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Protein

Zinc finger CCHC domain-containing protein 24

Gene

ZCCHC24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri132 – 149CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 24
Gene namesi
Name:ZCCHC24
Synonyms:C10orf56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165424.6.
HGNCiHGNC:26911. ZCCHC24.

Pathology & Biotechi

Organism-specific databases

DisGeNETi219654.
OpenTargetsiENSG00000165424.
PharmGKBiPA162409573.

Polymorphism and mutation databases

BioMutaiZCCHC24.
DMDMi74759814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002742891 – 241Zinc finger CCHC domain-containing protein 24Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineCombined sources1
Modified residuei93PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8N2G6.
MaxQBiQ8N2G6.
PaxDbiQ8N2G6.
PeptideAtlasiQ8N2G6.
PRIDEiQ8N2G6.

PTM databases

iPTMnetiQ8N2G6.
PhosphoSitePlusiQ8N2G6.

Expressioni

Gene expression databases

BgeeiENSG00000165424.
CleanExiHS_ZCCHC24.
ExpressionAtlasiQ8N2G6. baseline and differential.
GenevisibleiQ8N2G6. HS.

Organism-specific databases

HPAiHPA038348.

Interactioni

Protein-protein interaction databases

BioGridi128561. 1 interactor.
STRINGi9606.ENSP00000361411.

Structurei

3D structure databases

ProteinModelPortaliQ8N2G6.
SMRiQ8N2G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri132 – 149CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IKHM. Eukaryota.
ENOG410ZS5N. LUCA.
GeneTreeiENSGT00390000008264.
HOGENOMiHOG000273902.
HOVERGENiHBG089647.
InParanoidiQ8N2G6.
OMAiTDHFSDL.
OrthoDBiEOG091G0BHI.
PhylomeDBiQ8N2G6.
TreeFamiTF319664.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiView protein in InterPro
IPR033446. Zcchc24_zf-3CxxC.
IPR025829. Zn_knuckle_CX2CX3GHX4C.
IPR027377. Znf-3CxxC.
IPR001878. Znf_CCHC.
PfamiView protein in Pfam
PF17180. zf-3CxxC_2. 1 hit.
PF13696. zf-CCHC_2. 1 hit.
SMARTiView protein in SMART
SM01328. zf-3CxxC. 1 hit.
SUPFAMiSSF57756. SSF57756. 1 hit.
PROSITEiView protein in PROSITE
PS50158. ZF_CCHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8N2G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLSAIDTS AASVYQPAQL LNWVYLSLQD THQASAFDAF RPEPTAGAAP
60 70 80 90 100
PELAFGKGRP EQLGSPLHSS YLNSFFQLQR GEALSNSVYK GASPYGSLNN
110 120 130 140 150
IADGLSSLTE HFSDLTLTSE ARKPSKRPPP NYLCHLCFNK GHYIKDCPQA
160 170 180 190 200
RPKGEGLTPY QGKKRCFGEY KCPKCKRKWM SGNSWANMGQ ECIKCHINVY
210 220 230 240
PHKQRPLEKP DGLDVSDQSK EHPQHLCEKC KVLGYYCRRV Q
Length:241
Mass (Da):26,955
Last modified:October 1, 2002 - v1
Checksum:iF5C8C8E5AEE241FC
GO

Sequence cautioni

The sequence AAH39249 differs from that shown. Reason: Frameshift at position 33.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48A → T in AAH39249 (PubMed:15489334).Curated1
Sequence conflicti152P → T in AAH39249 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03024943E → V1 PublicationCorresponds to variant dbSNP:rs17852581Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075279 mRNA. Translation: BAC11516.1.
AL133481 Genomic DNA. No translation available.
BC028617 mRNA. Translation: AAH28617.1.
BC039249 mRNA. Translation: AAH39249.1. Frameshift.
BC053564 mRNA. Translation: AAH53564.1.
CCDSiCCDS7359.1.
RefSeqiNP_699198.2. NM_153367.3.
UniGeneiHs.523080.

Genome annotation databases

EnsembliENST00000372336; ENSP00000361411; ENSG00000165424.
GeneIDi219654.
KEGGihsa:219654.
UCSCiuc001kak.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZCH24_HUMAN
AccessioniPrimary (citable) accession number: Q8N2G6
Secondary accession number(s): Q5U5T9, Q8TAG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2002
Last modified: September 27, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations