Q8N2H3 (PYRD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2
EC=1.-.-.-

Gene names

Name:	PYROXD2
Synonyms:	C10orf33

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	581 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable oxidoreductase By similarity.
Sequence similarities	Belongs to the carotenoid/retinoid oxidoreductase family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	FAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 581	581	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2		PRO_0000244071
Regions
	Nucleotide binding	38 – 71	34	FAD Potential
Natural variations
	Natural variant	428	1	P → S. Ref.4 Corresponds to variant rs17856170 [ dbSNP | Ensembl ].		VAR_026877
	Natural variant	461	1	M → T. Ref.1 Ref.4 Corresponds to variant rs2147896 [ dbSNP | Ensembl ].		VAR_026878
	Natural variant	533	1	A → T. Ref.1 Corresponds to variant rs2296441 [ dbSNP | Ensembl ].		VAR_026879

Sequences

	Sequence		Length	Mass (Da)
	Q8N2H3 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 64A9FB0B283939EE	FASTA	581	63,068
	10 20 30 40 50 60 MAASGRGLCK AVAASPFPAW RRDNTEARGG LKPEYDAVVI GAGHNGLVAA AYLQRLGVNT 70 80 90 100 110 120 AVFERRHVIG GAAVTEEIIP GFKFSRASYL LSLLRPQIYT DLELKKHGLR LHLRNPYSFT 130 140 150 160 170 180 PMLEEGAGSK VPRCLLLGTD MAENQKQIAQ FSQKDAQVFP KYEEFMHRLA LAIDPLLDAA 190 200 210 220 230 240 PVDMAAFQHG SLLQRMRSLS TLKPLLKAGR ILGAQLPRYY EVLTAPITKV LDQWFESEPL 250 260 270 280 290 300 KATLATDAVI GAMTSPHTPG SGYVLLHHVM GGLEGMQGAW GYVQGGMGAL SDAIASSATT 310 320 330 340 350 360 HGASIFTEKT VAKVQVNSEG CVQGVVLEDG TEVRSKMVLS NTSPQITFLK LTPQEWLPEE 370 380 390 400 410 420 FLERISQLDT RSPVTKINVA VDRLPSFLAA PNAPRGQPLP HHQCSIHLNC EDTLLLHQAF 430 440 450 460 470 480 EDAMDGLPSH RPVIELCIPS SLDPTLAPPG CHVVSLFTQY MPYTLAGGKA WDEQERDAYA 490 500 510 520 530 540 DRVFDCIEVY APGFKDSVVG RDILTPPDLE RIFGLPGGNI FHCAMSLDQL YFARPVPLHS 550 560 570 580 GYRCPLQGLY LCGSGAHPGG GVMGAAGRNA AHVAFRDLKS M

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-461 AND THR-533. Tissue: Thyroid.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-428 AND THR-461. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK075265 mRNA. Translation: BAC11507.1. AL139243 Genomic DNA. Translation: CAI14149.1. CH471066 Genomic DNA. Translation: EAW49884.1. CH471066 Genomic DNA. Translation: EAW49885.1. BC006131 mRNA. Translation: AAH06131.1.
IPI	IPI00296156.
RefSeq	NP_116098.2. NM_032709.2.
UniGene	Hs.238303. Hs.676105.
3D structure databases
ProteinModelPortal	Q8N2H3.
SMR	Q8N2H3. Positions 35-103, 288-344.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8N2H3. 1 interaction.
STRING	Q8N2H3.
Polymorphism databases
DMDM	109820933.
Proteomic databases
PRIDE	Q8N2H3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370575; ENSP00000359607; ENSG00000119943.
GeneID	84795.
KEGG	hsa:84795.
NMPDR	fig|9606.3.peg.4469.
UCSC	uc001kpc.1. human.
Organism-specific databases
CTD	84795.
GeneCards	GC10M100134.
HGNC	HGNC:23517. PYROXD2.
HPA	HPA037566.
neXtProt	NX_Q8N2H3.
PharmGKB	PA134888498. PA165549043.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19817.
GeneTree	ENSGT00390000011684.
InParanoid	Q8N2H3.
OMA	QEWLPEE.
OrthoDB	EOG4WM4TG.
PhylomeDB	Q8N2H3.
Gene expression databases
ArrayExpress	Q8N2H3.
Bgee	Q8N2H3.
CleanEx	HS_C10orf33.
Genevestigator	Q8N2H3.
GermOnline	ENSG00000119943. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	74960.

Entry information

Entry name

PYRD2_HUMAN

Accession

Primary (citable) accession number: Q8N2H3
Secondary accession number(s): D3DR61, Q5TAA9, Q9BRQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.