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Protein

Ly6/PLAUR domain-containing protein 1

Gene

LYPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ly6/PLAUR domain-containing protein 1
Alternative name(s):
Putative HeLa tumor suppressor
Short name:
PHTS
Gene namesi
Name:LYPD1
Synonyms:LYPDC1
ORF Names:PSEC0181, UNQ3079/PRO9917
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28431. LYPD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134862471.

Polymorphism and mutation databases

BioMutaiLYPD1.
DMDMi92058725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 11797Ly6/PLAUR domain-containing protein 1PRO_0000226741Add
BLAST
Propeptidei118 – 14124Removed in mature formSequence analysisPRO_0000226742Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis
Lipidationi117 – 1171GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ8N2G4.
PeptideAtlasiQ8N2G4.
PRIDEiQ8N2G4.

Expressioni

Gene expression databases

BgeeiENSG00000150551.
CleanExiHS_LYPD1.
ExpressionAtlasiQ8N2G4. baseline and differential.
GenevisibleiQ8N2G4. HS.

Organism-specific databases

HPAiCAB020783.

Interactioni

Protein-protein interaction databases

BioGridi125502. 19 interactions.
MINTiMINT-4723178.
STRINGi9606.ENSP00000380605.

Structurei

3D structure databases

ProteinModelPortaliQ8N2G4.
SMRiQ8N2G4. Positions 23-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 10783UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWWH. Eukaryota.
ENOG410XU3J. LUCA.
GeneTreeiENSGT00390000002215.
HOGENOMiHOG000113415.
HOVERGENiHBG081940.
InParanoidiQ8N2G4.
OMAiTFCGLFW.
OrthoDBiEOG091G0UX4.
PhylomeDBiQ8N2G4.
TreeFamiTF332325.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8N2G4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWVLGIAATF CGLFLLPGFA LQIQCYQCEE FQLNNDCSSP EFIVNCTVNV
60 70 80 90 100
QDMCQKEVME QSAGIMYRKS CASSAACLIA SAGYQSFCSP GKLNSVCISC
110 120 130 140
CNTPLCNGPR PKKRGSSASA LRPGLRTTIL FLKLALFSAH C
Length:141
Mass (Da):15,240
Last modified:March 7, 2006 - v2
Checksum:iCFA6D98BA90792E3
GO
Isoform 2 (identifier: Q8N2G4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MQAPRAAPAAPLSYDRRPRDSGRM

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):17,762
Checksum:iF0775B25672A1252
GO
Isoform 3 (identifier: Q8N2G4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MWVLG → MQAPRAAPAAPLSYDRRLRGS

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):16,920
Checksum:i126998C032DB6AC5
GO
Isoform 4 (identifier: Q8N2G4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Note: Gene prediction based on EST data.
Show »
Length:89
Mass (Da):9,423
Checksum:i471F6EDA17CC2E71
GO

Sequence cautioni

The sequence BAC11647 differs from that shown. Reason: Frameshift at position 136. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1071N → S in BAC85518 (PubMed:14702039).Curated
Sequence conflicti133 – 1331K → R in BAC85518 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5252Missing in isoform 4. CuratedVSP_046981Add
BLAST
Alternative sequencei1 – 55MWVLG → MQAPRAAPAAPLSYDRRLRG S in isoform 3. 1 PublicationVSP_021583
Alternative sequencei1 – 11M → MQAPRAAPAAPLSYDRRPRD SGRM in isoform 2. 1 PublicationVSP_021584

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358628 mRNA. Translation: AAQ88991.1.
AK094501 mRNA. Translation: BAC04368.1.
AK130005 mRNA. Translation: BAC85273.1.
AK123029 mRNA. Translation: BAC85518.1.
AK075487 mRNA. Translation: BAC11647.1. Frameshift.
AC010974 Genomic DNA. No translation available.
AC079773 Genomic DNA. No translation available.
BC017318 mRNA. Translation: AAH17318.1.
CCDSiCCDS42759.1. [Q8N2G4-1]
CCDS46416.1. [Q8N2G4-4]
RefSeqiNP_001070895.1. NM_001077427.3. [Q8N2G4-4]
NP_001308163.1. NM_001321234.1. [Q8N2G4-3]
NP_001308164.1. NM_001321235.1. [Q8N2G4-4]
NP_653187.3. NM_144586.6. [Q8N2G4-1]
UniGeneiHs.432395.

Genome annotation databases

EnsembliENST00000345008; ENSP00000340563; ENSG00000150551. [Q8N2G4-4]
ENST00000397463; ENSP00000380605; ENSG00000150551. [Q8N2G4-1]
GeneIDi116372.
KEGGihsa:116372.
UCSCiuc002ttn.4. human. [Q8N2G4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358628 mRNA. Translation: AAQ88991.1.
AK094501 mRNA. Translation: BAC04368.1.
AK130005 mRNA. Translation: BAC85273.1.
AK123029 mRNA. Translation: BAC85518.1.
AK075487 mRNA. Translation: BAC11647.1. Frameshift.
AC010974 Genomic DNA. No translation available.
AC079773 Genomic DNA. No translation available.
BC017318 mRNA. Translation: AAH17318.1.
CCDSiCCDS42759.1. [Q8N2G4-1]
CCDS46416.1. [Q8N2G4-4]
RefSeqiNP_001070895.1. NM_001077427.3. [Q8N2G4-4]
NP_001308163.1. NM_001321234.1. [Q8N2G4-3]
NP_001308164.1. NM_001321235.1. [Q8N2G4-4]
NP_653187.3. NM_144586.6. [Q8N2G4-1]
UniGeneiHs.432395.

3D structure databases

ProteinModelPortaliQ8N2G4.
SMRiQ8N2G4. Positions 23-111.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125502. 19 interactions.
MINTiMINT-4723178.
STRINGi9606.ENSP00000380605.

Polymorphism and mutation databases

BioMutaiLYPD1.
DMDMi92058725.

Proteomic databases

PaxDbiQ8N2G4.
PeptideAtlasiQ8N2G4.
PRIDEiQ8N2G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345008; ENSP00000340563; ENSG00000150551. [Q8N2G4-4]
ENST00000397463; ENSP00000380605; ENSG00000150551. [Q8N2G4-1]
GeneIDi116372.
KEGGihsa:116372.
UCSCiuc002ttn.4. human. [Q8N2G4-1]

Organism-specific databases

CTDi116372.
GeneCardsiLYPD1.
HGNCiHGNC:28431. LYPD1.
HPAiCAB020783.
MIMi610450. gene.
neXtProtiNX_Q8N2G4.
PharmGKBiPA134862471.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWWH. Eukaryota.
ENOG410XU3J. LUCA.
GeneTreeiENSGT00390000002215.
HOGENOMiHOG000113415.
HOVERGENiHBG081940.
InParanoidiQ8N2G4.
OMAiTFCGLFW.
OrthoDBiEOG091G0UX4.
PhylomeDBiQ8N2G4.
TreeFamiTF332325.

Miscellaneous databases

GeneWikiiLYPD1.
GenomeRNAii116372.
PROiQ8N2G4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150551.
CleanExiHS_LYPD1.
ExpressionAtlasiQ8N2G4. baseline and differential.
GenevisibleiQ8N2G4. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiLYPD1_HUMAN
AccessioniPrimary (citable) accession number: Q8N2G4
Secondary accession number(s): H7BXW6
, Q6ZP52, Q6ZWI4, Q96AC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.