Q8N2G8 (GHDC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GH3 domain-containing protein

Gene names

Name:	GHDC
Synonyms:	D11LGP1E, LGP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Endoplasmic reticulum. Nucleus envelope By similarity.
Sequence similarities	Belongs to the GH3 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Nucleus
Coding sequence diversity	Alternative splicing
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell nuclear envelope Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8N2G8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8N2G8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     430-474: DSSAGSAPHY...EASPRYKSLR → EWGRTDRAED...LLPTTRCLWR
     475-530: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 530	513	GH3 domain-containing protein		PRO_0000021593
Amino acid modifications
	Glycosylation	450	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	430 – 474	45	DSSAG…YKSLR → EWGRTDRAEDTRLGSCPFTG SMCAHGVYSQIPLRALLPTT RCLWR in isoform 2.		VSP_010835
	Alternative sequence	475 – 530	56	Missing in isoform 2.		VSP_010836
Experimental info
	Sequence conflict	420	1	D → G in BAC11514. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: BC0D92AC78889C16	FASTA	530	57,523
	10 20 30 40 50 60 MLLWPLLLLL LLLPTLALLR QQRSQDARLS WLAGLQHRVA WGALVWAATW QRRRLEQSTL 70 80 90 100 110 120 HVHQSQQQAL RWCLQGAQRP HCSLRRSTDI STFRNHLPLT KASQTQQEDS GEQPLPPTSN 130 140 150 160 170 180 QDLGEASLQA TLLGLAALNK AYPEVLAQGR TARVTLTSPW PRPLPWPGNT LGQVGTPGTK 190 200 210 220 230 240 DPRALLLDAL RSPGLRALEA GTAVELLDVF LGLETDGEEL AGAIAAGNPG APLRERAAEL 250 260 270 280 290 300 REALEQGPRG LALRLWPKLQ VVVTLDAGGQ AEAVAALGAL WCQGLAFFSP AYAASGGVLG 310 320 330 340 350 360 LNLQPEQPHG LYLLPPGAPF IELLPVKEGT QEEAASTLLL AEAQQGKEYE LVLTDRASLT 370 380 390 400 410 420 RCRLGDVVRV VGAYNQCPVV RFICRLDQTL SVRGEDIGED LFSEALGRAV GQWAGAKLLD 430 440 450 460 470 480 HGCVESSILD SSAGSAPHYE VFVALRGLRN LSEENRDKLD HCLQEASPRY KSLRFWGSVG 490 500 510 520 530 PARVHLVGQG AFRALRAALA ACPSSPFPPA MPRVLRHRHL AQCLQERVVS
	Isoform 2 [UniParc]. Checksum: C790C90825214706	FASTA	474	51,460
	10 20 30 40 50 60 MLLWPLLLLL LLLPTLALLR QQRSQDARLS WLAGLQHRVA WGALVWAATW QRRRLEQSTL 70 80 90 100 110 120 HVHQSQQQAL RWCLQGAQRP HCSLRRSTDI STFRNHLPLT KASQTQQEDS GEQPLPPTSN 130 140 150 160 170 180 QDLGEASLQA TLLGLAALNK AYPEVLAQGR TARVTLTSPW PRPLPWPGNT LGQVGTPGTK 190 200 210 220 230 240 DPRALLLDAL RSPGLRALEA GTAVELLDVF LGLETDGEEL AGAIAAGNPG APLRERAAEL 250 260 270 280 290 300 REALEQGPRG LALRLWPKLQ VVVTLDAGGQ AEAVAALGAL WCQGLAFFSP AYAASGGVLG 310 320 330 340 350 360 LNLQPEQPHG LYLLPPGAPF IELLPVKEGT QEEAASTLLL AEAQQGKEYE LVLTDRASLT 370 380 390 400 410 420 RCRLGDVVRV VGAYNQCPVV RFICRLDQTL SVRGEDIGED LFSEALGRAV GQWAGAKLLD 430 440 450 460 470 HGCVESSILE WGRTDRAEDT RLGSCPFTGS MCAHGVYSQI PLRALLPTTR CLWR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse." Miyoshi K., Cui Y., Riedlinger G., Robinson P., Lehoczky J., Zon L., Oka T., Dewar K., Hennighausen L. Genomics 71:150-155(2001) [PubMed: 11161808] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Mammary gland and Thyroid.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF316997 mRNA. Translation: AAK15472.1. AK074700 mRNA. Translation: BAC11146.1. AK075277 mRNA. Translation: BAC11514.1. BC022784 mRNA. Translation: AAH22784.1.
IPI	IPI00427501. IPI00427502.
RefSeq	NP_001136094.1. NM_001142622.1. NP_001136095.1. NM_001142623.1. NP_115873.1. NM_032484.4.
UniGene	Hs.38039.
3D structure databases
ProteinModelPortal	Q8N2G8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8N2G8.
Polymorphism databases
DMDM	50401069.
Proteomic databases
PRIDE	Q8N2G8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301671; ENSP00000301671; ENSG00000167925. ENST00000393854; ENSP00000377436; ENSG00000167925.
GeneID	84514.
KEGG	hsa:84514.
UCSC	uc002hzd.1. human. uc002hze.2. human.
Organism-specific databases
CTD	84514.
GeneCards	GC17M040341.
H-InvDB	HIX0013836.
HGNC	HGNC:24438. GHDC.
HPA	HPA031650.
MIM	608587. gene.
neXtProt	NX_Q8N2G8.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08463.
GeneTree	ENSGT00390000016401.
HOGENOM	HBG127295.
HOVERGEN	HBG080045.
InParanoid	Q8N2G8.
OMA	AFFSPAY.
PhylomeDB	Q8N2G8.
Gene expression databases
ArrayExpress	Q8N2G8.
Bgee	Q8N2G8.
CleanEx	HS_GHDC.
Genevestigator	Q8N2G8.
GermOnline	ENSG00000167925. Homo sapiens.
Family and domain databases
InterPro	IPR004993. GH3. [Graphical view]
Pfam	PF03321. GH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	74312.
SOURCE	Search...

Entry information

Entry name

GHDC_HUMAN

Accession

Primary (citable) accession number: Q8N2G8
Secondary accession number(s): Q9BXM6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.