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Protein

Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2

Gene

PYROXD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable oxidoreductase.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 71FADSequence analysisAdd BLAST34

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2 (EC:1.-.-.-)
Gene namesi
Name:PYROXD2
Synonyms:C10orf33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000119943.10
HGNCiHGNC:23517 PYROXD2
MIMi617889 gene
neXtProtiNX_Q8N2H3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119943
PharmGKBiPA165549043

Polymorphism and mutation databases

BioMutaiPYROXD2
DMDMi109820933

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002440711 – 581Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2Add BLAST581

Proteomic databases

MaxQBiQ8N2H3
PaxDbiQ8N2H3
PeptideAtlasiQ8N2H3
PRIDEiQ8N2H3

PTM databases

iPTMnetiQ8N2H3
PhosphoSitePlusiQ8N2H3

Expressioni

Gene expression databases

BgeeiENSG00000119943
CleanExiHS_C10orf33
GenevisibleiQ8N2H3 HS

Organism-specific databases

HPAiHPA037566
HPA037567
HPA067394

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
APPBP2Q926243EBI-3919450,EBI-743771

Protein-protein interaction databases

BioGridi124263, 3 interactors
IntActiQ8N2H3, 3 interactors
MINTiQ8N2H3
STRINGi9606.ENSP00000359607

Structurei

3D structure databases

ProteinModelPortaliQ8N2H3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4254 Eukaryota
COG1233 LUCA
GeneTreeiENSGT00390000011684
HOGENOMiHOG000238954
InParanoidiQ8N2H3
OMAiHRPMIEL
OrthoDBiEOG091G044J
PhylomeDBiQ8N2H3
TreeFamiTF315188

Family and domain databases

Gene3Di3.50.50.60, 2 hits
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits

Sequencei

Sequence statusi: Complete.

Q8N2H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASGRGLCK AVAASPFPAW RRDNTEARGG LKPEYDAVVI GAGHNGLVAA
60 70 80 90 100
AYLQRLGVNT AVFERRHVIG GAAVTEEIIP GFKFSRASYL LSLLRPQIYT
110 120 130 140 150
DLELKKHGLR LHLRNPYSFT PMLEEGAGSK VPRCLLLGTD MAENQKQIAQ
160 170 180 190 200
FSQKDAQVFP KYEEFMHRLA LAIDPLLDAA PVDMAAFQHG SLLQRMRSLS
210 220 230 240 250
TLKPLLKAGR ILGAQLPRYY EVLTAPITKV LDQWFESEPL KATLATDAVI
260 270 280 290 300
GAMTSPHTPG SGYVLLHHVM GGLEGMQGAW GYVQGGMGAL SDAIASSATT
310 320 330 340 350
HGASIFTEKT VAKVQVNSEG CVQGVVLEDG TEVRSKMVLS NTSPQITFLK
360 370 380 390 400
LTPQEWLPEE FLERISQLDT RSPVTKINVA VDRLPSFLAA PNAPRGQPLP
410 420 430 440 450
HHQCSIHLNC EDTLLLHQAF EDAMDGLPSH RPVIELCIPS SLDPTLAPPG
460 470 480 490 500
CHVVSLFTQY MPYTLAGGKA WDEQERDAYA DRVFDCIEVY APGFKDSVVG
510 520 530 540 550
RDILTPPDLE RIFGLPGGNI FHCAMSLDQL YFARPVPLHS GYRCPLQGLY
560 570 580
LCGSGAHPGG GVMGAAGRNA AHVAFRDLKS M
Length:581
Mass (Da):63,068
Last modified:June 27, 2006 - v2
Checksum:i64A9FB0B283939EE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026877428P → S1 PublicationCorresponds to variant dbSNP:rs17856170Ensembl.1
Natural variantiVAR_026878461M → T2 PublicationsCorresponds to variant dbSNP:rs2147896Ensembl.1
Natural variantiVAR_026879533A → T1 PublicationCorresponds to variant dbSNP:rs2296441Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075265 mRNA Translation: BAC11507.1
AL139243 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49884.1
CH471066 Genomic DNA Translation: EAW49885.1
BC006131 mRNA Translation: AAH06131.1
CCDSiCCDS7474.1
RefSeqiNP_116098.2, NM_032709.2
UniGeneiHs.238303

Genome annotation databases

EnsembliENST00000370575; ENSP00000359607; ENSG00000119943
GeneIDi84795
KEGGihsa:84795
UCSCiuc001kpc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPYRD2_HUMAN
AccessioniPrimary (citable) accession number: Q8N2H3
Secondary accession number(s): D3DR61, Q5TAA9, Q9BRQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: April 25, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health