAiIQYTPYK.
OrthoDBiEOG7PP568.
PhylomeDBiQ8N2H3.
TreeFamiTF315188.

Family and domain databases

Gene3Di3.50.50.60. 4 hits.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8N2H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGRGLCK AVAASPFPAW RRDNTEARGG LKPEYDAVVI GAGHNGLVAA
60 70 80 90 100
AYLQRLGVNT AVFERRHVIG GAAVTEEIIP GFKFSRASYL LSLLRPQIYT
110 120 130 140 150
DLELKKHGLR LHLRNPYSFT PMLEEGAGSK VPRCLLLGTD MAENQKQIAQ
160 170 180 190 200
FSQKDAQVFP KYEEFMHRLA LAIDPLLDAA PVDMAAFQHG SLLQRMRSLS
210 220 230 240 250
TLKPLLKAGR ILGAQLPRYY EVLTAPITKV LDQWFESEPL KATLATDAVI
260 270 280 290 300
GAMTSPHTPG SGYVLLHHVM GGLEGMQGAW GYVQGGMGAL SDAIASSATT
310 320 330 340 350
HGASIFTEKT VAKVQVNSEG CVQGVVLEDG TEVRSKMVLS NTSPQITFLK
360 370 380 390 400
LTPQEWLPEE FLERISQLDT RSPVTKINVA VDRLPSFLAA PNAPRGQPLP
410 420 430 440 450
HHQCSIHLNC EDTLLLHQAF EDAMDGLPSH RPVIELCIPS SLDPTLAPPG
460 470 480 490 500
CHVVSLFTQY MPYTLAGGKA WDEQERDAYA DRVFDCIEVY APGFKDSVVG
510 520 530 540 550
RDILTPPDLE RIFGLPGGNI FHCAMSLDQL YFARPVPLHS GYRCPLQGLY
560 570 580
LCGSGAHPGG GVMGAAGRNA AHVAFRDLKS M
Length:581
Mass (Da):63,068
Last modified:June 27, 2006 - v2
Checksum:i64A9FB0B283939EE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti428 – 4281P → S.1 Publication
Corresponds to variant rs17856170 [ dbSNP | Ensembl ].
VAR_026877
Natural varianti461 – 4611M → T.2 Publications
Corresponds to variant rs2147896 [ dbSNP | Ensembl ].
VAR_026878
Natural varianti533 – 5331A → T.1 Publication
Corresponds to variant rs2296441 [ dbSNP | Ensembl ].
VAR_026879

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075265 mRNA. Translation: BAC11507.1.
AL139243 Genomic DNA. Translation: CAI14149.1.
CH471066 Genomic DNA. Translation: EAW49884.1.
CH471066 Genomic DNA. Translation: EAW49885.1.
BC006131 mRNA. Translation: AAH06131.1.
CCDSiCCDS7474.1.
RefSeqiNP_116098.2. NM_032709.2.
UniGeneiHs.238303.

Genome annotation databases

EnsembliENST00000370575; ENSP00000359607; ENSG00000119943.
GeneIDi84795.
KEGGihsa:84795.
UCSCiuc001kpc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075265 mRNA. Translation: BAC11507.1.
AL139243 Genomic DNA. Translation: CAI14149.1.
CH471066 Genomic DNA. Translation: EAW49884.1.
CH471066 Genomic DNA. Translation: EAW49885.1.
BC006131 mRNA. Translation: AAH06131.1.
CCDSiCCDS7474.1.
RefSeqiNP_116098.2. NM_032709.2.
UniGeneiHs.238303.

3D structure databases

ProteinModelPortaliQ8N2H3.
SMRiQ8N2H3. Positions 29-72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124263. 3 interactions.
IntActiQ8N2H3. 3 interactions.
MINTiMINT-8247423.
STRINGi9606.ENSP00000359607.

PTM databases

iPTMnetiQ8N2H3.
PhosphoSiteiQ8N2H3.

Polymorphism and mutation databases

BioMutaiPYROXD2.
DMDMi109820933.

Proteomic databases

MaxQBiQ8N2H3.
PaxDbiQ8N2H3.
PRIDEiQ8N2H3.

Protocols and materials databases

DNASUi84795.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370575; ENSP00000359607; ENSG00000119943.
GeneIDi84795.
KEGGihsa:84795.
UCSCiuc001kpc.4. human.

Organism-specific databases

CTDi84795.
GeneCardsiPYROXD2.
HGNCiHGNC:23517. PYROXD2.
HPAiHPA037566.
HPA037567.
neXtProtiNX_Q8N2H3.
PharmGKBiPA165549043.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4254. Eukaryota.
COG1233. LUCA.
GeneTreeiENSGT00390000011684.
HOGENOMiHOG000238954.
InParanoidiQ8N2H3.
OMAiIQYTPYK.
OrthoDBiEOG7PP568.
PhylomeDBiQ8N2H3.
TreeFamiTF315188.

Miscellaneous databases

GenomeRNAii84795.
PROiQ8N2H3.

Gene expression databases

BgeeiQ8N2H3.
CleanExiHS_C10orf33.
GenevisibleiQ8N2H3. HS.

Family and domain databases

Gene3Di3.50.50.60. 4 hits.
InterProiIPR002937. Amino_oxidase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-461 AND THR-533.
    Tissue: Thyroid.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-428 AND THR-461.
    Tissue: Uterus.

Entry informationi

Entry nameiPYRD2_HUMAN
AccessioniPrimary (citable) accession number: Q8N2H3
Secondary accession number(s): D3DR61, Q5TAA9, Q9BRQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 8, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.