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Protein

GH3 domain-containing protein

Gene

GHDC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GH3 domain-containing protein
Gene namesi
Name:GHDC
Synonyms:D11LGP1E, LGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:24438. GHDC.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB
  3. nuclear envelope Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA147358034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 530513GH3 domain-containing proteinPRO_0000021593Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi450 – 4501N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8N2G8.
PaxDbiQ8N2G8.
PRIDEiQ8N2G8.

PTM databases

PhosphoSiteiQ8N2G8.

Expressioni

Gene expression databases

BgeeiQ8N2G8.
CleanExiHS_GHDC.
ExpressionAtlasiQ8N2G8. baseline and differential.
GenevestigatoriQ8N2G8.

Organism-specific databases

HPAiHPA031650.

Interactioni

Protein-protein interaction databases

BioGridi124108. 9 interactions.
STRINGi9606.ENSP00000301671.

Structurei

3D structure databases

ProteinModelPortaliQ8N2G8.
SMRiQ8N2G8. Positions 230-530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GH3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG86848.
GeneTreeiENSGT00390000016401.
HOGENOMiHOG000230989.
HOVERGENiHBG080045.
InParanoidiQ8N2G8.
OMAiHYEVFVA.
OrthoDBiEOG7HQN7M.
PhylomeDBiQ8N2G8.
TreeFamiTF333007.

Family and domain databases

InterProiIPR004993. GH3.
[Graphical view]
PfamiPF03321. GH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2G8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLWPLLLLL LLLPTLALLR QQRSQDARLS WLAGLQHRVA WGALVWAATW
60 70 80 90 100
QRRRLEQSTL HVHQSQQQAL RWCLQGAQRP HCSLRRSTDI STFRNHLPLT
110 120 130 140 150
KASQTQQEDS GEQPLPPTSN QDLGEASLQA TLLGLAALNK AYPEVLAQGR
160 170 180 190 200
TARVTLTSPW PRPLPWPGNT LGQVGTPGTK DPRALLLDAL RSPGLRALEA
210 220 230 240 250
GTAVELLDVF LGLETDGEEL AGAIAAGNPG APLRERAAEL REALEQGPRG
260 270 280 290 300
LALRLWPKLQ VVVTLDAGGQ AEAVAALGAL WCQGLAFFSP AYAASGGVLG
310 320 330 340 350
LNLQPEQPHG LYLLPPGAPF IELLPVKEGT QEEAASTLLL AEAQQGKEYE
360 370 380 390 400
LVLTDRASLT RCRLGDVVRV VGAYNQCPVV RFICRLDQTL SVRGEDIGED
410 420 430 440 450
LFSEALGRAV GQWAGAKLLD HGCVESSILD SSAGSAPHYE VFVALRGLRN
460 470 480 490 500
LSEENRDKLD HCLQEASPRY KSLRFWGSVG PARVHLVGQG AFRALRAALA
510 520 530
ACPSSPFPPA MPRVLRHRHL AQCLQERVVS
Length:530
Mass (Da):57,523
Last modified:July 19, 2004 - v2
Checksum:iBC0D92AC78889C16
GO
Isoform 2 (identifier: Q8N2G8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     430-474: DSSAGSAPHY...EASPRYKSLR → EWGRTDRAED...LLPTTRCLWR
     475-530: Missing.

Note: No experimental confirmation available.

Show »
Length:474
Mass (Da):51,460
Checksum:iC790C90825214706
GO
Isoform 3 (identifier: Q8N2G8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-139: Missing.

Note: No experimental confirmation available.

Show »
Length:491
Mass (Da):53,519
Checksum:iBF8D94485DD5F2BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti420 – 4201D → G in BAC11514 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei101 – 13939Missing in isoform 3. 1 PublicationVSP_044831Add
BLAST
Alternative sequencei430 – 47445DSSAG…YKSLR → EWGRTDRAEDTRLGSCPFTG SMCAHGVYSQIPLRALLPTT RCLWR in isoform 2. 1 PublicationVSP_010835Add
BLAST
Alternative sequencei475 – 53056Missing in isoform 2. 1 PublicationVSP_010836Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316997 mRNA. Translation: AAK15472.1.
AK074700 mRNA. Translation: BAC11146.1.
AK075277 mRNA. Translation: BAC11514.1.
AK298933 mRNA. Translation: BAG61036.1.
AC099811 Genomic DNA. No translation available.
BC022784 mRNA. Translation: AAH22784.1.
CCDSiCCDS11422.1. [Q8N2G8-1]
CCDS45682.1. [Q8N2G8-2]
RefSeqiNP_001136095.1. NM_001142623.1. [Q8N2G8-2]
NP_115873.1. NM_032484.4. [Q8N2G8-1]
UniGeneiHs.38039.

Genome annotation databases

EnsembliENST00000301671; ENSP00000301671; ENSG00000167925. [Q8N2G8-1]
ENST00000414034; ENSP00000399952; ENSG00000167925. [Q8N2G8-2]
ENST00000428494; ENSP00000410945; ENSG00000167925. [Q8N2G8-2]
ENST00000587427; ENSP00000467585; ENSG00000167925. [Q8N2G8-1]
GeneIDi84514.
KEGGihsa:84514.
UCSCiuc002hzd.3. human. [Q8N2G8-1]
uc002hze.4. human. [Q8N2G8-2]

Polymorphism databases

DMDMi50401069.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF316997 mRNA. Translation: AAK15472.1.
AK074700 mRNA. Translation: BAC11146.1.
AK075277 mRNA. Translation: BAC11514.1.
AK298933 mRNA. Translation: BAG61036.1.
AC099811 Genomic DNA. No translation available.
BC022784 mRNA. Translation: AAH22784.1.
CCDSiCCDS11422.1. [Q8N2G8-1]
CCDS45682.1. [Q8N2G8-2]
RefSeqiNP_001136095.1. NM_001142623.1. [Q8N2G8-2]
NP_115873.1. NM_032484.4. [Q8N2G8-1]
UniGeneiHs.38039.

3D structure databases

ProteinModelPortaliQ8N2G8.
SMRiQ8N2G8. Positions 230-530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124108. 9 interactions.
STRINGi9606.ENSP00000301671.

PTM databases

PhosphoSiteiQ8N2G8.

Polymorphism databases

DMDMi50401069.

Proteomic databases

MaxQBiQ8N2G8.
PaxDbiQ8N2G8.
PRIDEiQ8N2G8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301671; ENSP00000301671; ENSG00000167925. [Q8N2G8-1]
ENST00000414034; ENSP00000399952; ENSG00000167925. [Q8N2G8-2]
ENST00000428494; ENSP00000410945; ENSG00000167925. [Q8N2G8-2]
ENST00000587427; ENSP00000467585; ENSG00000167925. [Q8N2G8-1]
GeneIDi84514.
KEGGihsa:84514.
UCSCiuc002hzd.3. human. [Q8N2G8-1]
uc002hze.4. human. [Q8N2G8-2]

Organism-specific databases

CTDi84514.
GeneCardsiGC17M040341.
HGNCiHGNC:24438. GHDC.
HPAiHPA031650.
MIMi608587. gene.
neXtProtiNX_Q8N2G8.
PharmGKBiPA147358034.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG86848.
GeneTreeiENSGT00390000016401.
HOGENOMiHOG000230989.
HOVERGENiHBG080045.
InParanoidiQ8N2G8.
OMAiHYEVFVA.
OrthoDBiEOG7HQN7M.
PhylomeDBiQ8N2G8.
TreeFamiTF333007.

Miscellaneous databases

GenomeRNAii84514.
NextBioi74312.
PROiQ8N2G8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8N2G8.
CleanExiHS_GHDC.
ExpressionAtlasiQ8N2G8. baseline and differential.
GenevestigatoriQ8N2G8.

Family and domain databases

InterProiIPR004993. GH3.
[Graphical view]
PfamiPF03321. GH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse."
    Miyoshi K., Cui Y., Riedlinger G., Robinson P., Lehoczky J., Zon L., Oka T., Dewar K., Hennighausen L.
    Genomics 71:150-155(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Mammary gland and Thyroid.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGHDC_HUMAN
AccessioniPrimary (citable) accession number: Q8N2G8
Secondary accession number(s): B4DQS4, E9PDB5, Q9BXM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: March 4, 2015
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.